IL246361A0 - תצמידי נוגדן – תרופה נגד – trop 2,תכשירים המכילים אותם ושימושים בהם - Google Patents
תצמידי נוגדן – תרופה נגד – trop 2,תכשירים המכילים אותם ושימושים בהםInfo
- Publication number
- IL246361A0 IL246361A0 IL246361A IL24636116A IL246361A0 IL 246361 A0 IL246361 A0 IL 246361A0 IL 246361 A IL246361 A IL 246361A IL 24636116 A IL24636116 A IL 24636116A IL 246361 A0 IL246361 A0 IL 246361A0
- Authority
- IL
- Israel
- Prior art keywords
- trop
- antibody
- compositions
- same
- drug conjugates
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title 1
- 229940049595 antibody-drug conjugate Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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PCT/JP2014/006421 WO2015098099A1 (ja) | 2013-12-25 | 2014-12-24 | 抗trop2抗体-薬物コンジュゲート |
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IL267618A IL267618B (he) | 2013-12-25 | 2019-06-24 | שיטות ייצור תצמידי נוגדן–תרופה |
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