IL98025A - Analogs of 1,3-oxathioline nucleotides, methods for their preparation and pharmaceutical preparations containing them - Google Patents

Analogs of 1,3-oxathioline nucleotides, methods for their preparation and pharmaceutical preparations containing them

Info

Publication number
IL98025A
IL98025A IL9802591A IL9802591A IL98025A IL 98025 A IL98025 A IL 98025A IL 9802591 A IL9802591 A IL 9802591A IL 9802591 A IL9802591 A IL 9802591A IL 98025 A IL98025 A IL 98025A
Authority
IL
Israel
Prior art keywords
mixture
enantiomer
compound
pharmaceutically acceptable
oxathiolan
Prior art date
Application number
IL9802591A
Other languages
English (en)
Hebrew (he)
Other versions
IL98025A0 (en
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10675345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL98025(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of IL98025A0 publication Critical patent/IL98025A0/xx
Publication of IL98025A publication Critical patent/IL98025A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
IL9802591A 1990-05-02 1991-05-02 Analogs of 1,3-oxathioline nucleotides, methods for their preparation and pharmaceutical preparations containing them IL98025A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909009861A GB9009861D0 (en) 1990-05-02 1990-05-02 Chemical compounds

Publications (2)

Publication Number Publication Date
IL98025A0 IL98025A0 (en) 1992-06-21
IL98025A true IL98025A (en) 1996-10-16

Family

ID=10675345

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9802591A IL98025A (en) 1990-05-02 1991-05-02 Analogs of 1,3-oxathioline nucleotides, methods for their preparation and pharmaceutical preparations containing them

Country Status (35)

Country Link
US (3) US6180639B1 (ko)
EP (2) EP0625150A1 (ko)
JP (3) JP2927546B2 (ko)
KR (1) KR960007532B1 (ko)
CN (3) CN1036196C (ko)
AP (1) AP182A (ko)
BG (1) BG60679B1 (ko)
CA (2) CA2059263C (ko)
CZ (1) CZ288499B6 (ko)
EG (1) EG19958A (ko)
FI (1) FI111722B (ko)
GB (1) GB9009861D0 (ko)
GE (1) GEP19991705B (ko)
HK (1) HK1043940B (ko)
HU (2) HUT64335A (ko)
IE (1) IE911482A1 (ko)
IL (1) IL98025A (ko)
MA (1) MA22144A1 (ko)
MD (1) MD809C2 (ko)
MY (1) MY109796A (ko)
NO (1) NO180377B (ko)
NZ (1) NZ238017A (ko)
OA (1) OA09559A (ko)
PL (1) PL167682B1 (ko)
PT (1) PT97520B (ko)
RO (1) RO112616B1 (ko)
RU (1) RU2099338C1 (ko)
SG (1) SG46383A1 (ko)
SK (1) SK283430B6 (ko)
TN (1) TNSN91029A1 (ko)
TW (2) TWI222448B (ko)
UA (1) UA40589C2 (ko)
WO (1) WO1991017159A1 (ko)
YU (1) YU78291A (ko)
ZA (1) ZA913293B (ko)

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US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
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Also Published As

Publication number Publication date
US20030004175A1 (en) 2003-01-02
CN1326743A (zh) 2001-12-19
AU7771991A (en) 1991-11-27
MY109796A (en) 1997-07-30
CN1154500C (zh) 2004-06-23
AU651345B2 (en) 1994-07-21
HU9200302D0 (en) 1992-04-28
CA2059263A1 (en) 1991-11-03
NZ238017A (en) 1994-06-27
HU210803A9 (en) 1995-07-28
EP1062950A2 (en) 2000-12-27
PT97520A (pt) 1992-01-31
TNSN91029A1 (fr) 1992-10-25
PT97520B (pt) 1998-08-31
AP9100255A0 (en) 1991-07-31
KR920702682A (ko) 1992-10-06
JPH05501117A (ja) 1993-03-04
RU2099338C1 (ru) 1997-12-20
KR960007532B1 (ko) 1996-06-05
AP182A (en) 1992-06-30
BG60679B1 (bg) 1995-12-29
CA2337748A1 (en) 1991-11-14
CN1108655A (zh) 1995-09-20
UA40589C2 (uk) 2001-08-15
JPH1180153A (ja) 1999-03-26
MD809C2 (ro) 1998-07-31
EP1062950A3 (en) 2003-05-02
CN1056145C (zh) 2000-09-06
HK1043940A1 (en) 2002-10-04
MA22144A1 (fr) 1991-12-31
TWI222448B (en) 2004-10-21
CN1036196C (zh) 1997-10-22
CZ288499B6 (en) 2001-06-13
NO180377B (no) 1996-12-30
RO112616B1 (ro) 1997-11-28
HK1043940B (zh) 2005-03-24
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