IL296241A - Compositions and methods for immunotherapy of npm1c-positive cancer - Google Patents

Compositions and methods for immunotherapy of npm1c-positive cancer

Info

Publication number
IL296241A
IL296241A IL296241A IL29624122A IL296241A IL 296241 A IL296241 A IL 296241A IL 296241 A IL296241 A IL 296241A IL 29624122 A IL29624122 A IL 29624122A IL 296241 A IL296241 A IL 296241A
Authority
IL
Israel
Prior art keywords
antibody
seq
cell
antigen binding
amino acid
Prior art date
Application number
IL296241A
Other languages
English (en)
Hebrew (he)
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of IL296241A publication Critical patent/IL296241A/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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IL296241A 2020-03-10 2021-01-08 Compositions and methods for immunotherapy of npm1c-positive cancer IL296241A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062987612P 2020-03-10 2020-03-10
PCT/US2021/012701 WO2021183207A1 (en) 2020-03-10 2021-01-08 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF NPM1c-POSITIVE CANCER

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IL296241A true IL296241A (en) 2022-11-01

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IL296241A IL296241A (en) 2020-03-10 2021-01-08 Compositions and methods for immunotherapy of npm1c-positive cancer

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US (1) US11896619B2 (enExample)
EP (1) EP4118112A1 (enExample)
JP (1) JP7813235B2 (enExample)
KR (1) KR20220167276A (enExample)
CN (1) CN115485295A (enExample)
AU (1) AU2021232853A1 (enExample)
BR (1) BR112022017924A2 (enExample)
CA (1) CA3173981A1 (enExample)
IL (1) IL296241A (enExample)
MX (1) MX2022011178A (enExample)
WO (1) WO2021183207A1 (enExample)

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CN119487077A (zh) * 2022-04-27 2025-02-18 儿童医学中心公司 突变体和错误定位的细胞表面核仁磷蛋白1作为人疾病的诊断和治疗靶标
WO2023212632A2 (en) * 2022-04-27 2023-11-02 The Children's Medical Center Corporation Anti-nucleophosmin 1 antibody and antibody conjugate combination therapies

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