JP2006502183A5 - - Google Patents
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- JP2006502183A5 JP2006502183A5 JP2004537690A JP2004537690A JP2006502183A5 JP 2006502183 A5 JP2006502183 A5 JP 2006502183A5 JP 2004537690 A JP2004537690 A JP 2004537690A JP 2004537690 A JP2004537690 A JP 2004537690A JP 2006502183 A5 JP2006502183 A5 JP 2006502183A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- inhibitor
- kinase inhibitor
- norleusyl
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003112 inhibitor Substances 0.000 claims 9
- 230000015572 biosynthetic process Effects 0.000 claims 7
- 238000003786 synthesis reaction Methods 0.000 claims 7
- 102000004127 Cytokines Human genes 0.000 claims 5
- 108090000695 Cytokines Proteins 0.000 claims 5
- 229940043355 kinase inhibitor Drugs 0.000 claims 4
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 4
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 3
- 206010013774 Dry eye Diseases 0.000 claims 3
- 108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- RMWVZGDJPAKBDE-UHFFFAOYSA-N 2-acetyloxy-4-(trifluoromethyl)benzoic acid Chemical compound CC(=O)OC1=CC(C(F)(F)F)=CC=C1C(O)=O RMWVZGDJPAKBDE-UHFFFAOYSA-N 0.000 claims 1
- 102100034613 Annexin A2 Human genes 0.000 claims 1
- 229940115462 I kappa kinase inhibitor Drugs 0.000 claims 1
- PQFMNVGMJJMLAE-QMMMGPOBSA-N L-tyrosinamide Chemical compound NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 PQFMNVGMJJMLAE-QMMMGPOBSA-N 0.000 claims 1
- 229940122696 MAP kinase inhibitor Drugs 0.000 claims 1
- 102100023482 Mitogen-activated protein kinase 14 Human genes 0.000 claims 1
- 102000034527 Retinoid X Receptors Human genes 0.000 claims 1
- 108010038912 Retinoid X Receptors Proteins 0.000 claims 1
- VSPFURGQAYMVAN-UHFFFAOYSA-N SB220025 Chemical compound NC1=NC=CC(C=2N(C=NC=2C=2C=CC(F)=CC=2)C2CCNCC2)=N1 VSPFURGQAYMVAN-UHFFFAOYSA-N 0.000 claims 1
- NAVMQTYZDKMPEU-UHFFFAOYSA-N Targretin Chemical compound CC1=CC(C(CCC2(C)C)(C)C)=C2C=C1C(=C)C1=CC=C(C(O)=O)C=C1 NAVMQTYZDKMPEU-UHFFFAOYSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 108091006088 activator proteins Proteins 0.000 claims 1
- 229960002938 bexarotene Drugs 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000003226 mitogen Substances 0.000 claims 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 229960002268 triflusal Drugs 0.000 claims 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41246302P | 2002-09-20 | 2002-09-20 | |
| PCT/US2003/026689 WO2004026406A1 (en) | 2002-09-20 | 2003-08-26 | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006502183A JP2006502183A (ja) | 2006-01-19 |
| JP2006502183A5 true JP2006502183A5 (https=) | 2006-08-17 |
Family
ID=32030872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004537690A Pending JP2006502183A (ja) | 2002-09-20 | 2003-08-26 | ドライアイ障害の処置のためのサイトカイン合成インヒビターの使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7026296B2 (https=) |
| EP (1) | EP1542768A1 (https=) |
| JP (1) | JP2006502183A (https=) |
| KR (1) | KR20050057175A (https=) |
| CN (1) | CN1684738A (https=) |
| AR (1) | AR041262A1 (https=) |
| AU (1) | AU2003278727A1 (https=) |
| BR (1) | BR0314603A (https=) |
| CA (1) | CA2497977A1 (https=) |
| MX (1) | MXPA05003063A (https=) |
| PL (1) | PL374700A1 (https=) |
| TW (1) | TW200404534A (https=) |
| WO (1) | WO2004026406A1 (https=) |
| ZA (1) | ZA200502119B (https=) |
Families Citing this family (61)
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| JP2006516546A (ja) * | 2002-11-15 | 2006-07-06 | サングスタット メディカル コーポレイション | 間質性膀胱炎の治療用細胞調節性ペプチド |
| WO2004093878A1 (en) | 2003-04-16 | 2004-11-04 | Alcon, Inc. | Use of fused pyridazine derivatives for treating dry eye disorders |
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| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
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| DK2444079T3 (en) | 2005-05-17 | 2017-01-30 | Sarcode Bioscience Inc | Compositions and Methods for the Treatment of Eye Diseases |
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| BRPI0610876B8 (pt) | 2005-06-08 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, formulação farmacêutica, e métodos de inibir uma atividade de uma jak cinase, e de inibir uma cascata de transdução de sinal em que jak3 cinase desempenha um papel |
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| ES2830024T3 (es) | 2007-10-19 | 2021-06-02 | Novartis Ag | Composiciones y métodos para el tratamiento del edema macular |
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| AR076794A1 (es) | 2009-05-22 | 2011-07-06 | Incyte Corp | Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen |
| SI2432472T1 (sl) | 2009-05-22 | 2019-11-29 | Incyte Holdings Corp | 3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK |
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| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| JP2015500213A (ja) * | 2011-11-30 | 2015-01-05 | ザイジェン インフラメーション リミテッド | 眼乾燥症候群を処置するためのｊｎｋシグナル伝達経路の細胞透過性ペプチド阻害剤の使用 |
| WO2013091670A1 (en) * | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
| KR20200108932A (ko) | 2012-07-25 | 2020-09-21 | 에스에이알코드 바이오사이언스 인코포레이티드 | Lfa-1 저해제 및 그의 다형체 |
| PH12020551186B1 (en) | 2012-11-15 | 2024-03-20 | Incyte Holdings Corp | Sustained-release dosage forms of ruxolitinib |
| RS62867B1 (sr) | 2013-03-06 | 2022-02-28 | Incyte Holdings Corp | Postupci i intermedijeri za dobijanje inhibitora jak |
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| KR20160023669A (ko) | 2013-06-26 | 2016-03-03 | 자이겐 인플라메이션 리미티드 | 다양한 질병의 치료를 위한 jnk 신호 전달 경로의 세포 투과성 펩타이드 억제자의 새로운 용도 |
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| AU2001288271A1 (en) | 2000-08-17 | 2002-02-25 | Harrihar A. Pershadsingh | Methods for treating inflammatory diseases |
| US20020151491A1 (en) | 2000-11-28 | 2002-10-17 | Jian-Dong Li | Composition and method for treating the over-production of mucin in diseases such as otitis media using an inhibitor of MUC5AC |
| US20020132823A1 (en) * | 2001-01-17 | 2002-09-19 | Jiahuai Han | Assay method |
| GB0108770D0 (en) * | 2001-04-06 | 2001-05-30 | Eisai London Res Lab Ltd | Inhibitors |
| JP2004527578A (ja) | 2001-05-21 | 2004-09-09 | アルコン，インコーポレイテッド | ドライアイ障害を処置するためのＮＦ−κＢインヒビターの使用 |
| PT1511516E (pt) | 2002-05-28 | 2009-02-20 | Nycomed Gmbh | Preparação farmacêutica para aplicação tópica |
| EP1542768A1 (en) * | 2002-09-20 | 2005-06-22 | Alcon, Inc. | Use of cytokine synthesis inhibitors for the treatment of dry eye disorders |
-
2003
- 2003-08-26 EP EP03770254A patent/EP1542768A1/en not_active Withdrawn
- 2003-08-26 PL PL03374700A patent/PL374700A1/xx not_active Application Discontinuation
- 2003-08-26 WO PCT/US2003/026689 patent/WO2004026406A1/en not_active Ceased
- 2003-08-26 CN CNA03822514XA patent/CN1684738A/zh active Pending
- 2003-08-26 CA CA002497977A patent/CA2497977A1/en not_active Abandoned
- 2003-08-26 KR KR1020057003759A patent/KR20050057175A/ko not_active Withdrawn
- 2003-08-26 MX MXPA05003063A patent/MXPA05003063A/es not_active Application Discontinuation
- 2003-08-26 US US10/650,006 patent/US7026296B2/en not_active Expired - Fee Related
- 2003-08-26 AU AU2003278727A patent/AU2003278727A1/en not_active Abandoned
- 2003-08-26 JP JP2004537690A patent/JP2006502183A/ja active Pending
- 2003-08-26 BR BR0314603-0A patent/BR0314603A/pt not_active IP Right Cessation
- 2003-09-04 TW TW092124459A patent/TW200404534A/zh unknown
- 2003-09-15 AR ARP030103339A patent/AR041262A1/es not_active Application Discontinuation
-
2005
- 2005-03-14 ZA ZA200502119A patent/ZA200502119B/en unknown
-
2006
- 2006-03-28 US US11/390,874 patent/US20060189541A1/en not_active Abandoned
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