DK1423376T3 - Bicyklisk forbindelse, fremstilling og anvendelse deraf - Google Patents
Bicyklisk forbindelse, fremstilling og anvendelse derafInfo
- Publication number
- DK1423376T3 DK1423376T3 DK02762751.2T DK02762751T DK1423376T3 DK 1423376 T3 DK1423376 T3 DK 1423376T3 DK 02762751 T DK02762751 T DK 02762751T DK 1423376 T3 DK1423376 T3 DK 1423376T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- bicyclic compound
- bicyclic
- compound
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/16—Eight-membered rings
- C07D313/20—Eight-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001240750 | 2001-08-08 | ||
JP2002066809 | 2002-03-12 | ||
PCT/JP2002/008043 WO2003014105A1 (en) | 2001-08-08 | 2002-08-07 | Bicyclic compound, production and use as hiv inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1423376T3 true DK1423376T3 (da) | 2010-06-28 |
Family
ID=26620186
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02762751.2T DK1423376T3 (da) | 2001-08-08 | 2002-08-07 | Bicyklisk forbindelse, fremstilling og anvendelse deraf |
DK10150963.6T DK2206702T3 (da) | 2001-08-08 | 2002-08-07 | Bicyklisk forbindelse, fremstilling og anvendelse deraf |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10150963.6T DK2206702T3 (da) | 2001-08-08 | 2002-08-07 | Bicyklisk forbindelse, fremstilling og anvendelse deraf |
Country Status (14)
Country | Link |
---|---|
US (7) | US7371772B2 (da) |
EP (3) | EP2206702B1 (da) |
JP (4) | JP4316203B2 (da) |
AR (1) | AR034985A1 (da) |
AT (2) | ATE539062T1 (da) |
AU (1) | AU2002328092A1 (da) |
CA (2) | CA2459172C (da) |
DE (1) | DE60235632D1 (da) |
DK (2) | DK1423376T3 (da) |
ES (2) | ES2339340T3 (da) |
HK (1) | HK1142886A1 (da) |
PE (1) | PE20030329A1 (da) |
PT (2) | PT1423376E (da) |
WO (1) | WO2003014105A1 (da) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2459172C (en) | 2001-08-08 | 2011-07-05 | Takeda Chemical Industries, Ltd. | Bicyclic compound, production and use thereof |
WO2003076411A1 (fr) * | 2002-03-12 | 2003-09-18 | Takeda Pharmaceutical Company Limited | Procede de production d'un derive sulfoxyde actif sur le plan optique |
EP1593680A4 (en) | 2003-02-07 | 2008-05-07 | Takeda Pharmaceutical | PYRIDINE DERIVATIVES WITH CONDENSED RING, PROCESS FOR THEIR PREPARATION AND USE |
WO2004069834A1 (ja) * | 2003-02-07 | 2004-08-19 | Takeda Pharmaceutical Company Limited | 三環性化合物、その製造方法および用途 |
US20060160864A1 (en) * | 2003-02-07 | 2006-07-20 | Mitsuru Shiraishi | Acrylamide derivative, process for producing the same, and use |
CA2560298A1 (en) * | 2004-03-24 | 2005-09-29 | Takeda Pharmaceutical Company Limited | Preparation with elevated content |
WO2005089714A1 (ja) * | 2004-03-24 | 2005-09-29 | Takeda Pharmaceutical Company Limited | エマルション安定化製剤 |
US20050260139A1 (en) * | 2004-03-30 | 2005-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on anticholinergics and CCR2 receptor antagonists |
JP2007269628A (ja) * | 2004-05-28 | 2007-10-18 | Takeda Chem Ind Ltd | 医薬化合物の結晶 |
JPWO2006059716A1 (ja) * | 2004-12-03 | 2008-06-05 | 武田薬品工業株式会社 | 固形製剤 |
US8426387B2 (en) * | 2006-03-31 | 2013-04-23 | Stephen Carper | Treatments for cancer |
WO2008030853A2 (en) * | 2006-09-06 | 2008-03-13 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
TWI499414B (zh) * | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第2型共同運輸體(co-transporter 2)的抑制物與其應用方法 |
US7846945B2 (en) * | 2007-03-08 | 2010-12-07 | Lexicon Pharmaceuticals, Inc. | Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use |
JP2012505919A (ja) * | 2008-10-17 | 2012-03-08 | インヴアスク セラピューテイックス インコーポレイテッド | レニン−アンギオテンシンアルドステロン系関連疾病の治療用組成物及び治療方法。 |
KR20200013105A (ko) | 2009-11-27 | 2020-02-05 | 젠자임 코포레이션 | 글루코실세라마이드 신타아제의 억제제로서 genz 112638 헤미타르타르산염의 무정형 및 결정질 형태 |
PE20130529A1 (es) | 2010-04-02 | 2013-05-14 | Phivco 1 Llc | Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico |
WO2012047630A2 (en) * | 2010-09-27 | 2012-04-12 | Martin Teintze | N-alkyl or n-aryl substituted guanide and biguanide compounds and methods of their use |
US20140271680A1 (en) | 2011-08-12 | 2014-09-18 | Universite Paris-Est Creteil Val De Marne | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
EP3922246A1 (en) * | 2014-03-21 | 2021-12-15 | Tobira Therapeutics, Inc. | Cenicriviroc for the treatment of fibrosis |
MA39991A (fr) * | 2014-06-02 | 2015-12-10 | Tobira Therapeutics Inc | Cénicriviroc pour le traitement de l'infection à vih-2 |
AU2015314830B2 (en) | 2014-09-12 | 2021-01-07 | Tobira Therapeutics, Inc. | Cenicriviroc combination therapy for the treatment of fibrosis |
BR112017013130A2 (pt) * | 2014-12-23 | 2017-12-26 | Tobira Therapeutics Inc | processo de fabricação de cenicriviroc e análogos relacionados |
RU2722641C2 (ru) | 2015-02-10 | 2020-06-02 | Тобира Терапьютикс, Инк. | Ценикривирок для лечения заболеваний печени и перитонита |
KR101938036B1 (ko) * | 2015-04-16 | 2019-01-14 | 서울대학교산학협력단 | 고혈압 치료제를 이용한 흡연 및 비흡연자의 폐암 억제 방법 |
CN109862890A (zh) | 2016-06-21 | 2019-06-07 | 妥必徕疗治公司 | 纯化cenicriviroc和用于制备cenicriviroc的纯化中间体 |
JP2019526628A (ja) | 2016-08-31 | 2019-09-19 | トビラ セラピューティクス, インコーポレイテッド | セニクリビロクメシレートの固体形態及びセニクリビロクメシレートの固体形態を製造するプロセス |
US11155523B2 (en) | 2016-12-09 | 2021-10-26 | Medshine Discovery, Inc. | Biphenyl compound as CCR2/CCR5 receptor antagonist |
EP3585384A1 (en) | 2017-02-24 | 2020-01-01 | Genfit | Pharmaceutical compositions for combination therapy |
KR20200116912A (ko) | 2018-02-02 | 2020-10-13 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 카르복실산기를 포함하는 질소-함유 벤조헤테로시클 화합물, 이의 제조 방법 및 이의 용도 |
EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHIC RESIN WITH A LIGAND WITH ANION EXCHANGE-HYDROPHOBIC MIXED MODE |
WO2019238041A1 (zh) * | 2018-06-12 | 2019-12-19 | 南京明德新药研发有限公司 | 一种丙烯酰胺类化合物的晶型及其制备方法 |
WO2020207263A1 (zh) * | 2019-04-08 | 2020-10-15 | 四川科伦博泰生物医药股份有限公司 | 苯并咪唑化合物、其制备方法及其用途 |
WO2020259620A1 (zh) | 2019-06-24 | 2020-12-30 | 南京明德新药研发有限公司 | 作为ccr2/ccr5拮抗剂的杂环烷基类化合物 |
WO2021133811A1 (en) | 2019-12-26 | 2021-07-01 | Teva Pharmaceuticals International Gmbh | Solid state forms of cenicriviroc and process for preparation thereof |
US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
AU2021276287A1 (en) | 2020-05-22 | 2023-01-19 | Medshine Discovery Inc. | Pyridine derivative and application thereof |
CN112472678A (zh) * | 2020-11-12 | 2021-03-12 | 澳美制药厂有限公司 | 肾素那敏制剂及其制备方法 |
WO2023143112A1 (zh) * | 2022-01-26 | 2023-08-03 | 无锡瓴方生物医药科技有限公司 | 氮杂苯并八元环化合物的盐型、晶型及其应用 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62265270A (ja) | 1986-05-13 | 1987-11-18 | Zeria Shinyaku Kogyo Kk | 新規イミダゾ−ル誘導体およびそれらを有効成分とする抗潰瘍剤 |
CN1151744A (zh) | 1994-07-04 | 1997-06-11 | 武田药品工业株式会社 | 膦酸化合物及其制备和应用 |
RU2167649C2 (ru) | 1995-08-11 | 2001-05-27 | Ниссан Кемикал Индастриз, Лтд. | Способ получения твердой дисперсии умеренно водорастворимого лекарственного вещества (варианты) и фармацевтическая композиция |
DK1038525T3 (da) | 1997-10-20 | 2004-08-02 | Dainippon Pharmaceutical Co | Stabiliseret farmaceutisk præparat af tetrahydropyrrolo[1,2-a]pyrazin-4-spiro-3'-pyrrolidin |
BR9813691A (pt) * | 1997-12-19 | 2000-10-10 | Takeda Chemical Industries Ltd | Composição farmacêutica para antagonizar o ccr5, uso do composto ou um sal deste em combinação com um inibidor de protease e/ou um inibidor da transcriptase reversa, e, processo para antagonizar o ccr5. |
WO2000010965A2 (en) | 1998-08-20 | 2000-03-02 | Takeda Chemical Industries, Ltd. | Quaternary ammonium salts and their use as anti-hiv agents |
CA2244097A1 (en) | 1998-08-21 | 2000-02-21 | Bernard Charles Sherman | Pharmaceutical composition comprising bupropion hydrochloride and fumaric acid |
WO2000037455A1 (en) | 1998-12-21 | 2000-06-29 | Takeda Chemical Industries, Ltd. | Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5 |
WO2000061109A1 (fr) | 1999-04-12 | 2000-10-19 | Shionogi & Co., Ltd. | Procede de production de composition medicamenteuse renfermant un compose medicamenteux hydrophobe basique |
JP2001026586A (ja) | 1999-05-07 | 2001-01-30 | Takeda Chem Ind Ltd | 環状化合物およびその用途 |
AU6870600A (en) | 1999-09-06 | 2001-04-10 | Takeda Chemical Industries Ltd. | Process for the preparation of 2,3-dihydroazepine compounds |
CA2459172C (en) * | 2001-08-08 | 2011-07-05 | Takeda Chemical Industries, Ltd. | Bicyclic compound, production and use thereof |
WO2003076411A1 (fr) | 2002-03-12 | 2003-09-18 | Takeda Pharmaceutical Company Limited | Procede de production d'un derive sulfoxyde actif sur le plan optique |
CA2560298A1 (en) * | 2004-03-24 | 2005-09-29 | Takeda Pharmaceutical Company Limited | Preparation with elevated content |
WO2005089714A1 (ja) * | 2004-03-24 | 2005-09-29 | Takeda Pharmaceutical Company Limited | エマルション安定化製剤 |
JPWO2006059716A1 (ja) * | 2004-12-03 | 2008-06-05 | 武田薬品工業株式会社 | 固形製剤 |
WO2008030853A2 (en) | 2006-09-06 | 2008-03-13 | Incyte Corporation | Combination therapy for human immunodeficiency virus infection |
PE20130529A1 (es) | 2010-04-02 | 2013-05-14 | Phivco 1 Llc | Terapia de combinacion que comprende un antagonista de ccr5, un inhibidor de proteasa de vih-1, y un potenciador farmacocinetico |
EA201390726A1 (ru) | 2010-11-18 | 2014-06-30 | Йельский Университет | Бифункциональные молекулы с активностью, привлекающей антитела и ингибирующей проникновение вируса иммунодефицита человека |
ES2636679T3 (es) | 2011-06-27 | 2017-10-06 | Université Pierre Et Marie Curie (Paris 6) | Péptidos antagonistas de CCR2 |
JP6391674B2 (ja) | 2013-05-15 | 2018-09-19 | トビラ セラピューティクス, インコーポレイテッド | セニクリビロック組成物並びにその製造及び使用方法 |
EP3922246A1 (en) | 2014-03-21 | 2021-12-15 | Tobira Therapeutics, Inc. | Cenicriviroc for the treatment of fibrosis |
BR112017013130A2 (pt) | 2014-12-23 | 2017-12-26 | Tobira Therapeutics Inc | processo de fabricação de cenicriviroc e análogos relacionados |
RU2722641C2 (ru) | 2015-02-10 | 2020-06-02 | Тобира Терапьютикс, Инк. | Ценикривирок для лечения заболеваний печени и перитонита |
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2002
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- 2002-08-07 AU AU2002328092A patent/AU2002328092A1/en not_active Abandoned
- 2002-08-07 PT PT02762751T patent/PT1423376E/pt unknown
- 2002-08-07 ES ES02762751T patent/ES2339340T3/es not_active Expired - Lifetime
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- 2002-08-07 DK DK02762751.2T patent/DK1423376T3/da active
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- 2002-08-07 WO PCT/JP2002/008043 patent/WO2003014105A1/en active Application Filing
- 2002-08-07 DK DK10150963.6T patent/DK2206702T3/da active
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- 2002-08-07 CA CA002607992A patent/CA2607992A1/en not_active Abandoned
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2006
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2007
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2008
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2009
- 2009-06-22 JP JP2009147839A patent/JP5275148B2/ja not_active Expired - Lifetime
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2010
- 2010-09-27 HK HK10109225.6A patent/HK1142886A1/xx not_active IP Right Cessation
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2012
- 2012-05-21 US US13/476,454 patent/US8741943B2/en not_active Expired - Lifetime
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2013
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2014
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2018
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