IL179063A - Pyrimido [4,5– d] azine tricyclic histories and pharmaceuticals containing them as Aurora kinase inhibitors - Google Patents

Pyrimido [4,5– d] azine tricyclic histories and pharmaceuticals containing them as Aurora kinase inhibitors

Info

Publication number
IL179063A
IL179063A IL179063A IL17906306A IL179063A IL 179063 A IL179063 A IL 179063A IL 179063 A IL179063 A IL 179063A IL 17906306 A IL17906306 A IL 17906306A IL 179063 A IL179063 A IL 179063A
Authority
IL
Israel
Prior art keywords
inhibitiors
pharmaceutical compositions
aurora kinase
condensed derivatives
pyrimido
Prior art date
Application number
IL179063A
Other languages
English (en)
Hebrew (he)
Other versions
IL179063A0 (en
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of IL179063A0 publication Critical patent/IL179063A0/en
Publication of IL179063A publication Critical patent/IL179063A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Small-Scale Networks (AREA)
IL179063A 2004-05-14 2006-11-06 Pyrimido [4,5– d] azine tricyclic histories and pharmaceuticals containing them as Aurora kinase inhibitors IL179063A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57165304P 2004-05-14 2004-05-14
US61722104P 2004-10-08 2004-10-08
PCT/US2005/016445 WO2005111039A2 (en) 2004-05-14 2005-05-12 Compounds and methods for inhibiting mitotic progression by inhibition of aurora kinase

Publications (2)

Publication Number Publication Date
IL179063A0 IL179063A0 (en) 2007-03-08
IL179063A true IL179063A (en) 2016-05-31

Family

ID=35262144

Family Applications (1)

Application Number Title Priority Date Filing Date
IL179063A IL179063A (en) 2004-05-14 2006-11-06 Pyrimido [4,5– d] azine tricyclic histories and pharmaceuticals containing them as Aurora kinase inhibitors

Country Status (25)

Country Link
US (9) US7572784B2 (enExample)
EP (4) EP2261226B1 (enExample)
JP (4) JP4467616B2 (enExample)
KR (3) KR101792651B1 (enExample)
CN (1) CN104193750B (enExample)
AR (1) AR049277A1 (enExample)
AT (1) ATE381566T1 (enExample)
AU (1) AU2005243175B2 (enExample)
BR (1) BRPI0511139B8 (enExample)
CA (1) CA2565411C (enExample)
CY (2) CY1108092T1 (enExample)
DE (1) DE602005003951T4 (enExample)
DK (1) DK1771450T5 (enExample)
EA (1) EA012112B1 (enExample)
ES (3) ES2391577T3 (enExample)
HR (2) HRP20080120T5 (enExample)
IL (1) IL179063A (enExample)
MX (1) MXPA06013042A (enExample)
MY (1) MY139355A (enExample)
NZ (1) NZ551370A (enExample)
PL (1) PL1771450T3 (enExample)
PT (2) PT1771450E (enExample)
RS (2) RS52436B (enExample)
TW (1) TWI338688B (enExample)
WO (1) WO2005111039A2 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101792651B1 (ko) * 2004-05-14 2017-11-20 밀레니엄 파머슈티컬스 인코퍼레이티드 아우로라 키나아제의 억제에 의해 유사분열 진행을 억제하기 위한 화합물 및 그 화합물을 포함하는 약학적 조성물
EP1799684B1 (en) 2004-10-04 2014-12-03 Millennium Pharmaceuticals, Inc. Lactam compounds useful as protein kinase inhibitors
WO2006046734A2 (ja) * 2004-10-29 2006-05-04 Banyu Pharma Co Ltd オーロラa選択的阻害作用を有する新規アミノピリジン誘導体
CN101166732B (zh) 2005-04-28 2013-04-17 田边三菱制药株式会社 氰基吡啶衍生物及其作为药物的应用
MX2007013257A (es) * 2005-05-05 2008-01-21 Chroma Therapeutics Ltd Conjugados de ester de alfa-aminoacido-farmaco hidrolizables por carboxilesterasa.
US8624027B2 (en) * 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7572809B2 (en) * 2005-12-19 2009-08-11 Hoffmann-La Roche Inc. Isoquinoline aminopyrazole derivatives
WO2007087246A2 (en) * 2006-01-24 2007-08-02 Merck & Co., Inc. Jak2 tyrosine kinase inhibition
WO2007108936A2 (en) * 2006-03-15 2007-09-27 Wyeth N-substituted-azacyclylamines as histamine-3 antagonists
WO2007107469A1 (en) * 2006-03-20 2007-09-27 F. Hoffmann-La Roche Ag Methods of inhibiting btk and syk protein kinases
CA2649913A1 (en) * 2006-05-19 2007-11-29 Wyeth N-benzoyl- and n-benzylpyrrolidin-3-ylamines as histamine-3 antagonists
WO2008021038A2 (en) 2006-08-09 2008-02-21 Millennium Pharmaceuticals, Inc. Pyridobenzazepine compounds and methods for inhibiting mitotic progression
PE20081152A1 (es) * 2006-10-06 2008-08-10 Wyeth Corp Azaciclilaminas n-sustituidas como antagonistas de histamina-3
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
AU2014280932B2 (en) * 2006-11-16 2016-10-06 Millennium Pharmaceuticals, Inc. Compounds for inhibiting mitotic progression
CL2007003244A1 (es) * 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
AU2012203952B2 (en) * 2006-11-16 2014-12-11 Millennium Pharmaceuticals, Inc. Compounds for inhibiting mitotic progression
AR066721A1 (es) * 2007-05-24 2009-09-09 Wyeth Corp Derivados de benzo[d]imidazol-1-il, composicion farmaceutica, proceso de preparacion y uso.
TW200914457A (en) * 2007-05-31 2009-04-01 Kyowa Hakko Kogyo Kk Pyrimidodiazepinone derivative
CA2693138A1 (en) * 2007-07-16 2009-01-22 Wyeth Llc Aminoalkylazole derivatives as histamine-3 antagonists
KR20100067102A (ko) * 2007-09-04 2010-06-18 바이올리폭스 에이비 염증의 치료에 유용한 비스-방향족 화합물
US20090069300A1 (en) * 2007-09-12 2009-03-12 Wyeth Isoquinolinyl and isoindolinyl derivatives as histamine-3 antagonists
TW200918062A (en) * 2007-09-12 2009-05-01 Wyeth Corp Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists
JP2009108036A (ja) * 2007-09-28 2009-05-21 Fujifilm Corp 新規アセチレン化合物、その製造方法、それを構成単位として含むポリマー、該化合物及び／又は該ポリマーを含む組成物、該組成物を硬化させてなる硬化物
ES2427892T3 (es) * 2008-02-29 2013-11-04 Chroma Therapeutics Limited Inhibidores de MAP quinasa p38
GB0803747D0 (en) * 2008-02-29 2008-04-09 Martin Enzyme and receptor modulation
AU2009241469B2 (en) 2008-04-30 2015-05-07 National Health Research Institutes Fused bicyclic pyrimidine compounds as Aurora kinase inhibitors
US20110112193A1 (en) * 2008-05-14 2011-05-12 Peter Nilsson Bis-aryl compounds for use as medicaments
US7998952B2 (en) * 2008-12-05 2011-08-16 Millennium Pharmaceuticals, Inc. Thiolactams and uses thereof
CN102264368B (zh) 2008-12-22 2014-09-10 米伦纽姆医药公司 极光激酶抑制剂与抗cd20抗体的组合
US20120035217A1 (en) 2009-03-12 2012-02-09 Biolipox Ab Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors
WO2010103297A2 (en) 2009-03-12 2010-09-16 Biolipox Ab Bis aromatic compounds for use as ltc4 synthase inhibitors
TW201035050A (en) 2009-03-12 2010-10-01 Biolipox Ab Bis aromatic compounds for use as LTC4 synthase inhibitors
CN102341371A (zh) 2009-03-12 2012-02-01 比奥里波克斯公司 用作ltc4合酶抑制剂的双芳族化合物
US8546377B2 (en) * 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
JO3635B1 (ar) * 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
JO3434B1 (ar) * 2009-07-31 2019-10-20 Millennium Pharm Inc مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
WO2011103089A1 (en) 2010-02-19 2011-08-25 Millennium Pharmaceuticals, Inc. Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6--methoxyphenyl)-5h -pyrimido[5,4-d][2]benzazepin-2yl]amino}-2-methoxybenzoate
EP2545036A1 (en) 2010-03-12 2013-01-16 Biolipox AB Bis aromatic compounds for use as ltc4 synthase inhibitors
AR086656A1 (es) 2011-06-03 2014-01-15 Millennium Pharm Inc Combinacion de inhibidores de mek e inhibidores selectivos de la quinasa aurora a
GB201202027D0 (en) * 2012-02-06 2012-03-21 Sareum Ltd Pharmaceutical compounds
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
WO2013142817A2 (en) 2012-03-23 2013-09-26 Dennis Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
CN103804391A (zh) * 2012-11-01 2014-05-21 韩冰 一类治疗神经退行性疾病的化合物及其用途
EP2976086B1 (en) 2013-03-22 2020-10-14 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
CN103408552B (zh) * 2013-07-25 2015-07-01 苏州明锐医药科技有限公司 阿立塞替的制备方法
US10335494B2 (en) 2013-12-06 2019-07-02 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-CD30 antibodies
EP3324976A4 (en) * 2015-07-21 2019-03-27 Millennium Pharmaceuticals, Inc. ADMINISTRATION OF KINASE AURORA INHIBITOR AND CHEMOTHERAPEUTIC AGENTS
WO2019195658A1 (en) 2018-04-05 2019-10-10 Dana-Farber Cancer Institute, Inc. Sting levels as a biomarker for cancer immunotherapy
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica
WO2021041532A1 (en) 2019-08-26 2021-03-04 Dana-Farber Cancer Institute, Inc. Use of heparin to promote type 1 interferon signaling
CN112062768B (zh) * 2020-07-20 2021-08-31 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 具有Aurora激酶降解活性的小分子及其制备方法和应用
AU2022415778A1 (en) * 2021-12-14 2024-07-04 Prazer Therapeutics Inc. Novel compound for degrading target protein or polypeptide by using polyubiquitination
WO2025087695A1 (en) 2023-10-23 2025-05-01 Ascend Advanced Therapies Ltd Method for producing recombinant adeno-associated virus particles

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022801A (en) 1974-06-03 1977-05-10 Ciba-Geigy Corporation Pyrazolobenzazepines
US3947585A (en) * 1974-06-03 1976-03-30 Ciba-Geigy Corporation Pyrazolobenzazepines
US4028381A (en) 1975-05-05 1977-06-07 Ciba-Geigy Corporation Pyrazolobenzazepines
US4099012A (en) 1975-08-28 1978-07-04 Ciba-Geigy Corporation 2-pyrazolyl-benzophenones
ZA80492B (en) * 1979-02-07 1981-01-28 Hoffmann La Roche Benzazepine derivatives
KR840000061B1 (ko) 1979-02-07 1984-01-31 에프. 호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트 벤즈아제핀 유도체의 제조방법
SU1181547A3 (ru) 1979-02-07 1985-09-23 Ф.Хоффманн-Ля Рош Унд Ко,Аг (Фирма) Способ получени пиримидо-2-бензазепинов или их фармакологически совместимых кислотно-аддитивных солей (и его вариант)
US4547581A (en) 1979-02-07 1985-10-15 Hoffmann-La Roche Inc. Pyrimido-2-benzazepines and intermediates in their preparation
US4481142A (en) 1979-02-07 1984-11-06 Hoffmann-La Roche Inc. Pyrimido-2-benzazepines
US4318854A (en) 1979-02-07 1982-03-09 Hoffmann-La Roche Inc. Intermediates in the production of 2-benzazepines
US4469633A (en) 1980-05-16 1984-09-04 Hoffmann-La Roche Inc. N-oxides of 5-oxo-1-phenyl-2-benzazepines
NL8102182A (nl) 1981-05-04 1982-12-01 Philips Nv Kleurenbeeldbuis.
EP0273697A3 (en) 1986-12-30 1989-11-29 Merck & Co. Inc. 2-benzazepines with 5- and 6- membered heterocyclic rings
US5166151A (en) 1988-03-25 1992-11-24 Merck & Co., Inc. 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
US5210082A (en) 1991-05-16 1993-05-11 Merck & Co., Inc. 2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders
US5747487A (en) 1993-07-29 1998-05-05 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
EP0888350A1 (en) 1996-03-08 1999-01-07 Zeneca Limited Azolobenzazepine derivatives as neurologically active agents
AU5330698A (en) * 1996-12-23 1998-07-17 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
DK1026167T3 (da) 1997-09-29 2003-05-26 Meiji Seika Kaisha Tricykliske triazolobenzazepinderivater, fremgangsmåde til fremstilling af disse samt antiallergiske midler
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
US6417207B1 (en) 1999-05-12 2002-07-09 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
AU2001290912A1 (en) * 2000-09-15 2002-03-26 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
BR0116493A (pt) 2000-12-21 2003-09-30 Vertex Pharma Compostos de pirazol úteis como inibidores de proteìna cinase
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
HUP0401107A3 (en) 2001-08-09 2004-10-28 Actelion Pharmaceuticals Ltd Novel benzo-fused heterocycles, their use process for their preparation and pharmaceutical compositions containing them
CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
KR101792651B1 (ko) * 2004-05-14 2017-11-20 밀레니엄 파머슈티컬스 인코퍼레이티드 아우로라 키나아제의 억제에 의해 유사분열 진행을 억제하기 위한 화합물 및 그 화합물을 포함하는 약학적 조성물
MX2007005857A (es) 2004-11-17 2007-10-10 Mikana Therapeutics Inc Inhibidores de cinasa.
EP1836188A1 (en) 2004-12-30 2007-09-26 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
CL2007003244A1 (es) * 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
US20090203671A1 (en) 2007-11-27 2009-08-13 Abbott Laboratories Method of treating cancer
JO3434B1 (ar) * 2009-07-31 2019-10-20 Millennium Pharm Inc مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري

Also Published As

Publication number Publication date
PT1771450E (pt) 2008-03-31
BRPI0511139B8 (pt) 2021-05-25
DK1771450T3 (da) 2008-04-28
HK1114853A1 (en) 2008-11-14
US20160185782A1 (en) 2016-06-30
DE602005003951T4 (de) 2012-10-11
RS50568B (sr) 2010-05-07
HK1102500A1 (en) 2007-11-23
US20240083906A1 (en) 2024-03-14
BRPI0511139A (pt) 2007-11-27
IL179063A0 (en) 2007-03-08
US7572784B2 (en) 2009-08-11
US8399659B2 (en) 2013-03-19
PL1771450T3 (pl) 2008-05-30
DE602005003951D1 (de) 2008-01-31
NZ551370A (en) 2009-08-28
EP2261226B1 (en) 2015-04-01
US20090299060A1 (en) 2009-12-03
CA2565411C (en) 2010-04-20
US11014928B2 (en) 2021-05-25
JP2014114319A (ja) 2014-06-26
US20200247810A1 (en) 2020-08-06
JP4467616B2 (ja) 2010-05-26
RS50568B9 (sr) 2019-06-28
ES2540987T3 (es) 2015-07-15
HRP20080120T3 (hr) 2008-04-30
KR20070011606A (ko) 2007-01-24
KR101792651B1 (ko) 2017-11-20
HK1205102A1 (en) 2015-12-11
US9765078B2 (en) 2017-09-19
EP2261226A1 (en) 2010-12-15
CN104193750B (zh) 2018-04-27
US20180134716A1 (en) 2018-05-17
PT1905773E (pt) 2012-10-25
US10414770B2 (en) 2019-09-17
DE602005003951T2 (de) 2008-12-11
JP2008285484A (ja) 2008-11-27
RS52436B (sr) 2013-02-28
KR20120091275A (ko) 2012-08-17
MXPA06013042A (es) 2007-02-12
EP2719698B1 (en) 2016-10-05
HK1199254A1 (en) 2015-06-26
HRP20080120T5 (hr) 2012-07-31
EA200602100A1 (ru) 2007-04-27
RS50568B8 (sr) 2019-08-30
US20050256102A1 (en) 2005-11-17
WO2005111039A3 (en) 2006-04-20
CY1113192T1 (el) 2016-04-13
US20220041605A1 (en) 2022-02-10
JP2007537268A (ja) 2007-12-20
KR20130073993A (ko) 2013-07-03
CN104193750A (zh) 2014-12-10
TWI338688B (en) 2011-03-11
CY1108092T1 (el) 2014-02-12
HRP20120785T1 (hr) 2012-11-30
JP5148358B2 (ja) 2013-02-20
AU2005243175B2 (en) 2011-12-01
MY139355A (en) 2009-09-30
AU2005243175A1 (en) 2005-11-24
TW200604192A (en) 2006-02-01
ES2391577T3 (es) 2012-11-27
EP2719698A1 (en) 2014-04-16
JP5827708B2 (ja) 2015-12-02
JP2012006972A (ja) 2012-01-12
EA012112B1 (ru) 2009-08-28
CA2565411A1 (en) 2005-11-24
BRPI0511139B1 (pt) 2019-05-21
DK1771450T5 (da) 2012-01-09
AR049277A1 (es) 2006-07-12
EP1771450A2 (en) 2007-04-11
ATE381566T1 (de) 2008-01-15
EP1771450B9 (en) 2008-12-24
KR101748290B1 (ko) 2017-06-16
EP2746285A1 (en) 2014-06-25
WO2005111039A2 (en) 2005-11-24
ES2299080T3 (es) 2008-05-16
US9102678B2 (en) 2015-08-11
US20070185087A1 (en) 2007-08-09
EP2746285B1 (en) 2016-09-14
US20140046055A1 (en) 2014-02-13
EP1771450B1 (en) 2007-12-19

Similar Documents

Publication Publication Date Title
IL183512A (en) Annals of 5-Amino-2-Oxo-Thiazolo [d-5,4] Pyrimidine-3 (or 2) Ill- Tetrahydroporan, Containing and Using Pharmaceutical Preparations
HUP0401047A3 (en) Triazolo[4,5-d]pyrimidine derivatives, their use as purinergic receptor antagonist and pharmaceutical compositions containing same
HUP0402018A3 (en) 5-amino-7h-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives, their use and pharmaceutical compositions containing them
ZA200609837B (en) Octahydro-pyrrolo[3,4-c] derivatives and their use as antiviral compounds
IL221869A (en) Annals of 5-phenyl-tetrahydro [5,1- a] (azine / pyridine) and pharmaceutical preparations containing them
HUP0500332A3 (en) Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)-one derivatives, their use and pharmaceutical compositions containing them
TWI319320B (en) 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
IL180757A0 (en) Imidazo[4,5-d] pyrimidines, their uses and methods of preparation
HUP0303350A3 (en) Use of substituted imidazo[1,2-a]pyridine-, imidazo[1,2-a]pyrimidine and imidazo[1,2-a]pyrazine-3-yl-amine derivatives for producing nos-inhibiting pharmaceutical compositions
HUP0303653A3 (en) Tricyclic and heterocyclic derivative and pharmaceutical compositions containing them as the active ingredient
HUP0203509A3 (en) Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same
HUP0402454A3 (en) Substituted quinazoline derivatives as inhibitors of aurora kinases, process for their preparation and pharmaceutical compositions containing them
HUP0500328A3 (en) Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)-one derivatives, their use and pharmaceutical compositions containing them
WO2007044426A3 (en) Pyrazolopyrimidines as protein kinase inhibitors
ZA200703623B (en) Formulations of [1,4]diazepino[6,7,1-ij]quinoline derivatives
HUP0203288A3 (en) Pyrrole derivatives as phosphodiesterase vii inhibitors, pharmaceutical compositions containing them and their use
IL156536A0 (en) Pyrazolo [3,4-d] pyrimidin-4-one derivatives and pharmaceutical compositions containing the same
IL176385A (en) Compressed history of pyrrolo [34, -c] carbazol-1-van and pyrrolo [34, -c] carbazol-3,1-discussion and pharmaceutical preparations containing them
HUP0500330A3 (en) Heterocondensated tricyclic imidazopyridines, their use and pharmaceutical compositions containing them
IL213589A0 (en) DIPYRIDO [2,3-d;4-d] PYRROL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU2001281067A1 (en) Novel bicyclic and tricyclic pyrrolidine derivatives as gnrh antagonists
HUP0303138A3 (en) Pyrrolo[3,4-d]pyrimidines as corticotropin releasing factor (crf) antagonists, pharmaceutical compositions containing them and their use
PL375709A1 (en) Derivatives of [6,7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide
EE200400078A (et) Tritsüklilisi 5,6-dihüdro-9H-pürasolo[3,4-c]-1,2,4-triasolo[4,3-alfa]püridiine sisaldavad inhalatsioonikompositsioonid
HUP0301173A3 (en) Quinazoline derivatives and their use for the preparation of pharmaceutical compositions inhibiting parp enzyme

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed