JP2001512964A - 分化した胎仔および成体ドナー細胞による核移植 - Google Patents

分化した胎仔および成体ドナー細胞による核移植

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Publication number
JP2001512964A
JP2001512964A JP53095898A JP53095898A JP2001512964A JP 2001512964 A JP2001512964 A JP 2001512964A JP 53095898 A JP53095898 A JP 53095898A JP 53095898 A JP53095898 A JP 53095898A JP 2001512964 A JP2001512964 A JP 2001512964A
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cell
cells
disease
differentiated
cicm
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JP2001512964A5 (enExample
Inventor
スティーヴン エル スティース
ホセ シーベリー
ジェームズ ローブル
ポール ゴルーク
デ リーオン エフ エイベル ポンセ
ディー ジョセフ ジェリー
Original Assignee
ユニヴァーシティー オヴ マサチューセッツ ア パブリック インスティテューション オヴ ハイアー エデュケイション オヴ ザ コモンウェルス オヴ マサチューセッツ
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25123802&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2001512964(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ユニヴァーシティー オヴ マサチューセッツ ア パブリック インスティテューション オヴ ハイアー エデュケイション オヴ ザ コモンウェルス オヴ マサチューセッツ filed Critical ユニヴァーシティー オヴ マサチューセッツ ア パブリック インスティテューション オヴ ハイアー エデュケイション オヴ ザ コモンウェルス オヴ マサチューセッツ
Publication of JP2001512964A publication Critical patent/JP2001512964A/ja
Publication of JP2001512964A5 publication Critical patent/JP2001512964A5/ja
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/106—Primate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
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  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
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  • Plant Pathology (AREA)
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  • Physics & Mathematics (AREA)
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  • Animal Husbandry (AREA)
  • Diabetes (AREA)
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  • Reproductive Health (AREA)
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  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
JP53095898A 1997-01-10 1998-01-05 分化した胎仔および成体ドナー細胞による核移植 Ceased JP2001512964A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/781,752 1997-01-10
US08/781,752 US5945577A (en) 1997-01-10 1997-01-10 Cloning using donor nuclei from proliferating somatic cells
PCT/US1998/000002 WO1998030683A2 (en) 1997-01-10 1998-01-05 Nuclear transfer with differentiated fetal and adult donor cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2007084406A Division JP2007167078A (ja) 1997-01-10 2007-03-28 分化した胎仔および成体ドナー細胞による核移植

Publications (2)

Publication Number Publication Date
JP2001512964A true JP2001512964A (ja) 2001-08-28
JP2001512964A5 JP2001512964A5 (enExample) 2006-01-05

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ID=25123802

Family Applications (2)

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JP53095898A Ceased JP2001512964A (ja) 1997-01-10 1998-01-05 分化した胎仔および成体ドナー細胞による核移植
JP2007084406A Pending JP2007167078A (ja) 1997-01-10 2007-03-28 分化した胎仔および成体ドナー細胞による核移植

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JP2007084406A Pending JP2007167078A (ja) 1997-01-10 2007-03-28 分化した胎仔および成体ドナー細胞による核移植

Country Status (13)

Country Link
US (4) US5945577A (enExample)
EP (2) EP1015572B1 (enExample)
JP (2) JP2001512964A (enExample)
CN (1) CN1248288B (enExample)
AT (1) ATE356203T1 (enExample)
AU (1) AU742363C (enExample)
BR (1) BR9806872A (enExample)
CA (1) CA2277192C (enExample)
DE (1) DE69837270T2 (enExample)
ES (1) ES2284197T3 (enExample)
IL (2) IL130829A0 (enExample)
NZ (1) NZ336612A (enExample)
WO (1) WO1998030683A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000512159A (ja) * 1998-01-16 2000-09-19 アグロバイオジェン ゲーエムベーハー 胎仔線維芽細胞による効率的な核移入
JP2002500864A (ja) * 1998-01-21 2002-01-15 ユニバーシティ・オブ・ハワイ 成体の体細胞核を再構成した被核除去卵母細胞からの動物の満期の成長
JP2006522609A (ja) * 2003-04-09 2006-10-05 マギー−ウイメンズ・ヘルス・コーポレイション 動物の体細胞核移植と関係する紡錘体欠損を修正するための方法
JPWO2016140353A1 (ja) * 2015-03-04 2018-01-25 株式会社医療実験用大動物供給事業準備会社 安定した表現型を示す疾患モデルブタおよびその作製方法

Families Citing this family (215)

* Cited by examiner, † Cited by third party
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GB9517779D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517780D0 (en) * 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US20090092588A1 (en) * 1997-01-10 2009-04-09 University Of Massachusetts As Represented By Its Amherst Campus Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease
US6235969B1 (en) 1997-01-10 2001-05-22 University Of Massachusetts Cloning pigs using donor nuclei from non-quiescent differentiated cells
US6215041B1 (en) * 1997-01-10 2001-04-10 University Of Mmassachusetts Cloning using donor nuclei from a non-quiesecent somatic cells
US5945577A (en) * 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US6011197A (en) * 1997-03-06 2000-01-04 Infigen, Inc. Method of cloning bovines using reprogrammed non-embryonic bovine cells
NZ337495A (en) * 1997-03-06 2001-06-29 Infigen Inc Bovine primordial germ cells and their use in cloning
IL133786A0 (en) 1997-07-03 2001-04-30 Univ Massachusetts Cloning using donor nuclei from non-serum starved, differentiated cells
WO1999005266A2 (en) * 1997-07-26 1999-02-04 Wisconsin Alumni Research Foundation Trans-species nuclear transfer
JP2002511234A (ja) * 1998-03-16 2002-04-16 リレグ ピーティーワイ リミテッド ブタの核移植
AUPP294898A0 (en) * 1998-04-15 1998-05-07 Monash University Method of nuclear transfer
GB9808325D0 (en) * 1998-04-20 1998-06-17 Ltr Ciz Di Associazione Italia Source of nuclei for nuclear transfer
GB9811859D0 (en) * 1998-06-02 1998-07-29 Biotech & Biolog Scien Res Biological manipulation
JP2002524054A (ja) * 1998-08-11 2002-08-06 アンソニー・シー・エフ・ペリー 遺伝子転移を行う方法
CA2342205A1 (en) * 1998-09-01 2000-03-09 Wisconsin Alumni Research Foundation Primate embryonic stem cells with compatible histocompatibility genes
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
JP2003523719A (ja) * 1998-11-02 2003-08-12 トラスティーズ・オブ・タフツ・カレッジ 動物のクローン化方法
US6580017B1 (en) * 1998-11-02 2003-06-17 Genzyme Transgenics Corporation Methods of reconstructed goat embryo transfer
US20030177513A1 (en) * 1998-11-02 2003-09-18 Yann Echelard Transgenic and cloned mammals
US6700037B2 (en) 1998-11-24 2004-03-02 Infigen, Inc. Method of cloning porcine animals
US7531715B1 (en) 1999-01-13 2009-05-12 Ppl Therapeutics (Scotland) Double nuclear transfer method and results thereof
US20020012660A1 (en) * 1999-03-04 2002-01-31 Alan Colman Method of preparing a somatic cells for nuclear transfer
AU780754B2 (en) * 1999-03-04 2005-04-14 Revivicor Inc Genetic modification of somatic cells and uses thereof
IL146296A0 (en) * 1999-05-06 2002-07-25 Stem Cell Sciences Pty Ltd Cell reprogramming
WO2001000794A1 (en) * 1999-06-30 2001-01-04 Hwang, Woo-Suk Method for producing cloned tigers by employing inter-species nuclear transplantation technique
JP2003503044A (ja) * 1999-06-30 2003-01-28 ワン，ウー−サク 種間核移植技術を用いたヒトクローン胚の作製方法
US6590139B1 (en) 1999-06-30 2003-07-08 Woo-Suk Hwang Method for producing cloned cows
WO2001018236A1 (en) * 1999-09-07 2001-03-15 Advanced Cell Technology, Inc. Telomere restoration and extension of cell life-span in animals cloned from senescent somatic cells
US20040180430A1 (en) * 1999-09-07 2004-09-16 West Michael D. Methods of restoring telomere length and extending cell lifespan using nuclear transfer
US20050255596A1 (en) * 1999-09-07 2005-11-17 West Michael D Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer
EP1241931A4 (en) * 1999-09-13 2004-12-29 Univ Massachusetts CLONING PIGS USING DONORATION CELLS OR NUCLEAR CELLS OF DIFFERENTIATED CELLS AND PRODUCING PLURIPOTENT PIGS
EP2275559A3 (en) 1999-09-28 2011-03-23 Shire Human Genetic Therapies, Inc. Optimized messenger RNA
WO2002064799A2 (en) 1999-09-28 2002-08-22 Transkaryotic Therapies, Inc. Optimized messenger rna
BR0014864A (pt) * 1999-10-15 2002-11-19 Advanced Cell Tech Inc Métodos de produzir células progenitoras diferenciadas e células tronco embriÈnicas defeituosas em linhagem
JP2003514516A (ja) 1999-10-28 2003-04-22 ユニバーシティ オブ マサチューセッツ 多能性細胞と細胞株の雌性発生的または雄性発生的産生および分化した細胞と組織を産生するためのその使用
WO2001032854A1 (en) * 1999-10-29 2001-05-10 Nexia Biotechnologies Inc. Production of transgenic animals using nuclear transfer and oocytes recovered by lopu
CA2388510A1 (en) * 1999-11-02 2001-05-10 James M. Robl Use of haploid genomes for genetic diagnosis, modification and multiplication
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
AU1777301A (en) * 1999-11-19 2001-05-30 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
KR100417566B1 (ko) * 1999-11-19 2004-02-05 한국생명공학연구원 체세포 핵치환 복제수정란의 대량생산방법
US7071372B2 (en) * 2000-01-04 2006-07-04 University Of Connecticut Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells
WO2001049112A2 (en) 2000-01-04 2001-07-12 University Of Connecticut Oocyte vitrification technique
US20060174358A1 (en) * 2001-01-04 2006-08-03 Xiangzhong Yang Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells
US6635802B1 (en) * 2000-01-10 2003-10-21 The Texas A&M University System Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors
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CA2277192C (en) 2011-03-15
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CA2277192A1 (en) 1998-07-16
CN1248288B (zh) 2011-11-09
EP1015572B1 (en) 2007-03-07
DE69837270D1 (de) 2007-04-19
ATE356203T1 (de) 2007-03-15
AU6014598A (en) 1998-08-03
ES2284197T3 (es) 2007-11-01
IL130829A0 (en) 2001-01-28
US20020010949A1 (en) 2002-01-24
CN1248288A (zh) 2000-03-22
US6235970B1 (en) 2001-05-22
JP2007167078A (ja) 2007-07-05
WO1998030683A2 (en) 1998-07-16
IL130829A (en) 2008-11-26
WO1998030683A3 (en) 1998-09-17
US5945577A (en) 1999-08-31
AU742363B2 (en) 2002-01-03
US20050108785A1 (en) 2005-05-19
BR9806872A (pt) 2000-04-18
EP1015572A2 (en) 2000-07-05
NZ336612A (en) 2002-09-27

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