IL162376A0 - Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-ir) - Google Patents

Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-ir)

Info

Publication number
IL162376A0
IL162376A0 IL16237602A IL16237602A IL162376A0 IL 162376 A0 IL162376 A0 IL 162376A0 IL 16237602 A IL16237602 A IL 16237602A IL 16237602 A IL16237602 A IL 16237602A IL 162376 A0 IL162376 A0 IL 162376A0
Authority
IL
Israel
Prior art keywords
igf
modulators
insulin
receptor
growth factor
Prior art date
Application number
IL16237602A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IL162376A0 publication Critical patent/IL162376A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL16237602A 2001-12-07 2002-12-03 Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-ir) IL162376A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104140A SE0104140D0 (sv) 2001-12-07 2001-12-07 Novel Compounds
PCT/SE2002/002221 WO2003048133A1 (en) 2001-12-07 2002-12-03 Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (igf-i)

Publications (1)

Publication Number Publication Date
IL162376A0 true IL162376A0 (en) 2005-11-20

Family

ID=20286257

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16237602A IL162376A0 (en) 2001-12-07 2002-12-03 Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-ir)
IL162376A IL162376A (en) 2001-12-07 2004-06-06 Pyrimidine derivatives wherein a nitrogen heteroatom is attached at positions 2 and 4 thereof, process for their preparation, pharmaceutical compositions containing them and use of such pyrimidine derivatives in the manufacture of medicaments and as medicaments for modulating insulin-like growth factor-1 receptor activity in a patient

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL162376A IL162376A (en) 2001-12-07 2004-06-06 Pyrimidine derivatives wherein a nitrogen heteroatom is attached at positions 2 and 4 thereof, process for their preparation, pharmaceutical compositions containing them and use of such pyrimidine derivatives in the manufacture of medicaments and as medicaments for modulating insulin-like growth factor-1 receptor activity in a patient

Country Status (33)

Country Link
US (3) US7521453B2 (xx)
EP (1) EP1456182B1 (xx)
JP (1) JP4347051B2 (xx)
KR (1) KR100930558B1 (xx)
CN (1) CN1289486C (xx)
AR (1) AR037736A1 (xx)
AT (1) ATE425150T1 (xx)
AU (1) AU2002365864B2 (xx)
BR (1) BR0214605A (xx)
CA (1) CA2467838C (xx)
CO (1) CO5590919A2 (xx)
CY (1) CY1109101T1 (xx)
DE (1) DE60231542D1 (xx)
DK (1) DK1456182T3 (xx)
EG (1) EG24930A (xx)
ES (1) ES2323125T3 (xx)
HK (1) HK1067631A1 (xx)
HU (1) HUP0401855A3 (xx)
IL (2) IL162376A0 (xx)
IS (1) IS7294A (xx)
MX (1) MXPA04005347A (xx)
MY (1) MY135705A (xx)
NO (1) NO327502B1 (xx)
NZ (1) NZ533130A (xx)
PL (1) PL369528A1 (xx)
PT (1) PT1456182E (xx)
RU (1) RU2317291C2 (xx)
SE (1) SE0104140D0 (xx)
SI (1) SI1456182T1 (xx)
TW (1) TWI324152B (xx)
UA (1) UA78259C2 (xx)
WO (1) WO2003048133A1 (xx)
ZA (1) ZA200404223B (xx)

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RU2317291C2 (ru) 2008-02-20
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