FR2773801B1 - Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant - Google Patents

Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant

Info

Publication number
FR2773801B1
FR2773801B1 FR9800514A FR9800514A FR2773801B1 FR 2773801 B1 FR2773801 B1 FR 2773801B1 FR 9800514 A FR9800514 A FR 9800514A FR 9800514 A FR9800514 A FR 9800514A FR 2773801 B1 FR2773801 B1 FR 2773801B1
Authority
FR
France
Prior art keywords
pentasaccharides
preparations
novel
methods
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9800514A
Other languages
English (en)
French (fr)
Other versions
FR2773801A1 (fr
Inventor
Maurice Petitou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9800514A priority Critical patent/FR2773801B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to HU0102042A priority patent/HU228335B1/hu
Priority to KR10-2000-7007850A priority patent/KR100533565B1/ko
Priority to US09/600,516 priority patent/US6670338B1/en
Priority to AU19746/99A priority patent/AU744137B2/en
Priority to PL341874A priority patent/PL191098B1/pl
Priority to UA2000074112A priority patent/UA61124C2/xx
Priority to DK99900525T priority patent/DK1049706T3/da
Priority to CA2318326A priority patent/CA2318326C/en
Priority to DZ990007A priority patent/DZ2706A1/xx
Priority to PT99900525T priority patent/PT1049706E/pt
Priority to HK01101002.3A priority patent/HK1029999B/xx
Priority to JP2000540143A priority patent/JP4695756B2/ja
Priority to CZ20002636A priority patent/CZ299817B6/cs
Priority to ES99900525T priority patent/ES2200494T3/es
Priority to SK1079-2000A priority patent/SK284176B6/sk
Priority to BRPI9907100-2B1A priority patent/BR9907100B1/pt
Priority to NZ505614A priority patent/NZ505614A/xx
Priority to AT99900525T priority patent/ATE241637T1/de
Priority to CNB998041386A priority patent/CN1172948C/zh
Priority to SI9930357T priority patent/SI1049706T1/xx
Priority to EEP200000421A priority patent/EE04194B1/xx
Priority to PCT/FR1999/000045 priority patent/WO1999036428A1/fr
Priority to RU2000119750/04A priority patent/RU2193040C2/ru
Priority to TR2000/02077T priority patent/TR200002077T2/xx
Priority to EP99900525A priority patent/EP1049706B1/fr
Priority to IL13724099A priority patent/IL137240A0/xx
Priority to DE69908298T priority patent/DE69908298T2/de
Priority to EG5599A priority patent/EG23760A/xx
Priority to MYPI99000205A priority patent/MY125636A/en
Priority to UY25357A priority patent/UY25357A1/es
Priority to ARP990100171A priority patent/AR012779A1/es
Priority to TW088100711A priority patent/TW550267B/zh
Priority to GT199900006A priority patent/GT199900006A/es
Priority to CO99002525A priority patent/CO4970823A1/es
Priority to ZA9900357A priority patent/ZA99357B/xx
Priority to SA99191114A priority patent/SA99191114B1/ar
Publication of FR2773801A1 publication Critical patent/FR2773801A1/fr
Application granted granted Critical
Publication of FR2773801B1 publication Critical patent/FR2773801B1/fr
Priority to IL137240A priority patent/IL137240A/en
Priority to NO20003661A priority patent/NO316894B1/no
Priority to HRP20000479AA priority patent/HRP20000479B8/hr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FR9800514A 1998-01-19 1998-01-19 Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant Expired - Lifetime FR2773801B1 (fr)

Priority Applications (40)

Application Number Priority Date Filing Date Title
FR9800514A FR2773801B1 (fr) 1998-01-19 1998-01-19 Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
KR10-2000-7007850A KR100533565B1 (ko) 1998-01-19 1999-01-13 신규한 오당류, 이의 제조방법 및 이를 포함하는 제약 조성물
US09/600,516 US6670338B1 (en) 1998-01-19 1999-01-13 Pentasaccharides processes for their preparation and pharmaceutical compositions containing them
AU19746/99A AU744137B2 (en) 1998-01-19 1999-01-13 New pentasaccharides, their methods of production and pharmaceutical compositions containing same
PL341874A PL191098B1 (pl) 1998-01-19 1999-01-13 Pentasacharyd, kompozycja farmaceutyczna zawierająca ten pentasacharyd oraz jego zastosowanie
UA2000074112A UA61124C2 (en) 1998-01-19 1999-01-13 New pentasaccharides, a method for preparing thereof and pharmaceutical compositions containing them
DK99900525T DK1049706T3 (da) 1998-01-19 1999-01-13 Hidtil ukendte pentasaccharider, fremgangsmåder til deres fremstilling og farmaceutiske præparater, der indeholder dem
CA2318326A CA2318326C (en) 1998-01-19 1999-01-13 Novel pentasaccharides, processes for their preparation and pharmaceutical compositions containing them
DZ990007A DZ2706A1 (fr) 1998-01-19 1999-01-13 Nouveaux pentasaccharides procédés pour leur préparations et compositions.
PT99900525T PT1049706E (pt) 1998-01-19 1999-01-13 Novos penta-sacaridos os respectivos metodos de producao e as composicoes farmaceuticas que os contem
HK01101002.3A HK1029999B (en) 1998-01-19 1999-01-13 New pentasaccharides, their methods of production and pharmaceutical compositions containing same
JP2000540143A JP4695756B2 (ja) 1998-01-19 1999-01-13 新規な五糖類、その製造法およびそれを含む医薬組成物
CZ20002636A CZ299817B6 (cs) 1998-01-19 1999-01-13 Nové pentasacharidy, zpusob jejich prípravy a farmaceutické kompozice, které je obsahují
ES99900525T ES2200494T3 (es) 1998-01-19 1999-01-13 Pentasacaridos, sus procedimientos de preparacion y composiciones farmaceuticas que los contienen.
SK1079-2000A SK284176B6 (sk) 1998-01-19 1999-01-13 Pentasacharidy, farmaceutické kompozície, ktoré ich obsahujú, a ich použitie
BRPI9907100-2B1A BR9907100B1 (pt) 1998-01-19 1999-01-13 pentassacarídeos, composição farmacêutica compreendendo os mesmos e utilização dos ditos pentassacarídeos
NZ505614A NZ505614A (en) 1998-01-19 1999-01-13 Pentasaccharides and pharmaceutical compositions thereof, useful as anti blood clotting agnets
AT99900525T ATE241637T1 (de) 1998-01-19 1999-01-13 Pentasaccharide, verfahren zu ihrer herstellung und pharmazeutische zubereitungen die sie enthalten
CNB998041386A CN1172948C (zh) 1998-01-19 1999-01-13 新的五糖及其制备方法和含有它们的药物组合物
SI9930357T SI1049706T1 (en) 1998-01-19 1999-01-13 New pentasaccharides, their methods of production and pharmaceutical compositions containing same
HU0102042A HU228335B1 (en) 1998-01-19 1999-01-13 New pentasaccharides, their methods of production and pharmaceutical compositions comprising same
RU2000119750/04A RU2193040C2 (ru) 1998-01-19 1999-01-13 Новые пентасахариды и содержащие их фармацевтические композиции
EEP200000421A EE04194B1 (et) 1998-01-19 1999-01-13 Pentasahhariidid, nende valmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
TR2000/02077T TR200002077T2 (tr) 1998-01-19 1999-01-13 Yeni pentasakaritler ve bunların hazırlanışı için prosesler ile bunları içinde bulunduran farmasötik kompozisyonlar.
EP99900525A EP1049706B1 (fr) 1998-01-19 1999-01-13 Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
IL13724099A IL137240A0 (en) 1998-01-19 1999-01-13 Novel pentasaccharides, processes for their preparation and pharmaceutical compositions containing them
DE69908298T DE69908298T2 (de) 1998-01-19 1999-01-13 Pentasaccharide, verfahren zu ihrer herstellung und pharmazeutische zubereitungen die sie enthalten
PCT/FR1999/000045 WO1999036428A1 (fr) 1998-01-19 1999-01-13 Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
EG5599A EG23760A (en) 1998-01-19 1999-01-16 Novel pentasaccharides, processes for their preparation and pharmaceutical compositions containing them
MYPI99000205A MY125636A (en) 1998-01-19 1999-01-18 Novel pentasaccharides, processes for their preparation and pharmaceutical compositions containing them
UY25357A UY25357A1 (es) 1998-01-19 1999-01-18 Nuevos pentasacáridos, procedimiento para su preparación y composiciones farmacéuticas que los contienen.
ARP990100171A AR012779A1 (es) 1998-01-19 1999-01-18 Pentasacarido bajo forma acida y sus sales faramceuticamente aceptables, su utilizacion y composiciones farmaceuticas que lo contienen.
TW088100711A TW550267B (en) 1998-01-19 1999-01-18 Novel pentasaccharides, processes for their preparation and pharmaceutical compositions containing them
CO99002525A CO4970823A1 (es) 1998-01-19 1999-01-19 Nuevos pentasacaridos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
GT199900006A GT199900006A (es) 1998-01-19 1999-01-19 Nuevos pentasacaridos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ZA9900357A ZA99357B (en) 1998-01-19 1999-01-19 Pentasaccharides, process for their preparation and pharmaceutical compositions containing them.
SA99191114A SA99191114B1 (ar) 1998-01-19 1999-02-27 خامس سكاريدات pentasaccharides جديدة، طرق تحضيرها والتركيبات الصيدلية المحتوية عليها
IL137240A IL137240A (en) 1998-01-19 2000-07-10 Pentasaccharides
NO20003661A NO316894B1 (no) 1998-01-19 2000-07-17 Nye pentasakkarider, farmasoytiske preparater inneholdende de samme samt anvendelse derav
HRP20000479AA HRP20000479B8 (hr) 1998-01-19 2001-02-28 Novi pentasaharidi, postupci njihove priprave i farmaceutske mješavine koje ih sadržavaju

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9800514A FR2773801B1 (fr) 1998-01-19 1998-01-19 Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
FR2773801A1 FR2773801A1 (fr) 1999-07-23
FR2773801B1 true FR2773801B1 (fr) 2000-05-12

Family

ID=9521913

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9800514A Expired - Lifetime FR2773801B1 (fr) 1998-01-19 1998-01-19 Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant

Country Status (38)

Country Link
US (1) US6670338B1 (enExample)
EP (1) EP1049706B1 (enExample)
JP (1) JP4695756B2 (enExample)
KR (1) KR100533565B1 (enExample)
CN (1) CN1172948C (enExample)
AR (1) AR012779A1 (enExample)
AT (1) ATE241637T1 (enExample)
AU (1) AU744137B2 (enExample)
BR (1) BR9907100B1 (enExample)
CA (1) CA2318326C (enExample)
CO (1) CO4970823A1 (enExample)
CZ (1) CZ299817B6 (enExample)
DE (1) DE69908298T2 (enExample)
DK (1) DK1049706T3 (enExample)
DZ (1) DZ2706A1 (enExample)
EE (1) EE04194B1 (enExample)
EG (1) EG23760A (enExample)
ES (1) ES2200494T3 (enExample)
FR (1) FR2773801B1 (enExample)
GT (1) GT199900006A (enExample)
HR (1) HRP20000479B8 (enExample)
HU (1) HU228335B1 (enExample)
IL (2) IL137240A0 (enExample)
MY (1) MY125636A (enExample)
NO (1) NO316894B1 (enExample)
NZ (1) NZ505614A (enExample)
PL (1) PL191098B1 (enExample)
PT (1) PT1049706E (enExample)
RU (1) RU2193040C2 (enExample)
SA (1) SA99191114B1 (enExample)
SI (1) SI1049706T1 (enExample)
SK (1) SK284176B6 (enExample)
TR (1) TR200002077T2 (enExample)
TW (1) TW550267B (enExample)
UA (1) UA61124C2 (enExample)
UY (1) UY25357A1 (enExample)
WO (1) WO1999036428A1 (enExample)
ZA (1) ZA99357B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
CA2507707C (en) 2002-12-03 2011-06-21 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US7875592B2 (en) * 2004-03-04 2011-01-25 Progen Pharmaceuticals Limited Sulfated oligosaccharide derivatives
CN100338084C (zh) * 2004-07-02 2007-09-19 北京大学 抑制异种器官移植免疫排斥反应的五糖抗原的合成方法
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
US20070191306A1 (en) * 2005-08-17 2007-08-16 Bristol-Myers Squibb Company FACTOR Xa INHIBITOR FORMULATION AND METHOD
EP1908768A1 (en) * 2006-10-05 2008-04-09 Endotis Pharma Anticoagulant compounds
CA2724910C (en) 2008-05-30 2015-09-01 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
WO2010029552A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
EP2464668B1 (en) 2009-07-31 2022-12-07 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
WO2012172104A1 (en) 2011-06-17 2012-12-20 Endotis Pharma Synthetic pentasaccharides having short half-life and high activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
EP0454220B1 (en) * 1990-04-23 1993-08-18 Akzo Nobel N.V. Carbohydrate derivatives comprising a trisaccharide unit
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
FR2704226B1 (fr) * 1993-04-22 1995-07-21 Sanofi Elf 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
NZ264340A (en) * 1993-09-01 1995-04-27 Akzo Nobel Nv Bisconjugate comprising two saccharides and a spacer, use in pharmaceutical compositions
FR2751334B1 (fr) * 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
HU228335B1 (en) 2013-03-28
PT1049706E (pt) 2003-09-30
ATE241637T1 (de) 2003-06-15
NZ505614A (en) 2003-02-28
UY25357A1 (es) 2000-12-29
CN1172948C (zh) 2004-10-27
DE69908298T2 (de) 2004-04-01
DZ2706A1 (fr) 2003-09-01
NO20003661L (no) 2000-09-19
WO1999036428A1 (fr) 1999-07-22
HK1029999A1 (zh) 2001-04-20
ES2200494T3 (es) 2004-03-01
PL341874A1 (en) 2001-05-07
EE04194B1 (et) 2003-12-15
HRP20000479B1 (hr) 2006-04-30
BR9907100A (pt) 2000-10-24
EP1049706A1 (fr) 2000-11-08
HRP20000479A8 (hr) 2025-09-12
US6670338B1 (en) 2003-12-30
DK1049706T3 (da) 2003-09-29
DE69908298D1 (de) 2003-07-03
IL137240A (en) 2007-10-31
NO316894B1 (no) 2004-06-14
IL137240A0 (en) 2001-07-24
EE200000421A (et) 2001-12-17
AU1974699A (en) 1999-08-02
KR20010034205A (ko) 2001-04-25
NO20003661D0 (no) 2000-07-17
BR9907100B1 (pt) 2013-09-03
ZA99357B (en) 2000-07-19
AR012779A1 (es) 2000-11-08
TR200002077T2 (tr) 2000-12-21
UA61124C2 (en) 2003-11-17
CA2318326A1 (en) 1999-07-22
CZ299817B6 (cs) 2008-12-03
MY125636A (en) 2006-08-30
EG23760A (en) 2007-08-08
CA2318326C (en) 2010-07-06
KR100533565B1 (ko) 2005-12-06
JP4695756B2 (ja) 2011-06-08
RU2193040C2 (ru) 2002-11-20
PL191098B1 (pl) 2006-03-31
HRP20000479A2 (en) 2001-02-28
SA99191114B1 (ar) 2006-10-11
CO4970823A1 (es) 2000-11-07
EP1049706B1 (fr) 2003-05-28
SK10792000A3 (sk) 2001-01-18
CZ20002636A3 (cs) 2000-11-15
SI1049706T1 (en) 2003-12-31
JP2002509154A (ja) 2002-03-26
TW550267B (en) 2003-09-01
HRP20000479B8 (hr) 2025-09-12
SK284176B6 (sk) 2004-10-05
GT199900006A (es) 2000-07-12
EE200000421A1 (et) 2003-06-16
AU744137B2 (en) 2002-02-14
HUP0102042A1 (hu) 2001-10-28
HUP0102042A3 (en) 2003-07-28
CN1293679A (zh) 2001-05-02
FR2773801A1 (fr) 1999-07-23

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