IL94227A - Chymopapain, process for purifying it and pharmaceutical compositions containing it - Google Patents

Chymopapain, process for purifying it and pharmaceutical compositions containing it

Info

Publication number
IL94227A
IL94227A IL9422790A IL9422790A IL94227A IL 94227 A IL94227 A IL 94227A IL 9422790 A IL9422790 A IL 9422790A IL 9422790 A IL9422790 A IL 9422790A IL 94227 A IL94227 A IL 94227A
Authority
IL
Israel
Prior art keywords
chymopapain
solution
added
minutes
aqueous
Prior art date
Application number
IL9422790A
Other languages
English (en)
Other versions
IL94227A0 (en
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Plc filed Critical Boots Co Plc
Publication of IL94227A0 publication Critical patent/IL94227A0/xx
Publication of IL94227A publication Critical patent/IL94227A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL9422790A 1989-04-28 1990-04-27 Chymopapain, process for purifying it and pharmaceutical compositions containing it IL94227A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898909836A GB8909836D0 (en) 1989-04-28 1989-04-28 Therapeutic agent

Publications (2)

Publication Number Publication Date
IL94227A0 IL94227A0 (en) 1991-01-31
IL94227A true IL94227A (en) 1994-12-29

Family

ID=10655944

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9422790A IL94227A (en) 1989-04-28 1990-04-27 Chymopapain, process for purifying it and pharmaceutical compositions containing it

Country Status (34)

Country Link
US (2) US5380656A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0470136B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH04506003A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR920701241A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1047340A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE107660T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU631641B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BG (1) BG60916B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2056402C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD296960A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69010199T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0470136T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EG (1) EG19583A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2055427T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI914995A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB8909836D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR1001011B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HR (1) HRP930700A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (2) HUT58345A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE64351B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL94227A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (2) IN170683B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LT (1) LT3827B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LV (1) LV10200B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX20503A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO914206L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ233475A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL166810B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT93921B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RO (1) RO112032B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2074891C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1990013561A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU87090A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA903228B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909836D0 (en) * 1989-04-28 1989-06-14 Boots Co Plc Therapeutic agent
JPH06506921A (ja) * 1991-02-22 1994-08-04 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 置換α−アミノアルデヒドおよび誘導体
CA2061861A1 (en) * 1991-03-04 1992-09-05 Jonathan Duvick Plant polypeptides with inhibitory activity towards pathogenic microorganisms
CN1060519C (zh) * 1991-05-09 2001-01-10 广西亚热带作物研究所 桄榔植物蛋白酶的提取方法
AU668110B2 (en) * 1991-10-14 1996-04-26 Cash Engineering Research Pty Ltd Inlet control combination for a compressor system
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
WO1994028012A1 (en) * 1993-05-28 1994-12-08 Warner-Lambert Company Hydroxamate inhibitors of endothelin converting enzyme
EP1159273A1 (en) 1999-03-02 2001-12-05 Boehringer Ingelheim Pharmaceuticals Inc. Compounds useful as reversible inhibitors of cathepsin s
DK1178958T3 (da) 1999-03-15 2004-06-21 Axys Pharm Inc N-cyanomethylamider som proteaseinhibitorer
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US6703040B2 (en) * 2000-01-11 2004-03-09 Intralytix, Inc. Polymer blends as biodegradable matrices for preparing biocomposites
SI1593391T1 (sl) 2002-12-25 2013-11-29 Komori, Hiromichi Zdravilo za degenerativne intervertebralne diske
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
WO2006004226A1 (en) * 2004-07-06 2006-01-12 Y S Therapeutics Co Ltd Compositions for cancer prevention, treatment, or amelioration comprising papaya extract
CN1320111C (zh) * 2004-08-09 2007-06-06 王美岭 一种制备木瓜凝乳酶的方法
US20060241566A1 (en) * 2005-04-11 2006-10-26 Orthox, Llc Nucleus Extraction from Spine Intervertebral Disc
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US8642059B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US20070265633A1 (en) * 2006-05-11 2007-11-15 Moon Jon K Implement and method to extract nucleus from spine intervertebral disc
US8257938B2 (en) * 2009-02-27 2012-09-04 Medical Diagnostic Laboratories, Llc Hemolysin and its protein fragments in sero-detection of Anaplasma phagocytophilum
WO2013038936A1 (ja) * 2011-09-13 2013-03-21 タカラバイオ株式会社 ペルオキシダーゼ反応の停止方法及び反応停止剤
US9375519B2 (en) 2012-06-25 2016-06-28 Surmodics, Inc. Bioerodable poly(etheresteramides) and medical article uses
CN118878631B (zh) * 2024-06-05 2025-04-04 中国海洋大学 一种基于配体垂钓筛选合成牡蛎ace抑制肽的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE270723C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
US2313875A (en) * 1940-12-17 1943-03-16 Eugene F Jansen Proteolytic enzyme process
US3320131A (en) * 1964-10-23 1967-05-16 Baxter Laboratories Inc Method for the treatment of herniation of intervertebral discs
US3558433A (en) * 1967-11-07 1971-01-26 Baxter Laboratories Inc Process for purification of chymopapain
YU40433B (en) * 1975-02-20 1986-02-28 Lek Tovarna Farmacevtskih Process for obtaining pure, proteolytically active anzymes
DE3212846A1 (de) 1981-04-13 1982-11-04 Sintokogio, Ltd., Nagoya, Aichi Apparat und verfahren zum herstellen eines kerns
US4439423A (en) * 1981-05-13 1984-03-27 Smith Laboratories, Inc. Chymopapain and method for its use
US4719108A (en) * 1981-05-13 1988-01-12 Smith Laboratories, Inc. Chymopapain composition and method for its use
US4374926A (en) * 1981-05-13 1983-02-22 Smith Laboratories, Inc. Method for the production of improved chymopapain
EP0065395B1 (en) * 1981-05-13 1988-08-24 BOOTS-FLINT, INC. (a Delaware corp.) Improved chymopapain and method for its production and use
WO1984000365A1 (en) * 1982-07-19 1984-02-02 Nat Res Dev Synthetic peptides and their preparation
GB2156821A (en) * 1984-04-03 1985-10-16 Simmons James W Process for purifying chymopapain
HU196624B (en) * 1986-12-08 1988-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing chymopapain with high specific activity
GB8909836D0 (en) * 1989-04-28 1989-06-14 Boots Co Plc Therapeutic agent

Also Published As

Publication number Publication date
HU903342D0 (en) 1992-01-28
GB8909836D0 (en) 1989-06-14
IN173230B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-03-12
US5380656A (en) 1995-01-10
CA2056402A1 (en) 1990-10-29
AU631641B2 (en) 1992-12-03
PL166810B1 (pl) 1995-06-30
NO914206L (no) 1991-12-17
DK0470136T3 (da) 1994-08-01
PT93921B (pt) 1996-10-31
BG60916B1 (bg) 1996-06-28
IE901538L (en) 1990-10-28
LV10200A (lv) 1994-10-20
PT93921A (pt) 1990-11-20
IE64351B1 (en) 1995-07-26
KR920701241A (ko) 1992-08-11
ES2055427T3 (es) 1994-08-16
LV10200B (en) 1995-04-20
JPH04506003A (ja) 1992-10-22
CA2056402C (en) 1999-11-16
HUT58345A (en) 1992-02-28
WO1990013561A1 (en) 1990-11-15
GR900100315A (en) 1991-09-27
LTIP1645A (en) 1995-07-25
IL94227A0 (en) 1991-01-31
EP0470136A1 (en) 1992-02-12
DE69010199T2 (de) 1994-10-13
IN170683B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-05-02
CN1047340A (zh) 1990-11-28
US5468480A (en) 1995-11-21
FI914995A0 (fi) 1991-10-23
NZ233475A (en) 1991-10-25
EP0470136B1 (en) 1994-06-22
MX20503A (es) 1993-12-01
ATE107660T1 (de) 1994-07-15
DD296960A5 (de) 1991-12-19
RO112032B1 (ro) 1997-04-30
GR1001011B (el) 1993-03-31
HRP930700A2 (en) 1995-06-30
YU87090A (sh) 1992-09-07
BG95362A (bg) 1993-12-24
ZA903228B (en) 1990-12-28
DE69010199D1 (de) 1994-07-28
AU5547290A (en) 1990-11-29
RU2074891C1 (ru) 1997-03-10
HU211746A9 (en) 1995-12-28
NO914206D0 (no) 1991-10-25
FI914995A7 (fi) 1991-10-23
EG19583A (en) 1995-09-30
LT3827B (en) 1996-03-25

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