JP2003335776A5 - - Google Patents

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Publication number
JP2003335776A5
JP2003335776A5 JP2002229532A JP2002229532A JP2003335776A5 JP 2003335776 A5 JP2003335776 A5 JP 2003335776A5 JP 2002229532 A JP2002229532 A JP 2002229532A JP 2002229532 A JP2002229532 A JP 2002229532A JP 2003335776 A5 JP2003335776 A5 JP 2003335776A5
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JP
Japan
Prior art keywords
phenyl
benzoazosin
butoxyethoxy
sulfinyl
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002229532A
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English (en)
Japanese (ja)
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JP4316203B2 (ja
JP2003335776A (ja
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Publication of JP2003335776A publication Critical patent/JP2003335776A/ja
Publication of JP2003335776A5 publication Critical patent/JP2003335776A5/ja
Application granted granted Critical
Publication of JP4316203B2 publication Critical patent/JP4316203B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2002229532A 2001-08-08 2002-08-07 二環性化合物、その製造法および用途 Expired - Lifetime JP4316203B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001-240750 2001-08-08
JP2001240750 2001-08-08
JP2002-66809 2002-03-12
JP2002066809 2002-03-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006355701A Division JP4358851B2 (ja) 2001-08-08 2006-12-28 二環性化合物、その製造法および用途

Publications (3)

Publication Number Publication Date
JP2003335776A JP2003335776A (ja) 2003-11-28
JP2003335776A5 true JP2003335776A5 (enExample) 2007-12-13
JP4316203B2 JP4316203B2 (ja) 2009-08-19

Family

ID=26620186

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2002229532A Expired - Lifetime JP4316203B2 (ja) 2001-08-08 2002-08-07 二環性化合物、その製造法および用途
JP2006355701A Expired - Lifetime JP4358851B2 (ja) 2001-08-08 2006-12-28 二環性化合物、その製造法および用途
JP2009147839A Expired - Lifetime JP5275148B2 (ja) 2001-08-08 2009-06-22 二環性化合物、その製造法および用途
JP2013050937A Pending JP2013136629A (ja) 2001-08-08 2013-03-13 二環性化合物、その製造法および用途

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2006355701A Expired - Lifetime JP4358851B2 (ja) 2001-08-08 2006-12-28 二環性化合物、その製造法および用途
JP2009147839A Expired - Lifetime JP5275148B2 (ja) 2001-08-08 2009-06-22 二環性化合物、その製造法および用途
JP2013050937A Pending JP2013136629A (ja) 2001-08-08 2013-03-13 二環性化合物、その製造法および用途

Country Status (13)

Country Link
US (7) US7371772B2 (enExample)
EP (3) EP1423376B1 (enExample)
JP (4) JP4316203B2 (enExample)
AR (1) AR034985A1 (enExample)
AT (2) ATE460406T1 (enExample)
AU (1) AU2002328092A1 (enExample)
CA (2) CA2607992A1 (enExample)
DE (1) DE60235632D1 (enExample)
DK (2) DK1423376T3 (enExample)
ES (2) ES2376855T3 (enExample)
PE (1) PE20030329A1 (enExample)
PT (2) PT1423376E (enExample)
WO (1) WO2003014105A1 (enExample)

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WO2008109591A1 (en) * 2007-03-08 2008-09-12 Lexicon Pharmaceuticals, Inc. Phlorizin analogs as inhibitors of sodium glucose co-transporter 2
BRPI0914457A2 (pt) * 2008-10-17 2015-10-27 Invasc Therapeutics Inc composto, composição farmacêutica, método para reduzir angiotensão convertendo atividade de enzima, método para tratar uma perturbação relacionada com o sistema de renina-angiotensina aldosterona, método para tratar derrame cerebral
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BR112012024522A2 (pt) 2010-04-02 2017-08-08 Phivco 1 Llc combinação, uso de uma combinação, composição farmacêutica, forma de dosagem única , kit, e, método para tratar um distúrbio
WO2012047630A2 (en) * 2010-09-27 2012-04-12 Martin Teintze N-alkyl or n-aryl substituted guanide and biguanide compounds and methods of their use
WO2013024022A1 (en) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary hypertension
JP6556825B2 (ja) * 2014-03-21 2019-08-07 トビラ セラピューティクス， インコーポレイテッド 線維症を処置するためのセニクリビロック
EP3148538A4 (en) * 2014-06-02 2018-01-17 Tobira Therapeutics, Inc. Cenicriviroc for the treatment of hiv-2 infection
AU2015314830B2 (en) 2014-09-12 2021-01-07 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
CN107207538A (zh) * 2014-12-23 2017-09-26 妥必徕疗治公司 制备cenicriviroc及相关类似物的方法
SG11201706028RA (en) 2015-02-10 2017-08-30 Tobira Therapeutics Inc Cenicriviroc for the treatment of fibrosis
KR101938036B1 (ko) * 2015-04-16 2019-01-14 서울대학교산학협력단 고혈압 치료제를 이용한 흡연 및 비흡연자의 폐암 억제 방법
BR112018076449A2 (pt) * 2016-06-21 2019-04-09 Tobira Therapeutics, Inc. cenicriviroc purificado e intermediários purificados para fazer cenicriviroc
TW201823235A (zh) 2016-08-31 2018-07-01 美商托彼拉治療公司 西克里維羅（ｃｅｎｉｃｒｉｖｉｒｏｃ）甲磺酸鹽之固體型式和製造西克里維羅甲磺酸鹽之固體型式的方法
EP3567028B1 (en) * 2016-12-09 2022-01-05 Medshine Discovery Inc. Biphenyl compound as ccr2/ccr5 receptor antagonist
AU2018223976B2 (en) 2017-02-24 2023-08-17 Genfit Pharmaceutical compositions for combination therapy
US11292785B2 (en) 2018-02-02 2022-04-05 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Nitrogen-containing benzoheterocycle compound comprising carboxylic acid group, preparation method and use thereof
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
WO2019238041A1 (zh) * 2018-06-12 2019-12-19 南京明德新药研发有限公司 一种丙烯酰胺类化合物的晶型及其制备方法
WO2020207263A1 (zh) * 2019-04-08 2020-10-15 四川科伦博泰生物医药股份有限公司 苯并咪唑化合物、其制备方法及其用途
EP3988098B1 (en) * 2019-06-24 2024-07-24 Wuxi Life Fountain Biotech Co., Ltd. Heterocyclo alkyl compounds used as ccr2/ccr5 antagonists
WO2021133811A1 (en) 2019-12-26 2021-07-01 Teva Pharmaceuticals International Gmbh Solid state forms of cenicriviroc and process for preparation thereof
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
CN115667247B (zh) * 2020-05-22 2024-04-12 南京明德新药研发有限公司 吡啶类衍生物及其应用
CN112472678A (zh) * 2020-11-12 2021-03-12 澳美制药厂有限公司 肾素那敏制剂及其制备方法
WO2023143112A1 (zh) * 2022-01-26 2023-08-03 无锡瓴方生物医药科技有限公司 氮杂苯并八元环化合物的盐型、晶型及其应用
WO2024240025A1 (zh) * 2023-05-22 2024-11-28 无锡瓴方生物医药科技有限公司 一种联合用药物组合物及其应用

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DK1423376T3 (da) 2001-08-08 2010-06-28 Tobira Therapeutics Inc Bicyklisk forbindelse, fremstilling og anvendelse deraf
CN1649847A (zh) 2002-03-12 2005-08-03 武田药品工业株式会社 制备旋光亚砜衍生物的方法
EP1728505B1 (en) * 2004-03-24 2014-06-04 Takeda Pharmaceutical Company Limited Preparation with elevated content
EP1728504B1 (en) * 2004-03-24 2013-07-31 Takeda Pharmaceutical Company Limited Emulsion stabilizer
EP1825866A4 (en) 2004-12-03 2008-03-12 Takeda Pharmaceutical SOLID PREPARATION
US20080108586A1 (en) 2006-09-06 2008-05-08 Incyte Corporation Combination therapy for human immunodeficiency virus infection
BR112012024522A2 (pt) 2010-04-02 2017-08-08 Phivco 1 Llc combinação, uso de uma combinação, composição farmacêutica, forma de dosagem única , kit, e, método para tratar um distúrbio
BR112013012309A2 (pt) 2010-11-18 2016-08-23 Univ Yale composto, composição, métodos de tratamento e usos de um composto
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KR20160013068A (ko) 2013-05-15 2016-02-03 토비라 쎄라퓨틱스, 인크. 세니크리비록 조성물 및 이들을 만들고 이용하는 방법
JP6556825B2 (ja) 2014-03-21 2019-08-07 トビラ セラピューティクス， インコーポレイテッド 線維症を処置するためのセニクリビロック
CN107207538A (zh) 2014-12-23 2017-09-26 妥必徕疗治公司 制备cenicriviroc及相关类似物的方法
SG11201706028RA (en) 2015-02-10 2017-08-30 Tobira Therapeutics Inc Cenicriviroc for the treatment of fibrosis

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