IN186768B - - Google Patents

Info

Publication number
IN186768B
IN186768B IN2893DE1996A IN186768B IN 186768 B IN186768 B IN 186768B IN 2893DE1996 A IN2893DE1996 A IN 2893DE1996A IN 186768 B IN186768 B IN 186768B
Authority
IN
India
Application number
Other languages
English (en)
Inventor
Herve Bouchard
Alain Commercon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Priority to IN419DE2000 priority Critical patent/IN188680B/en
Publication of IN186768B publication Critical patent/IN186768B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN2893DE1996 1995-12-22 1996-12-20 IN186768B (en, 2012)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IN419DE2000 IN188680B (en, 2012) 1995-12-22 2000-04-10

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
IN186768B true IN186768B (en, 2012) 2001-11-03

Family

ID=9485871

Family Applications (4)

Application Number Title Priority Date Filing Date
IN2893DE1996 IN186768B (en, 2012) 1995-12-22 1996-12-20
IN421DE2000 IN188470B (en, 2012) 1995-12-22 2000-04-10
IN419DE2000 IN188680B (en, 2012) 1995-12-22 2000-04-10
IN420DE2000 IN188469B (en, 2012) 1995-12-22 2000-04-10

Family Applications After (3)

Application Number Title Priority Date Filing Date
IN421DE2000 IN188470B (en, 2012) 1995-12-22 2000-04-10
IN419DE2000 IN188680B (en, 2012) 1995-12-22 2000-04-10
IN420DE2000 IN188469B (en, 2012) 1995-12-22 2000-04-10

Country Status (40)

Country Link
US (1) US5728849A (en, 2012)
EP (1) EP0876362B1 (en, 2012)
JP (1) JP3953106B2 (en, 2012)
KR (1) KR100500351B1 (en, 2012)
CN (1) CN1103766C (en, 2012)
AR (1) AR005197A1 (en, 2012)
AT (1) ATE250593T1 (en, 2012)
AU (1) AU712597B2 (en, 2012)
BG (1) BG63204B1 (en, 2012)
BR (1) BR9612135A (en, 2012)
CA (1) CA2238884C (en, 2012)
CO (1) CO4520184A1 (en, 2012)
CZ (1) CZ294972B6 (en, 2012)
DE (1) DE69630145T2 (en, 2012)
DK (1) DK0876362T3 (en, 2012)
DZ (1) DZ2149A1 (en, 2012)
EA (1) EA001533B1 (en, 2012)
ES (1) ES2202490T3 (en, 2012)
FR (1) FR2742751B1 (en, 2012)
HU (1) HU225032B1 (en, 2012)
IL (1) IL124994A (en, 2012)
IN (4) IN186768B (en, 2012)
MA (1) MA26412A1 (en, 2012)
MX (1) MX9804688A (en, 2012)
MY (1) MY113934A (en, 2012)
NO (1) NO317358B1 (en, 2012)
NZ (1) NZ324337A (en, 2012)
OA (1) OA10700A (en, 2012)
PE (1) PE25198A1 (en, 2012)
PL (1) PL189311B1 (en, 2012)
PT (1) PT876362E (en, 2012)
RO (1) RO116194B1 (en, 2012)
SK (1) SK282835B6 (en, 2012)
TN (1) TNSN96169A1 (en, 2012)
TR (1) TR199801179T2 (en, 2012)
TW (1) TW371659B (en, 2012)
UA (1) UA48205C2 (en, 2012)
UY (1) UY24386A1 (en, 2012)
WO (1) WO1997023473A1 (en, 2012)
ZA (1) ZA9610737B (en, 2012)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
CZ20013405A3 (cs) 2000-02-02 2002-03-13 Florida State University Research Foundation, Inc. C10 karbonátem substituované taxany jako protinádorová činidla
DK2298769T3 (da) * 2001-02-24 2014-01-20 Boehringer Ingelheim Pharma Xanthinderivater, deres fremstilling og deres anvendelse som lægemiddel
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
CA2526278A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
KR101541791B1 (ko) * 2006-05-04 2015-08-04 베링거 인겔하임 인터내셔날 게엠베하 다형태
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
RU2569749C2 (ru) * 2007-08-17 2015-11-27 Бёрингер Ингельхайм Интернациональ Гмбх Производные пурина, предназначенные для применения для лечения заболеваний, связанных с баф (белок-активатор фибробластов)
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
BRPI0916997A2 (pt) 2008-08-06 2020-12-15 Boehringer Ingelheim International Gmbh Inibidor de dpp-4 e seu uso
WO2010018217A2 (en) * 2008-08-15 2010-02-18 Boehringer Ingelheim International Gmbh Organic compounds for wound healing
CN102149407A (zh) 2008-09-10 2011-08-10 贝林格尔.英格海姆国际有限公司 治疗糖尿病和相关病症的组合疗法
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
KR20110103968A (ko) 2008-12-23 2011-09-21 베링거 인겔하임 인터내셔날 게엠베하 유기 화합물의 염 형태
TW201036975A (en) 2009-01-07 2010-10-16 Boehringer Ingelheim Int Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
KR20190071840A (ko) 2009-11-27 2019-06-24 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
WO2011138421A1 (en) 2010-05-05 2011-11-10 Boehringer Ingelheim International Gmbh Combination therapy
AU2011268940B2 (en) 2010-06-24 2015-05-21 Boehringer Ingelheim International Gmbh Diabetes therapy
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
US8883800B2 (en) 2011-07-15 2014-11-11 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
WO2013171166A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis
WO2013171167A1 (en) 2012-05-14 2013-11-21 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
CN106414465B (zh) 2014-02-28 2021-11-16 杭州多禧生物科技有限公司 带电荷链接体及其在共轭反应上的应用
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
CN113350518A (zh) 2015-07-12 2021-09-07 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
JP2019517542A (ja) 2016-06-10 2019-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング リナグリプチンおよびメトホルミンの組合せ
WO2018086139A1 (en) 2016-11-14 2018-05-17 Hangzhou Dac Biotech Co., Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
EP4426727A2 (en) 2021-11-03 2024-09-11 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
US5059699A (en) * 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
RU2059631C1 (ru) * 1991-11-29 1996-05-10 Дзе Юниверсити оф Канзас Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
JPH07505887A (ja) * 1992-04-17 1995-06-29 アボツト・ラボラトリーズ タキソール誘導体
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
DK0876362T3 (da) 2004-02-02
NO317358B1 (no) 2004-10-18
WO1997023473A1 (fr) 1997-07-03
HUP9904046A3 (en) 2001-08-28
UA48205C2 (uk) 2002-08-15
MA26412A1 (fr) 2004-12-20
PE25198A1 (es) 1998-05-10
PT876362E (pt) 2004-02-27
IL124994A (en) 2000-12-06
HU225032B1 (en) 2006-05-29
FR2742751B1 (fr) 1998-01-30
EA001533B1 (ru) 2001-04-23
CO4520184A1 (es) 1997-10-15
PL189311B1 (pl) 2005-07-29
AR005197A1 (es) 1999-04-14
HUP9904046A1 (hu) 2001-04-28
NO982580L (no) 1998-06-05
KR19990076680A (ko) 1999-10-15
BG63204B1 (bg) 2001-06-29
ATE250593T1 (de) 2003-10-15
KR100500351B1 (ko) 2005-12-21
EP0876362B1 (fr) 2003-09-24
UY24386A1 (es) 2001-08-27
JP3953106B2 (ja) 2007-08-08
DE69630145D1 (de) 2003-10-30
CA2238884C (fr) 2007-02-06
BG102569A (en) 1999-04-30
TR199801179T2 (xx) 1998-10-21
NZ324337A (en) 2000-03-27
ES2202490T3 (es) 2004-04-01
DE69630145T2 (de) 2004-07-15
CN1205697A (zh) 1999-01-20
CN1103766C (zh) 2003-03-26
SK282835B6 (sk) 2002-12-03
CZ294972B6 (cs) 2005-04-13
ZA9610737B (en) 1997-06-27
EA199800588A1 (ru) 1998-12-24
JP2000502671A (ja) 2000-03-07
MY113934A (en) 2002-06-29
HK1017895A1 (en) 1999-12-03
EP0876362A1 (fr) 1998-11-11
FR2742751A1 (fr) 1997-06-27
DZ2149A1 (fr) 2002-10-23
CZ196198A3 (cs) 1998-09-16
OA10700A (fr) 2002-11-27
IL124994A0 (en) 1999-01-26
NO982580D0 (no) 1998-06-05
AU712597B2 (en) 1999-11-11
MX9804688A (es) 1998-10-31
RO116194B1 (ro) 2000-11-30
AU1180997A (en) 1997-07-17
CA2238884A1 (fr) 1997-07-03
BR9612135A (pt) 1999-07-13
TNSN96169A1 (fr) 2005-03-15
IN188469B (en, 2012) 2002-09-28
SK85398A3 (en) 1998-11-04
PL327405A1 (en) 1998-12-07
IN188680B (en, 2012) 2002-10-26
US5728849A (en) 1998-03-17
IN188470B (en, 2012) 2002-09-28
TW371659B (en) 1999-10-11

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