IL97730A - Stable suspensions of tiny bubbles that can be injected into living bodies - Google Patents
Stable suspensions of tiny bubbles that can be injected into living bodiesInfo
- Publication number
- IL97730A IL97730A IL9773091A IL9773091A IL97730A IL 97730 A IL97730 A IL 97730A IL 9773091 A IL9773091 A IL 9773091A IL 9773091 A IL9773091 A IL 9773091A IL 97730 A IL97730 A IL 97730A
- Authority
- IL
- Israel
- Prior art keywords
- suspension
- gas
- air
- microbubbles
- phospholipid
- Prior art date
Links
- 239000000725 suspension Substances 0.000 title claims abstract description 72
- 239000004094 surface-active agent Substances 0.000 claims abstract description 61
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Catching Or Destruction (AREA)
- Farming Of Fish And Shellfish (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90810262 | 1990-04-02 |
Publications (2)
| Publication Number | Publication Date |
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| IL97730A0 IL97730A0 (en) | 1992-06-21 |
| IL97730A true IL97730A (en) | 1995-12-08 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9773091A IL97730A (en) | 1990-04-02 | 1991-03-29 | Stable suspensions of tiny bubbles that can be injected into living bodies |
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|---|---|
| US (13) | US5271928A (es) |
| EP (1) | EP0474833B2 (es) |
| JP (3) | JP2842453B2 (es) |
| KR (1) | KR960002184B1 (es) |
| CN (1) | CN1055413C (es) |
| AT (1) | ATE125711T1 (es) |
| AU (1) | AU630030B2 (es) |
| CA (1) | CA2056371C (es) |
| DE (1) | DE69111719T3 (es) |
| DK (1) | DK0474833T4 (es) |
| ES (1) | ES2075438T5 (es) |
| GR (1) | GR3017324T3 (es) |
| IE (1) | IE69018B1 (es) |
| IL (1) | IL97730A (es) |
| IN (1) | IN172208B (es) |
| IS (1) | IS3686A7 (es) |
| NZ (1) | NZ237637A (es) |
| WO (1) | WO1991015244A2 (es) |
| ZA (1) | ZA912427B (es) |
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| US5305757A (en) | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
| US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
| US5228446A (en) * | 1989-12-22 | 1993-07-20 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
| US6551576B1 (en) * | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US5585112A (en) * | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
| US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
| US5656211A (en) | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
| US5705187A (en) * | 1989-12-22 | 1998-01-06 | Imarx Pharmaceutical Corp. | Compositions of lipids and stabilizing materials |
| US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
| US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US5773024A (en) * | 1989-12-22 | 1998-06-30 | Imarx Pharmaceutical Corp. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
| US20020150539A1 (en) * | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
| US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US5334381A (en) * | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
| US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| IN172208B (es) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
| US20040208826A1 (en) * | 1990-04-02 | 2004-10-21 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US7083778B2 (en) | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US6989141B2 (en) * | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US5556610A (en) * | 1992-01-24 | 1996-09-17 | Bracco Research S.A. | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method |
| US20010024638A1 (en) * | 1992-11-02 | 2001-09-27 | Michel Schneider | Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof |
| US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
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1991
- 1991-03-26 IN IN247/MAS/91A patent/IN172208B/en unknown
- 1991-03-27 IS IS3686A patent/IS3686A7/is unknown
- 1991-03-28 NZ NZ237637A patent/NZ237637A/en unknown
- 1991-03-28 IE IE104891A patent/IE69018B1/en not_active IP Right Cessation
- 1991-03-29 IL IL9773091A patent/IL97730A/en not_active IP Right Cessation
- 1991-04-02 AT AT91907163T patent/ATE125711T1/de not_active IP Right Cessation
- 1991-04-02 CN CN91102163A patent/CN1055413C/zh not_active Expired - Lifetime
- 1991-04-02 CA CA002056371A patent/CA2056371C/en not_active Expired - Lifetime
- 1991-04-02 WO PCT/EP1991/000620 patent/WO1991015244A2/en active IP Right Grant
- 1991-04-02 DE DE69111719T patent/DE69111719T3/de not_active Expired - Lifetime
- 1991-04-02 AU AU75828/91A patent/AU630030B2/en not_active Expired
- 1991-04-02 EP EP91907163A patent/EP0474833B2/en not_active Expired - Lifetime
- 1991-04-02 DK DK91907163T patent/DK0474833T4/da active
- 1991-04-02 ZA ZA912427A patent/ZA912427B/xx unknown
- 1991-04-02 JP JP3506829A patent/JP2842453B2/ja not_active Expired - Lifetime
- 1991-04-02 KR KR1019910701733A patent/KR960002184B1/ko not_active IP Right Cessation
- 1991-04-02 ES ES91907163T patent/ES2075438T5/es not_active Expired - Lifetime
- 1991-04-02 US US07/775,989 patent/US5271928A/en not_active Expired - Lifetime
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1993
- 1993-09-29 US US08/128,540 patent/US5380519A/en not_active Expired - Lifetime
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1994
- 1994-09-30 US US08/315,347 patent/US5531980A/en not_active Expired - Lifetime
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1995
- 1995-06-01 US US08/456,385 patent/US5658551A/en not_active Expired - Lifetime
- 1995-06-01 US US08/457,581 patent/US5567414A/en not_active Expired - Lifetime
- 1995-09-06 GR GR950402454T patent/GR3017324T3/el unknown
- 1995-09-26 US US08/534,198 patent/US5643553A/en not_active Expired - Lifetime
-
1997
- 1997-05-09 US US08/853,936 patent/US6110443A/en not_active Expired - Lifetime
- 1997-07-15 US US08/893,371 patent/US7033574B1/en not_active Expired - Fee Related
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1998
- 1998-02-10 US US09/021,150 patent/US6136293A/en not_active Expired - Fee Related
- 1998-02-11 US US09/022,868 patent/US5911972A/en not_active Expired - Lifetime
- 1998-06-26 JP JP18050498A patent/JP4205779B2/ja not_active Expired - Lifetime
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2000
- 2000-08-01 US US09/630,537 patent/US6485705B1/en not_active Expired - Fee Related
-
2002
- 2002-08-23 US US10/226,244 patent/US6896875B2/en not_active Expired - Fee Related
-
2003
- 2003-02-27 JP JP2003050459A patent/JP2003221350A/ja active Pending
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2005
- 2005-03-22 US US11/085,169 patent/US20050207980A1/en not_active Abandoned
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