ATE132974T1 - Test, indikatoren, immunogene und antikörper für benzodiazepine - Google Patents

Test, indikatoren, immunogene und antikörper für benzodiazepine

Info

Publication number
ATE132974T1
ATE132974T1 AT87114982T AT87114982T ATE132974T1 AT E132974 T1 ATE132974 T1 AT E132974T1 AT 87114982 T AT87114982 T AT 87114982T AT 87114982 T AT87114982 T AT 87114982T AT E132974 T1 ATE132974 T1 AT E132974T1
Authority
AT
Austria
Prior art keywords
benzodiazepines
antibodies
assay
immunogenic
indicators
Prior art date
Application number
AT87114982T
Other languages
English (en)
Inventor
Nai-Yi Wang
Candace Linda Keegan
Daniel Fuelner Heiman
Charles Arthur Flentge
Philip Pei Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE132974T1 publication Critical patent/ATE132974T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT87114982T 1986-10-24 1987-10-14 Test, indikatoren, immunogene und antikörper für benzodiazepine ATE132974T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92259586A 1986-10-24 1986-10-24

Publications (1)

Publication Number Publication Date
ATE132974T1 true ATE132974T1 (de) 1996-01-15

Family

ID=25447288

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87114982T ATE132974T1 (de) 1986-10-24 1987-10-14 Test, indikatoren, immunogene und antikörper für benzodiazepine

Country Status (9)

Country Link
EP (1) EP0264797B1 (de)
JP (1) JPH0660166B2 (de)
KR (1) KR880005101A (de)
AT (1) ATE132974T1 (de)
AU (1) AU604766B2 (de)
CA (1) CA1339439C (de)
DE (1) DE3751673T2 (de)
ES (1) ES2084577T3 (de)
GR (1) GR3019283T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352803A (en) * 1992-03-30 1994-10-04 Abbott Laboratories 5(6)-methyl substituted fluorescein derivatives
CA2131727A1 (en) * 1992-03-30 1993-10-14 Diana E. Clarisse Reagents and methods for the detection and quantification of thyroxine in fluid samples
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
US5492841A (en) * 1994-02-18 1996-02-20 E. I. Du Pont De Nemours And Company Quaternary ammonium immunogenic conjugates and immunoassay reagents
DE19503320A1 (de) * 1995-02-02 1996-08-08 Boehringer Mannheim Gmbh Neue Benzodiazepinkonjugate
AU7342496A (en) * 1996-10-25 1998-05-22 Elimo B.V. Non radioactive receptor assay suitable for quantitative and qualitative analysis of trace amounts of receptor binding analyte
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
WO2001010846A2 (en) * 1999-08-05 2001-02-15 Igt Pharma Inc. 1,4-diazepine derivatives for the treatment of diseases related to the central nervous system
US7026166B2 (en) 2002-01-22 2006-04-11 Chiron Corporation Fluorogenic dyes
US7029918B2 (en) * 2002-01-25 2006-04-18 Roche Diagnostics Operations, Inc. Water-soluble derivatives of lipophilic drugs
US7704756B2 (en) 2003-01-21 2010-04-27 Novartis Vaccines And Diagnostics, Inc. Fluorogenic dyes
US9193730B2 (en) 2006-07-10 2015-11-24 Paion Uk Limited Short-acting benzodiazepine salts and their polymorphic forms
EP2450039A1 (de) 2010-11-08 2012-05-09 PAION UK Ltd. Dosierschema zur Sedierung mit CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA714391B (en) * 1970-07-29 1972-04-26 Hoffmann La Roche Benzodiazepine derivatives
CH566324A5 (en) * 1970-10-07 1975-09-15 Hoffmann La Roche 1-Carbamoylalkyl substd. 1,4-benzodiazepin-2-ones prodn - from corresp acids or derivs by reacting with amines, useful as CNS depressants
CH538492A (de) * 1970-10-07 1973-06-30 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
US4243654A (en) * 1978-09-11 1981-01-06 Syva Company Oxazepam derivatives for immunoassay reagents
AT361492B (de) * 1978-12-18 1981-03-10 Gerot Pharmazeutika Verfahren zur herstellung von neuen 3-hydroxy- 1,4-benzodiazepin-2-onen
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
EP0218010A3 (de) * 1985-07-10 1988-01-07 Abbott Laboratories Verfahren zur Bestimmung von Liganden und substituierte Carboxyfluoreszein-Markers zur Durchführung desselben

Also Published As

Publication number Publication date
EP0264797A3 (en) 1990-02-07
AU604766B2 (en) 1991-01-03
JPS63246666A (ja) 1988-10-13
KR880005101A (ko) 1988-06-28
JPH0660166B2 (ja) 1994-08-10
CA1339439C (en) 1997-09-02
EP0264797A2 (de) 1988-04-27
EP0264797B1 (de) 1996-01-10
GR3019283T3 (en) 1996-06-30
DE3751673D1 (de) 1996-02-22
ES2084577T3 (es) 1996-05-16
AU7997587A (en) 1988-04-28
DE3751673T2 (de) 1996-08-01

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