EP0238551A4 - Procedes de recuperation d'un activateur de plasminogene des tissus. - Google Patents

Procedes de recuperation d'un activateur de plasminogene des tissus.

Info

Publication number
EP0238551A4
EP0238551A4 EP19860905624 EP86905624A EP0238551A4 EP 0238551 A4 EP0238551 A4 EP 0238551A4 EP 19860905624 EP19860905624 EP 19860905624 EP 86905624 A EP86905624 A EP 86905624A EP 0238551 A4 EP0238551 A4 EP 0238551A4
Authority
EP
European Patent Office
Prior art keywords
recovery
methods
plasminogen activator
tissue plasminogen
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19860905624
Other languages
German (de)
English (en)
Other versions
EP0238551A1 (fr
Inventor
Craig W Rice
Michael John Morser
Peter Donner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Berlex Laboratories Inc
Original Assignee
Codon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codon filed Critical Codon
Publication of EP0238551A1 publication Critical patent/EP0238551A1/fr
Publication of EP0238551A4 publication Critical patent/EP0238551A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19860905624 1985-09-06 1986-09-05 Procedes de recuperation d'un activateur de plasminogene des tissus. Withdrawn EP0238551A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77333485A 1985-09-06 1985-09-06
US773334 1985-09-06

Publications (2)

Publication Number Publication Date
EP0238551A1 EP0238551A1 (fr) 1987-09-30
EP0238551A4 true EP0238551A4 (fr) 1988-02-01

Family

ID=25097914

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19860905624 Withdrawn EP0238551A4 (fr) 1985-09-06 1986-09-05 Procedes de recuperation d'un activateur de plasminogene des tissus.

Country Status (3)

Country Link
EP (1) EP0238551A4 (fr)
AU (1) AU606582B2 (fr)
WO (1) WO1987001389A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
US4960702A (en) * 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
US4898825A (en) * 1986-05-07 1990-02-06 Mitsui Toatsu Chemicals, Incorporated Methods for purification of single-chain and double-chain tissue plasminogen activator
PT84991B (pt) * 1986-06-06 1990-03-08 Genentech Inc Processo para a producao de actividador do plasminogenio biologicamente activo
EP0275282A1 (fr) * 1986-07-16 1988-07-27 Celltech Limited Procede de purification d'un activateur de plasminogene
JPS6463378A (en) * 1986-08-11 1989-03-09 Mitsui Toatsu Chemicals Separation of single stranded tpa and double standard tpa
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
AU1668988A (en) * 1987-06-03 1988-12-08 Smithkline Beckman Corporation Purification of tpa
US4929560A (en) * 1988-02-03 1990-05-29 Damon Biotech, Inc. Recovery of tissue plasminogen activator
WO1990002175A1 (fr) * 1988-08-16 1990-03-08 Novo Nordisk A/S Procede de production de polypeptides par culture de cellules eukaryotiques en presence d'inhibiteurs de protease
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
JP3045307B2 (ja) * 1989-08-11 2000-05-29 ザイモジェネティクス，インコーポレイティド 活性化プロテインｃを生成するための細胞培養法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4245051A (en) * 1978-03-30 1981-01-13 Rockefeller University Human serum plasminogen activator
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
AU593264B2 (en) * 1985-07-10 1990-02-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor

Also Published As

Publication number Publication date
AU6336986A (en) 1987-03-24
EP0238551A1 (fr) 1987-09-30
AU606582B2 (en) 1991-02-14
WO1987001389A1 (fr) 1987-03-12

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

17P Request for examination filed

Effective date: 19870909

A4 Supplementary search report drawn up and despatched

Effective date: 19880201

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: BERLEX LABORATORIES, INC.

17Q First examination report despatched

Effective date: 19920918

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19940708

RIN1 Information on inventor provided before grant (corrected)

Inventor name: RICE, CRAIG, W.

Inventor name: MORSER, MICHAEL, JOHN

Inventor name: DONNER, PETER