AR049277A1 - Compuestos para inhibir l a progresion mitotica - Google Patents
Compuestos para inhibir l a progresion mitoticaInfo
- Publication number
- AR049277A1 AR049277A1 ARP050102001A ARP050102001A AR049277A1 AR 049277 A1 AR049277 A1 AR 049277A1 AR P050102001 A ARP050102001 A AR P050102001A AR P050102001 A ARP050102001 A AR P050102001A AR 049277 A1 AR049277 A1 AR 049277A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- heterocyclyl
- heteroaryl
- ring
- independently
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 125000001931 aliphatic group Chemical group 0.000 abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- 102000003989 Aurora kinases Human genes 0.000 abstract 1
- 108090000433 Aurora kinases Proteins 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Small-Scale Networks (AREA)
Abstract
Se refiere a compuestos para el tratamiento del cáncer. En particular, proporciona compuestos que inhiben la quinasa Aurora, composiciones farmacéuticas que comprenden los compuestos y métodos para usar los compuestos para el tratamiento del cáncer. Reivindicacion 1: Un compuesto de formula (1), o una sal farmacéuticamente aceptable del mismo; en el que: El anillo A está sustituido con 0-3 Rb; El anillo B es un anillo arilo sustituido o no sustituido, heteroarilo, heterociclilo o cicloalifático; El anillo C es un anillo arilo sustituido o no sustituido, heteroarilo, heterociclilo o cicloalifático; cada Rb independientemente es -halo, -NO2, -CN, -C(R5)=C(R5)2, -C(R5)=C(R5)(R10), -C:::C-R5, -C:::C-R10, -OR5, SR6, -S(O)R6, - SO2R6, -SO2N(R4)2, -N(R4)2, -NR4C(O)R5, -NR4C(O)N(R4)2, -NR4CO2R6, -O-CO2R5,-OC(O)N(R4)2, -O-C(O)R5, -CO2R5, -C(O)-C(O)R5, -C(O)R5, -C(O)N(R4)2, -C(=NR4)-N(R4)2, -C(=NR4)-OR5, -N(R4)-N(R4)2, N(R4)C(=NR4)-N(R4)2, -N(R4)SO2R6, -N(R4)SO2N(R4)2, - P(O)(R5)2, -P(O)(OR5)2, un grupo alifático opcionalmente sustituido, o un grupo arilo, heterociclilo, o heteroarilo opcionalmente sustituido; Re es hidrogeno, -OR5, -N(R4)2, -SR5, o un alifático C1-3 opcionalmente sustituido co R3 o R7; cada uno de Rx y Ry es independientemente hidrogeno, fluoro o un alifático C1-6 opcionalmente sustituido; o Rx y Ry, tomados junto con el átomo de carbono al que están unidos, forman un anillo cicloalifático de 3 a 6 miembros opcionalmente sustituido; cada R3 se selecciona independientemente entre el grupo compuesto -halo, -OH, -O(alquiloC1-3), -CN, -N(R4)2, -C(O)alquiloC1-3, -CO2H, -CO2alquiloC1-3, -C(O)NH2, y -C(O)NHalquiloC1-3; cada R4 es independientemente hidrogeno o un grupo alifático opcionalmente sustituido, arilo, heteroarilo o heterociclilo; o dos R4 en el mismo átomo de nitrogeno, tomados junto con el átomo de nitrogeno, forman un heteroarilo de 5 a 6 miembros opcionalmente sustituido o heterociclilo de 4 a 8 miembros que tiene, además del átomo de nitrogeno, 0-2 heteroátomos en el anillo seleccionados entre N, O y S; cada R5 es independientemente hidrogeno o un grupo alifático opcionalmente sustituido, arilo, heteroarilo o heterociclilo; cada R6 es independientemente un grupo alifático opcionalmente sustituido o arilo; cada R7 es independientemente un grupo arilo opcionalmente sustituido, heterociclilo o heteroarilo; y cada R10 es independientemente -CO2R5 o -C(O)N(R4)2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57165304P | 2004-05-14 | 2004-05-14 | |
US61722104P | 2004-10-08 | 2004-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR049277A1 true AR049277A1 (es) | 2006-07-12 |
Family
ID=35262144
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050102001A AR049277A1 (es) | 2004-05-14 | 2005-05-16 | Compuestos para inhibir l a progresion mitotica |
Country Status (26)
Country | Link |
---|---|
US (9) | US7572784B2 (es) |
EP (4) | EP2261226B1 (es) |
JP (4) | JP4467616B2 (es) |
KR (3) | KR101748290B1 (es) |
CN (1) | CN104193750B (es) |
AR (1) | AR049277A1 (es) |
AT (1) | ATE381566T1 (es) |
AU (1) | AU2005243175B2 (es) |
BR (1) | BRPI0511139B8 (es) |
CA (1) | CA2565411C (es) |
CY (2) | CY1108092T1 (es) |
DE (1) | DE602005003951T4 (es) |
DK (1) | DK1771450T5 (es) |
EA (1) | EA012112B1 (es) |
ES (3) | ES2299080T3 (es) |
HK (4) | HK1102500A1 (es) |
HR (2) | HRP20080120T5 (es) |
IL (1) | IL179063A (es) |
MX (1) | MXPA06013042A (es) |
MY (1) | MY139355A (es) |
NZ (1) | NZ551370A (es) |
PL (1) | PL1771450T3 (es) |
PT (2) | PT1771450E (es) |
RS (2) | RS50568B8 (es) |
TW (1) | TWI338688B (es) |
WO (1) | WO2005111039A2 (es) |
Families Citing this family (57)
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RS50568B8 (sr) | 2004-05-14 | 2019-08-30 | Millennium Pharm Inc | Jedinjenja i postupci za inhibiciju mitotičke progresije inhibiranjem aurora kinaze |
JP5002460B2 (ja) * | 2004-10-04 | 2012-08-15 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | タンパク質キナーゼインヒビターとして有用なラクタム化合物 |
JP4973190B2 (ja) * | 2004-10-29 | 2012-07-11 | Msd株式会社 | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
US7928126B2 (en) | 2005-04-28 | 2011-04-19 | Mitsubishi Tanabe Pharma Corporation | Cyanopyridine derivative and use thereof as medicine |
PL1877098T3 (pl) * | 2005-05-05 | 2013-09-30 | Glaxosmithkline Ip Dev Ltd | Koniugaty estru alfa-aminokwasu z lekiem ulegające hydrolizie z udziałem karboksyloesterazy |
US8624027B2 (en) * | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
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CN101405001A (zh) * | 2006-03-20 | 2009-04-08 | 霍夫曼-拉罗奇有限公司 | 抑制btk和syk蛋白质激酶的方法 |
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JP2010500352A (ja) * | 2006-08-09 | 2010-01-07 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 有糸分裂の進行を阻止するためのピリドベンゾアゼピン化合物および方法 |
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JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
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CN101778838A (zh) * | 2007-05-24 | 2010-07-14 | 惠氏有限责任公司 | 作为组胺-3拮抗剂的氮杂环基苯甲酰胺衍生物 |
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JO3434B1 (ar) | 2009-07-31 | 2019-10-20 | Millennium Pharm Inc | مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري |
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CN103804391A (zh) * | 2012-11-01 | 2014-05-21 | 韩冰 | 一类治疗神经退行性疾病的化合物及其用途 |
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