JP2002534508A5 - - Google Patents
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- Publication number
- JP2002534508A5 JP2002534508A5 JP2000593588A JP2000593588A JP2002534508A5 JP 2002534508 A5 JP2002534508 A5 JP 2002534508A5 JP 2000593588 A JP2000593588 A JP 2000593588A JP 2000593588 A JP2000593588 A JP 2000593588A JP 2002534508 A5 JP2002534508 A5 JP 2002534508A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- phenyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100694 | 1999-01-15 | ||
| EP99100694.1 | 1999-01-15 | ||
| PCT/EP2000/000172 WO2000042020A1 (en) | 1999-01-15 | 2000-01-12 | Phenylphenanthridines with pde-iv inhibiting activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002534508A JP2002534508A (ja) | 2002-10-15 |
| JP2002534508A5 true JP2002534508A5 (https=) | 2007-03-01 |
| JP4653314B2 JP4653314B2 (ja) | 2011-03-16 |
Family
ID=8237351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000593588A Expired - Fee Related JP4653314B2 (ja) | 1999-01-15 | 2000-01-12 | Ｐｄｅ−ｉｖ阻害作用を有するフェニルフェナントリジン |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6476025B1 (https=) |
| EP (2) | EP1650193A3 (https=) |
| JP (1) | JP4653314B2 (https=) |
| KR (1) | KR100720906B1 (https=) |
| CN (1) | CN1152864C (https=) |
| AT (1) | ATE312081T1 (https=) |
| AU (1) | AU774868B2 (https=) |
| BG (1) | BG65126B1 (https=) |
| BR (1) | BR0007527B1 (https=) |
| CA (1) | CA2359440C (https=) |
| CY (1) | CY1106436T1 (https=) |
| CZ (1) | CZ300366B6 (https=) |
| DE (1) | DE60024581T2 (https=) |
| DK (1) | DK1147089T3 (https=) |
| EA (1) | EA003780B1 (https=) |
| EE (1) | EE05105B1 (https=) |
| ES (1) | ES2254132T3 (https=) |
| HK (1) | HK1040997B (https=) |
| HR (1) | HRP20010578A2 (https=) |
| HU (1) | HU227624B1 (https=) |
| ID (1) | ID29070A (https=) |
| IL (2) | IL144026A0 (https=) |
| NO (1) | NO320182B1 (https=) |
| NZ (1) | NZ512872A (https=) |
| PL (1) | PL205670B1 (https=) |
| RS (1) | RS50297B (https=) |
| SI (1) | SI1147089T1 (https=) |
| SK (1) | SK286946B6 (https=) |
| TR (2) | TR200501553T2 (https=) |
| UA (1) | UA69436C2 (https=) |
| WO (1) | WO2000042020A1 (https=) |
| ZA (1) | ZA200104864B (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002006238A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines |
| AU2003253408A1 (en) * | 2002-08-17 | 2004-03-11 | Nycomed Gmbh | Novel phenanthridines |
| CA2495827C (en) | 2002-08-29 | 2012-05-08 | Altana Pharma Ag | 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| ES2281658T3 (es) * | 2002-08-29 | 2007-10-01 | Nycomed Gmbh | 3-hidroxi-6-fenilfenantridinas como inhibidores de pde-4. |
| US6894061B2 (en) | 2002-12-04 | 2005-05-17 | Wyeth | Substituted dihydrophenanthridinesulfonamides |
| EP1658270A1 (en) * | 2003-07-31 | 2006-05-24 | ALTANA Pharma AG | Novel 6-phenylphenantridines |
| CA2533636A1 (en) * | 2003-07-31 | 2005-02-10 | Altana Pharma Ag | Novel 6-phenylphenanthridines |
| WO2005023253A1 (en) * | 2003-09-05 | 2005-03-17 | Altana Pharma Ag | Use of pde4 inhibitors for the treatment of diabetes mellitus |
| AU2005212857B2 (en) * | 2004-02-18 | 2011-04-28 | Takeda Gmbh | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| CN104803974A (zh) | 2004-03-03 | 2015-07-29 | 塔科达有限责任公司 | 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途 |
| JP2007527899A (ja) * | 2004-03-09 | 2007-10-04 | アルタナ ファルマ アクチエンゲゼルシャフト | 新規のイソアミド置換されたヒドロキシ−６−フェニルフェナントリジン |
| CA2558390A1 (en) * | 2004-03-10 | 2005-09-22 | Altana Pharma Ag | Novel thio-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| JP2007527901A (ja) * | 2004-03-10 | 2007-10-04 | アルタナ ファルマ アクチエンゲゼルシャフト | アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用 |
| EP1725532A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| CA2579000C (en) * | 2004-09-08 | 2013-02-05 | Altana Pharma Ag | Novel 3-thia-10-aza-phenanthrene derivatives |
| US7411093B2 (en) * | 2004-12-20 | 2008-08-12 | Hoffman-La Roche Inc. | Aminocycloalkanes as DPP-IV inhibitors |
| ES2337083T3 (es) * | 2005-03-02 | 2010-04-20 | Nycomed Gmbh | (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1. |
| AU2006222060B2 (en) | 2005-03-08 | 2011-09-01 | Takeda Gmbh | Roflumilast for the treatment of diabetes mellitus |
| CA2599368A1 (en) * | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
| MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
| WO2013096744A1 (en) | 2011-12-21 | 2013-06-27 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
| EA038942B1 (ru) | 2012-08-28 | 2021-11-12 | Янссен Сайенсиз Айрлэнд Юси | Сульфамоил-ариламиды и их применение в качестве лекарственных препаратов для лечения гепатита b |
| HUE034820T2 (en) | 2013-02-28 | 2018-02-28 | Janssen Sciences Ireland Uc | Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B |
| EA027068B1 (ru) | 2013-04-03 | 2017-06-30 | Янссен Сайенсиз Айрлэнд Юси | Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b |
| EA035500B1 (ru) | 2013-05-17 | 2020-06-25 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b |
| TWI651300B (zh) | 2013-05-17 | 2019-02-21 | 健生科學愛爾蘭無限公司 | 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途 |
| DK3024819T3 (en) | 2013-07-25 | 2018-06-06 | Janssen Sciences Ireland Uc | GLYOXAMIDE-SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B |
| KR102290189B1 (ko) | 2013-10-23 | 2021-08-17 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도 |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| JP6553059B2 (ja) | 2014-02-05 | 2019-07-31 | ノヴィラ・セラピューティクス・インコーポレイテッド | Ｈｂｖ感染の治療のための併用療法 |
| WO2015118057A1 (en) | 2014-02-06 | 2015-08-13 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| EP3271019A1 (en) | 2015-03-19 | 2018-01-24 | Novira Therapeutics Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| HK1259410A1 (zh) | 2015-09-29 | 2019-11-29 | 诺维拉治疗公司 | 乙型肝炎抗病毒剂的晶体形式 |
| SG10202011827YA (en) | 2016-04-15 | 2021-01-28 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
| CA3090125A1 (en) | 2018-03-14 | 2019-09-19 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| MX2021010145A (es) | 2019-02-22 | 2021-09-14 | Janssen Sciences Ireland Unlimited Co | Derivados de amida utiles en el tratamiento de una infeccion por vhb o de enfermedades inducidas por vhb. |
| MA55879A (fr) | 2019-05-06 | 2022-03-16 | Janssen Sciences Ireland Unlimited Co | Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899494A (en) * | 1970-05-13 | 1975-08-12 | Sandoz Ltd | Substituted 6-phenyl benzo-naphthyridines |
| UA48216C2 (uk) | 1996-01-31 | 2002-08-15 | Бік Гулден Ломберг Кеміше Фабрік Гмбх | Фенантридини та лікарський засіб для лікування захворювань дихальних шляхів |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| WO1997035854A1 (de) * | 1996-03-26 | 1997-10-02 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue in 6-position substituierte phenanthridine |
| EE03829B1 (et) * | 1996-11-11 | 2002-08-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim |
| JP2001514640A (ja) | 1997-03-07 | 2001-09-11 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規のテトラゾール |
| CA2291153A1 (en) | 1997-06-03 | 1998-12-10 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine |
| DE69822162T2 (de) * | 1997-07-25 | 2005-01-27 | Altana Pharma Ag | Neue tetrazolderivate |
| JP2001510827A (ja) * | 1997-07-25 | 2001-08-07 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 置換６−フェニルフェナントリジン |
| ATE294793T1 (de) * | 1999-01-15 | 2005-05-15 | Altana Pharma Ag | Phenantrhridin-n-oxides mit pde-iv hemmender wirkung |
| WO2000042019A1 (en) * | 1999-01-15 | 2000-07-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 6-arylphenanthridines with pde-iv inhibiting activity |
| SI1147087T1 (en) * | 1999-01-15 | 2005-10-31 | Altana Pharma Ag | Phenanthridine-n-oxides with pde-iv inhibiting activity |
-
2000
- 2000-01-12 EP EP05108689A patent/EP1650193A3/en not_active Withdrawn
- 2000-01-12 EA EA200100731A patent/EA003780B1/ru not_active IP Right Cessation
- 2000-01-12 KR KR1020017008670A patent/KR100720906B1/ko not_active Expired - Fee Related
- 2000-01-12 TR TR2005/01553T patent/TR200501553T2/xx unknown
- 2000-01-12 ES ES00901534T patent/ES2254132T3/es not_active Expired - Lifetime
- 2000-01-12 EP EP00901534A patent/EP1147089B1/en not_active Expired - Lifetime
- 2000-01-12 EE EEP200100350A patent/EE05105B1/xx not_active IP Right Cessation
- 2000-01-12 CA CA002359440A patent/CA2359440C/en not_active Expired - Fee Related
- 2000-01-12 NZ NZ512872A patent/NZ512872A/en not_active IP Right Cessation
- 2000-01-12 SI SI200030806T patent/SI1147089T1/sl unknown
- 2000-01-12 PL PL348925A patent/PL205670B1/pl unknown
- 2000-01-12 AU AU22896/00A patent/AU774868B2/en not_active Ceased
- 2000-01-12 WO PCT/EP2000/000172 patent/WO2000042020A1/en not_active Ceased
- 2000-01-12 CN CNB008027951A patent/CN1152864C/zh not_active Expired - Fee Related
- 2000-01-12 HU HU0105001A patent/HU227624B1/hu not_active IP Right Cessation
- 2000-01-12 DK DK00901534T patent/DK1147089T3/da active
- 2000-01-12 AT AT00901534T patent/ATE312081T1/de active
- 2000-01-12 DE DE60024581T patent/DE60024581T2/de not_active Expired - Lifetime
- 2000-01-12 BR BRPI0007527-2A patent/BR0007527B1/pt not_active IP Right Cessation
- 2000-01-12 IL IL14402600A patent/IL144026A0/xx active IP Right Grant
- 2000-01-12 HR HR20010578A patent/HRP20010578A2/hr not_active Application Discontinuation
- 2000-01-12 SK SK980-2001A patent/SK286946B6/sk not_active IP Right Cessation
- 2000-01-12 US US09/889,144 patent/US6476025B1/en not_active Expired - Lifetime
- 2000-01-12 TR TR2001/01938T patent/TR200101938T2/xx unknown
- 2000-01-12 RS YUP-487/01A patent/RS50297B/sr unknown
- 2000-01-12 ID IDW00200101411A patent/ID29070A/id unknown
- 2000-01-12 HK HK02102714.9A patent/HK1040997B/en not_active IP Right Cessation
- 2000-01-12 CZ CZ20012248A patent/CZ300366B6/cs not_active IP Right Cessation
- 2000-01-12 JP JP2000593588A patent/JP4653314B2/ja not_active Expired - Fee Related
- 2000-12-01 UA UA2001085778A patent/UA69436C2/uk unknown
-
2001
- 2001-06-04 BG BG105561A patent/BG65126B1/bg unknown
- 2001-06-14 ZA ZA200104864A patent/ZA200104864B/en unknown
- 2001-06-27 IL IL144026A patent/IL144026A/en not_active IP Right Cessation
- 2001-07-05 NO NO20013341A patent/NO320182B1/no not_active IP Right Cessation
-
2006
- 2006-02-14 CY CY20061100209T patent/CY1106436T1/el unknown
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