JP2002509154A5 - - Google Patents
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- Publication number
- JP2002509154A5 JP2002509154A5 JP2000540143A JP2000540143A JP2002509154A5 JP 2002509154 A5 JP2002509154 A5 JP 2002509154A5 JP 2000540143 A JP2000540143 A JP 2000540143A JP 2000540143 A JP2000540143 A JP 2000540143A JP 2002509154 A5 JP2002509154 A5 JP 2002509154A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- sulfo
- tri
- glucopyranosyl
- anhydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical class [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 150000003385 sodium Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR98/00514 | 1998-01-19 | ||
| FR9800514A FR2773801B1 (fr) | 1998-01-19 | 1998-01-19 | Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant |
| PCT/FR1999/000045 WO1999036428A1 (fr) | 1998-01-19 | 1999-01-13 | Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002509154A JP2002509154A (ja) | 2002-03-26 |
| JP2002509154A5 true JP2002509154A5 (enExample) | 2006-02-16 |
| JP4695756B2 JP4695756B2 (ja) | 2011-06-08 |
Family
ID=9521913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000540143A Expired - Fee Related JP4695756B2 (ja) | 1998-01-19 | 1999-01-13 | 新規な五糖類、その製造法およびそれを含む医薬組成物 |
Country Status (38)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2814463B1 (fr) * | 2000-09-22 | 2002-11-15 | Sanofi Synthelabo | Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine |
| CN100513398C (zh) | 2002-12-03 | 2009-07-15 | Axys药物公司 | 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物 |
| KR101156273B1 (ko) * | 2004-03-04 | 2012-06-13 | 프로젠 파마슈티칼즈 리미티드 | 황산화 올리고사카라이드 유도체 |
| CN100338084C (zh) * | 2004-07-02 | 2007-09-19 | 北京大学 | 抑制异种器官移植免疫排斥反应的五糖抗原的合成方法 |
| FR2874924B1 (fr) | 2004-09-09 | 2006-12-01 | Sanofi Aventis Sa | Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique |
| TWI403334B (zh) | 2004-12-23 | 2013-08-01 | Merck Sharp & Dohme | 包含生物素殘基之抗血栓雙重抑制劑 |
| TWI376234B (en) * | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| US20070191306A1 (en) * | 2005-08-17 | 2007-08-16 | Bristol-Myers Squibb Company | FACTOR Xa INHIBITOR FORMULATION AND METHOD |
| EP1908768A1 (en) * | 2006-10-05 | 2008-04-09 | Endotis Pharma | Anticoagulant compounds |
| CN102046781A (zh) | 2008-05-30 | 2011-05-04 | 动量制药公司 | 糖结构以及制造和使用此类结构的方法 |
| WO2010029552A1 (en) * | 2008-09-10 | 2010-03-18 | Transpharma Medical Ltd. | Transdermal delivery of oligosaccharides |
| WO2011014793A2 (en) * | 2009-07-31 | 2011-02-03 | Reliable Biopharmaceutical Corporation | Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof |
| US8420790B2 (en) | 2009-10-30 | 2013-04-16 | Reliable Biopharmaceutical Corporation | Efficient and scalable process for the manufacture of Fondaparinux sodium |
| CN103917552B (zh) * | 2011-06-17 | 2017-03-29 | 卡博梅麦特斯公司 | 具有短半衰期和高活性的合成五糖 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0300099A1 (en) * | 1987-07-20 | 1989-01-25 | Akzo N.V. | New pentasaccharides |
| DK0454220T3 (da) * | 1990-04-23 | 1993-11-22 | Sanofi Elf | Carbohydratderivater omfattende en trisaccharidenhed |
| IL102758A (en) * | 1991-08-23 | 1997-03-18 | Akzo Nv | Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them |
| FR2704226B1 (fr) * | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| ES2147216T3 (es) * | 1993-09-01 | 2000-09-01 | Akzo Nobel Nv | Bisconjugados que comprenden dos sacaridos y un grupo de union. |
| FR2751334B1 (fr) * | 1996-07-19 | 1998-10-16 | Sanofi Sa | Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant |
-
1998
- 1998-01-19 FR FR9800514A patent/FR2773801B1/fr not_active Expired - Lifetime
-
1999
- 1999-01-13 TR TR2000/02077T patent/TR200002077T2/xx unknown
- 1999-01-13 SI SI9930357T patent/SI1049706T1/xx unknown
- 1999-01-13 WO PCT/FR1999/000045 patent/WO1999036428A1/fr not_active Ceased
- 1999-01-13 DE DE69908298T patent/DE69908298T2/de not_active Expired - Lifetime
- 1999-01-13 BR BRPI9907100-2B1A patent/BR9907100B1/pt not_active IP Right Cessation
- 1999-01-13 UA UA2000074112A patent/UA61124C2/xx unknown
- 1999-01-13 JP JP2000540143A patent/JP4695756B2/ja not_active Expired - Fee Related
- 1999-01-13 SK SK1079-2000A patent/SK284176B6/sk not_active IP Right Cessation
- 1999-01-13 ES ES99900525T patent/ES2200494T3/es not_active Expired - Lifetime
- 1999-01-13 RU RU2000119750/04A patent/RU2193040C2/ru not_active IP Right Cessation
- 1999-01-13 NZ NZ505614A patent/NZ505614A/xx not_active IP Right Cessation
- 1999-01-13 CZ CZ20002636A patent/CZ299817B6/cs not_active IP Right Cessation
- 1999-01-13 AU AU19746/99A patent/AU744137B2/en not_active Ceased
- 1999-01-13 PL PL341874A patent/PL191098B1/pl unknown
- 1999-01-13 AT AT99900525T patent/ATE241637T1/de active
- 1999-01-13 HU HU0102042A patent/HU228335B1/hu not_active IP Right Cessation
- 1999-01-13 PT PT99900525T patent/PT1049706E/pt unknown
- 1999-01-13 IL IL13724099A patent/IL137240A0/xx active IP Right Grant
- 1999-01-13 US US09/600,516 patent/US6670338B1/en not_active Expired - Lifetime
- 1999-01-13 EE EEP200000421A patent/EE04194B1/xx unknown
- 1999-01-13 CA CA2318326A patent/CA2318326C/en not_active Expired - Fee Related
- 1999-01-13 DZ DZ990007A patent/DZ2706A1/xx active
- 1999-01-13 CN CNB998041386A patent/CN1172948C/zh not_active Expired - Fee Related
- 1999-01-13 KR KR10-2000-7007850A patent/KR100533565B1/ko not_active Expired - Fee Related
- 1999-01-13 DK DK99900525T patent/DK1049706T3/da active
- 1999-01-13 EP EP99900525A patent/EP1049706B1/fr not_active Expired - Lifetime
- 1999-01-16 EG EG5599A patent/EG23760A/xx active
- 1999-01-18 TW TW088100711A patent/TW550267B/zh active
- 1999-01-18 MY MYPI99000205A patent/MY125636A/en unknown
- 1999-01-18 AR ARP990100171A patent/AR012779A1/es active IP Right Grant
- 1999-01-18 UY UY25357A patent/UY25357A1/es not_active IP Right Cessation
- 1999-01-19 GT GT199900006A patent/GT199900006A/es unknown
- 1999-01-19 ZA ZA9900357A patent/ZA99357B/xx unknown
- 1999-01-19 CO CO99002525A patent/CO4970823A1/es unknown
- 1999-02-27 SA SA99191114A patent/SA99191114B1/ar unknown
-
2000
- 2000-07-10 IL IL137240A patent/IL137240A/en not_active IP Right Cessation
- 2000-07-17 NO NO20003661A patent/NO316894B1/no not_active IP Right Cessation
-
2001
- 2001-02-28 HR HRP20000479AA patent/HRP20000479A8/hr not_active IP Right Cessation
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