JP2003335776A5 - - Google Patents

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Publication number
JP2003335776A5
JP2003335776A5 JP2002229532A JP2002229532A JP2003335776A5 JP 2003335776 A5 JP2003335776 A5 JP 2003335776A5 JP 2002229532 A JP2002229532 A JP 2002229532A JP 2002229532 A JP2002229532 A JP 2002229532A JP 2003335776 A5 JP2003335776 A5 JP 2003335776A5
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JP
Japan
Prior art keywords
phenyl
benzoazosin
butoxyethoxy
sulfinyl
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2002229532A
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English (en)
Japanese (ja)
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JP4316203B2 (ja
JP2003335776A (ja
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Publication date
Application filed filed Critical
Publication of JP2003335776A publication Critical patent/JP2003335776A/ja
Publication of JP2003335776A5 publication Critical patent/JP2003335776A5/ja
Application granted granted Critical
Publication of JP4316203B2 publication Critical patent/JP4316203B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2002229532A 2001-08-08 2002-08-07 二環性化合物、その製造法および用途 Expired - Lifetime JP4316203B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001240750 2001-08-08
JP2002066809 2002-03-12
JP2001-240750 2002-03-12
JP2002-66809 2002-03-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006355701A Division JP4358851B2 (ja) 2001-08-08 2006-12-28 二環性化合物、その製造法および用途

Publications (3)

Publication Number Publication Date
JP2003335776A JP2003335776A (ja) 2003-11-28
JP2003335776A5 true JP2003335776A5 (enExample) 2007-12-13
JP4316203B2 JP4316203B2 (ja) 2009-08-19

Family

ID=26620186

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2002229532A Expired - Lifetime JP4316203B2 (ja) 2001-08-08 2002-08-07 二環性化合物、その製造法および用途
JP2006355701A Expired - Lifetime JP4358851B2 (ja) 2001-08-08 2006-12-28 二環性化合物、その製造法および用途
JP2009147839A Expired - Lifetime JP5275148B2 (ja) 2001-08-08 2009-06-22 二環性化合物、その製造法および用途
JP2013050937A Pending JP2013136629A (ja) 2001-08-08 2013-03-13 二環性化合物、その製造法および用途

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2006355701A Expired - Lifetime JP4358851B2 (ja) 2001-08-08 2006-12-28 二環性化合物、その製造法および用途
JP2009147839A Expired - Lifetime JP5275148B2 (ja) 2001-08-08 2009-06-22 二環性化合物、その製造法および用途
JP2013050937A Pending JP2013136629A (ja) 2001-08-08 2013-03-13 二環性化合物、その製造法および用途

Country Status (13)

Country Link
US (7) US7371772B2 (enExample)
EP (3) EP2206702B1 (enExample)
JP (4) JP4316203B2 (enExample)
AR (1) AR034985A1 (enExample)
AT (2) ATE460406T1 (enExample)
AU (1) AU2002328092A1 (enExample)
CA (2) CA2607992A1 (enExample)
DE (1) DE60235632D1 (enExample)
DK (2) DK1423376T3 (enExample)
ES (2) ES2376855T3 (enExample)
PE (1) PE20030329A1 (enExample)
PT (2) PT1423376E (enExample)
WO (1) WO2003014105A1 (enExample)

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WO2005089716A1 (ja) * 2004-03-24 2005-09-29 Takeda Pharmaceutical Company Limited 高含量化製剤
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US7846945B2 (en) * 2007-03-08 2010-12-07 Lexicon Pharmaceuticals, Inc. Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use
CA2741060A1 (en) * 2008-10-17 2010-04-22 Invasc Therapeutics, Inc. Compositions and methods for treatment of renin-angiotensin aldosterone system (raas)-related disorders
MY192644A (en) 2009-11-27 2022-08-29 Genzyme Corp An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase
MX2012011415A (es) 2010-04-02 2013-02-26 Phivco 1 Llc Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico.
WO2012047630A2 (en) * 2010-09-27 2012-04-12 Martin Teintze N-alkyl or n-aryl substituted guanide and biguanide compounds and methods of their use
WO2013024022A1 (en) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treatment of pulmonary hypertension
CA2941411A1 (en) * 2014-03-21 2015-09-24 Tobira Therapeutics, Inc. Cenicriviroc for the treatment of fibrosis
WO2015187663A1 (en) * 2014-06-02 2015-12-10 Tobira Therapeutics, Inc. Cenicriviroc for the treatment of hiv-2 infection
AU2015314830B2 (en) 2014-09-12 2021-01-07 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
SG11201704837VA (en) 2014-12-23 2017-07-28 Tobira Therapeutics Inc Process of making cenicriviroc and related analogs
MX2017010277A (es) 2015-02-10 2017-12-07 Tobira Therapeutics Inc Cenicriviroc para el tratamiento de la fibrosis.
KR101938036B1 (ko) * 2015-04-16 2019-01-14 서울대학교산학협력단 고혈압 치료제를 이용한 흡연 및 비흡연자의 폐암 억제 방법
BR112018076449A2 (pt) * 2016-06-21 2019-04-09 Tobira Therapeutics, Inc. cenicriviroc purificado e intermediários purificados para fazer cenicriviroc
JP2019526628A (ja) 2016-08-31 2019-09-19 トビラ セラピューティクス， インコーポレイテッド セニクリビロクメシレートの固体形態及びセニクリビロクメシレートの固体形態を製造するプロセス
JP7086075B2 (ja) * 2016-12-09 2022-06-17 南京明徳新薬研発有限公司 Ｃｃｒ２／ｃｃｒ５受容体拮抗剤としてのビフェニル化合物
CA3051977A1 (en) 2017-02-24 2018-08-30 Genfit Pharmaceutical compositions for combination therapy
WO2019149089A1 (zh) 2018-02-02 2019-08-08 四川科伦博泰生物医药股份有限公司 含有羧酸基团的苯并氮杂环类化合物及其制备方法和用途
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
WO2019238041A1 (zh) * 2018-06-12 2019-12-19 南京明德新药研发有限公司 一种丙烯酰胺类化合物的晶型及其制备方法
CN113412261A (zh) * 2019-04-08 2021-09-17 四川科伦博泰生物医药股份有限公司 苯并咪唑化合物、其制备方法及其用途
WO2020259620A1 (zh) 2019-06-24 2020-12-30 南京明德新药研发有限公司 作为ccr2/ccr5拮抗剂的杂环烷基类化合物
WO2021133811A1 (en) 2019-12-26 2021-07-01 Teva Pharmaceuticals International Gmbh Solid state forms of cenicriviroc and process for preparation thereof
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
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CN112472678A (zh) * 2020-11-12 2021-03-12 澳美制药厂有限公司 肾素那敏制剂及其制备方法
WO2023143112A1 (zh) * 2022-01-26 2023-08-03 无锡瓴方生物医药科技有限公司 氮杂苯并八元环化合物的盐型、晶型及其应用
WO2024240025A1 (zh) * 2023-05-22 2024-11-28 无锡瓴方生物医药科技有限公司 一种联合用药物组合物及其应用

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CA2384145A1 (en) 1999-09-06 2001-03-15 Takeda Chemical Industries, Ltd. Process for the preparation of 2,3-dihydroazepine compounds
US7371772B2 (en) * 2001-08-08 2008-05-13 Takeda Pharmaceutical Company Limited Bicyclic compound, production and use thereof
JP2004123694A (ja) 2002-03-12 2004-04-22 Takeda Chem Ind Ltd 光学活性スルホキシド誘導体の製造法
EP1728504B1 (en) * 2004-03-24 2013-07-31 Takeda Pharmaceutical Company Limited Emulsion stabilizer
WO2005089716A1 (ja) * 2004-03-24 2005-09-29 Takeda Pharmaceutical Company Limited 高含量化製剤
EP1825866A4 (en) 2004-12-03 2008-03-12 Takeda Pharmaceutical SOLID PREPARATION
WO2008030853A2 (en) 2006-09-06 2008-03-13 Incyte Corporation Combination therapy for human immunodeficiency virus infection
MX2012011415A (es) 2010-04-02 2013-02-26 Phivco 1 Llc Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico.
CA2818308A1 (en) 2010-11-18 2012-05-24 Yale University Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus
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KR20160013068A (ko) 2013-05-15 2016-02-03 토비라 쎄라퓨틱스, 인크. 세니크리비록 조성물 및 이들을 만들고 이용하는 방법
CA2941411A1 (en) 2014-03-21 2015-09-24 Tobira Therapeutics, Inc. Cenicriviroc for the treatment of fibrosis
SG11201704837VA (en) 2014-12-23 2017-07-28 Tobira Therapeutics Inc Process of making cenicriviroc and related analogs
MX2017010277A (es) 2015-02-10 2017-12-07 Tobira Therapeutics Inc Cenicriviroc para el tratamiento de la fibrosis.

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