IL295418B2 - Cell-D-2'-deoxy-2'-alpha-fluoro-2'-cell-C-modified-2-different-N6-purine modified nucleotides for the treatment of hepatitis C virus - Google Patents

Cell-D-2'-deoxy-2'-alpha-fluoro-2'-cell-C-modified-2-different-N6-purine modified nucleotides for the treatment of hepatitis C virus

Info

Publication number
IL295418B2
IL295418B2 IL295418A IL29541822A IL295418B2 IL 295418 B2 IL295418 B2 IL 295418B2 IL 295418 A IL295418 A IL 295418A IL 29541822 A IL29541822 A IL 29541822A IL 295418 B2 IL295418 B2 IL 295418B2
Authority
IL
Israel
Prior art keywords
compound
methyl
fluoro
hydrogen
formula
Prior art date
Application number
IL295418A
Other languages
English (en)
Hebrew (he)
Other versions
IL295418B1 (en
IL295418A (en
Original Assignee
Atea Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atea Pharmaceuticals Inc filed Critical Atea Pharmaceuticals Inc
Publication of IL295418A publication Critical patent/IL295418A/en
Publication of IL295418B1 publication Critical patent/IL295418B1/en
Publication of IL295418B2 publication Critical patent/IL295418B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
IL295418A 2015-03-06 2016-03-07 Cell-D-2'-deoxy-2'-alpha-fluoro-2'-cell-C-modified-2-different-N6-purine modified nucleotides for the treatment of hepatitis C virus IL295418B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562129319P 2015-03-06 2015-03-06
US201562253958P 2015-11-11 2015-11-11
US201662276597P 2016-01-08 2016-01-08
PCT/US2016/021276 WO2016144918A1 (en) 2015-03-06 2016-03-07 β-D-2'-DEOXY-2'α-FLUORO-2'-β-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT

Publications (3)

Publication Number Publication Date
IL295418A IL295418A (en) 2022-10-01
IL295418B1 IL295418B1 (en) 2023-06-01
IL295418B2 true IL295418B2 (en) 2023-10-01

Family

ID=56850466

Family Applications (3)

Application Number Title Priority Date Filing Date
IL295418A IL295418B2 (en) 2015-03-06 2016-03-07 Cell-D-2'-deoxy-2'-alpha-fluoro-2'-cell-C-modified-2-different-N6-purine modified nucleotides for the treatment of hepatitis C virus
IL302877A IL302877A (en) 2015-03-06 2016-03-07 Cell-D-2'-deoxy-2'-alpha-fluoro-2'-cell-C-modified-2-different-N6-purine modified nucleotides for the treatment of hepatitis C virus
IL254111A IL254111B (en) 2015-03-06 2017-08-23 Beta-d-2'-deoxy-2' alpha-fluoro-2'-bata-c-modified-2-different-n6-purine modified nucleotides for the treatment of hepatitis c virus

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL302877A IL302877A (en) 2015-03-06 2016-03-07 Cell-D-2'-deoxy-2'-alpha-fluoro-2'-cell-C-modified-2-different-N6-purine modified nucleotides for the treatment of hepatitis C virus
IL254111A IL254111B (en) 2015-03-06 2017-08-23 Beta-d-2'-deoxy-2' alpha-fluoro-2'-bata-c-modified-2-different-n6-purine modified nucleotides for the treatment of hepatitis c virus

Country Status (29)

Country Link
US (12) US9828410B2 (OSRAM)
EP (2) EP3265102B1 (OSRAM)
JP (4) JP6776273B2 (OSRAM)
KR (2) KR102363946B1 (OSRAM)
CN (2) CN107427530B (OSRAM)
AU (5) AU2016229966B2 (OSRAM)
CA (2) CA3182565A1 (OSRAM)
CO (1) CO2017010162A2 (OSRAM)
DK (1) DK3265102T3 (OSRAM)
EA (1) EA037098B1 (OSRAM)
ES (1) ES3049645T3 (OSRAM)
FI (1) FI3265102T3 (OSRAM)
GE (3) GEP20217282B (OSRAM)
HK (1) HK1247829A1 (OSRAM)
IL (3) IL295418B2 (OSRAM)
LT (1) LT3265102T (OSRAM)
MX (2) MX2017011386A (OSRAM)
MY (2) MY190867A (OSRAM)
NZ (1) NZ773652A (OSRAM)
PH (1) PH12017501598B1 (OSRAM)
PT (1) PT3265102T (OSRAM)
RU (1) RU2764767C2 (OSRAM)
SA (1) SA517382236B1 (OSRAM)
SG (1) SG11201706841PA (OSRAM)
SI (1) SI3265102T1 (OSRAM)
SM (1) SMT202500392T1 (OSRAM)
UA (1) UA124966C2 (OSRAM)
WO (1) WO2016144918A1 (OSRAM)
ZA (1) ZA201705852B (OSRAM)

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KR102363946B1 (ko) 2015-03-06 2022-02-17 아테아 파마슈티컬즈, 인크. HCV 치료를 위한 β-D-2'-데옥시-2'-α-플루오로-2'-β-C-치환된-2-변형된-N6-치환된 퓨린 뉴클레오티드
US10202412B2 (en) 2016-07-08 2019-02-12 Atea Pharmaceuticals, Inc. β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections
TW201811339A (zh) * 2016-08-12 2018-04-01 美商艾洛斯生物製藥公司 經取代之核苷、核苷酸及其類似物
HRP20220278T1 (hr) 2016-09-07 2022-05-13 Atea Pharmaceuticals, Inc. 2'-supstituirani-n6-supstituirani purinski nukleotidi za liječenje bolesti izazvanih rnk virusima
CN106432327A (zh) * 2016-09-14 2017-02-22 江苏福瑞生物医药有限公司 一种索非布韦关键中间体的制备方法
IL295609B2 (en) * 2017-02-01 2023-11-01 Atea Pharmaceuticals Inc Nucleotide hemisulfate salt for the treatment of hepatitis C virus
WO2019200005A1 (en) 2018-04-10 2019-10-17 Atea Pharmaceuticals, Inc. Treatment of hcv infected patients with cirrhosis
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
AU2021327241A1 (en) * 2020-08-19 2023-04-20 Atea Pharmaceuticals, Inc. Stereoselective manufacture of selected purine phosphoramidates
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
CA3173656A1 (en) 2021-01-26 2022-08-04 Adel Moussa Advantageous morphic form of at-527 hemi-sulfate salt
CN112961198B (zh) * 2021-02-24 2022-03-25 南京欧信医药技术有限公司 一种嘌呤核苷酸中间体的制备方法
MX2023014898A (es) 2021-06-17 2024-04-29 Atea Pharmaceuticals Inc Terapia combinada anti-vhc ventajosa.
TW202348228A (zh) 2022-02-24 2023-12-16 德商艾斯巴赫生物有限公司 病毒組合療法
WO2025014360A1 (en) 2023-07-07 2025-01-16 Erasmus University Medical Center Rotterdam Guanosine nucleotide analogs for use in preventing and/or treating hepatitis e virus infection
WO2025225661A1 (ja) * 2024-04-26 2025-10-30 旭化成株式会社 感光性樹脂組成物、並びにこれを用いた硬化レリーフパターンの製造方法、硬化膜及びポリイミド膜の製造方法

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