LT3265102T - Beta-d-2'-deoksi-2'alfa-fluor-2'-beta-c-pakeistieji-2-modifikuoti-n6- pakeistieji purino nukleotidai, skirti hcv gydymui - Google Patents

Beta-d-2'-deoksi-2'alfa-fluor-2'-beta-c-pakeistieji-2-modifikuoti-n6- pakeistieji purino nukleotidai, skirti hcv gydymui

Info

Publication number
LT3265102T
LT3265102T LTEPPCT/US2016/021276T LTUS2016021276T LT3265102T LT 3265102 T LT3265102 T LT 3265102T LT US2016021276 T LTUS2016021276 T LT US2016021276T LT 3265102 T LT3265102 T LT 3265102T
Authority
LT
Lithuania
Prior art keywords
beta
substituted
hcv
deoxy
fluoro
Prior art date
Application number
LTEPPCT/US2016/021276T
Other languages
English (en)
Lithuanian (lt)
Inventor
Jean-Pierre Sommadossi
Adel Moussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of LT3265102T publication Critical patent/LT3265102T/lt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
LTEPPCT/US2016/021276T 2015-03-06 2016-03-07 Beta-d-2'-deoksi-2'alfa-fluor-2'-beta-c-pakeistieji-2-modifikuoti-n6- pakeistieji purino nukleotidai, skirti hcv gydymui LT3265102T (lt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562129319P 2015-03-06 2015-03-06
US201562253958P 2015-11-11 2015-11-11
US201662276597P 2016-01-08 2016-01-08
PCT/US2016/021276 WO2016144918A1 (en) 2015-03-06 2016-03-07 β-D-2'-DEOXY-2'α-FLUORO-2'-β-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT

Publications (1)

Publication Number Publication Date
LT3265102T true LT3265102T (lt) 2025-10-27

Family

ID=56850466

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2016/021276T LT3265102T (lt) 2015-03-06 2016-03-07 Beta-d-2'-deoksi-2'alfa-fluor-2'-beta-c-pakeistieji-2-modifikuoti-n6- pakeistieji purino nukleotidai, skirti hcv gydymui

Country Status (29)

Country Link
US (12) US9828410B2 (OSRAM)
EP (2) EP3265102B1 (OSRAM)
JP (4) JP6776273B2 (OSRAM)
KR (2) KR102363946B1 (OSRAM)
CN (2) CN107427530B (OSRAM)
AU (5) AU2016229966B2 (OSRAM)
CA (2) CA3182565A1 (OSRAM)
CO (1) CO2017010162A2 (OSRAM)
DK (1) DK3265102T3 (OSRAM)
EA (1) EA037098B1 (OSRAM)
ES (1) ES3049645T3 (OSRAM)
FI (1) FI3265102T3 (OSRAM)
GE (3) GEP20217282B (OSRAM)
HK (1) HK1247829A1 (OSRAM)
IL (3) IL295418B2 (OSRAM)
LT (1) LT3265102T (OSRAM)
MX (2) MX2017011386A (OSRAM)
MY (2) MY190867A (OSRAM)
NZ (1) NZ773652A (OSRAM)
PH (1) PH12017501598B1 (OSRAM)
PT (1) PT3265102T (OSRAM)
RU (1) RU2764767C2 (OSRAM)
SA (1) SA517382236B1 (OSRAM)
SG (1) SG11201706841PA (OSRAM)
SI (1) SI3265102T1 (OSRAM)
SM (1) SMT202500392T1 (OSRAM)
UA (1) UA124966C2 (OSRAM)
WO (1) WO2016144918A1 (OSRAM)
ZA (1) ZA201705852B (OSRAM)

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AU2021327241A1 (en) * 2020-08-19 2023-04-20 Atea Pharmaceuticals, Inc. Stereoselective manufacture of selected purine phosphoramidates
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CA3173656A1 (en) 2021-01-26 2022-08-04 Adel Moussa Advantageous morphic form of at-527 hemi-sulfate salt
CN112961198B (zh) * 2021-02-24 2022-03-25 南京欧信医药技术有限公司 一种嘌呤核苷酸中间体的制备方法
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US10239911B2 (en) 2019-03-26
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US20180030081A1 (en) 2018-02-01
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