IL72763A - Polyol esters,their preparation and their use as depot matrix material for pharmacologically active substances - Google Patents

Polyol esters,their preparation and their use as depot matrix material for pharmacologically active substances

Info

Publication number
IL72763A
IL72763A IL72763A IL7276384A IL72763A IL 72763 A IL72763 A IL 72763A IL 72763 A IL72763 A IL 72763A IL 7276384 A IL7276384 A IL 7276384A IL 72763 A IL72763 A IL 72763A
Authority
IL
Israel
Prior art keywords
preparation
matrix material
active substances
pharmacologically active
polyol esters
Prior art date
Application number
IL72763A
Other languages
English (en)
Other versions
IL72763A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL72763A0 publication Critical patent/IL72763A0/xx
Publication of IL72763A publication Critical patent/IL72763A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL72763A 1983-08-26 1984-08-24 Polyol esters,their preparation and their use as depot matrix material for pharmacologically active substances IL72763A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH4671/83A CH656884A5 (de) 1983-08-26 1983-08-26 Polyolester, deren herstellung und verwendung.

Publications (2)

Publication Number Publication Date
IL72763A0 IL72763A0 (en) 1984-11-30
IL72763A true IL72763A (en) 1988-02-29

Family

ID=4280440

Family Applications (1)

Application Number Title Priority Date Filing Date
IL72763A IL72763A (en) 1983-08-26 1984-08-24 Polyol esters,their preparation and their use as depot matrix material for pharmacologically active substances

Country Status (27)

Country Link
US (2) US5922682A (ja)
JP (1) JPH0819226B2 (ja)
AT (1) AT395584B (ja)
AU (1) AU575066B2 (ja)
BE (1) BE900406A (ja)
CH (1) CH656884A5 (ja)
CY (1) CY1556A (ja)
DE (1) DE3430852C2 (ja)
DK (1) DK173556B1 (ja)
ES (1) ES8706750A1 (ja)
FR (1) FR2551072B1 (ja)
GB (1) GB2145422B (ja)
GR (1) GR80184B (ja)
HK (1) HK67390A (ja)
HU (1) HU195426B (ja)
IE (1) IE58818B1 (ja)
IL (1) IL72763A (ja)
IT (1) IT1176629B (ja)
LU (1) LU85514A1 (ja)
MY (1) MY101861A (ja)
NL (2) NL190415C (ja)
NZ (1) NZ209335A (ja)
PH (1) PH23556A (ja)
PT (1) PT79129B (ja)
SE (1) SE462098B (ja)
SG (1) SG53590G (ja)
ZA (1) ZA846634B (ja)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
GB8801863D0 (en) * 1988-01-28 1988-02-24 Fulmer Yarsley Ltd Pharmaceutical formulations with controlled drug release
CA2025893A1 (en) * 1989-01-27 1990-07-28 Hosei Shinoda Biocompatible polyester and production thereof
US5247013A (en) * 1989-01-27 1993-09-21 Mitsui Toatsu Chemicals, Inc. Biocompatible polyester and production thereof
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
US6353030B1 (en) * 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
EP0502194B1 (en) * 1990-10-01 1997-10-01 Toppan Printing Co., Ltd. Cyclodextrin polymer and cyclodextrin film formed therefrom
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6005067A (en) 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
GB9206736D0 (en) * 1992-03-27 1992-05-13 Sandoz Ltd Improvements of organic compounds and their use in pharmaceutical compositions
FR2692168B1 (fr) * 1992-06-16 1995-03-24 Centre Nat Rech Scient Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
FR2692167B1 (fr) * 1992-06-16 1994-09-16 Centre Nat Rech Scient Préparation et application de nouveaux systèmes colloïdaux nanovésiculaires dispersibles à base de cyclodextrine, sous forme de nanocapsules.
AU4198793A (en) † 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
US6005068A (en) * 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
WO1994008078A1 (en) * 1992-10-02 1994-04-14 Cargill, Incorporated A melt-stable lactide polymer fabric and process for manufacture thereof
ATE173520T1 (de) * 1992-10-02 1998-12-15 Cargill Inc Papier mit einer beschichtung aus schmelzstabilem polymer und dessen verfahren zur herstellung
TW333456B (en) 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
DE69508985T2 (de) * 1994-02-21 1999-08-19 Takeda Chemical Industries Polyester Matrix für eine pharmazeutische Zusammensetzung mit verzögerter Freigabe
DE4406172C2 (de) * 1994-02-25 2003-10-02 Sanol Arznei Schwarz Gmbh Polyester
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
US5817728A (en) * 1995-03-16 1998-10-06 Mitsui Chemicals, Inc. Preparation of degradable copolymers
US5914381A (en) * 1996-09-12 1999-06-22 Mitsui Chemicals, Inc. Degradable polymer and preparation process of the same
US5916883A (en) * 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives
AR020650A1 (es) * 1998-08-10 2002-05-22 Poly Med Inc Polimeros fosforilados y conjugados de los mismos
DE19839515B4 (de) * 1998-08-29 2012-02-02 Nanohale Gmbh Neue pharmazeutische Zubereitung, enthaltend kolloidale Polymer-Wirkstoff-Assoziate, insbesondere auch für mucosale Wirkstoffverabreichung
EP1144013B1 (en) 1998-11-02 2007-03-21 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Lactone bearing absorbable polymers
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US8614291B2 (en) 1999-08-10 2013-12-24 Poly-Med, Inc. Phosphorylated polymers and conjugates thereof
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
EP1132416B1 (de) * 2000-03-08 2010-04-28 LAB International Barbados, SRL Kolloidale nanopartikuläre Träger enthaltend geladene oder ungeladene wasserlösliche Kammpolymere und deren Verwendung zur mucosalen Applikation
US6616944B2 (en) * 2000-03-08 2003-09-09 Medinnova Gesellschaft Fur Medizinsche Innovationen Aus Adkademischer Forschung Mbh Self-assembling colloidal carriers for protein delivery
WO2002012369A1 (fr) † 2000-08-07 2002-02-14 Wako Pure Chemical Industries, Ltd. Polymere d'acide lactique et son procede de preparation
DE10055742B4 (de) * 2000-11-10 2006-05-11 Schwarz Pharma Ag Neue Polyester, Verfahren zu ihrer Herstellung und aus den Polyestern hergestellte Depot-Arzneiformen
DE10111767B4 (de) * 2001-03-12 2005-03-24 Schwarz Pharma Ag Verfahren zur Herstellung von Polyestern aus Hydroxycarbonsäuren und Polyolen durch Polykondensation
TWI332407B (en) 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
GB0122318D0 (en) * 2001-09-14 2001-11-07 Novartis Ag Organic compounds
CN101912367A (zh) 2001-10-30 2010-12-15 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
US20040097419A1 (en) 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US20060148899A1 (en) * 2004-10-25 2006-07-06 Green Kenneth E Ophthalmic compositions and methods of using the same
US20060089384A1 (en) * 2004-10-25 2006-04-27 Minno George E Ophthalmic compositions and methods of using the same
GB2422839B (en) 2005-01-11 2009-06-24 Schlumberger Holdings Degradable polymers for wellbore fluids and processes
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
EP2065421B1 (en) * 2006-09-04 2014-05-07 Bio-Energy Corporation Polyester polyol
CN100460441C (zh) * 2006-09-25 2009-02-11 南开大学 生物可降解星型结构聚乙丙交酯载药微球及其制备方法
KR101522035B1 (ko) 2006-12-18 2015-05-20 다케다 야쿠힌 고교 가부시키가이샤 서방성 조성물 및 이의 제조 방법
AR066677A1 (es) 2007-05-24 2009-09-02 Novartis Ag Formulacion de pasireotida. composicion farmaceutica para liberacion prolongada. microparticulas.
RU2490009C2 (ru) 2008-02-22 2013-08-20 Торэй Индастриз, Инк. Микрочастица и ее фармацевтическая композиция
EP2172189A1 (en) 2008-10-01 2010-04-07 Novartis AG Pharmaceutical Compositions
EP2213307A1 (en) 2009-02-03 2010-08-04 Novartis AG Injectable depot formulations
US20100086597A1 (en) * 2008-10-06 2010-04-08 Oakwood Laboratories LLC Microspheres for the sustained release of octreotide with a low initial burst
US20100086596A1 (en) * 2008-10-06 2010-04-08 Oakwood Laboratories LLC Microspheres for releasing an octreotide compound without an initial time lag
CN102282194B (zh) * 2009-01-16 2015-02-25 生物基础塑料开发有限公司 聚乳酸树脂组合物和聚乳酸树脂用添加剂
JP5362400B2 (ja) * 2009-03-17 2013-12-11 株式会社クレハ 低溶融粘度化ポリグリコール酸の製造方法
MX339805B (es) 2010-04-22 2016-06-10 Intra Cellular Therapies Inc Compuestos organicos.
GB201016436D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Method of making solid beads
GB201016433D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Apparatus and method for making solid beads
EP2455414A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung
EP2455415A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung
US20120156304A1 (en) * 2010-12-15 2012-06-21 Thomas Tice Branched polyol polyesters, blends, and pharmaceutical formulations comprising same
CA2870303A1 (en) 2012-04-14 2013-10-17 Intra-Cellular Therapies, Inc. Organic compounds
JP2014095067A (ja) * 2012-10-11 2014-05-22 Ricoh Co Ltd 高分子化合物、包接化合物、シート、および、水分散体
US9708322B2 (en) 2013-03-15 2017-07-18 Intra-Cellular Therapies, Inc. Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
TW201605488A (zh) * 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及／或治療多囊腎病之藥物
WO2015085004A1 (en) 2013-12-03 2015-06-11 Intra-Cellular Therapies, Inc. Novel methods
PL3125893T3 (pl) 2014-04-04 2024-02-12 Intra-Cellular Therapies, Inc. Deuterowane gamma-karboliny w fuzji z heterocyklami jako antagoniści receptorów 5-HT2A
CN106456638A (zh) 2014-04-04 2017-02-22 细胞内治疗公司 有机化合物
WO2015191554A1 (en) 2014-06-09 2015-12-17 Intra-Cellular Therapies, Inc. Compounds and methods of use to treat schizophrenia
JP2016186055A (ja) * 2015-03-27 2016-10-27 株式会社クレハ ポリグリコール酸組成物および一時目止め材
PL3407888T3 (pl) 2016-01-26 2021-08-30 Intra-Cellular Therapies, Inc. Związki pirydopirolochinoksaliny, ich kompozycje i zastosowania
RU2733975C2 (ru) 2016-03-25 2020-10-08 Интра-Селлулар Терапиз, Инк. Органические соединения
EP3436083A4 (en) 2016-03-28 2019-11-27 Intra-Cellular Therapies, Inc. NEW COMPOSITIONS AND METHODS
CN110072518B (zh) 2016-10-12 2021-10-26 细胞内治疗公司 无定形固体分散体
US10961245B2 (en) 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
US10906906B2 (en) 2016-12-29 2021-02-02 Intra-Cellular Therapies, Inc. Organic compounds
CN110430879B (zh) 2017-03-24 2023-04-21 细胞内治疗公司 新组合物和方法
KR102664171B1 (ko) 2017-07-07 2024-05-17 스테판 컴파니 폴리우레탄 적용을 위한 저점도 폴리올
WO2019023062A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
CN111093664B (zh) 2017-07-26 2023-06-02 细胞内治疗公司 有机化合物
WO2019104225A1 (en) 2017-11-22 2019-05-31 Dauntless 2, Inc. Therapeutic compound formulations
WO2019104214A1 (en) 2017-11-22 2019-05-31 Dauntless 2, Inc. Membrane emulsification device for microsphere creation
MX2020009668A (es) 2018-03-16 2021-01-08 Intra Cellular Therapies Inc Métodos novedosos.
US20210009592A1 (en) 2018-03-23 2021-01-14 Intra-Cellular Therapies, Inc. Organic compounds
CA3094949A1 (en) 2018-03-23 2019-09-26 Intra-Cellular Therapies, Inc. Deuterated heterocycle fused gamma-carbolines
CA3102948A1 (en) 2018-06-08 2019-12-12 Intra-Cellular Therapies, Inc. Novel methods
WO2020005842A1 (en) 2018-06-25 2020-01-02 Dauntless 2, Inc. Membrane emulsification device with impeller for microsphere creation
KR20210052471A (ko) 2018-08-31 2021-05-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
MX2021002321A (es) 2018-08-31 2021-04-28 Intra Cellular Therapies Inc Nuevos metodos.
CN114072150A (zh) 2019-07-07 2022-02-18 细胞内治疗公司 新方法
WO2024145659A1 (en) 2022-12-30 2024-07-04 Intra-Cellular Therapies, Inc. Heterocycle fused gamma-carbolines acting on the serotonine 5-ht2a receptor

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1020324B (de) * 1954-12-17 1957-12-05 Boehringer Sohn Ingelheim Verfahren zur Herstellung von esterartigen Milchsaeurederivaten mit definierter Kettenlaenge und endstaendiger Ester-, Amid- oder Nitrilgruppe
FR1584732A (ja) * 1968-03-13 1970-01-02
FR1590574A (ja) * 1968-05-09 1970-04-20
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE35855B1 (en) * 1970-12-18 1976-06-09 Ethicon Inc Absorbable copolymer suture
US3963699A (en) * 1974-01-10 1976-06-15 The Procter & Gamble Company Synthesis of higher polyol fatty acid polyesters
NO142306C (no) * 1975-04-18 1980-07-30 Tate & Lyle Ltd Fremgangsmaate til rensing av et fast stoff i form av et omestringsprodukt frembrakt ved reaksjon mellom sukrose og minst ett fettsyretriglycerid
US4328204A (en) * 1977-03-02 1982-05-04 Ethicon, Inc. Absorbable polymer-drug compounds and method for making same
WO1978000011A1 (en) * 1977-06-07 1978-12-21 Garching Instrumente Form of implant medicament and preparation process
US4130639A (en) * 1977-09-28 1978-12-19 Ethicon, Inc. Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
US4165432A (en) * 1977-10-18 1979-08-21 Olin Corporation Peroxy di-ester polyols
DE2824112A1 (de) * 1978-06-01 1979-12-06 Garching Instrumente Mikropellets, verfahren zu ihrer herstellung und deren verwendung
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
US4334061A (en) * 1979-10-29 1982-06-08 Ethyl Corporation Process for recovery of polyol fatty acid polyesters
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same
FR2537980B1 (fr) * 1982-12-17 1986-12-19 Sandoz Sa Derives d'acides hydroxycarboxyliques oligomeres, leur preparation et leur utilisation

Also Published As

Publication number Publication date
LU85514A1 (fr) 1985-04-24
PT79129B (en) 1986-07-17
AU575066B2 (en) 1988-07-21
NZ209335A (en) 1988-08-30
GB8421273D0 (en) 1984-09-26
DK407284D0 (da) 1984-08-24
HUT38265A (en) 1986-05-28
IT1176629B (it) 1987-08-18
SE8404225L (sv) 1985-02-27
AU3234884A (en) 1985-02-28
JPH0819226B2 (ja) 1996-02-28
HK67390A (en) 1990-09-07
NL8402547A (nl) 1985-03-18
IT8422413A0 (it) 1984-08-24
AT395584B (de) 1993-01-25
JPS6076531A (ja) 1985-05-01
GB2145422A (en) 1985-03-27
IL72763A0 (en) 1984-11-30
NL960014I1 (nl) 1996-10-01
BE900406A (fr) 1985-02-22
SE8404225D0 (sv) 1984-08-24
ATA271384A (de) 1992-06-15
DE3430852A1 (de) 1985-03-14
SE462098B (sv) 1990-05-07
US5922338A (en) 1999-07-13
ES8706750A1 (es) 1987-06-16
GB2145422B (en) 1987-08-26
IE58818B1 (en) 1993-11-17
ZA846634B (en) 1986-04-30
PH23556A (en) 1989-08-25
GR80184B (en) 1985-01-02
US5922682A (en) 1999-07-13
CY1556A (en) 1991-03-22
DK173556B1 (da) 2001-03-12
PT79129A (en) 1984-09-01
DK407284A (da) 1985-02-27
ES535399A0 (es) 1987-06-16
CH656884A5 (de) 1986-07-31
FR2551072B1 (fr) 1988-01-15
MY101861A (en) 1992-01-31
DE3430852C2 (de) 2003-08-14
IE842171L (en) 1985-02-26
NL190415C (nl) 1994-02-16
HU195426B (en) 1988-05-30
NL190415B (nl) 1993-09-16
FR2551072A1 (fr) 1985-03-01
SG53590G (en) 1990-10-26

Similar Documents

Publication Publication Date Title
IL72763A0 (en) Polyol esters,their preparation and their use as depot matrix material for pharmacologically active substances
AR240608A1 (es) Matriz biodegradable y metodos para producirla
GB2140019B (en) Matrix composition for transdermal drug delivery systems
GB2221157B (en) Intravenous pharmaceutical composition comprising cyclosporin and process for preparing the same
DE3372705D1 (en) Pharmaceutical composition and its use
AU3459084A (en) Slow-release pharmaceutical pellets
HUT38502A (en) Microbicidal composition comprising 1-heteroaryl-4-aryl-pyrazoline-5-on-derivatives as active substance and process for preparing 1-heteroaryl-4-aryl-pyrazoline-5-on-derivatives
PH19849A (en) Steroids and their pharmaceutical composition
GB8924286D0 (en) Pharmaceutical composition and process for preparing the same
HUT42292A (en) Insecticidal compositions comprising fluorbenzyl esters as active substance and process for preparing the active substances
JPS55100313A (en) Drug composition and its manufacture
EP0332739A3 (en) Preserving material and method for producing the same
EP0069399A3 (en) Ubidecarenone-containing liposome and pharmaceutical composition containing the same
HUT41398A (en) Insecticidal compositions comprising tetrazolyl derivatives as active substance and process for preparing the active substances
HUT37421A (en) Process for preparing new 4-piperidino-quinazolines and pharmaceutical compositions containing thereof with cardiostimulant activity
EP0168005A3 (en) Semicarbazide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
AU530479B2 (en) Material distribution in vertical furnace - apparatus
DE3373623D1 (en) Pharmaceutical combination composition and associated method
GB2159715B (en) Pharmaceutical composition in sustained release unit dose form and process for its preparation
EP0169716A3 (en) Pharmaceutical composition and method for producing antiallergic activity
GB2160864B (en) 10-aryl-1, 8-dihydroxyanthrones and their esters, the process for preparation thereof and pharmaceutical and cosmetic compositions containing them
HUT38214A (en) Fungicidal and anti-ectoparasitic compositions comprising azolyl-vinyl-ether as active substance and process for producing the active substance
PH23064A (en) Quinolizinone compound and pharmaceutical composition comprising the same
JPS5622785A (en) Pharmaceutical composition and manufacture thereof
ZA805716B (en) Pharmaceutical composition comprising modified polyriboinosi-interferonin primates

Legal Events

Date Code Title Description
HC Change of name of proprietor(s)
KB Patent renewed
KB Patent renewed
EXP Patent expired