JP2002544266A5 - - Google Patents

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Publication number
JP2002544266A5
JP2002544266A5 JP2000618253A JP2000618253A JP2002544266A5 JP 2002544266 A5 JP2002544266 A5 JP 2002544266A5 JP 2000618253 A JP2000618253 A JP 2000618253A JP 2000618253 A JP2000618253 A JP 2000618253A JP 2002544266 A5 JP2002544266 A5 JP 2002544266A5
Authority
JP
Japan
Prior art keywords
methyl
benzodiazepin
propanoate
imidazo
pyridinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000618253A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002544266A (ja
JP3773792B2 (ja
Filing date
Publication date
Priority claimed from GBGB9911152.8A external-priority patent/GB9911152D0/en
Application filed filed Critical
Publication of JP2002544266A publication Critical patent/JP2002544266A/ja
Publication of JP2002544266A5 publication Critical patent/JP2002544266A5/ja
Application granted granted Critical
Publication of JP3773792B2 publication Critical patent/JP3773792B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2000618253A 1999-05-14 2000-05-12 短時間作用性ベンゾジアゼピン類 Expired - Lifetime JP3773792B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9911152.8A GB9911152D0 (en) 1999-05-14 1999-05-14 Short-acting benzodiazepines
GB9911152.8 1999-05-14
PCT/US2000/013134 WO2000069836A1 (en) 1999-05-14 2000-05-12 Short-acting benzodiazepines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005353914A Division JP4769562B2 (ja) 1999-05-14 2005-12-07 短時間作用性ベンゾジアゼピン類

Publications (3)

Publication Number Publication Date
JP2002544266A JP2002544266A (ja) 2002-12-24
JP2002544266A5 true JP2002544266A5 (enExample) 2006-02-02
JP3773792B2 JP3773792B2 (ja) 2006-05-10

Family

ID=10853415

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2000618253A Expired - Lifetime JP3773792B2 (ja) 1999-05-14 2000-05-12 短時間作用性ベンゾジアゼピン類
JP2005353914A Expired - Lifetime JP4769562B2 (ja) 1999-05-14 2005-12-07 短時間作用性ベンゾジアゼピン類
JP2007127264A Expired - Lifetime JP4769760B2 (ja) 1999-05-14 2007-05-11 短時間作用性ベンゾジアゼピン類
JP2007127245A Expired - Lifetime JP4769759B2 (ja) 1999-05-14 2007-05-11 短時間作用性ベンゾジアゼピン類

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2005353914A Expired - Lifetime JP4769562B2 (ja) 1999-05-14 2005-12-07 短時間作用性ベンゾジアゼピン類
JP2007127264A Expired - Lifetime JP4769760B2 (ja) 1999-05-14 2007-05-11 短時間作用性ベンゾジアゼピン類
JP2007127245A Expired - Lifetime JP4769759B2 (ja) 1999-05-14 2007-05-11 短時間作用性ベンゾジアゼピン類

Country Status (11)

Country Link
EP (1) EP1183243B1 (enExample)
JP (4) JP3773792B2 (enExample)
AT (1) ATE317390T1 (enExample)
AU (1) AU4846300A (enExample)
DE (1) DE60025921T2 (enExample)
DK (1) DK1183243T3 (enExample)
ES (1) ES2258008T3 (enExample)
GB (1) GB9911152D0 (enExample)
HK (1) HK1042296B (enExample)
PT (1) PT1183243E (enExample)
WO (1) WO2000069836A1 (enExample)

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CN102964349A (zh) * 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途
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EP2864336B1 (en) 2012-06-06 2016-11-23 Constellation Pharmaceuticals, Inc. Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
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CN104146970A (zh) * 2013-05-05 2014-11-19 王元青 治疗精神疾病的冻干粉针剂
CN103230595B (zh) * 2013-05-05 2014-10-08 李友香 治疗精神疾病的组合物
US9969747B2 (en) 2014-06-20 2018-05-15 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide
US9994578B2 (en) 2014-07-23 2018-06-12 Jiangsu Nhwaluokang Pharmceutical Research And Development Co., Ltd Benzodiazepine derivative and use thereof
CN106892924B (zh) * 2015-12-17 2021-01-08 四川科伦博泰生物医药股份有限公司 短效苯并二氮*衍生物、其制备方法及其用途
CN107266452A (zh) * 2016-04-08 2017-10-20 四川科伦药物研究院有限公司 苯并二氮杂*衍生物的盐及其晶体形式、制备方法和用途
KR20180131617A (ko) 2016-04-14 2018-12-10 파이온 유케이 리미티드 경구 흡입 및 비 벤조디아제핀
WO2018035246A1 (en) 2016-08-16 2018-02-22 Uwm Research Foundation, Inc. Gaba(a) receptor modulators and methods to control airway hyperresponsiveness and inflammation in asthma
CN108503644B (zh) * 2016-12-09 2019-06-14 成都倍特药业有限公司 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途
CN108264499B (zh) * 2017-01-04 2020-10-20 江苏恒瑞医药股份有限公司 一种苯并二氮杂*衍生物的制备方法
WO2018196662A1 (zh) * 2017-04-28 2018-11-01 四川科伦博泰生物医药股份有限公司 包含苯并二氮䓬类化合物的注射用组合物及其制备方法
CN108948018B (zh) * 2017-05-17 2021-03-30 四川科伦博泰生物医药股份有限公司 苯并二氮*衍生物及其盐和相关晶体形式、制备方法和用途
ES2697918A1 (es) 2017-07-28 2019-01-29 Moehs Iberica Sl Procedimiento para preparar ester metilico del acido 3-[(3s)-7-bromo-2-oxo-5-(piridin-2-il)-2,3-dihidro-1h-[1,4]-benzodiazepin-3-il] propionico, y compuestos utiles en ese procedimiento
ES2709298B2 (es) 2017-10-13 2019-08-21 Moehs Iberica Sl Procedimiento para preparar metil ester de acido 3-[(4s)-8-bromo-1-metil-6-(piridin-2-il)-4h-imidazo[1,2-a][1,4]benzodiazepin-4-il]-propionico, y compuestos utiles en ese procedimiento
RU2701557C2 (ru) * 2017-11-24 2019-09-30 Общество С Ограниченной Ответственностью "Инновационные Фармакологические Разработки" (Ооо "Ифар") Производные 1,4-бензодиазепин-2-она и их применение
CN108003164A (zh) * 2017-12-15 2018-05-08 宜昌人福药业有限责任公司 苯并二氮杂*类化合物
CN108084187A (zh) * 2017-12-15 2018-05-29 宜昌人福药业有限责任公司 苯并二氮杂*类氢化物
CN107868088A (zh) * 2017-12-15 2018-04-03 宜昌人福药业有限责任公司 苯并二氮杂*类氮氧化物
CN108033964B (zh) * 2017-12-28 2021-02-09 杭州奥默医药股份有限公司 一种吡啶基咪唑并苯并二氮杂卓丙酸酯化合物及其合成和应用
WO2019158075A1 (zh) 2018-02-13 2019-08-22 江苏恩华络康药物研发有限公司 苯二氮卓衍生物盐酸盐与晶型、制备方法及其应用
CN112142746B (zh) * 2019-06-28 2021-09-24 四川大学华西医院 苯二氮卓类化合物及其制备方法和在医药上的作用
ES2803099B2 (es) 2019-07-22 2021-11-08 Moehs Iberica Sl Procedimiento de obtención de besilato de remimazolam amorfo
KR102526590B1 (ko) * 2020-06-19 2023-04-28 하나제약 주식회사 3-[(4S)-8-브로모-1-메틸-6-(2-피리디닐)-4H-이미다조[1,2-a][1,4]벤조디아제핀-4-일]프로피온산 메틸 에스테르의 제조방법
CN112358483A (zh) * 2020-11-09 2021-02-12 中国药科大学 一类新型苯并二氮*类化合物、其制备方法及其用途
CN114644612B (zh) * 2020-12-17 2023-04-28 成都苑东生物制药股份有限公司 一种苯二氮杂类神经抑制剂中间体化合物的制备方法
CN116102557B (zh) * 2021-11-09 2024-04-26 四川大学华西医院 苯二氮卓类化合物及其制备方法和在医药上的用途
CN116253761A (zh) * 2021-12-10 2023-06-13 宜昌人福药业有限责任公司 一种制备瑞马唑仑o-磷酰化中间体的方法
US20250263414A1 (en) * 2022-04-08 2025-08-21 Fresenius Kabi Oncology Limited An improved process for the preparation of remimazolam
CN115322144B (zh) * 2022-08-30 2024-05-24 上海药坦药物研究开发有限公司 一种2-(2-氨基-5-溴-苯甲酰基)吡啶的制备方法
CN115385891A (zh) * 2022-09-06 2022-11-25 上海药坦药物研究开发有限公司 一种瑞马唑仑中间体的制备方法
CN119101054A (zh) * 2023-06-09 2024-12-10 成都麻沸散医药科技有限公司 一种氮杂䓬类化合物及其组合物和应用

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