JP2000510865A5 - - Google Patents

Download PDF

Info

Publication number
JP2000510865A5
JP2000510865A5 JP1997541788A JP54178897A JP2000510865A5 JP 2000510865 A5 JP2000510865 A5 JP 2000510865A5 JP 1997541788 A JP1997541788 A JP 1997541788A JP 54178897 A JP54178897 A JP 54178897A JP 2000510865 A5 JP2000510865 A5 JP 2000510865A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1997541788A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000510865A (ja
Filing date
Publication date
Priority claimed from GBGB9610506.9A external-priority patent/GB9610506D0/en
Priority claimed from GBGB9623234.3A external-priority patent/GB9623234D0/en
Priority claimed from GBGB9626883.4A external-priority patent/GB9626883D0/en
Priority claimed from GBGB9708072.5A external-priority patent/GB9708072D0/en
Application filed filed Critical
Priority claimed from PCT/GB1997/001359 external-priority patent/WO1997044036A1/en
Publication of JP2000510865A publication Critical patent/JP2000510865A/ja
Publication of JP2000510865A5 publication Critical patent/JP2000510865A5/ja
Pending legal-status Critical Current

Links

JP09541788A 1996-05-20 1997-05-20 Tnfとpde―ivのインヒビターとしてのキノリンカルボキサミド Pending JP2000510865A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB9610506.9A GB9610506D0 (en) 1996-05-20 1996-05-20 Novel compounds
GB9610506.9 1996-05-20
GB9623234.3 1996-11-07
GBGB9623234.3A GB9623234D0 (en) 1996-11-07 1996-11-07 Novel compounds
GB9626883.4 1996-12-24
GBGB9626883.4A GB9626883D0 (en) 1996-12-24 1996-12-24 Compounds
GB9708072.5 1997-04-22
GBGB9708072.5A GB9708072D0 (en) 1997-04-22 1997-04-22 Compounds
PCT/GB1997/001359 WO1997044036A1 (en) 1996-05-20 1997-05-20 Quinoline carboxamides as tnf inhibitors and as pde-iv inhibitors

Publications (2)

Publication Number Publication Date
JP2000510865A JP2000510865A (ja) 2000-08-22
JP2000510865A5 true JP2000510865A5 (OSRAM) 2005-01-13

Family

ID=27451451

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09541788A Pending JP2000510865A (ja) 1996-05-20 1997-05-20 Tnfとpde―ivのインヒビターとしてのキノリンカルボキサミド

Country Status (19)

Country Link
US (1) US5804588A (OSRAM)
EP (1) EP0952832B1 (OSRAM)
JP (1) JP2000510865A (OSRAM)
KR (1) KR20000065219A (OSRAM)
CN (1) CN1148189C (OSRAM)
AT (1) ATE406163T1 (OSRAM)
AU (1) AU722472B2 (OSRAM)
BR (1) BR9709015A (OSRAM)
CA (1) CA2252531A1 (OSRAM)
CZ (1) CZ296163B6 (OSRAM)
DE (1) DE69738949D1 (OSRAM)
IL (1) IL126557A (OSRAM)
NO (1) NO312099B1 (OSRAM)
NZ (1) NZ332341A (OSRAM)
PL (1) PL329922A1 (OSRAM)
RU (1) RU2170730C2 (OSRAM)
SK (1) SK283162B6 (OSRAM)
TR (1) TR199802385T2 (OSRAM)
WO (1) WO1997044036A1 (OSRAM)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69633196D1 (de) * 1995-10-16 2004-09-23 Fujisawa Pharmaceutical Co Heterocyclische verbindungen als h+-atpasen
GB9712761D0 (en) * 1997-06-17 1997-08-20 Chiroscience Ltd Quinolines and their therapeutic use
GB9824160D0 (en) * 1998-11-04 1998-12-30 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
US6262070B1 (en) 1998-11-04 2001-07-17 Darwin Discovery Ltd. Heterocyclic compounds and their therapeutic use
HRP20020158B1 (en) * 1999-08-21 2007-08-31 Altana Pharma Ag Action of synergistic combination
AU1053501A (en) * 1999-11-02 2001-05-14 Ajinomoto Co., Inc. Polyazanaphthalene compound and medicinal use thereof
JP4603646B2 (ja) * 1999-11-15 2010-12-22 富士フイルムファインケミカルズ株式会社 新規なジピリジル誘導体
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
GB0003256D0 (en) * 2000-02-11 2000-04-05 Darwin Discovery Ltd Heterocyclic compounds and their therapeutic use
US6521618B2 (en) 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
AU2001277731A1 (en) * 2000-08-09 2002-02-18 Welfide Corporation Fused bicyclic amide compounds and medicinal use thereof
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
JP2002300373A (ja) * 2001-03-30 2002-10-11 Minolta Co Ltd 画像処理方法、画像処理装置、記録媒体及びプログラム
CA2447618A1 (en) * 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. A composition for regenerative treatment of cartilage disease
WO2002094321A1 (en) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Compositions for promoting healing of bone fracture
EP1409481B1 (en) 2001-07-16 2006-10-04 Astrazeneca AB Quinoline derivatives and their use as tyrosine kinase inhibitors
EP1417204B1 (en) * 2001-08-15 2006-01-18 E. I. du Pont de Nemours and Company Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests
JP4532115B2 (ja) 2001-12-14 2010-08-25 メルク セローノ ソシエテ アノニム 非ポリペプチドcAMPレベル調節剤を使用する排卵誘発方法
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
SE0200920D0 (sv) * 2002-03-25 2002-03-25 Astrazeneca Ab Novel compounds
ES2195785B1 (es) * 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
AU2002950217A0 (en) 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
TWI324150B (en) * 2003-02-28 2010-05-01 Novartis Ag Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt
EP1624893A2 (en) 2003-04-01 2006-02-15 Applied Research Systems ARS Holding N.V. Inhibitors of phosphodiesterases in infertility
PE20050211A1 (es) * 2003-04-02 2005-04-27 Novartis Ag Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas
WO2004105796A1 (en) * 2003-05-29 2004-12-09 Astrazeneca Ab A pharmaceutical composition containing a p2x7 receptor antagonist and methotrexate
WO2004105797A1 (en) * 2003-05-29 2004-12-09 Astrazeneca Ab A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine
KR20060037258A (ko) * 2003-05-29 2006-05-03 아스트라제네카 아베 P2X7-수용체 길항제 및 종양 괴사 인자 α를 포함하는제약 조성물
GB0312609D0 (en) * 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
SE0302139D0 (sv) * 2003-07-28 2003-07-28 Astrazeneca Ab Novel compounds
SE0302192D0 (sv) * 2003-08-08 2003-08-08 Astrazeneca Ab Novel compounds
JP2007505834A (ja) * 2003-09-15 2007-03-15 シェーリング コーポレイション Pdeivインヒビターの調製のために有用なキノリン5−カルボキサミドの合成
SE0302488D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab New combination
PA8619901A1 (es) 2003-12-12 2005-11-25 Wyeth Corp Quinolinas utiles en el tratamiento de enfermedades cardiovasculares
EP2666481B9 (en) 2003-12-26 2019-05-22 HAGIWARA, Masatoshi Method of regulating phosphorylation of sr protein and antiviral agents comprising sr protein activity regulator as the active ingredient
KR100799802B1 (ko) 2004-02-04 2008-01-31 화이자 프로덕츠 인크. 치환된 퀴놀린 화합물
CA2561660C (en) * 2004-04-01 2012-10-30 F. Hoffmann-La Roche Ag Pharmaceutical compositions of pyrimidine-2,4,6-triones
JP4584990B2 (ja) * 2004-05-18 2010-11-24 シェーリング コーポレイション Pde4インヒビターとして有用な置換2−キノリル−オキサゾール
ES2251866B1 (es) * 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
GB0413960D0 (en) * 2004-06-22 2004-07-28 Novartis Ag Organic compounds
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
PT1773816E (pt) * 2004-06-24 2015-04-29 Vertex Pharma Moduladores de transportadores de cassete de ligação de atp
SA05260265A (ar) * 2004-08-30 2005-12-03 استرازينيكا ايه بي مركبات جديدة
KR101271372B1 (ko) * 2004-10-12 2013-06-07 액테리온 파마슈티칼 리미티드 결정질 술페이트 염으로서의 1-〔2-(4-벤질-4-하이드록시-피페리딘-1-일)-에틸〕-3-(2-메틸-퀴놀린-4-일)-유레아
KR100867071B1 (ko) * 2004-10-19 2008-11-04 에프. 호프만-라 로슈 아게 퀴놀린 유도체
SE0402925D0 (sv) * 2004-11-30 2004-11-30 Astrazeneca Ab Novel Compounds
US8686002B2 (en) 2005-08-21 2014-04-01 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as binding partners for 5-HT5 receptors
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
EP1979367A2 (en) * 2005-12-24 2008-10-15 Vertex Pharmaceuticals Incorporated Quinolin-4-one derivatives as modulators of abc transporters
RS55940B1 (sr) 2005-12-28 2017-09-29 Vertex Pharma Čvrsti oblici n-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksohinolin-3-karboksamida
KR100821649B1 (ko) * 2006-01-24 2008-04-11 서울시립대학교 산학협력단 클리오퀴놀을 유효성분으로 포함하는 HIF-1α 활성제
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
RU2009104346A (ru) * 2006-07-11 2010-08-20 Шеринг Корпорейшн (US) Ксинафоатная соль замещенного 5-оксазол-2-ил-хинолинового соединения
EP2058310A4 (en) 2006-09-01 2010-11-17 Kyorin Seiyaku Kk PYRAZOLOPYRIDINE CARBOXAMIDE DERIVATIVE AND PHOSPHODIESTERASE INHIBITOR (PDE) COMPRISING THE DERIVATIVE
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
CL2007003874A1 (es) * 2007-01-03 2008-05-16 Boehringer Ingelheim Int Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio
ES2306595B1 (es) * 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
ES2320954B1 (es) * 2007-03-02 2010-03-16 Laboratorio Almirall S.A. Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.
ES2388454T3 (es) * 2007-03-22 2012-10-15 Astrazeneca Ab Derivados de quinolina para el tratamiento de enfermedades inflamatorias
US9321730B2 (en) 2007-08-21 2016-04-26 The Hong Kong Polytechnic University Method of making and administering quinoline derivatives as anti-cancer agents
PE20091036A1 (es) 2007-11-30 2009-08-15 Astrazeneca Ab Derivado de quinolina como antagonista del receptor p2x7
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2821400B1 (en) 2009-03-20 2017-09-27 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
JP2011042643A (ja) * 2009-07-24 2011-03-03 Bayer Cropscience Ag 殺虫性カルボキサミド類
US8367829B2 (en) 2010-05-10 2013-02-05 Gilead Sciences, Inc. Bi-functional pyrazolopyridine compounds
US8394829B2 (en) 2010-05-10 2013-03-12 Gilead Sciences, Inc. Bi-functional quinoline analogs
WO2013074059A2 (en) * 2010-11-05 2013-05-23 Regents Of The University Of Minnesota Cytosine deaminase modulators for enhancement of dna transfection
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CN102603628B (zh) 2010-12-22 2016-08-17 香港理工大学 作为抗癌试剂的喹啉衍生物
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
MX2014010253A (es) 2012-02-27 2014-11-12 Vertex Pharma Composicion farmaceutica y administraciones de la misma.
CN103254291B (zh) * 2013-05-30 2014-06-25 常州亚当生物技术有限公司 肿瘤坏死因子-α多肽抑制剂及其应用
CN103285373A (zh) * 2013-05-30 2013-09-11 苏州普罗达生物科技有限公司 肿瘤坏死因子-α多肽抑制剂制备及其应用
WO2015057659A1 (en) * 2013-10-14 2015-04-23 Eisai R&D Management Co., Ltd. Selectively substituted quinoline compounds
RU2749213C2 (ru) 2014-10-07 2021-06-07 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе
RU2624906C2 (ru) * 2015-12-22 2017-07-10 федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации Производные 2-хинальдинкарбоновой кислоты и их противогриппозная активность
CN111050558B (zh) 2017-09-13 2022-05-27 先正达参股股份有限公司 杀微生物的喹啉(硫代)羧酰胺衍生物
CN107812006A (zh) * 2017-11-13 2018-03-20 全椒先奇医药科技有限公司 一种治疗急性肾衰药物组合物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2517229A1 (de) * 1975-04-18 1976-10-28 Boehringer Mannheim Gmbh Phenylalkylcarbonsaeure-derivate und verfahren zu ihrer herstellung
US4186201A (en) * 1977-02-07 1980-01-29 Riker Laboratories, Inc. Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds
US4147694A (en) * 1977-02-07 1979-04-03 Riker Laboratories, Inc. 8-(1H-Tetrazol-5-yl-carbamoyl)quinoline compounds
BR8606663A (pt) * 1985-05-07 1987-08-11 Alkaloida Vegyeszeti Gyar Derivados de triazolil-quinolina
EP0498722B1 (fr) * 1991-02-07 1997-07-30 Roussel Uclaf Dérivés bicycliques azotés, leur procédé de préparation, les intermédiaires obtenus, leur application comme médicaments et les compositions pharmaceutiques les renfermant
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
SE9302490D0 (sv) * 1993-07-26 1993-07-26 Kabi Pharmacia Ab New use of old drugs

Similar Documents

Publication Publication Date Title
JP2000502280A5 (OSRAM)
JP2000501771A5 (OSRAM)
JP2000501599A5 (OSRAM)
JP2000511380A5 (OSRAM)
JP2000510865A5 (OSRAM)
JP2000500026A5 (OSRAM)
JP2000502472A5 (OSRAM)
JP2000501825A5 (OSRAM)
JP2000501338A5 (OSRAM)
JP2000510661A5 (OSRAM)
JP2000502425A5 (OSRAM)
JP2000502485A5 (OSRAM)
JP2000502568A5 (OSRAM)
JP2000501774A5 (OSRAM)
JP2000502570A5 (OSRAM)
JP2000501876A5 (OSRAM)
JP2000501744A5 (OSRAM)
JP2001502249A5 (OSRAM)
JP2000502316A5 (OSRAM)
JP2001526805A5 (OSRAM)
JP2000502714A5 (OSRAM)
JP2000501569A5 (OSRAM)
JP2000500318A5 (OSRAM)
JP2000500184A5 (OSRAM)
JP2000502479A5 (OSRAM)