ATE250593T1 - Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen - Google Patents

Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen

Info

Publication number
ATE250593T1
ATE250593T1 AT96942433T AT96942433T ATE250593T1 AT E250593 T1 ATE250593 T1 AT E250593T1 AT 96942433 T AT96942433 T AT 96942433T AT 96942433 T AT96942433 T AT 96942433T AT E250593 T1 ATE250593 T1 AT E250593T1
Authority
AT
Austria
Prior art keywords
taxal
derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
AT96942433T
Other languages
German (de)
English (en)
Inventor
Herve Bouchard
Alain Commercon
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE250593T1 publication Critical patent/ATE250593T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96942433T 1995-12-22 1996-12-19 Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen ATE250593T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515379A FR2742751B1 (fr) 1995-12-22 1995-12-22 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/002031 WO1997023473A1 (fr) 1995-12-22 1996-12-19 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ATE250593T1 true ATE250593T1 (de) 2003-10-15

Family

ID=9485871

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96942433T ATE250593T1 (de) 1995-12-22 1996-12-19 Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammenstellungen

Country Status (40)

Country Link
US (1) US5728849A (en, 2012)
EP (1) EP0876362B1 (en, 2012)
JP (1) JP3953106B2 (en, 2012)
KR (1) KR100500351B1 (en, 2012)
CN (1) CN1103766C (en, 2012)
AR (1) AR005197A1 (en, 2012)
AT (1) ATE250593T1 (en, 2012)
AU (1) AU712597B2 (en, 2012)
BG (1) BG63204B1 (en, 2012)
BR (1) BR9612135A (en, 2012)
CA (1) CA2238884C (en, 2012)
CO (1) CO4520184A1 (en, 2012)
CZ (1) CZ294972B6 (en, 2012)
DE (1) DE69630145T2 (en, 2012)
DK (1) DK0876362T3 (en, 2012)
DZ (1) DZ2149A1 (en, 2012)
EA (1) EA001533B1 (en, 2012)
ES (1) ES2202490T3 (en, 2012)
FR (1) FR2742751B1 (en, 2012)
HU (1) HU225032B1 (en, 2012)
IL (1) IL124994A (en, 2012)
IN (4) IN186768B (en, 2012)
MA (1) MA26412A1 (en, 2012)
MX (1) MX9804688A (en, 2012)
MY (1) MY113934A (en, 2012)
NO (1) NO317358B1 (en, 2012)
NZ (1) NZ324337A (en, 2012)
OA (1) OA10700A (en, 2012)
PE (1) PE25198A1 (en, 2012)
PL (1) PL189311B1 (en, 2012)
PT (1) PT876362E (en, 2012)
RO (1) RO116194B1 (en, 2012)
SK (1) SK282835B6 (en, 2012)
TN (1) TNSN96169A1 (en, 2012)
TR (1) TR199801179T2 (en, 2012)
TW (1) TW371659B (en, 2012)
UA (1) UA48205C2 (en, 2012)
UY (1) UY24386A1 (en, 2012)
WO (1) WO1997023473A1 (en, 2012)
ZA (1) ZA9610737B (en, 2012)

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EA007485B1 (ru) * 2001-02-24 2006-10-27 Берингер Ингельхайм Фарма Гмбх Унд Ко. Кг Производные ксантина, способ их получения, фармацевтическая композиция на их основе и способ ее получения
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
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US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
EP1669358A1 (en) * 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
DE102005035891A1 (de) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
NZ573360A (en) 2006-05-04 2012-08-31 Boehringer Ingelheim Int Polymorphic forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
NZ600126A (en) * 2007-08-17 2013-12-20 Boehringer Ingelheim Int Purine derivatives for use in the treatment of fap-related diseases
PE20140960A1 (es) 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
MY164581A (en) * 2008-08-15 2018-01-15 Boehringer Ingelheim Int Purin derivatives for use in the treatment of fab-related diseases
WO2010029089A2 (en) 2008-09-10 2010-03-18 Boehringer Ingelheim International Gmbh Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN102256976A (zh) 2008-12-23 2011-11-23 贝林格尔.英格海姆国际有限公司 有机化合物的盐形式
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
AU2010323068B2 (en) 2009-11-27 2015-09-03 Boehringer Ingelheim International Gmbh Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin
JP6034781B2 (ja) 2010-05-05 2016-11-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 併用療法
AU2011268940B2 (en) 2010-06-24 2015-05-21 Boehringer Ingelheim International Gmbh Diabetes therapy
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
EP3517539B1 (en) 2011-07-15 2022-12-14 Boehringer Ingelheim International GmbH Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
JP6218811B2 (ja) 2012-05-14 2017-10-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
JP6224084B2 (ja) 2012-05-14 2017-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
FR3010839B1 (fr) * 2013-09-17 2017-04-21 Schneider Electric Ind Sas Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique
US9526728B2 (en) 2014-02-28 2016-12-27 Boehringer Ingelheim International Gmbh Medical use of a DPP-4 inhibitor
JP6417421B2 (ja) 2014-02-28 2018-11-07 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 荷電連結体及び共役体のためのその使用
WO2015151081A2 (en) 2015-07-12 2015-10-08 Suzhou M-Conj Biotech Co., Ltd Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
EP4233840A3 (en) 2016-06-10 2023-10-18 Boehringer Ingelheim International GmbH Combinations of linagliptin and metformin
KR20220147720A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联

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RU2017724C1 (ru) * 1990-07-12 1994-08-15 Дзе Юниверсити оф Канзас Способ получения производных таксола
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Also Published As

Publication number Publication date
MA26412A1 (fr) 2004-12-20
TW371659B (en) 1999-10-11
TNSN96169A1 (fr) 2005-03-15
NO982580L (no) 1998-06-05
CZ294972B6 (cs) 2005-04-13
NO317358B1 (no) 2004-10-18
AU712597B2 (en) 1999-11-11
EP0876362A1 (fr) 1998-11-11
TR199801179T2 (xx) 1998-10-21
PL189311B1 (pl) 2005-07-29
ZA9610737B (en) 1997-06-27
PL327405A1 (en) 1998-12-07
PE25198A1 (es) 1998-05-10
IN188680B (en, 2012) 2002-10-26
SK282835B6 (sk) 2002-12-03
CA2238884A1 (fr) 1997-07-03
US5728849A (en) 1998-03-17
DE69630145T2 (de) 2004-07-15
UA48205C2 (uk) 2002-08-15
DZ2149A1 (fr) 2002-10-23
UY24386A1 (es) 2001-08-27
CO4520184A1 (es) 1997-10-15
KR100500351B1 (ko) 2005-12-21
OA10700A (fr) 2002-11-27
NO982580D0 (no) 1998-06-05
NZ324337A (en) 2000-03-27
AR005197A1 (es) 1999-04-14
BG63204B1 (bg) 2001-06-29
EP0876362B1 (fr) 2003-09-24
CN1205697A (zh) 1999-01-20
AU1180997A (en) 1997-07-17
CN1103766C (zh) 2003-03-26
FR2742751A1 (fr) 1997-06-27
JP2000502671A (ja) 2000-03-07
MY113934A (en) 2002-06-29
BR9612135A (pt) 1999-07-13
HU225032B1 (en) 2006-05-29
EA199800588A1 (ru) 1998-12-24
HUP9904046A3 (en) 2001-08-28
IN186768B (en, 2012) 2001-11-03
IN188469B (en, 2012) 2002-09-28
RO116194B1 (ro) 2000-11-30
DK0876362T3 (da) 2004-02-02
CZ196198A3 (cs) 1998-09-16
IL124994A0 (en) 1999-01-26
PT876362E (pt) 2004-02-27
WO1997023473A1 (fr) 1997-07-03
CA2238884C (fr) 2007-02-06
HK1017895A1 (en) 1999-12-03
EA001533B1 (ru) 2001-04-23
ES2202490T3 (es) 2004-04-01
IN188470B (en, 2012) 2002-09-28
MX9804688A (es) 1998-10-31
DE69630145D1 (de) 2003-10-30
FR2742751B1 (fr) 1998-01-30
JP3953106B2 (ja) 2007-08-08
KR19990076680A (ko) 1999-10-15
HUP9904046A1 (hu) 2001-04-28
IL124994A (en) 2000-12-06
BG102569A (en) 1999-04-30
SK85398A3 (en) 1998-11-04

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