IL226300B - Therapeutic preparations containing rilfivirine hydrochloride and danofovir disoproxil fumarate - Google Patents

Therapeutic preparations containing rilfivirine hydrochloride and danofovir disoproxil fumarate

Info

Publication number
IL226300B
IL226300B IL226300A IL22630013A IL226300B IL 226300 B IL226300 B IL 226300B IL 226300 A IL226300 A IL 226300A IL 22630013 A IL22630013 A IL 22630013A IL 226300 B IL226300 B IL 226300B
Authority
IL
Israel
Prior art keywords
therapeutic compositions
tenofovir disoproxil
disoproxil fumarate
rilpivirine hcl
rilpivirine
Prior art date
Application number
IL226300A
Other languages
English (en)
Hebrew (he)
Original Assignee
Gilead Sciences Inc
Janssen Sciences Ireland Uc
Janssen R& D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45094284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL226300(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc, Janssen Sciences Ireland Uc, Janssen R& D Ireland filed Critical Gilead Sciences Inc
Publication of IL226300B publication Critical patent/IL226300B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL226300A 2010-11-19 2013-05-12 Therapeutic preparations containing rilfivirine hydrochloride and danofovir disoproxil fumarate IL226300B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41560010P 2010-11-19 2010-11-19
PCT/US2011/061515 WO2012068535A1 (en) 2010-11-19 2011-11-18 Therapeutic compositions comprising rilpivirine hcl and tenofovir disoproxil fumarate

Publications (1)

Publication Number Publication Date
IL226300B true IL226300B (en) 2019-05-30

Family

ID=45094284

Family Applications (1)

Application Number Title Priority Date Filing Date
IL226300A IL226300B (en) 2010-11-19 2013-05-12 Therapeutic preparations containing rilfivirine hydrochloride and danofovir disoproxil fumarate

Country Status (36)

Country Link
US (1) US10857102B2 (OSRAM)
EP (2) EP2640362B2 (OSRAM)
JP (2) JP2014500261A (OSRAM)
KR (1) KR101923103B1 (OSRAM)
CN (2) CN103491948B (OSRAM)
AP (1) AP3816A (OSRAM)
AR (2) AR084500A1 (OSRAM)
AU (3) AU2011329642B2 (OSRAM)
BR (1) BR112013012245B1 (OSRAM)
CA (1) CA2818097C (OSRAM)
CL (1) CL2013001402A1 (OSRAM)
CO (1) CO6761300A2 (OSRAM)
CR (1) CR20130293A (OSRAM)
DK (1) DK2640362T4 (OSRAM)
EA (2) EA025852B1 (OSRAM)
EC (2) ECSP13012700A (OSRAM)
ES (1) ES2524408T5 (OSRAM)
HK (1) HK1206592A1 (OSRAM)
HR (1) HRP20140946T1 (OSRAM)
IL (1) IL226300B (OSRAM)
MA (1) MA34735B1 (OSRAM)
ME (1) ME01980B (OSRAM)
MX (1) MX347512B (OSRAM)
MY (1) MY185604A (OSRAM)
NZ (1) NZ610729A (OSRAM)
PE (3) PE20170521A1 (OSRAM)
PH (1) PH12013501002A1 (OSRAM)
PL (1) PL2640362T5 (OSRAM)
PT (1) PT2640362E (OSRAM)
RS (1) RS53691B1 (OSRAM)
SG (3) SG190333A1 (OSRAM)
SM (1) SMT201400150B (OSRAM)
TW (1) TWI556840B (OSRAM)
UA (1) UA114075C2 (OSRAM)
WO (1) WO2012068535A1 (OSRAM)
ZA (1) ZA201304481B (OSRAM)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ540728A (en) 2003-01-14 2008-08-29 Gilead Sciences Inc Compositions and methods for combination antiviral therapy
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
CA2818097C (en) 2010-11-19 2019-07-30 Janssen R & D Ireland Therapeutic compositions comprising rilpivirine hcl and tenofovir disoproxil fumarate
TWI516499B (zh) 2011-08-16 2016-01-11 吉李德科學股份有限公司 泰諾福韋(tenofovir)亞拉芬醯胺(alafenamide)之半反式丁烯二酸鹽
CA2779052A1 (en) * 2012-05-31 2013-11-30 Pharmascience Inc. Pharmaceutical composition of entecavir and process of manufacturing
AU2013361401C1 (en) 2012-12-21 2018-08-09 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
EP2832351A1 (en) * 2013-07-29 2015-02-04 Sanovel Ilac Sanayi ve Ticaret A.S. Multilayer Tablet Formulations Comprising Tenofovir and Entecavir
CZ2013985A3 (cs) * 2013-12-09 2015-06-17 Zentiva, K.S. Stabilní farmaceutická kompozice obsahující tenofovir disoproxil fumarát
WO2015152433A1 (en) * 2014-03-31 2015-10-08 Hanmi Pharm. Co., Ltd. Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same
CN118286245A (zh) 2014-12-26 2024-07-05 埃莫里大学 N4-羟基胞苷和衍生物及与其相关的抗病毒用途
US9839212B2 (en) 2015-04-16 2017-12-12 Bio-Lab, Inc. Multicomponent and multilayer compacted tablets
KR20170003063A (ko) * 2015-06-30 2017-01-09 한미약품 주식회사 테노포비어 디소프록실 함유 경구용 고형제제 및 그 제조방법
CA2921336A1 (en) * 2015-06-30 2016-12-30 Gilead Sciences, Inc. Pharmaceutical formulations
CA2948021C (en) * 2015-11-09 2024-06-18 Gilead Sciences, Inc. Pharmaceutical formulations of (2r,5s,13 ar)-8hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzy1)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1'2':4,5]pyrazino [2,1-b][1,3] oxazepine-10-carboxamide
EP3439639A1 (en) * 2016-04-08 2019-02-13 Shionogi & Co., Ltd. Stabilized solid dosage form
TR201617448A2 (tr) * 2016-11-29 2018-06-21 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Tenofovi̇r ve emtri̇si̇tabi̇n i̇çeren kati oral farmasöti̇k bi̇leşi̇mler
US10561614B2 (en) * 2017-01-27 2020-02-18 Steerlife India Private Limited Tenofovir granules
EP3645003A4 (en) * 2017-06-30 2021-03-10 VIIV Healthcare Company COMBINATION AND USES AND TREATMENTS THEREOF
US11331331B2 (en) 2017-12-07 2022-05-17 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CA3144534A1 (en) * 2019-07-03 2021-01-07 Janssen Sciences Ireland Unlimited Company Methods of treating hiv in pediatric patients with rilpivirine
CN112137981A (zh) * 2020-11-02 2020-12-29 成都晶富医药科技有限公司 富马酸丙酚替诺福韦片及其制备工艺
WO2024211882A1 (en) * 2023-04-07 2024-10-10 Navinta, Llc Stable compositions of rilpivirine hcl in combination with other anti-retroviral agents
CN119174735A (zh) * 2024-09-03 2024-12-24 安徽贝克生物制药有限公司 一种含利匹韦林的复方片及制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100965A (en) 1991-02-22 1999-12-31 Univ Emory 2-Hydroxymethyl-5-(5-fluorocytosin-l-yl)-1,3-oxathiolane its resolution and pharmaceutical compositions containing it
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
MY169670A (en) * 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
EP1448170A4 (en) 2001-11-27 2010-05-12 Bristol Myers Squibb Co EFAVIRENZ STAMP PREPARATIONS HAVING UNIQUE BIOPHARMACEUTICAL CHARACTERISTICS
NZ540728A (en) 2003-01-14 2008-08-29 Gilead Sciences Inc Compositions and methods for combination antiviral therapy
CA2577288C (en) 2004-09-02 2010-11-30 Janssen Pharmaceutica N.V. Hydrochloride of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
MX2007002595A (es) 2004-09-02 2007-04-25 Janssen Pharmaceutica Nv Clorhidrato de 4-[[4-[[4- (2-cianoetenil)-2, 6-dimetilfenil] amino]-2- pirimidinil] amino] benzonitrilo.
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
CN101309675A (zh) 2005-10-14 2008-11-19 微量技术有限公司 口服剂量组合的药品包装
RU2008128424A (ru) 2005-12-14 2010-01-20 Сипла Лимитед (In) Фармацевтическая комбинация, включающая нуклеотидный и нуклеозидный ингибиторы обратной транскриптазы (такие как тенофовир и ламивудин) в различных частях дозы
LT2487163T (lt) * 2007-02-23 2016-10-25 Gilead Sciences, Inc. Terapinių agentų farmakokinetinių savybių moduliatoriai
US20080286344A1 (en) 2007-05-16 2008-11-20 Olivia Darmuzey Solid form
WO2008140461A1 (en) 2007-05-16 2008-11-20 Fmc Corporation Solid form
EP2160394A1 (en) 2007-05-22 2010-03-10 Ultimorphix Technologies B.v. Tenofovir disoproxil hemi-fumaric acid co-crystal
WO2009037449A1 (en) 2007-09-18 2009-03-26 Cipla Limited Solid pharmaceutical compositions comprising one or more herpes virus inhibitors and one or more reverse transcriptase inhibitors
WO2009106960A2 (en) 2008-02-27 2009-09-03 Aurobindo Pharma Limited Stable compositions of lamivudine, tenofovir and efavirenz
BRPI0911871A8 (pt) 2008-05-02 2018-03-06 Gilead Sciences Inc uso de partículas veículo sólidas para melhorar a processabilidade de um agente farmacêutico
HRP20151009T1 (hr) 2009-02-06 2015-10-23 Gilead Sciences, Inc. Dvoslojna tableta koja sadrži elvitegravir, kobicistat, emtricitabin i tenofovir
BR112012006261B1 (pt) 2009-09-21 2021-12-21 Gilead Sciences, Inc Compostos análogos de 2'-flúor substituído carbanucleosídeo, composto útil para a preparação do mesmo, composição farmacêutica e uso dos compostos análogos de 2'-flúor substituído carbanucleosídeo
WO2011077100A1 (en) 2009-12-24 2011-06-30 Cipla Limited Antiretroviral composition
CA2818097C (en) 2010-11-19 2019-07-30 Janssen R & D Ireland Therapeutic compositions comprising rilpivirine hcl and tenofovir disoproxil fumarate

Also Published As

Publication number Publication date
SG190333A1 (en) 2013-06-28
PE20170521A1 (es) 2017-05-27
ES2524408T3 (es) 2014-12-09
ME01980B (me) 2015-05-20
PL2640362T3 (pl) 2015-03-31
MY185604A (en) 2021-05-25
EP2826466A1 (en) 2015-01-21
RS53691B1 (sr) 2015-04-30
US10857102B2 (en) 2020-12-08
KR101923103B1 (ko) 2018-11-28
PL2640362T5 (pl) 2022-05-02
PH12013501002A1 (en) 2013-09-09
SG10201509521WA (en) 2015-12-30
ES2524408T5 (es) 2022-04-25
CA2818097A1 (en) 2012-05-24
UA114075C2 (xx) 2017-04-25
EA025852B1 (ru) 2017-02-28
AU2018202635A1 (en) 2018-05-10
HK1206592A1 (en) 2016-01-15
PE20140163A1 (es) 2014-02-08
CL2013001402A1 (es) 2013-12-27
WO2012068535A1 (en) 2012-05-24
SMT201400150B (it) 2015-01-15
SG10201912527XA (en) 2020-02-27
PE20211657A1 (es) 2021-08-24
AU2011329642A1 (en) 2013-05-02
JP2014500261A (ja) 2014-01-09
ZA201304481B (en) 2022-03-30
JP6138851B2 (ja) 2017-05-31
AU2016208417A1 (en) 2016-08-18
CN103491948B (zh) 2016-11-02
CN103491948A (zh) 2014-01-01
EA201390651A1 (ru) 2013-11-29
TWI556840B (zh) 2016-11-11
MX2013005669A (es) 2013-11-04
DK2640362T3 (en) 2014-12-01
HRP20140946T1 (hr) 2015-02-13
JP2015131853A (ja) 2015-07-23
MX347512B (es) 2017-04-28
AR123409A2 (es) 2022-11-30
KR20140037799A (ko) 2014-03-27
AP2013006931A0 (en) 2013-06-30
BR112013012245B1 (pt) 2022-09-27
EA201691695A1 (ru) 2017-11-30
EP2640362B2 (en) 2021-12-01
DK2640362T4 (da) 2022-03-07
ECSP19078196A (es) 2019-11-30
US20130243857A1 (en) 2013-09-19
NZ610729A (en) 2015-10-30
CR20130293A (es) 2013-10-03
AU2011329642B2 (en) 2016-08-11
CN106511357A (zh) 2017-03-22
TW201238612A (en) 2012-10-01
PT2640362E (pt) 2014-11-28
AP3816A (en) 2016-09-30
AU2016208417B2 (en) 2018-04-05
BR112013012245A2 (pt) 2016-08-09
AR084500A1 (es) 2013-05-22
MA34735B1 (fr) 2013-12-03
CA2818097C (en) 2019-07-30
HK1190064A1 (en) 2014-06-27
ECSP13012700A (es) 2013-08-30
EP2640362A1 (en) 2013-09-25
CO6761300A2 (es) 2013-09-30
EP2640362B1 (en) 2014-09-10

Similar Documents

Publication Publication Date Title
AP3816A (en) Therapeutic compositions comprising rilpivirine hcl and tenofovir disoproxil fumarate
EP2542086A4 (en) COMPOUNDS AND ITS THERAPEUTIC USE
EP2646468A4 (en) ANTI-NGF COMPOSITIONS AND THEIR USE
ZA201404099B (en) Human notch receptor mutations and their use
ZA201300286B (en) Manufacture of active highly phosphorylated human n-acetylgalactosamine-6-sulfactase and uses thereof
GB2501611B (en) Alpha-2-macroglobulin compositions and therapeutic uses
PL2593095T3 (pl) (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania
SI2529756T1 (sl) Formulacija vsadka z risperidonom in/ali paliperidonom
ZA201403372B (en) Therapeutic agents and uses thereof
EP2867209A4 (en) COMPOUNDS AND THEIR THERAPEUTIC USES
PL2605757T3 (pl) Preparaty oparte na nalbufinie i ich zastosowania
SG10201606161UA (en) Albumin Formulation and Use
IL239424A0 (en) Oral care products containing tetrabasic zinc chloride and trimethylglycine
PT2521445T (pt) Formulação e utilização da mesma
PT2563806E (pt) Leucolectinas humanas e suas utilizações
IL236548A0 (en) Preparations containing phosphonate esters of tanafovir and their uses
IL238461A0 (en) 1 hindole-3-carboxamide derivatives and their use as p2y12 inhibitors
SI2640362T1 (sl) Terapevtski sestavki, ki vsebujejo rilpivirin hcl in tenovofir disoproksil
EP2657236A4 (en) NEW 2-ALKYNYL-N9-PROPARGYLADENINE AND ITS MEDICAL USE
IL229936B (en) Albumin formulation and use
AU332227S (en) Therapeutic pillow
GB201012660D0 (en) Inhaler and formulation
GB201209296D0 (en) 'Flip and Walk'
GB201003741D0 (en) Methods and therapeutic compositions
GB201006380D0 (en) Excipients and their use

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed