NL190415C - Reactieprodukten en esters van polyolen met tenminste 3 hydroxylgroepen en melkzuur, depotmatrixmateriaal en parenteraal farmaceutisch depot preparaat. - Google Patents

Reactieprodukten en esters van polyolen met tenminste 3 hydroxylgroepen en melkzuur, depotmatrixmateriaal en parenteraal farmaceutisch depot preparaat.

Info

Publication number
NL190415C
NL190415C NLAANVRAGE8402547,A NL8402547A NL190415C NL 190415 C NL190415 C NL 190415C NL 8402547 A NL8402547 A NL 8402547A NL 190415 C NL190415 C NL 190415C
Authority
NL
Netherlands
Prior art keywords
depot
polyols
esters
lactic acid
hydroxyl groups
Prior art date
Application number
NLAANVRAGE8402547,A
Other languages
English (en)
Other versions
NL8402547A (nl
NL190415B (nl
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NL8402547A publication Critical patent/NL8402547A/nl
Publication of NL190415B publication Critical patent/NL190415B/nl
Application granted granted Critical
Publication of NL190415C publication Critical patent/NL190415C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NLAANVRAGE8402547,A 1983-08-26 1984-08-20 Reactieprodukten en esters van polyolen met tenminste 3 hydroxylgroepen en melkzuur, depotmatrixmateriaal en parenteraal farmaceutisch depot preparaat. NL190415C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH467183 1983-08-26
CH4671/83A CH656884A5 (de) 1983-08-26 1983-08-26 Polyolester, deren herstellung und verwendung.

Publications (3)

Publication Number Publication Date
NL8402547A NL8402547A (nl) 1985-03-18
NL190415B NL190415B (nl) 1993-09-16
NL190415C true NL190415C (nl) 1994-02-16

Family

ID=4280440

Family Applications (2)

Application Number Title Priority Date Filing Date
NLAANVRAGE8402547,A NL190415C (nl) 1983-08-26 1984-08-20 Reactieprodukten en esters van polyolen met tenminste 3 hydroxylgroepen en melkzuur, depotmatrixmateriaal en parenteraal farmaceutisch depot preparaat.
NL960014C NL960014I1 (nl) 1983-08-26 1996-06-06 Reactieprodukten en esters van polyolen met tenminste 3 hydroxylgroepen en melkzuur, depotmatrixmateriaal en parenferaal farmaceutisch depot preparaat.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL960014C NL960014I1 (nl) 1983-08-26 1996-06-06 Reactieprodukten en esters van polyolen met tenminste 3 hydroxylgroepen en melkzuur, depotmatrixmateriaal en parenferaal farmaceutisch depot preparaat.

Country Status (27)

Country Link
US (2) US5922682A (nl)
JP (1) JPH0819226B2 (nl)
AT (1) AT395584B (nl)
AU (1) AU575066B2 (nl)
BE (1) BE900406A (nl)
CH (1) CH656884A5 (nl)
CY (1) CY1556A (nl)
DE (1) DE3430852C2 (nl)
DK (1) DK173556B1 (nl)
ES (1) ES8706750A1 (nl)
FR (1) FR2551072B1 (nl)
GB (1) GB2145422B (nl)
GR (1) GR80184B (nl)
HK (1) HK67390A (nl)
HU (1) HU195426B (nl)
IE (1) IE58818B1 (nl)
IL (1) IL72763A (nl)
IT (1) IT1176629B (nl)
LU (1) LU85514A1 (nl)
MY (1) MY101861A (nl)
NL (2) NL190415C (nl)
NZ (1) NZ209335A (nl)
PH (1) PH23556A (nl)
PT (1) PT79129B (nl)
SE (1) SE462098B (nl)
SG (1) SG53590G (nl)
ZA (1) ZA846634B (nl)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
GB8801863D0 (en) * 1988-01-28 1988-02-24 Fulmer Yarsley Ltd Pharmaceutical formulations with controlled drug release
US5247013A (en) * 1989-01-27 1993-09-21 Mitsui Toatsu Chemicals, Inc. Biocompatible polyester and production thereof
EP0407617B1 (en) * 1989-01-27 1997-05-28 MITSUI TOATSU CHEMICALS, Inc. Process for the preparation of a biocompatible polyester
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US6353030B1 (en) * 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
CA2066616A1 (en) * 1990-10-01 1992-04-02 Masanobu Yoshinaga Cyclodextrin polymer and cyclodextrin membrane prepared using said polymer
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
GB9206736D0 (en) * 1992-03-27 1992-05-13 Sandoz Ltd Improvements of organic compounds and their use in pharmaceutical compositions
FR2692168B1 (fr) * 1992-06-16 1995-03-24 Centre Nat Rech Scient Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
FR2692167B1 (fr) * 1992-06-16 1994-09-16 Centre Nat Rech Scient Préparation et application de nouveaux systèmes colloïdaux nanovésiculaires dispersibles à base de cyclodextrine, sous forme de nanocapsules.
AU4198793A (en) † 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
DE69322155T2 (de) * 1992-10-02 1999-08-19 Cargill Inc Papier mit einer beschichtung aus schmelzstabilem polymer und dessen verfahren zur herstellung
JP3447289B2 (ja) * 1992-10-02 2003-09-16 カーギル， インコーポレイテッド 溶融安定性ラクチドポリマー繊維及びその製造方法
US6005068A (en) 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
TW333456B (en) 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
CA2143044C (en) * 1994-02-21 2005-04-12 Yasutaka Igari Matrix for sustained-release preparation
DE4406172C2 (de) * 1994-02-25 2003-10-02 Sanol Arznei Schwarz Gmbh Polyester
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
US5817728A (en) * 1995-03-16 1998-10-06 Mitsui Chemicals, Inc. Preparation of degradable copolymers
US5914381A (en) * 1996-09-12 1999-06-22 Mitsui Chemicals, Inc. Degradable polymer and preparation process of the same
US5916883A (en) 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives
AR020650A1 (es) * 1998-08-10 2002-05-22 Poly Med Inc Polimeros fosforilados y conjugados de los mismos
DE19839515B4 (de) * 1998-08-29 2012-02-02 Nanohale Gmbh Neue pharmazeutische Zubereitung, enthaltend kolloidale Polymer-Wirkstoff-Assoziate, insbesondere auch für mucosale Wirkstoffverabreichung
AU1603500A (en) 1998-11-02 2000-05-22 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Lactone bearing absorbable polymers
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US8614291B2 (en) 1999-08-10 2013-12-24 Poly-Med, Inc. Phosphorylated polymers and conjugates thereof
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
US6616944B2 (en) * 2000-03-08 2003-09-09 Medinnova Gesellschaft Fur Medizinsche Innovationen Aus Adkademischer Forschung Mbh Self-assembling colloidal carriers for protein delivery
EP1132416B1 (de) * 2000-03-08 2010-04-28 LAB International Barbados, SRL Kolloidale nanopartikuläre Träger enthaltend geladene oder ungeladene wasserlösliche Kammpolymere und deren Verwendung zur mucosalen Applikation
WO2002012369A1 (fr) † 2000-08-07 2002-02-14 Wako Pure Chemical Industries, Ltd. Polymere d'acide lactique et son procede de preparation
DE10055742B4 (de) * 2000-11-10 2006-05-11 Schwarz Pharma Ag Neue Polyester, Verfahren zu ihrer Herstellung und aus den Polyestern hergestellte Depot-Arzneiformen
DE10111767B4 (de) * 2001-03-12 2005-03-24 Schwarz Pharma Ag Verfahren zur Herstellung von Polyestern aus Hydroxycarbonsäuren und Polyolen durch Polykondensation
TW200526267A (en) 2001-06-29 2005-08-16 Takeda Chemical Industries Ltd Controlled release composition and method of producing the same
GB0122318D0 (en) * 2001-09-14 2001-11-07 Novartis Ag Organic compounds
ATE493129T1 (de) 2001-10-30 2011-01-15 Novartis Pharma Gmbh Depot formulierungen von iloperidone und einem sternförmigen polymer
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US20060089384A1 (en) * 2004-10-25 2006-04-27 Minno George E Ophthalmic compositions and methods of using the same
EP1845983B1 (en) * 2004-10-25 2010-04-07 Bausch & Lomb Incorporated Ophthalmic compositions and methods of using the same
GB2422839B (en) 2005-01-11 2009-06-24 Schlumberger Holdings Degradable polymers for wellbore fluids and processes
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
WO2008029527A1 (fr) * 2006-09-04 2008-03-13 Bio-Energy Corporation Polyol de polyester
CN100460441C (zh) * 2006-09-25 2009-02-11 南开大学 生物可降解星型结构聚乙丙交酯载药微球及其制备方法
EP2094246B1 (en) 2006-12-18 2020-04-01 Takeda Pharmaceutical Company Limited Sustained-release composition and method for producing the same
PE20090387A1 (es) 2007-05-24 2009-04-28 Novartis Ag Formulacion de pasireotida
KR101542433B1 (ko) 2008-02-22 2015-08-06 도레이 카부시키가이샤 마이크로 입자 및 그 의약품 조성물
EP2213307A1 (en) 2009-02-03 2010-08-04 Novartis AG Injectable depot formulations
EP2172189A1 (en) 2008-10-01 2010-04-07 Novartis AG Pharmaceutical Compositions
US20100086596A1 (en) * 2008-10-06 2010-04-08 Oakwood Laboratories LLC Microspheres for releasing an octreotide compound without an initial time lag
US20100086597A1 (en) * 2008-10-06 2010-04-08 Oakwood Laboratories LLC Microspheres for the sustained release of octreotide with a low initial burst
EP2388285B1 (en) * 2009-01-16 2016-07-06 Biobase Corporation Polylactic acid resin composition and additive for polylactic acid resin
JP5362400B2 (ja) * 2009-03-17 2013-12-11 株式会社クレハ 低溶融粘度化ポリグリコール酸の製造方法
CN103209704B (zh) 2010-04-22 2017-10-27 细胞内治疗公司 有机化合物
GB201016433D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Apparatus and method for making solid beads
GB201016436D0 (en) 2010-09-30 2010-11-17 Q Chip Ltd Method of making solid beads
EP2455414A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung
EP2455415A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung
WO2012083026A1 (en) * 2010-12-15 2012-06-21 Evonik Degussa Corporation Branched polyol polyesters, blends and pharmaceutical formulations comprising same
CA2870303A1 (en) 2012-04-14 2013-10-17 Intra-Cellular Therapies, Inc. Organic compounds
JP2014095067A (ja) * 2012-10-11 2014-05-22 Ricoh Co Ltd 高分子化合物、包接化合物、シート、および、水分散体
ES2846823T3 (es) 2013-03-15 2021-07-29 Intra Cellular Therapies Inc Compuestos orgánicos
TW201605488A (zh) * 2013-10-15 2016-02-16 大塚製藥股份有限公司 用以預防及／或治療多囊腎病之藥物
KR20230023817A (ko) 2013-12-03 2023-02-17 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
CN106535898A (zh) 2014-04-04 2017-03-22 细胞内治疗公司 有机化合物
WO2015154030A1 (en) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Organic compounds
US10179776B2 (en) 2014-06-09 2019-01-15 Intra-Cellular Therapies, Inc. Compounds and methods of use to treat schizophrenia
JP2016186055A (ja) * 2015-03-27 2016-10-27 株式会社クレハ ポリグリコール酸組成物および一時目止め材
BR112018015283B1 (pt) 2016-01-26 2023-09-26 Intra-Cellular Therapies, Inc Compostos orgânicos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para o tratamento ou profilaxia de um distúrbio do sistema nervoso central
EP3407889B1 (en) 2016-03-25 2021-05-19 Intra-Cellular Therapies, Inc. Organic compounds and their use in treating or preventing central nervous system disorders
JP2019510039A (ja) 2016-03-28 2019-04-11 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規組成物および方法
JP7013454B2 (ja) 2016-10-12 2022-02-15 イントラ－セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
US10906906B2 (en) 2016-12-29 2021-02-02 Intra-Cellular Therapies, Inc. Organic compounds
CN116327770A (zh) 2017-03-24 2023-06-27 细胞内治疗公司 新组合物和方法
CN111164122B (zh) 2017-07-07 2022-01-04 斯蒂潘公司 用于聚氨酯应用的低粘度多元醇
CA3071137A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. Organic compounds
CN111093665A (zh) 2017-07-26 2020-05-01 细胞内治疗公司 有机化合物
US20200353419A1 (en) 2017-11-22 2020-11-12 Dauntless 1, Inc. Membrane emulsification device for microsphere creation
US20200281857A1 (en) 2017-11-22 2020-09-10 Dauntless 1, Inc. Therapeutic compound formulations
AU2019240226A1 (en) 2018-03-23 2020-10-22 Intra-Cellular Therapies, Inc. Organic compounds
WO2020005842A1 (en) 2018-06-25 2020-01-02 Dauntless 2, Inc. Membrane emulsification device with impeller for microsphere creation
KR20210052471A (ko) 2018-08-31 2021-05-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
JP7457000B2 (ja) 2018-08-31 2024-03-27 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1020324B (de) * 1954-12-17 1957-12-05 Boehringer Sohn Ingelheim Verfahren zur Herstellung von esterartigen Milchsaeurederivaten mit definierter Kettenlaenge und endstaendiger Ester-, Amid- oder Nitrilgruppe
FR1584732A (nl) * 1968-03-13 1970-01-02
FR1590574A (nl) * 1968-05-09 1970-04-20
US3887699A (en) * 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE35855B1 (en) * 1970-12-18 1976-06-09 Ethicon Inc Absorbable copolymer suture
US3963699A (en) * 1974-01-10 1976-06-15 The Procter & Gamble Company Synthesis of higher polyol fatty acid polyesters
NO142306C (no) * 1975-04-18 1980-07-30 Tate & Lyle Ltd Fremgangsmaate til rensing av et fast stoff i form av et omestringsprodukt frembrakt ved reaksjon mellom sukrose og minst ett fettsyretriglycerid
US4328204A (en) * 1977-03-02 1982-05-04 Ethicon, Inc. Absorbable polymer-drug compounds and method for making same
DE2856901D2 (de) * 1977-06-07 1980-11-13 Garching Instrumente Form of implant medicament and preparation process
US4130639A (en) * 1977-09-28 1978-12-19 Ethicon, Inc. Absorbable pharmaceutical compositions based on isomorphic copolyoxalates
US4165432A (en) * 1977-10-18 1979-08-21 Olin Corporation Peroxy di-ester polyols
DE2824112A1 (de) * 1978-06-01 1979-12-06 Garching Instrumente Mikropellets, verfahren zu ihrer herstellung und deren verwendung
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
US4334061A (en) * 1979-10-29 1982-06-08 Ethyl Corporation Process for recovery of polyol fatty acid polyesters
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
ATE37983T1 (de) * 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same
FR2537980B1 (fr) * 1982-12-17 1986-12-19 Sandoz Sa Derives d'acides hydroxycarboxyliques oligomeres, leur preparation et leur utilisation

Also Published As

Publication number Publication date
SE462098B (sv) 1990-05-07
FR2551072A1 (fr) 1985-03-01
ES8706750A1 (es) 1987-06-16
GR80184B (en) 1985-01-02
IL72763A0 (en) 1984-11-30
NZ209335A (en) 1988-08-30
DE3430852C2 (de) 2003-08-14
PH23556A (en) 1989-08-25
US5922338A (en) 1999-07-13
IT8422413A0 (it) 1984-08-24
GB8421273D0 (en) 1984-09-26
IT1176629B (it) 1987-08-18
FR2551072B1 (fr) 1988-01-15
AT395584B (de) 1993-01-25
GB2145422A (en) 1985-03-27
NL8402547A (nl) 1985-03-18
IL72763A (en) 1988-02-29
US5922682A (en) 1999-07-13
JPH0819226B2 (ja) 1996-02-28
IE842171L (en) 1985-02-26
JPS6076531A (ja) 1985-05-01
SE8404225D0 (sv) 1984-08-24
SG53590G (en) 1990-10-26
DK407284D0 (da) 1984-08-24
DK173556B1 (da) 2001-03-12
LU85514A1 (fr) 1985-04-24
BE900406A (fr) 1985-02-22
DK407284A (da) 1985-02-27
CH656884A5 (de) 1986-07-31
AU3234884A (en) 1985-02-28
PT79129A (en) 1984-09-01
SE8404225L (sv) 1985-02-27
NL960014I1 (nl) 1996-10-01
GB2145422B (en) 1987-08-26
AU575066B2 (en) 1988-07-21
CY1556A (en) 1991-03-22
HUT38265A (en) 1986-05-28
ATA271384A (de) 1992-06-15
ES535399A0 (es) 1987-06-16
IE58818B1 (en) 1993-11-17
DE3430852A1 (de) 1985-03-14
PT79129B (en) 1986-07-17
MY101861A (en) 1992-01-31
NL190415B (nl) 1993-09-16
ZA846634B (en) 1986-04-30
HU195426B (en) 1988-05-30
HK67390A (en) 1990-09-07

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