BR112016013704A8 - conjugado de anticorpo-fármaco anti-trop2,fármaco antitumor e/ou anticâncer,composição farmacêutica e uso dos mesmos. - Google Patents
conjugado de anticorpo-fármaco anti-trop2,fármaco antitumor e/ou anticâncer,composição farmacêutica e uso dos mesmos. Download PDFInfo
- Publication number
- BR112016013704A8 BR112016013704A8 BR112016013704A BR112016013704A BR112016013704A8 BR 112016013704 A8 BR112016013704 A8 BR 112016013704A8 BR 112016013704 A BR112016013704 A BR 112016013704A BR 112016013704 A BR112016013704 A BR 112016013704A BR 112016013704 A8 BR112016013704 A8 BR 112016013704A8
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- Brazil
- Prior art keywords
- drug
- trop2 antibody
- tumor
- pharmaceutical composition
- antitumor
- Prior art date
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- 230000000259 anti-tumor effect Effects 0.000 title abstract 4
- 239000002246 antineoplastic agent Substances 0.000 title abstract 3
- 229940041181 antineoplastic drug Drugs 0.000 title abstract 3
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 2
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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Abstract
o propósito da presente invenção é fornecer um fármaco antitumor que se dintingue no efeito antitumor e segurança, e que tem um excelente efeito terapêutico. é fornecido um conjugado de anticorpo-fármaco caracterizado pelo fato de que um composto antitumor representado por uma fórmula e um anticorpo anti-trop2 são ligados por um ligante tendo uma estrutura representada pela fórmula: -l1-l2-lp-nh-(ch2)n1-la-(ch2)n2-c(=o)- (em que o anticorpo anti-trop2 liga-se ao terminal de l1, e o composto antitumor liga-se ao grupo carbonila da porção -(ch2)n2-c(=o)- usando o átomo de nitrogênio do grupo amino na posição 1 como o sítio de ligação).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013267548 | 2013-12-25 | ||
JP2013-267548 | 2013-12-25 | ||
PCT/JP2014/006421 WO2015098099A1 (ja) | 2013-12-25 | 2014-12-24 | 抗trop2抗体-薬物コンジュゲート |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112016013704A2 BR112016013704A2 (pt) | 2017-10-03 |
BR112016013704A8 true BR112016013704A8 (pt) | 2018-04-17 |
BR112016013704B1 BR112016013704B1 (pt) | 2023-07-25 |
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