IL82746A - A process for producing a biologically active tissue plasminogen activator - Google Patents

A process for producing a biologically active tissue plasminogen activator

Info

Publication number
IL82746A
IL82746A IL8274687A IL8274687A IL82746A IL 82746 A IL82746 A IL 82746A IL 8274687 A IL8274687 A IL 8274687A IL 8274687 A IL8274687 A IL 8274687A IL 82746 A IL82746 A IL 82746A
Authority
IL
Israel
Prior art keywords
medium
plasminogen activator
type plasminogen
human tissue
culture
Prior art date
Application number
IL8274687A
Other languages
English (en)
Hebrew (he)
Other versions
IL82746A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of IL82746A0 publication Critical patent/IL82746A0/xx
Publication of IL82746A publication Critical patent/IL82746A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL8274687A 1986-06-06 1987-06-02 A process for producing a biologically active tissue plasminogen activator IL82746A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87164286A 1986-06-06 1986-06-06

Publications (2)

Publication Number Publication Date
IL82746A0 IL82746A0 (en) 1987-12-20
IL82746A true IL82746A (en) 1994-10-07

Family

ID=25357832

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8274687A IL82746A (en) 1986-06-06 1987-06-02 A process for producing a biologically active tissue plasminogen activator

Country Status (21)

Country Link
US (1) US5053334A (fr)
EP (1) EP0248675B1 (fr)
JP (1) JPS6332484A (fr)
KR (1) KR930002888B1 (fr)
AT (1) ATE75775T1 (fr)
AU (1) AU601984B2 (fr)
DD (1) DD257087A5 (fr)
DE (2) DE3778758D1 (fr)
DK (1) DK175366B1 (fr)
ES (1) ES2032444T3 (fr)
FI (1) FI91886C (fr)
FR (1) FR2599625B1 (fr)
GB (1) GB2191493B (fr)
GR (1) GR3005245T3 (fr)
HU (1) HU205171B (fr)
IE (1) IE60485B1 (fr)
IL (1) IL82746A (fr)
NO (1) NO170595C (fr)
NZ (1) NZ220547A (fr)
PT (1) PT84991B (fr)
ZA (1) ZA874054B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc A process for producing a biologically active tissue plasminogen activator
JP2576200B2 (ja) * 1988-03-09 1997-01-29 味の素株式会社 生理活性タンパク質の製造法
EP0338716A3 (fr) * 1988-04-21 1990-04-11 Berlex Laboratories, Inc. Méthode et appareillage pour la production de protéines non dégradées par des cellules de mammifères
DE3829244A1 (de) * 1988-08-29 1990-03-01 Boehringer Mannheim Gmbh Verfahren zur herstellung von einkettigem t-pa
CA2011548A1 (fr) * 1989-03-07 1990-09-07 Hubertus Stockinger Procede de production de t-pa a deux chaines
GB2249099B (en) * 1990-09-26 1995-05-03 Squibb & Sons Inc Squalene synthetase
US5677184A (en) * 1994-04-19 1997-10-14 Takeda Chemical Industries, Ltd. CHO cells that express human LH-RH receptor
US6077940A (en) * 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
ES2713559T3 (es) * 2002-04-08 2019-05-22 Octane Biotech Inc Sistema automatizado de ingeniería de tejidos
EP2041259B1 (fr) * 2006-07-14 2015-10-14 DPx Holdings B.V. Processus amélioré de culture de cellules
WO2009023562A2 (fr) * 2007-08-09 2009-02-19 Wyeth Utilisation de la perfusion pour améliorer la production d'une culture cellulaire en mode semi-continu dans des bioréacteurs
CA2787656A1 (fr) * 2010-01-22 2011-07-28 Lonza Walkersville, Inc. Procede a rendement eleve et appareil pour la reduction de volume et le lavage de cellules therapeutiques utilisant la filtration a flux tangentiel
US10934519B2 (en) 2011-07-29 2021-03-02 Global Life Sciences Solutions Usa Llc Systems, methods and control laws for cell harvesting
CN110172405A (zh) * 2012-08-20 2019-08-27 泰尔茂比司特公司 浓缩穿过细胞生长腔室循环的流体的组分
JP2020528284A (ja) 2017-09-01 2020-09-24 ロンザ ウォーカーズヴィル，インコーポレーテッド エンドツーエンド細胞療法の自動化
CN113195725A (zh) 2018-12-21 2021-07-30 隆萨沃克斯维尔股份有限公司 病毒载体的自动化生产
EP3898932A4 (fr) 2018-12-21 2022-08-03 Octane Biotech Inc. Carrousel pour unités de production biologique modulaires
CN113227350A (zh) 2018-12-28 2021-08-06 奥克泰生物科技股份有限公司 具有受控环境区的细胞培养和组织工程系统
SG11202108473XA (en) 2019-02-08 2021-09-29 Lonza Walkersville Inc Cell concentration methods and devices for use in automated bioreactors
WO2023278883A1 (fr) 2021-07-02 2023-01-05 Combangio, Inc. Processus de préparation et d'utilisation d'une composition de fibronectine cellulaire

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904480A (en) * 1972-10-24 1975-09-09 Lilly Co Eli Enhanced production of plasminogen activator
JPS5329985A (en) * 1976-08-27 1978-03-20 Kanegafuchi Chem Ind Co Ltd High concentration culturing of yeast
JPS5571496A (en) * 1978-11-24 1980-05-29 Asahi Chem Ind Co Ltd Preparation of living substance
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4232124A (en) * 1979-04-23 1980-11-04 Mann George F Method of producing plasminogen activator
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
JPS5642584A (en) * 1979-09-18 1981-04-20 Asahi Chem Ind Co Ltd Cell cultivation method
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
GR79202B (fr) * 1982-05-05 1984-10-22 Genentech Inc
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
AU572108B2 (en) * 1983-01-19 1988-05-05 Genentech Inc. Human tpa production using vectors coding for dhfr protein
JPS59121172U (ja) * 1983-02-04 1984-08-15 ミネソタ・マイニング・アンド・マニユフアクチユアリング・コンパニ− ケーブル電線被覆の剥離部分のカバー装置
US4546083A (en) * 1983-04-22 1985-10-08 Stolle Research & Development Corporation Method and device for cell culture growth
EP0143081B1 (fr) * 1983-11-21 1989-08-23 Ciba-Geigy Ag Synthèse d'activateur du plasminogene tissulaire(TPA) par levure
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4888115A (en) * 1983-12-29 1989-12-19 Cuno, Incorporated Cross-flow filtration
US4757005A (en) * 1984-04-19 1988-07-12 Miles Inc. Method and cell line for obtaining plasminogen activators
JPH0740942B2 (ja) * 1985-03-22 1995-05-10 カイロン コ−ポレイシヨン 哺乳動物細胞におけるｔＰＡの発現
AU593264B2 (en) * 1985-07-10 1990-02-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor
EP0238551A4 (fr) * 1985-09-06 1988-02-01 Codon Procedes de recuperation d'un activateur de plasminogene des tissus.
JPH07110232B2 (ja) * 1985-10-14 1995-11-29 株式会社日立製作所 遺伝子組換え大腸菌の遺伝子生産物を採取する方法および装置
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc A process for producing a biologically active tissue plasminogen activator

Also Published As

Publication number Publication date
AU601984B2 (en) 1990-09-27
DK175366B1 (da) 2004-09-13
KR930002888B1 (ko) 1993-04-12
HU205171B (en) 1992-03-30
HUT43875A (en) 1987-12-28
GB8713267D0 (en) 1987-07-08
ES2032444T3 (es) 1993-02-16
FI872526A0 (fi) 1987-06-05
FR2599625A1 (fr) 1987-12-11
KR880000590A (ko) 1988-03-28
JPH0574346B2 (fr) 1993-10-18
PT84991B (pt) 1990-03-08
FI91886B (fi) 1994-05-13
DK288187A (da) 1987-12-07
NO872395D0 (no) 1987-06-05
NO170595C (no) 1992-11-04
AU7387287A (en) 1987-12-10
IE871504L (en) 1987-12-06
PT84991A (en) 1987-07-01
DK288187D0 (da) 1987-06-04
NO170595B (no) 1992-07-27
JPS6332484A (ja) 1988-02-12
DD257087A5 (de) 1988-06-01
EP0248675B1 (fr) 1992-05-06
DE3778758D1 (de) 1992-06-11
GR3005245T3 (fr) 1993-05-24
GB2191493A (en) 1987-12-16
FR2599625B1 (fr) 1992-03-13
GB2191493B (en) 1991-02-27
IE60485B1 (en) 1994-07-27
EP0248675A1 (fr) 1987-12-09
NO872395L (no) 1987-12-07
FI872526A (fi) 1987-12-07
ZA874054B (en) 1989-02-22
DE3718939A1 (de) 1987-12-17
FI91886C (fi) 1994-08-25
US5053334A (en) 1991-10-01
NZ220547A (en) 1990-01-29
ATE75775T1 (de) 1992-05-15
IL82746A0 (en) 1987-12-20
DE3718939C2 (de) 1998-09-17

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Legal Events

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