CN1152864C - 具有pde-iv抑制活性的苯基菲啶类化合物 - Google Patents

具有pde-iv抑制活性的苯基菲啶类化合物 Download PDF

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Publication number
CN1152864C
CN1152864C CNB008027951A CN00802795A CN1152864C CN 1152864 C CN1152864 C CN 1152864C CN B008027951 A CNB008027951 A CN B008027951A CN 00802795 A CN00802795 A CN 00802795A CN 1152864 C CN1152864 C CN 1152864C
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China
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phenyl
hydrogen
group
compound
alkyl
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Expired - Fee Related
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CNB008027951A
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English (en)
Chinese (zh)
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CN1336919A (zh
Inventor
D
D·弗洛克尔兹
H·阿姆施勒
G·格伦德勒
A·哈策尔曼
D·邦德苏
÷
R·贝伊梅
H·波斯
H·-P·克利
B·古特雷尔
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Takeda GmbH
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Altana Pharma AG
Byk Gulden Lomberg Chemische Fabrik GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P27/14—Decongestants or antiallergics
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
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CNB008027951A 1999-01-15 2000-01-12 具有pde-iv抑制活性的苯基菲啶类化合物 Expired - Fee Related CN1152864C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99100694 1999-01-15
EP99100694.1 1999-01-15

Publications (2)

Publication Number Publication Date
CN1336919A CN1336919A (zh) 2002-02-20
CN1152864C true CN1152864C (zh) 2004-06-09

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CNB008027951A Expired - Fee Related CN1152864C (zh) 1999-01-15 2000-01-12 具有pde-iv抑制活性的苯基菲啶类化合物

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Country Link
US (1) US6476025B1 (https=)
EP (2) EP1650193A3 (https=)
JP (1) JP4653314B2 (https=)
KR (1) KR100720906B1 (https=)
CN (1) CN1152864C (https=)
AT (1) ATE312081T1 (https=)
AU (1) AU774868B2 (https=)
BG (1) BG65126B1 (https=)
BR (1) BR0007527B1 (https=)
CA (1) CA2359440C (https=)
CY (1) CY1106436T1 (https=)
CZ (1) CZ300366B6 (https=)
DE (1) DE60024581T2 (https=)
DK (1) DK1147089T3 (https=)
EA (1) EA003780B1 (https=)
EE (1) EE05105B1 (https=)
ES (1) ES2254132T3 (https=)
HK (1) HK1040997B (https=)
HR (1) HRP20010578A2 (https=)
HU (1) HU227624B1 (https=)
ID (1) ID29070A (https=)
IL (2) IL144026A0 (https=)
NO (1) NO320182B1 (https=)
NZ (1) NZ512872A (https=)
PL (1) PL205670B1 (https=)
RS (1) RS50297B (https=)
SI (1) SI1147089T1 (https=)
SK (1) SK286946B6 (https=)
TR (2) TR200501553T2 (https=)
UA (1) UA69436C2 (https=)
WO (1) WO2000042020A1 (https=)
ZA (1) ZA200104864B (https=)

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US6894061B2 (en) 2002-12-04 2005-05-17 Wyeth Substituted dihydrophenanthridinesulfonamides
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AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
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JP2007527899A (ja) * 2004-03-09 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規のイソアミド置換されたヒドロキシ−６−フェニルフェナントリジン
CA2558390A1 (en) * 2004-03-10 2005-09-22 Altana Pharma Ag Novel thio-containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
JP2007527901A (ja) * 2004-03-10 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
EP1725532A1 (en) * 2004-03-10 2006-11-29 Altana Pharma AG Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors
CA2579000C (en) * 2004-09-08 2013-02-05 Altana Pharma Ag Novel 3-thia-10-aza-phenanthrene derivatives
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EA027068B1 (ru) 2013-04-03 2017-06-30 Янссен Сайенсиз Айрлэнд Юси Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b
EA035500B1 (ru) 2013-05-17 2020-06-25 Янссен Сайенсиз Айрлэнд Юси Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b
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