IT1096381B - 1,1-diossidi dell'acido penicillanico come inibitori di beta-lattamasi - Google Patents
1,1-diossidi dell'acido penicillanico come inibitori di beta-lattamasiInfo
- Publication number
- IT1096381B IT1096381B IT24270/78A IT2427078A IT1096381B IT 1096381 B IT1096381 B IT 1096381B IT 24270/78 A IT24270/78 A IT 24270/78A IT 2427078 A IT2427078 A IT 2427078A IT 1096381 B IT1096381 B IT 1096381B
- Authority
- IT
- Italy
- Prior art keywords
- dioxides
- beta
- penicillanic acid
- lactamase inhibitors
- lactamase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80432077A | 1977-06-07 | 1977-06-07 | |
US87938178A | 1978-02-21 | 1978-02-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7824270A0 IT7824270A0 (it) | 1978-06-06 |
IT1096381B true IT1096381B (it) | 1985-08-26 |
Family
ID=27122691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT24270/78A IT1096381B (it) | 1977-06-07 | 1978-06-06 | 1,1-diossidi dell'acido penicillanico come inibitori di beta-lattamasi |
Country Status (35)
Country | Link |
---|---|
AR (1) | AR224111A1 (de) |
AT (2) | AT360649B (de) |
AU (1) | AU513636B2 (de) |
BE (1) | BE867859A (de) |
BG (2) | BG34614A3 (de) |
CH (1) | CH634073A5 (de) |
CS (1) | CS208472B2 (de) |
DD (2) | DD140888A5 (de) |
DE (2) | DE2857263C3 (de) |
DK (1) | DK155740C (de) |
EG (1) | EG13869A (de) |
FI (1) | FI66003C (de) |
FR (2) | FR2393804A1 (de) |
GB (1) | GB2000138B (de) |
GR (1) | GR72255B (de) |
HK (1) | HK13184A (de) |
HU (1) | HU180042B (de) |
IE (1) | IE47079B1 (de) |
IL (2) | IL54867A (de) |
IN (1) | IN149747B (de) |
IT (1) | IT1096381B (de) |
KE (1) | KE3355A (de) |
LU (1) | LU79774A1 (de) |
MY (1) | MY8500092A (de) |
NL (2) | NL180009C (de) |
NO (2) | NO151746C (de) |
NZ (1) | NZ187476A (de) |
OA (1) | OA05964A (de) |
PH (3) | PH26810A (de) |
PL (1) | PL114501B1 (de) |
PT (1) | PT68146A (de) |
SE (2) | SE436206B (de) |
SG (1) | SG65383G (de) |
SU (1) | SU860706A1 (de) |
YU (1) | YU41829B (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU77306A1 (de) * | 1977-05-09 | 1979-01-18 | ||
DE2912511C2 (de) * | 1977-06-07 | 1982-06-24 | Pfizer Inc., 10017 New York, N.Y. | Pharmazeutische Zusammensetzung, enthaltend Penicillansäure |
DK155942C (da) * | 1977-12-23 | 1989-10-23 | Pfizer | Analogifremgangsmaade til fremstilling af 6-aminopenicillansyre-1,1-dioxid og fysiologisk acceptable syreadditions- og basesalte deraf. |
JPS54126735A (en) * | 1978-03-24 | 1979-10-02 | Toyama Chem Co Ltd | Bactericidal composition for medical use |
US4241050A (en) * | 1978-09-01 | 1980-12-23 | Pfizer Inc. | Penam 1,1-dioxides as beta-lactamase inhibitors |
CA1158639A (en) * | 1978-12-11 | 1983-12-13 | Eric M. Gordon | 6-bromopenicillanic acid sulfone |
IE49880B1 (en) * | 1979-02-13 | 1986-01-08 | Leo Pharm Prod Ltd | Penicillin derivatives |
US4420426A (en) | 1979-03-05 | 1983-12-13 | Pfizer Inc. | 6-Alpha-halopenicillanic acid 1,1-dioxides |
SE449103B (sv) * | 1979-03-05 | 1987-04-06 | Pfizer | Sett att framstella penicillansyra-1,1-dioxid samt estrar derav |
US4714761A (en) * | 1979-03-05 | 1987-12-22 | Pfizer Inc. | 6,6-dihalopenicillanic acid 1,1-dioxides and process |
GB2045236A (en) * | 1979-03-26 | 1980-10-29 | Hoechst Uk Ltd | Oxapenem derivatives |
US4309347A (en) * | 1979-05-16 | 1982-01-05 | Pfizer Inc. | Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide |
US4244951A (en) * | 1979-05-16 | 1981-01-13 | Pfizer Inc. | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide |
IL59948A0 (en) * | 1979-05-21 | 1980-06-30 | Rech Applications Therap | Penicillanic acid derivatives,their production and pharmaceutical compositions containing them |
DE3051044C2 (de) * | 1979-06-19 | 1989-03-30 | Leo Pharmaceutical Products Ltd. A/S (Loevens Kemiske Fabrik Produktionsaktieselskab), Ballerup, Dk | |
US4256733A (en) * | 1979-09-26 | 1981-03-17 | Pfizer Inc. | Acetoxymethyl penam compounds as β-lactamase inhibitors |
US4432970A (en) * | 1979-11-23 | 1984-02-21 | Pfizer Inc. | 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
IL61880A (en) * | 1980-01-21 | 1984-11-30 | Bristol Myers Co | 2beta-chloromethyl-2alpha-methylpenam-3alpha-carboxylic acid sulfone derivatives,their preparation and pharmaceutical compositions containing them |
US4432903A (en) * | 1980-09-08 | 1984-02-21 | Pfizer Inc. | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide |
US4488994A (en) * | 1980-09-08 | 1984-12-18 | Pfizer Inc. | Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide |
US4474698A (en) * | 1980-12-11 | 1984-10-02 | Pfizer Inc. | Process for preparing esters of penicillanic acid sulfone |
US4419284A (en) * | 1981-03-23 | 1983-12-06 | Pfizer Inc. | Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide |
DE3261759D1 (en) * | 1981-07-15 | 1985-02-14 | Kanebo Ltd | Novel ester of 1,1-dioxopenicillanic acid, process for production thereof, and use thereof as beta-lactamase inhibitor |
PT76527B (en) * | 1982-04-19 | 1985-12-09 | Gist Brocades Nv | A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof |
US4502988A (en) * | 1983-08-08 | 1985-03-05 | Eli Lilly And Company | Oxidation process |
EP0139047A1 (de) * | 1983-10-18 | 1985-05-02 | Gist-Brocades N.V. | Verfahren zur Herstellung von 6,6-Dibromopenicillansäure-1,1-Dioxyd |
US4647457A (en) * | 1983-12-16 | 1987-03-03 | Hoffmann-La Roche Inc. | Penicillanic acid derivatives |
JPH07103129B2 (ja) * | 1986-04-10 | 1995-11-08 | レオ・ファーマシューティカル・プロダクツ・リミテッド・エイ/エス(レーベンス・ケミスケ・ファブリック・プロデュクチオンスアクチーセルスカブ) | ペニシラン酸誘導体の改良された新規合成方法 |
GB8808701D0 (en) * | 1988-04-13 | 1988-05-18 | Erba Carlo Spa | Beta-lactam derivatives |
CN102977120B (zh) * | 2012-12-14 | 2015-05-27 | 江西富祥药业股份有限公司 | 一种舒巴坦匹酯制备及结晶方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3197466A (en) * | 1961-10-30 | 1965-07-27 | Smith Kline French Lab | Penicillin sulfoxides and process |
LU77306A1 (de) * | 1977-05-09 | 1979-01-18 | ||
AU3796278A (en) * | 1977-07-13 | 1980-01-17 | Glaxo Group Ltd | Penams and azetidinones |
-
1978
- 1978-05-04 IN IN327/DEL/78A patent/IN149747B/en unknown
- 1978-05-09 PH PH21116A patent/PH26810A/en unknown
- 1978-05-16 YU YU1170/78A patent/YU41829B/xx unknown
- 1978-05-18 OA OA56500A patent/OA05964A/xx unknown
- 1978-05-20 EG EG322/78A patent/EG13869A/xx active
- 1978-05-30 BG BG7839910A patent/BG34614A3/xx unknown
- 1978-05-30 BG BG7942176A patent/BG34615A3/xx unknown
- 1978-06-01 CS CS783579A patent/CS208472B2/cs unknown
- 1978-06-02 AU AU36838/78A patent/AU513636B2/en not_active Ceased
- 1978-06-02 GB GB7826308A patent/GB2000138B/en not_active Expired
- 1978-06-05 DE DE2857263A patent/DE2857263C3/de not_active Expired
- 1978-06-05 GR GR56439A patent/GR72255B/el unknown
- 1978-06-05 DE DE2824535A patent/DE2824535C3/de not_active Expired
- 1978-06-06 HU HU78PI630A patent/HU180042B/hu unknown
- 1978-06-06 SE SE7806628A patent/SE436206B/sv not_active IP Right Cessation
- 1978-06-06 NL NLAANVRAGE7806126,A patent/NL180009C/xx not_active IP Right Cessation
- 1978-06-06 IL IL54867A patent/IL54867A/xx unknown
- 1978-06-06 LU LU79774A patent/LU79774A1/fr unknown
- 1978-06-06 PL PL1978207396A patent/PL114501B1/pl unknown
- 1978-06-06 BE BE188352A patent/BE867859A/xx not_active IP Right Cessation
- 1978-06-06 DK DK251478A patent/DK155740C/da not_active IP Right Cessation
- 1978-06-06 PT PT68146A patent/PT68146A/pt unknown
- 1978-06-06 FI FI781800A patent/FI66003C/fi not_active IP Right Cessation
- 1978-06-06 IE IE1140/78A patent/IE47079B1/en not_active IP Right Cessation
- 1978-06-06 CH CH618078A patent/CH634073A5/fr not_active IP Right Cessation
- 1978-06-06 AT AT411278A patent/AT360649B/de active Protection Beyond IP Right Term
- 1978-06-06 SU SU782624408A patent/SU860706A1/ru active
- 1978-06-06 FR FR787816893A patent/FR2393804A1/fr active Granted
- 1978-06-06 NZ NZ187476A patent/NZ187476A/xx unknown
- 1978-06-06 NO NO781970A patent/NO151746C/no unknown
- 1978-06-06 IT IT24270/78A patent/IT1096381B/it active Protection Beyond IP Right Term
- 1978-06-07 DD DD78205839A patent/DD140888A5/de unknown
- 1978-06-07 DD DD78218400A patent/DD148585A5/de unknown
- 1978-08-18 AR AR272228A patent/AR224111A1/es active
- 1978-09-08 PH PH21587A patent/PH16465A/en unknown
- 1978-09-08 PH PH21586A patent/PH21116A/en unknown
- 1978-09-19 FR FR787826789A patent/FR2393805A1/fr active Granted
-
1980
- 1980-03-07 AT AT0128580A patent/AT364084B/de not_active IP Right Cessation
-
1981
- 1981-02-19 IL IL62168A patent/IL62168A0/xx unknown
-
1982
- 1982-09-15 NO NO823126A patent/NO152448C/no unknown
-
1983
- 1983-10-27 SE SE8305916A patent/SE447995B/xx not_active IP Right Cessation
- 1983-11-02 SG SG653/83A patent/SG65383G/en unknown
- 1983-11-22 KE KE3355A patent/KE3355A/xx unknown
-
1984
- 1984-02-16 HK HK131/84A patent/HK13184A/xx not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY92/85A patent/MY8500092A/xx unknown
-
1993
- 1993-06-11 NL NL930064C patent/NL930064I2/nl unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ITCP | Complementary protection certificate |
Free format text: CCP 122 |
|
MEDD | Supplementary protection certificate for pharmaceutical products: granted |
Free format text: CCP 122, 19920417; PFIZER INC. |
|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970417 |