JP2001517699A - セリン／トレオニンプロテインキナーゼ作用の変性のためのアザベンズイミダゾールを基礎とする化合物 - Google Patents

セリン／トレオニンプロテインキナーゼ作用の変性のためのアザベンズイミダゾールを基礎とする化合物

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Publication number
JP2001517699A
JP2001517699A JP2000513574A JP2000513574A JP2001517699A JP 2001517699 A JP2001517699 A JP 2001517699A JP 2000513574 A JP2000513574 A JP 2000513574A JP 2000513574 A JP2000513574 A JP 2000513574A JP 2001517699 A JP2001517699 A JP 2001517699A
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Japan
Prior art keywords
group
compound
formula
alkyl
protein kinase
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2000513574A
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English (en)
Japanese (ja)
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JP2001517699A5 (pt
Inventor
マックマホン ジェラルド
ヴァインベルガー ハインツ
クッチャー ベルンハルト
アップ ハラルト
Original Assignee
アスタ メディカ アクチエンゲゼルシャフト
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Publication of JP2001517699A publication Critical patent/JP2001517699A/ja
Publication of JP2001517699A5 publication Critical patent/JP2001517699A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2000513574A 1997-09-26 1998-09-23 セリン／トレオニンプロテインキナーゼ作用の変性のためのアザベンズイミダゾールを基礎とする化合物 Withdrawn JP2001517699A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6014597P 1997-09-26 1997-09-26
US60/060,145 1997-09-26
PCT/US1998/019973 WO1999016438A1 (en) 1997-09-26 1998-09-23 Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function

Publications (2)

Publication Number Publication Date
JP2001517699A true JP2001517699A (ja) 2001-10-09
JP2001517699A5 JP2001517699A5 (pt) 2006-01-05

Family

ID=22027657

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000513574A Withdrawn JP2001517699A (ja) 1997-09-26 1998-09-23 セリン／トレオニンプロテインキナーゼ作用の変性のためのアザベンズイミダゾールを基礎とする化合物

Country Status (28)

Country Link
US (2) US6093728A (pt)
EP (1) EP1017384B1 (pt)
JP (1) JP2001517699A (pt)
KR (1) KR100547929B1 (pt)
CN (1) CN1167420C (pt)
AR (1) AR017266A1 (pt)
AT (1) ATE281834T1 (pt)
AU (1) AU748849B2 (pt)
BG (1) BG64784B1 (pt)
BR (1) BR9812682A (pt)
CA (1) CA2305370C (pt)
DE (1) DE69827516T2 (pt)
DK (1) DK1017384T3 (pt)
ES (1) ES2230719T3 (pt)
HK (1) HK1032206A1 (pt)
HU (1) HUP0004024A3 (pt)
IL (4) IL158649A0 (pt)
NO (1) NO325663B1 (pt)
NZ (2) NZ503432A (pt)
PL (1) PL191618B1 (pt)
PT (1) PT1017384E (pt)
RU (1) RU2230553C2 (pt)
SK (1) SK285357B6 (pt)
TR (1) TR200001546T2 (pt)
TW (1) TW581815B (pt)
UA (1) UA72448C2 (pt)
WO (1) WO1999016438A1 (pt)
ZA (1) ZA988797B (pt)

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* Cited by examiner, † Cited by third party
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JP2010506934A (ja) * 2006-10-19 2010-03-04 シグナル ファーマシューティカルズ，エルエルシー ヘテロアリール化合物、その組成物、及びプロテインキナーゼ阻害剤としてのそれらの使用
WO2011016472A1 (ja) * 2009-08-06 2011-02-10 オンコセラピー・サイエンス株式会社 Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体

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US8324395B2 (en) 2007-08-23 2012-12-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
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JP6382946B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
JP6401250B2 (ja) 2013-05-29 2018-10-10 シグナル ファーマシューティカルズ，エルエルシー ７−（６−（２−ヒドロキシプロパン−２−イル）ピリジン−３−イル）−１−（（ｔｒａｎｓ）−４−メトキシシクロヘキシル）−３，４−ジヒドロピラジノ［２，３−ｂ］ピラジン−２（１Ｈ）−オン、その固体形態の医薬組成物、及びその使用方法
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010506934A (ja) * 2006-10-19 2010-03-04 シグナル ファーマシューティカルズ，エルエルシー ヘテロアリール化合物、その組成物、及びプロテインキナーゼ阻害剤としてのそれらの使用
WO2011016472A1 (ja) * 2009-08-06 2011-02-10 オンコセラピー・サイエンス株式会社 Ｔｔｋ阻害作用を有するピリジンおよびピリミジン誘導体

Also Published As

Publication number Publication date
IL158649A (en) 2006-12-10
IL135109A0 (en) 2001-05-20
ES2230719T3 (es) 2005-05-01
BR9812682A (pt) 2000-08-22
IL158649A0 (en) 2004-05-12
EP1017384A1 (en) 2000-07-12
US6093728A (en) 2000-07-25
RU2230553C2 (ru) 2004-06-20
TW581815B (en) 2004-04-01
HUP0004024A3 (en) 2001-10-29
DK1017384T3 (da) 2005-01-31
WO1999016438A1 (en) 1999-04-08
ZA988797B (en) 1999-12-02
ATE281834T1 (de) 2004-11-15
NZ503432A (en) 2002-11-26
KR20010015623A (ko) 2001-02-26
AR017266A1 (es) 2001-09-05
KR100547929B1 (ko) 2006-02-02
EP1017384B1 (en) 2004-11-10
AU748849B2 (en) 2002-06-13
PL191618B1 (pl) 2006-06-30
CA2305370C (en) 2006-11-28
TR200001546T2 (tr) 2000-10-23
UA72448C2 (en) 2005-03-15
HK1032206A1 (en) 2001-07-13
BG104356A (en) 2000-12-29
SK4152000A3 (en) 2002-02-05
PL339744A1 (en) 2001-01-02
BG64784B1 (bg) 2006-04-28
AU9578198A (en) 1999-04-23
NO20001555D0 (no) 2000-03-24
PT1017384E (pt) 2005-03-31
DE69827516T2 (de) 2005-12-01
HUP0004024A2 (hu) 2001-04-28
NO325663B1 (no) 2008-07-07
DE69827516D1 (de) 2004-12-16
US6855723B2 (en) 2005-02-15
CN1278172A (zh) 2000-12-27
CN1167420C (zh) 2004-09-22
US20030181480A1 (en) 2003-09-25
SK285357B6 (sk) 2006-11-03
NO20001555L (no) 2000-03-24
NZ517808A (en) 2003-07-25
IL135109A (en) 2007-07-04
CA2305370A1 (en) 1999-04-08

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