JP2000507609A - 抗菌性活性を有する薬剤および化粧用調製物 - Google Patents
抗菌性活性を有する薬剤および化粧用調製物Info
- Publication number
- JP2000507609A JP2000507609A JP10518894A JP51889498A JP2000507609A JP 2000507609 A JP2000507609 A JP 2000507609A JP 10518894 A JP10518894 A JP 10518894A JP 51889498 A JP51889498 A JP 51889498A JP 2000507609 A JP2000507609 A JP 2000507609A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- krameria
- pure compound
- species
- mesua ferrea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000002537 cosmetic Substances 0.000 title claims abstract description 14
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 10
- 239000003814 drug Substances 0.000 title claims description 4
- 229940079593 drug Drugs 0.000 title description 2
- 239000000284 extract Substances 0.000 claims abstract description 65
- 244000097724 Mesua ferrea Species 0.000 claims abstract description 23
- 235000010931 Mesua ferrea Nutrition 0.000 claims abstract description 23
- 241000934806 Krameria Species 0.000 claims abstract description 21
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- 241000331121 Krameria lappacea Species 0.000 claims description 19
- SDWZWUUOXFFJSA-UHFFFAOYSA-N (E)-2-(2,4-dihydroxyphenyl)-5-(1-propenyl)benzofuran Natural products C=1C2=CC(C=CC)=CC=C2OC=1C1=CC=C(O)C=C1O SDWZWUUOXFFJSA-UHFFFAOYSA-N 0.000 claims description 10
- 239000004615 ingredient Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 235000013305 food Nutrition 0.000 claims description 7
- 239000003755 preservative agent Substances 0.000 claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- OBRBRJGLHXRDNP-UHFFFAOYSA-N OC1=C(C=CC=C1)C=1OC2=C(C1)C=C(C=C2)C=CC Chemical compound OC1=C(C=CC=C1)C=1OC2=C(C1)C=C(C=C2)C=CC OBRBRJGLHXRDNP-UHFFFAOYSA-N 0.000 claims 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- KNFUWJAIDVAYOV-ONEGZZNKSA-N rataniaphenol II Chemical compound CC=1C2=CC(/C=C/C)=CC=C2OC=1C1=CC=C(O)C=C1 KNFUWJAIDVAYOV-ONEGZZNKSA-N 0.000 description 7
- KNFUWJAIDVAYOV-UHFFFAOYSA-N rataniaphenol II Natural products CC=1C2=CC(C=CC)=CC=C2OC=1C1=CC=C(O)C=C1 KNFUWJAIDVAYOV-UHFFFAOYSA-N 0.000 description 7
- 238000009472 formulation Methods 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- -1 aliphatic ethers Chemical class 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- TWGHXVKHVUGVCO-QJDCQMRJSA-N C\C=C\c1ccc2oc(c(C)c2c1)-c1ccc(O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)cc1 Chemical compound C\C=C\c1ccc2oc(c(C)c2c1)-c1ccc(O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)cc1 TWGHXVKHVUGVCO-QJDCQMRJSA-N 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- TWGHXVKHVUGVCO-UHFFFAOYSA-N Eupomatenoid 2 Natural products CC=1C2=CC(C=CC)=CC=C2OC=1C(C=C1)=CC=C1OC1OC(C)C(O)C(O)C1O TWGHXVKHVUGVCO-UHFFFAOYSA-N 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- JNELGWHKGNBSMD-UHFFFAOYSA-N xanthone Chemical class C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1 JNELGWHKGNBSMD-UHFFFAOYSA-N 0.000 description 2
- CKGUAQJNKKPYQU-UHFFFAOYSA-N 2-prop-1-enyl-1-benzofuran Chemical compound C1=CC=C2OC(C=CC)=CC2=C1 CKGUAQJNKKPYQU-UHFFFAOYSA-N 0.000 description 1
- WDYVUKGVKRZQNM-UHFFFAOYSA-N 6-phosphonohexylphosphonic acid Chemical compound OP(O)(=O)CCCCCCP(O)(O)=O WDYVUKGVKRZQNM-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
- NJCJBUHJQLFDSW-UHFFFAOYSA-N Rufloxacin Chemical group C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 NJCJBUHJQLFDSW-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 229960000956 coumarin Drugs 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 125000000332 coumarinyl group Chemical class O1C(=O)C(=CC2=CC=CC=C12)* 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000002035 hexane extract Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229960002509 miconazole Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229960004062 rufloxacin Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.抗菌性活性を有する次の成分を含んでなる薬剤および化粧用調製物: a)Krameria種、好ましくはKrameria triandraの親水性抽出物、または該抽出 物からの純粋化合物、および b)Mesua ferreaの脂肪親和性抽出物。 2.Krameriaの抽出物とMesua ferreaの抽出物の比が1:10〜10:1の範囲である 請求項1に記載の薬剤調製物。 3.該比が1:1である請求項2に記載の調製物。 4.Krameria抽出物からの純粋化合物がEupomatcnoid6および2−(2、4−ジ ヒドロキシフェニル)−5−プロペニルベンゾフランである請求項1に記載の調 製物。 5.抗菌性活性を有する医薬物の調製のための次の成分の使用: a)Krameria種、好ましくはKrameria triandraの親水性抽出物、または該抽 出物からの純粋化合物、および b)Mesua ferreaの脂肪親和性抽出物。 6.Krameria抽出物からの純粋化合物がEupomatenoid6または2−(2、4−ジ ヒドロキシフェニル)−5−プロペニルベンゾフランである請求項5に記載の使 用。 7.保存料として次の成分を含んでなる食物用および化粧用調製物: a)Krameria種、好ましくはKrameria triandraの親水性抽出物、または該抽出 物からの純粋化合物、および b)Mesua ferreaの脂肪親和性抽出物。 8. Krameria抽出物からの純粋化合物がEupomatenoid6または2−(2、4 −ジヒドロキシフェニル)−5−プロペニルベンゾフランである請求項7に記載 の調製物。 9.食物用または化粧用調製物のための保存料としての次の成分の使用: a)Krameria種、好ましくはKrameria triandraの親水性抽出物、または該抽 出物からの純粋化合物、および b)Mesua ferreaの脂肪親和性抽出物。 10. Krameria抽出物からの純粋化合物がEupomatenoid6または2−(2、 4−ジヒドロキシフェニル)−5−プロペニルベンゾフランである請求項9に記 載の調製物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96A002148 | 1996-10-17 | ||
IT96MI002148A IT1284970B1 (it) | 1996-10-17 | 1996-10-17 | Formulazioni farmaceutiche e cosmetiche ad attivita' antimicrobica |
PCT/EP1997/005529 WO1998017294A1 (en) | 1996-10-17 | 1997-10-08 | Pharmaceutical and cosmetic formulations with antimicrobial activity |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2000507609A true JP2000507609A (ja) | 2000-06-20 |
JP3279321B2 JP3279321B2 (ja) | 2002-04-30 |
Family
ID=11375046
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51889498A Expired - Fee Related JP3279321B2 (ja) | 1996-10-17 | 1997-10-08 | 抗菌性活性を有する薬剤および化粧用調製物 |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0932408B1 (ja) |
JP (1) | JP3279321B2 (ja) |
KR (1) | KR100324860B1 (ja) |
CN (1) | CN1114436C (ja) |
AT (1) | ATE211388T1 (ja) |
AU (1) | AU717765B2 (ja) |
CA (1) | CA2268914C (ja) |
CZ (1) | CZ289845B6 (ja) |
DE (1) | DE69709886T2 (ja) |
DK (1) | DK0932408T3 (ja) |
ES (1) | ES2170374T3 (ja) |
HK (1) | HK1022278A1 (ja) |
HU (1) | HUP9904679A3 (ja) |
IT (1) | IT1284970B1 (ja) |
NO (1) | NO321146B1 (ja) |
PL (1) | PL187940B1 (ja) |
PT (1) | PT932408E (ja) |
RU (1) | RU2196599C2 (ja) |
SI (1) | SI0932408T1 (ja) |
SK (1) | SK282410B6 (ja) |
WO (1) | WO1998017294A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002302416A (ja) * | 2001-03-30 | 2002-10-18 | Naris Cosmetics Co Ltd | 脂肪合成促進剤および化粧料 |
JP2011518792A (ja) * | 2008-04-24 | 2011-06-30 | インデナ エッセ ピ ア | 口腔感染の治療および予防組成物 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102014906A (zh) * | 2008-04-24 | 2011-04-13 | 因德纳有限公司 | 治疗具有慢性炎症的阴道感染的组合物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62126128A (ja) * | 1985-11-27 | 1987-06-08 | Sato Seiyaku Kk | 抗菌剤 |
JPH07106972B2 (ja) * | 1987-04-24 | 1995-11-15 | 佐藤製薬株式会社 | 歯科口腔用薬剤 |
DK0464297T3 (da) * | 1990-07-05 | 1995-10-09 | Indena Spa | Komplekser af neolignanderivater med phospholipider, anvendelsen deraf samt farmaceutiske og kosmetiske formuleringer indeholdende disse |
-
1996
- 1996-10-17 IT IT96MI002148A patent/IT1284970B1/it active IP Right Grant
-
1997
- 1997-10-08 AT AT97911196T patent/ATE211388T1/de active
- 1997-10-08 HU HU9904679A patent/HUP9904679A3/hu unknown
- 1997-10-08 SI SI9730161T patent/SI0932408T1/xx unknown
- 1997-10-08 CN CN97198872A patent/CN1114436C/zh not_active Expired - Fee Related
- 1997-10-08 WO PCT/EP1997/005529 patent/WO1998017294A1/en active IP Right Grant
- 1997-10-08 EP EP97911196A patent/EP0932408B1/en not_active Expired - Lifetime
- 1997-10-08 PT PT97911196T patent/PT932408E/pt unknown
- 1997-10-08 ES ES97911196T patent/ES2170374T3/es not_active Expired - Lifetime
- 1997-10-08 CA CA002268914A patent/CA2268914C/en not_active Expired - Fee Related
- 1997-10-08 CZ CZ19991330A patent/CZ289845B6/cs not_active IP Right Cessation
- 1997-10-08 RU RU99110382/14A patent/RU2196599C2/ru not_active IP Right Cessation
- 1997-10-08 JP JP51889498A patent/JP3279321B2/ja not_active Expired - Fee Related
- 1997-10-08 SK SK495-99A patent/SK282410B6/sk not_active IP Right Cessation
- 1997-10-08 PL PL33287097A patent/PL187940B1/pl not_active IP Right Cessation
- 1997-10-08 AU AU48657/97A patent/AU717765B2/en not_active Ceased
- 1997-10-08 DE DE69709886T patent/DE69709886T2/de not_active Expired - Lifetime
- 1997-10-08 KR KR1019997003259A patent/KR100324860B1/ko not_active IP Right Cessation
- 1997-10-08 DK DK97911196T patent/DK0932408T3/da active
-
1999
- 1999-04-13 NO NO19991740A patent/NO321146B1/no not_active IP Right Cessation
-
2000
- 2000-03-01 HK HK00101283A patent/HK1022278A1/xx not_active IP Right Cessation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002302416A (ja) * | 2001-03-30 | 2002-10-18 | Naris Cosmetics Co Ltd | 脂肪合成促進剤および化粧料 |
JP4611565B2 (ja) * | 2001-03-30 | 2011-01-12 | 株式会社ナリス化粧品 | 脂肪合成促進剤および化粧料 |
JP2011518792A (ja) * | 2008-04-24 | 2011-06-30 | インデナ エッセ ピ ア | 口腔感染の治療および予防組成物 |
Also Published As
Publication number | Publication date |
---|---|
DK0932408T3 (da) | 2002-04-22 |
SK49599A3 (en) | 2000-03-13 |
RU2196599C2 (ru) | 2003-01-20 |
DE69709886T2 (de) | 2002-08-22 |
SI0932408T1 (en) | 2002-04-30 |
CA2268914A1 (en) | 1998-04-30 |
HUP9904679A2 (hu) | 2000-05-28 |
KR20000049164A (ko) | 2000-07-25 |
CZ289845B6 (cs) | 2002-04-17 |
HK1022278A1 (en) | 2000-08-04 |
IT1284970B1 (it) | 1998-05-28 |
EP0932408B1 (en) | 2002-01-02 |
CZ133099A3 (cs) | 1999-08-11 |
WO1998017294A1 (en) | 1998-04-30 |
ATE211388T1 (de) | 2002-01-15 |
ES2170374T3 (es) | 2002-08-01 |
JP3279321B2 (ja) | 2002-04-30 |
CN1233184A (zh) | 1999-10-27 |
NO991740D0 (no) | 1999-04-13 |
HUP9904679A3 (en) | 2001-11-28 |
ITMI962148A1 (it) | 1998-04-17 |
DE69709886D1 (de) | 2002-02-28 |
PT932408E (pt) | 2002-04-29 |
KR100324860B1 (ko) | 2002-02-28 |
AU4865797A (en) | 1998-05-15 |
NO991740L (no) | 1999-06-10 |
CA2268914C (en) | 2004-02-10 |
SK282410B6 (sk) | 2002-01-07 |
CN1114436C (zh) | 2003-07-16 |
EP0932408A1 (en) | 1999-08-04 |
PL187940B1 (pl) | 2004-11-30 |
PL332870A1 (en) | 1999-10-25 |
AU717765B2 (en) | 2000-03-30 |
NO321146B1 (no) | 2006-03-27 |
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