BR112016013704A8 - conjugado de anticorpo-fármaco anti-trop2,fármaco antitumor e/ou anticâncer,composição farmacêutica e uso dos mesmos. - Google Patents

conjugado de anticorpo-fármaco anti-trop2,fármaco antitumor e/ou anticâncer,composição farmacêutica e uso dos mesmos. Download PDF

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Publication number
BR112016013704A8
BR112016013704A8 BR112016013704A BR112016013704A BR112016013704A8 BR 112016013704 A8 BR112016013704 A8 BR 112016013704A8 BR 112016013704 A BR112016013704 A BR 112016013704A BR 112016013704 A BR112016013704 A BR 112016013704A BR 112016013704 A8 BR112016013704 A8 BR 112016013704A8
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BR
Brazil
Prior art keywords
drug
trop2 antibody
tumor
pharmaceutical composition
antitumor
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BR112016013704A
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English (en)
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BR112016013704B1 (pt
BR112016013704A2 (pt
Inventor
Okajima Daisuke
Hamada Hirofumi
Hasegawa Jun
Yamaguchi Miki
Takahashi Shu
Agatsuma Toshinori
Original Assignee
Daiichi Sankyo Co Ltd
Univ Sapporo Medical
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53477995&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016013704(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd, Univ Sapporo Medical filed Critical Daiichi Sankyo Co Ltd
Publication of BR112016013704A2 publication Critical patent/BR112016013704A2/pt
Publication of BR112016013704A8 publication Critical patent/BR112016013704A8/pt
Publication of BR112016013704B1 publication Critical patent/BR112016013704B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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    • C—CHEMISTRY; METALLURGY
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Abstract

o propósito da presente invenção é fornecer um fármaco antitumor que se dintingue no efeito antitumor e segurança, e que tem um excelente efeito terapêutico. é fornecido um conjugado de anticorpo-fármaco caracterizado pelo fato de que um composto antitumor representado por uma fórmula e um anticorpo anti-trop2 são ligados por um ligante tendo uma estrutura representada pela fórmula: -l1-l2-lp-nh-(ch2)n1-la-(ch2)n2-c(=o)- (em que o anticorpo anti-trop2 liga-se ao terminal de l1, e o composto antitumor liga-se ao grupo carbonila da porção -(ch2)n2-c(=o)- usando o átomo de nitrogênio do grupo amino na posição 1 como o sítio de ligação).
BR112016013704-3A 2013-12-25 2014-12-24 Conjugado de anticorpo-fármaco anti-trop2,fármaco antitumor e/ou anticâncer,composição farmacêutica e uso dos mesmos. BR112016013704B1 (pt)

Applications Claiming Priority (3)

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JP2013-267548 2013-12-25
JP2013267548 2013-12-25
PCT/JP2014/006421 WO2015098099A1 (ja) 2013-12-25 2014-12-24 抗ｔｒｏｐ２抗体－薬物コンジュゲート

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BR112016013704A2 BR112016013704A2 (pt) 2017-10-03
BR112016013704A8 true BR112016013704A8 (pt) 2018-04-17
BR112016013704B1 BR112016013704B1 (pt) 2023-07-25

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