ATE199721T1 - Phosphonsäure verbindungen imre herstellung und verwendung - Google Patents

Phosphonsäure verbindungen imre herstellung und verwendung

Info

Publication number
ATE199721T1
ATE199721T1 AT95923575T AT95923575T ATE199721T1 AT E199721 T1 ATE199721 T1 AT E199721T1 AT 95923575 T AT95923575 T AT 95923575T AT 95923575 T AT95923575 T AT 95923575T AT E199721 T1 ATE199721 T1 AT E199721T1
Authority
AT
Austria
Prior art keywords
ring
group
pct
substituted
formula
Prior art date
Application number
AT95923575T
Other languages
English (en)
Inventor
Takashi Sohda
Shigehisa Taketomi
Tsuneo Oda
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE199721T1 publication Critical patent/ATE199721T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882—Arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655381—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring
    • C07F9/65539—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95923575T 1994-07-04 1995-07-03 Phosphonsäure verbindungen imre herstellung und verwendung ATE199721T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15248294 1994-07-04
PCT/JP1995/001328 WO1996001267A1 (en) 1994-07-04 1995-07-03 Phosphonic acid compounds, their production and use

Publications (1)

Publication Number Publication Date
ATE199721T1 true ATE199721T1 (de) 2001-03-15

Family

ID=15541464

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95923575T ATE199721T1 (de) 1994-07-04 1995-07-03 Phosphonsäure verbindungen imre herstellung und verwendung

Country Status (8)

Country Link
US (1) US5716944A (de)
EP (1) EP0769015B1 (de)
CN (1) CN1151744A (de)
AT (1) ATE199721T1 (de)
AU (1) AU2808495A (de)
CA (1) CA2191980A1 (de)
DE (1) DE69520360T2 (de)
WO (1) WO1996001267A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2188011C2 (ru) * 1995-06-05 2002-08-27 Такеда Кемикал Индастриз, Лтд. Активирующая остеогенез фармацевтическая композиция
US5910492A (en) * 1995-06-05 1999-06-08 Takeda Chemical Industries, Ltd. Osteogenic promoting pharmaceutical composition
JP2001524468A (ja) * 1997-11-21 2001-12-04 エヌピーエス ファーマシューティカルズ インコーポレーテッド 中枢神経系疾患を治療するための代謝調節型グルタミン酸受容体アンタゴニスト
ZA9811576B (en) * 1997-12-19 2000-06-19 Takeda Chemical Industries Ltd Anilide derivative, production and use thereof.
BR9813691A (pt) 1997-12-19 2000-10-10 Takeda Chemical Industries Ltd Composição farmacêutica para antagonizar o ccr5, uso do composto ou um sal deste em combinação com um inibidor de protease e/ou um inibidor da transcriptase reversa, e, processo para antagonizar o ccr5.
WO1999045016A2 (en) 1998-03-06 1999-09-10 Metabasis Therapeutics, Inc. Novel prodrugs for phosphorus-containing compounds
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
CA2337307A1 (en) 1998-08-20 2000-03-02 Osamu Nishimura Quaternary ammonium salts and their use
CA2353635A1 (en) 1998-12-21 2000-06-29 Takeda Chemical Industries, Ltd. Anilide derivative, production and use thereof
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
EP1182195A4 (de) 1999-05-07 2003-03-26 Takeda Chemical Industries Ltd Cyclische verbindungen und anwendungen davon
AU4777500A (en) 1999-05-18 2000-12-05 Takeda Chemical Industries Ltd. Processes for the preparation of 2,3-dihydrothiepine derivatives
AU5426500A (en) 1999-06-16 2001-01-02 Takeda Chemical Industries Ltd. Benzazepine derivatives, process for the preparation of the same and uses thereof
MXPA02002624A (es) * 1999-09-13 2002-07-30 Wyeth Corp Composiciones farmaceuticas y metodos de uso de proteinas secretadas relacionadas con la familia "frizzled".
JP4316203B2 (ja) 2001-08-08 2009-08-19 トビラ セラピューティクス インク 二環性化合物、その製造法および用途
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
CA2479071A1 (en) * 2002-03-12 2003-09-18 Hiroyuki Tawada Process for producing optically active sulfoxide derivative
AU2003213436A1 (en) * 2002-03-12 2003-09-22 Ube Industries, Ltd. Method for preparing 6,7-dihydroxycoumarin-3-carboxy compound
CA2485597C (en) 2002-05-13 2013-07-02 Metabasis Therapeutics, Inc. Process for preparation of cyclic prodrugs of pmea and pmpa
JP4476811B2 (ja) 2002-05-13 2010-06-09 メタバシス・セラピューティクス・インコーポレイテッド Ｐｍｅａおよびそのアナログの新規ホスホン酸系プロドラッグ
WO2004041837A1 (en) 2002-10-31 2004-05-21 Metabasis Therapeutics, Inc. Novel cytarabine monophosphate prodrugs
WO2004069834A1 (ja) * 2003-02-07 2004-08-19 Takeda Pharmaceutical Company Limited 三環性化合物、その製造方法および用途
US20060160864A1 (en) * 2003-02-07 2006-07-20 Mitsuru Shiraishi Acrylamide derivative, process for producing the same, and use
WO2004069833A1 (ja) * 2003-02-07 2004-08-19 Takeda Pharmaceutical Company Limited 縮環ピリジン誘導体、その製造法および用途
RU2403237C2 (ru) * 2004-05-14 2010-11-10 Эмисфире Текнолоджис, Инк. Составы и смеси для доставки активных агентов
CN1964967B (zh) 2004-06-08 2014-04-16 症变治疗公司 路易斯酸介导的环状酯的合成
GB201102468D0 (en) * 2011-02-11 2011-03-30 Univ Manchester Biocompatible composite materials
EP3105238A4 (de) 2014-02-13 2017-11-08 Ligand Pharmaceuticals, Inc. Organische verbindungen und deren verwendungen
WO2016003812A1 (en) 2014-07-02 2016-01-07 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
US20170327457A1 (en) 2014-09-09 2017-11-16 Bristol-Myers Squibb Company Phenyl-(aza)cycloalkyl carboxylic acid gpr120 modulators
CN104497043B (zh) * 2014-11-28 2016-09-14 浙江大学 芳醛与h-膦酸酯脱氢偶联制备甲酰基芳基膦酸酯的方法
AU2015371250B2 (en) 2014-12-23 2021-01-28 Tobira Therapeutics, Inc. Process of making cenicriviroc and related analogs
RU2019101242A (ru) 2016-06-21 2020-07-21 Тобира Терапьютикс, Инк. Очищенный ценикривирок и очищенные промежуточные соединения для получения ценикривирока
AU2017321594A1 (en) 2016-08-31 2019-04-18 Tobira Therapeutics, Inc. Solid forms of cenicriviroc mesylate and processes of making solid forms of cenicriviroc mesylate
CN106822089B (zh) * 2017-01-23 2019-09-20 广州中大南沙科技创新产业园有限公司 一类苯內酰烯酯酰胺类衍生物在制备抗骨质疏松药物中的应用
CN107019687B (zh) * 2017-05-08 2020-10-27 上海市伤骨科研究所 N-(4-氯苯基)-3-羟基-2-萘甲酰胺类化合物的用途
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85700A0 (en) * 1987-03-24 1988-08-31 Takeda Chemical Industries Ltd 1,4-disubstituted piperazine compounds,their production and use
EP0318235A3 (de) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. PAF-Antagonist, 1,4-disubstituierte Piperazin-Verbindungen und deren Herstellung
DK656789A (da) * 1988-12-28 1990-06-29 Takeda Chemical Industries Ltd Benzoheterocykliske forbindelser
ATE203020T1 (de) * 1990-05-30 2001-07-15 Takeda Chemical Industries Ltd Schwefel enthaltende heterocyclische verbindungen
JP3165866B2 (ja) * 1990-06-06 2001-05-14 武田薬品工業株式会社 含硫黄複素環化合物
US5300687A (en) * 1991-07-18 1994-04-05 Ortho Pharmaceutical Corporation Trifluoromethylbenzylphosphonates useful in treating osteoporosis
EP0625522B1 (de) * 1993-05-18 1998-08-19 Takeda Chemical Industries, Ltd. Benzopyran-Derivate und ihre Verwendung

Also Published As

Publication number Publication date
WO1996001267A1 (en) 1996-01-18
EP0769015B1 (de) 2001-03-14
US5716944A (en) 1998-02-10
DE69520360D1 (de) 2001-04-19
CA2191980A1 (en) 1996-01-18
EP0769015A1 (de) 1997-04-23
CN1151744A (zh) 1997-06-11
DE69520360T2 (de) 2001-08-09
AU2808495A (en) 1996-01-25

Similar Documents

Publication Publication Date Title
DE69520360D1 (de) Phosphonsäure verbindungen imre herstellung und verwendung
NZ511739A (en) New esters derived from substituted phenyl-cyclohexyl compounds
AU5899896A (en) Diaryldiamine derivatives and their use as delta opioid (ant)-agonists
SE0104334D0 (sv) Therapeutic agents
ATE268752T1 (de) Aralkyl-1,2-diaminen mit calcimimetischer wirkung und verfahren zu ihrer herstellung
NZ331549A (en) Compounds useful in treating sexual dysfunction
ATE43344T1 (de) Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verf. zu ihrer herstellung u. pharmakologische zubereitungen, insb. zur behandlung von knochentumoren.
TW427979B (en) A condensed piperidine compound
ZA952531B (en) Indeno [1,2-e]pyrazin-4-ones and preparation thereof
DE59409248D1 (de) Verwendung von Phenalkylaminen zur Herstellung von cholesterinsenkenden Arzneimitteln
DE60228724D1 (de) Verfahren zur herstellung von beraprost und dessen salzen
ATE18549T1 (de) 1-carboxyalkanoylindolin-2-carbonsaeure-ester, verfahren zu ihrer herstellung, pharmazeutische praeparate enthaltend diese verbindungen, sowie ihre therapeutische verwendung.
HUP0301553A2 (hu) Gyógyászati készítmények és alkalmazásuk neurológiai rendellenességek kezelésére
DE69508781D1 (de) Texol-derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
DE69917615D1 (de) Ein verfahren zur herstellung von (2s,2'r,3'r)-2-(2,3-dicarboxycyclopropyl)-glycin
ATE193209T1 (de) Kontrastmittel
ATE206113T1 (de) Verfahren zur herstellung von substituierten 4- ethylpiperidinen
DE69616357D1 (de) Benzocycloalken-verbindungen mit bindungsaffinität an den melatonin-rezeptor, ihre herstellung und verwendung
DE69725167D1 (de) N-benzolsulfonyl-l-prolin derivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung
NO902449D0 (no) Fremgangsmaate for fremstilling av p-substituerte propan-fosfinsyre forbindelser.
ES8707951A1 (es) Derivados de tetrazol
DE69412085D1 (de) Neues verfahren zur herstellung von beta-alkoxyacrylsäure
ATE114318T1 (de) Ausgangsverbindungen für die herstellung von 10- g(b)-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen.
ATE245986T1 (de) Verwendung von 8-nitro-2,3,4,5-tetrahydro-1h-3- benzazepinen zur herstellung von pharmazeutischen zusammenstellungen zur behandlung von schlafstörungen
DE59403035D1 (de) Neue bis(aminomethyl)phosphinsäure-derivate und verfahren zur herstellung von bis(aminomethyl)phosphinsäure-derivaten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties