YU48701A - Fenilfenantridini sa dejstvom inhibicije pde-iv - Google Patents

Fenilfenantridini sa dejstvom inhibicije pde-iv

Info

Publication number
YU48701A
YU48701A YU48701A YUP48701A YU48701A YU 48701 A YU48701 A YU 48701A YU 48701 A YU48701 A YU 48701A YU P48701 A YUP48701 A YU P48701A YU 48701 A YU48701 A YU 48701A
Authority
YU
Yugoslavia
Prior art keywords
phenylphenanthridines
pde
inhibiting activity
compounds
formula
Prior art date
Application number
YU48701A
Other languages
English (en)
Inventor
Beate Gutterer
Dieter Flockerzi
Hermann Amschler
Gerhard Grundler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Original Assignee
Altana Pharm Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharm Ag. filed Critical Altana Pharm Ag.
Publication of YU48701A publication Critical patent/YU48701A/sh
Publication of RS50297B publication Critical patent/RS50297B/sr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P11/02—Nasal agents, e.g. decongestants
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P11/16—Central respiratory analeptics
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    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
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  • Dermatology (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Hospice & Palliative Care (AREA)
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Abstract

Jedinjenje formule (I) u kojima R1, R2, R3, R31, R4, R5, R51, R6, R13 i R20 imaju značenja naznačena u opisu, i predstavljaju nove aktivne bronhijalne lekove.
YUP-487/01A 1999-01-15 2000-01-12 Fenilfenantridini sa dejstvom inhibicije pde-iv RS50297B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99100694 1999-01-15

Publications (2)

Publication Number Publication Date
YU48701A true YU48701A (sh) 2004-05-12
RS50297B RS50297B (sr) 2009-09-08

Family

ID=8237351

Country Status (32)

Country Link
US (1) US6476025B1 (sh)
EP (2) EP1147089B1 (sh)
JP (1) JP4653314B2 (sh)
KR (1) KR100720906B1 (sh)
CN (1) CN1152864C (sh)
AT (1) ATE312081T1 (sh)
AU (1) AU774868B2 (sh)
BG (1) BG65126B1 (sh)
BR (1) BR0007527B1 (sh)
CA (1) CA2359440C (sh)
CY (1) CY1106436T1 (sh)
CZ (1) CZ300366B6 (sh)
DE (1) DE60024581T2 (sh)
DK (1) DK1147089T3 (sh)
EA (1) EA003780B1 (sh)
EE (1) EE05105B1 (sh)
ES (1) ES2254132T3 (sh)
HK (1) HK1040997B (sh)
HR (1) HRP20010578A2 (sh)
HU (1) HU227624B1 (sh)
ID (1) ID29070A (sh)
IL (2) IL144026A0 (sh)
NO (1) NO320182B1 (sh)
NZ (1) NZ512872A (sh)
PL (1) PL205670B1 (sh)
RS (1) RS50297B (sh)
SI (1) SI1147089T1 (sh)
SK (1) SK286946B6 (sh)
TR (2) TR200101938T2 (sh)
UA (1) UA69436C2 (sh)
WO (1) WO2000042020A1 (sh)
ZA (1) ZA200104864B (sh)

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CN104803973A (zh) 2004-03-03 2015-07-29 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
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BRPI0609371A2 (pt) 2005-03-08 2010-03-30 Nycomed Gmbh usos de roflumilast na produção de composições farmacêuticas para o tratamento de diabetes mellitus
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IL144026A (en) 2007-05-15
UA69436C2 (uk) 2004-09-15
HUP0105001A3 (en) 2002-10-28
PL348925A1 (en) 2002-06-17
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IL144026A0 (en) 2002-04-21
DE60024581T2 (de) 2006-08-10
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BR0007527A (pt) 2001-12-04
BG65126B1 (bg) 2007-03-30
SI1147089T1 (sl) 2006-04-30
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