SE0104140D0 - Novel Compounds - Google Patents
Novel CompoundsInfo
- Publication number
- SE0104140D0 SE0104140D0 SE0104140A SE0104140A SE0104140D0 SE 0104140 D0 SE0104140 D0 SE 0104140D0 SE 0104140 A SE0104140 A SE 0104140A SE 0104140 A SE0104140 A SE 0104140A SE 0104140 D0 SE0104140 D0 SE 0104140D0
- Authority
- SE
- Sweden
- Prior art keywords
- novel compounds
- pharmaceutical compositions
- therapy
- preparing
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (36)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0104140A SE0104140D0 (sv) | 2001-12-07 | 2001-12-07 | Novel Compounds |
UA20040705367A UA78259C2 (en) | 2001-12-07 | 2002-03-12 | Pyrimidine derivatives, application thereof, process for preparation (variants) thereof, pharmaceutical compositions, process for preparing pharmaceutical compositions, method for treating cancer, and method for modulating activity of receptor of insuline-like growth factor (igf-i) |
TW091134937A TWI324152B (en) | 2001-12-07 | 2002-12-02 | Pyrimidine derivatives and their process for preparation and use as modulators of insulin-like growth factor-1 receptor(igf-1) |
CA2467838A CA2467838C (en) | 2001-12-07 | 2002-12-03 | Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (igf-i) |
AU2002365864A AU2002365864B2 (en) | 2001-12-07 | 2002-12-03 | Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (IGF-I) |
MXPA04005347A MXPA04005347A (es) | 2001-12-07 | 2002-12-03 | Derivados de pirimidina como moduladores del receptor (igf-i) del factor-1 de crecimiento similares a la insulina. |
ES02791165T ES2323125T3 (es) | 2001-12-07 | 2002-12-03 | Derivados de pirimidina como moduladores del receptor del factor-1 de crecimiento de tipo insulina (igf-i). |
SI200230824T SI1456182T1 (sl) | 2001-12-07 | 2002-12-03 | Pirimidinski derivati kot modulatorji insulinu podobnega receptorja rastnega faktorja-1 (IGF-I) |
PCT/SE2002/002221 WO2003048133A1 (en) | 2001-12-07 | 2002-12-03 | Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (igf-i) |
EP02791165A EP1456182B1 (en) | 2001-12-07 | 2002-12-03 | Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (igf-i) |
HU0401855A HUP0401855A3 (en) | 2001-12-07 | 2002-12-03 | Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (igf-ir), process for their preparation, their use and pharmaceutical compositions containing them |
AT02791165T ATE425150T1 (de) | 2001-12-07 | 2002-12-03 | Pyrimidinderivate als modulatoren des insulinähnlichen wachstumsfaktor-1-rezeptors (igf-i) |
KR1020047008612A KR100930558B1 (ko) | 2001-12-07 | 2002-12-03 | 인슐린-유사 성장 인자-1 수용체 (igf-1)의조절제로서의 피리미딘 유도체 |
RU2004121029/04A RU2317291C2 (ru) | 2001-12-07 | 2002-12-03 | Производные пиримидина в качестве модуляторов рецептора инсулинподобного фактора роста 1 (igf-1), фармацевтическая композиция, способы получения (варианты) и применение |
BR0214605-3A BR0214605A (pt) | 2001-12-07 | 2002-12-03 | Composto, composição farmacêutica, processos para preparar os mesmos, uso de um composto, e, método para tratar câncer, e para modular a atividade do receptor do fator-1 de crescimento semelhante à insulina |
IL16237602A IL162376A0 (en) | 2001-12-07 | 2002-12-03 | Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-ir) |
JP2003549325A JP4347051B2 (ja) | 2001-12-07 | 2002-12-03 | インスリン様成長因子1受容体(igf−i)のモジュレーターとしてのピリミジン誘導体 |
NZ533130A NZ533130A (en) | 2001-12-07 | 2002-12-03 | Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (IGF-I) |
DE60231542T DE60231542D1 (de) | 2001-12-07 | 2002-12-03 | Chen wachstumsfaktor-1-rezeptors (igf-i) |
DK02791165T DK1456182T3 (da) | 2001-12-07 | 2002-12-03 | Pyrimidinderivater som modulatorer af insulinlignende vækstfaktor-1-receptor(1GF-1) |
US10/497,744 US7521453B2 (en) | 2001-12-07 | 2002-12-03 | Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (IGF-I) |
PL02369528A PL369528A1 (en) | 2001-12-07 | 2002-12-03 | Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (igf-i) |
CNB02827802XA CN1289486C (zh) | 2001-12-07 | 2002-12-03 | 作为胰岛素样生长因子-1受体(igf-i)调节剂的嘧啶衍生物 |
PT02791165T PT1456182E (pt) | 2001-12-07 | 2002-12-03 | Derivados de pirimidina como moduladores do receptor do factor de crescimento semelhante à insulina-1 (igf-i) |
MYPI20024549A MY135705A (en) | 2001-12-07 | 2002-12-04 | Pyrimidine derivatives as modulators of insulin-like growth factor-1 receptor (igf-i) |
ARP020104747A AR037736A1 (es) | 2001-12-07 | 2002-12-06 | Derivados de pirimidina como moduladores o inhibidores de la actividad del factor de crecimiento insulinico tipo 1 (igf-1r) |
ZA200404223A ZA200404223B (en) | 2001-12-07 | 2004-05-28 | Pyrimidine derivatives as modulars of insuline-like growth factor-1 receptor (IGF-I). |
CO04052141A CO5590919A2 (es) | 2001-12-07 | 2004-06-03 | Derivados de pirimidina como moduladores de receptor de factor-1 de crecimiento similara la insulina (igf-1) |
IS7294A IS7294A (is) | 2001-12-07 | 2004-06-03 | Pýrimídínafleiður sem stillar vaxtarþáttar-1 viðtaka sem líkist insúlíni (IGF-I) |
IL162376A IL162376A (en) | 2001-12-07 | 2004-06-06 | Pyrimidine derivatives wherein a nitrogen heteroatom is attached at positions 2 and 4 thereof, process for their preparation, pharmaceutical compositions containing them and use of such pyrimidine derivatives in the manufacture of medicaments and as medicaments for modulating insulin-like growth factor-1 receptor activity in a patient |
EGNA2004000039 EG24930A (en) | 2001-12-07 | 2004-06-06 | Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (IGF-I) |
NO20042872A NO327502B1 (no) | 2001-12-07 | 2004-07-06 | Pyrimidinderivater, fremgangsmate for fremstilling av disse, farmasoytiske preparater innehodende dem og anvendelse av slike for fremstilling av medikamenter for behandling av sykdom |
HK05100089.7A HK1067631A1 (en) | 2001-12-07 | 2005-01-06 | Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (igf-i) |
US12/359,541 US20090131463A1 (en) | 2001-12-07 | 2009-01-26 | Novel compounds |
CY20091100558T CY1109101T1 (el) | 2001-12-07 | 2009-05-25 | Παραγωγα πυριμιδινης ως ρυθμιστες υποδοχεα (igf-i) ινσουλινοειδους αυξητικου παραγοντα-1 |
US13/313,097 US20120095011A1 (en) | 2001-12-07 | 2011-12-07 | Novel compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0104140A SE0104140D0 (sv) | 2001-12-07 | 2001-12-07 | Novel Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0104140D0 true SE0104140D0 (sv) | 2001-12-07 |
Family
ID=20286257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0104140A SE0104140D0 (sv) | 2001-12-07 | 2001-12-07 | Novel Compounds |
Country Status (33)
Country | Link |
---|---|
US (3) | US7521453B2 (xx) |
EP (1) | EP1456182B1 (xx) |
JP (1) | JP4347051B2 (xx) |
KR (1) | KR100930558B1 (xx) |
CN (1) | CN1289486C (xx) |
AR (1) | AR037736A1 (xx) |
AT (1) | ATE425150T1 (xx) |
AU (1) | AU2002365864B2 (xx) |
BR (1) | BR0214605A (xx) |
CA (1) | CA2467838C (xx) |
CO (1) | CO5590919A2 (xx) |
CY (1) | CY1109101T1 (xx) |
DE (1) | DE60231542D1 (xx) |
DK (1) | DK1456182T3 (xx) |
EG (1) | EG24930A (xx) |
ES (1) | ES2323125T3 (xx) |
HK (1) | HK1067631A1 (xx) |
HU (1) | HUP0401855A3 (xx) |
IL (2) | IL162376A0 (xx) |
IS (1) | IS7294A (xx) |
MX (1) | MXPA04005347A (xx) |
MY (1) | MY135705A (xx) |
NO (1) | NO327502B1 (xx) |
NZ (1) | NZ533130A (xx) |
PL (1) | PL369528A1 (xx) |
PT (1) | PT1456182E (xx) |
RU (1) | RU2317291C2 (xx) |
SE (1) | SE0104140D0 (xx) |
SI (1) | SI1456182T1 (xx) |
TW (1) | TWI324152B (xx) |
UA (1) | UA78259C2 (xx) |
WO (1) | WO2003048133A1 (xx) |
ZA (1) | ZA200404223B (xx) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0104140D0 (sv) * | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
MXPA05001096A (es) | 2002-07-29 | 2005-11-23 | Rigel Pharmaceuticals Inc | Metodos para tratamiento o prevencion de enfermedades autoinmunes con compuestos de 2,4-diamino-pirimidina. |
US7504396B2 (en) | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
US7442698B2 (en) | 2003-07-24 | 2008-10-28 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
KR20120062863A (ko) | 2003-07-30 | 2012-06-14 | 리겔 파마슈티칼스, 인크. | 자가면역 질환의 치료 또는 예방에 사용하기 위한 2,4-피리미딘디아민 화합물 |
DE602004032446D1 (de) * | 2003-08-07 | 2011-06-09 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiamin-verbindungen und verwendungen als antiproliferative mittel |
AU2004282219C1 (en) * | 2003-10-15 | 2009-12-17 | Osi Pharmaceuticals, Inc. | Imidazo [1, 5 - a] pyrazine tyrosine kinase inhibitors |
EP1678169B1 (en) | 2003-10-17 | 2009-07-22 | Astrazeneca AB | 4-(pyrazol-3-ylamino)pyrimidine derivatives for use in the treatment of cancer |
MY141220A (en) * | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
ATE384700T1 (de) | 2004-03-12 | 2008-02-15 | Analytecon Sa | Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren |
JP2008502595A (ja) * | 2004-03-31 | 2008-01-31 | エグゼリクシス, インコーポレイテッド | 未分化リンパ腫キナーゼモジュレータおよびその使用方法 |
SG163576A1 (en) | 2004-04-02 | 2010-08-30 | Osi Pharm Inc | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
DE102004022897A1 (de) * | 2004-05-10 | 2005-12-08 | Bayer Cropscience Ag | Azinyl-imidazoazine |
AR053090A1 (es) | 2004-07-20 | 2007-04-25 | Osi Pharm Inc | Imidazotriazinas como inhibidores de proteina quinasas y su uso para la preparacion de medicamentos |
CA2584295C (en) | 2004-11-24 | 2014-08-26 | Rigel Pharmaceuticals, Inc. | Spiro-2, 4-pyrimidinediamine compounds and their uses |
WO2006074057A2 (en) * | 2004-12-30 | 2006-07-13 | Exelixis, Inc. | Pyrimidine derivatives as kinase modulators and method of use |
EP2161275A1 (en) | 2005-01-19 | 2010-03-10 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
ES2375735T3 (es) | 2005-02-04 | 2012-03-05 | Astrazeneca Ab | Derivados de pirazolilaminopiridina útiles como inhibidores de quinasas. |
ES2308731T3 (es) | 2005-02-16 | 2008-12-01 | Astrazeneca Ab | Compuestos quimicos. |
GB0507347D0 (en) * | 2005-04-12 | 2005-05-18 | Astrazeneca Ab | Chemical compounds |
JP2008540335A (ja) * | 2005-04-27 | 2008-11-20 | アストラゼネカ・アクチエボラーグ | ピラゾリル・ピリミジン誘導体の疼痛治療における使用 |
US20080287437A1 (en) * | 2005-05-16 | 2008-11-20 | Astrazeneca Ab | Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors |
WO2006133426A2 (en) | 2005-06-08 | 2006-12-14 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
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US7566721B2 (en) * | 2005-08-08 | 2009-07-28 | Osi Pharmaceuticals, Inc. | Substituted thienol[2,3-d]pyrimidines as kinase inhibitors |
CA2620174A1 (en) | 2005-08-24 | 2007-03-01 | Wyeth | Bazedoxifene acetate formulations and manufacturing process thereof |
ES2374450T3 (es) | 2005-09-20 | 2012-02-16 | OSI Pharmaceuticals, LLC | Marcadores biológicos predictivos de respuesta anticancerígena para inhibidores de cinasa del receptor del factor de crecimiento 1 similar a insulina. |
PT1945631E (pt) * | 2005-10-28 | 2012-10-15 | Astrazeneca Ab | Derivados de 4-(3-aminopirazole)pirimidina para utilização como inibidores da tirosina-cinase no tratamento do cancro |
AR057960A1 (es) * | 2005-12-02 | 2007-12-26 | Osi Pharm Inc | Inhibidores de proteina quinasa biciclicos |
US8575164B2 (en) * | 2005-12-19 | 2013-11-05 | OSI Pharmaceuticals, LLC | Combination cancer therapy |
US8343918B2 (en) * | 2006-06-09 | 2013-01-01 | Novartis Ag | Stabilized insulin-like growth factor polypeptides |
AU2007257701A1 (en) * | 2006-06-15 | 2007-12-21 | Boehringer Ingelheim International Gmbh | 2-anilino-4-aminoalkyleneaminopyrimidines |
MX2008016523A (es) * | 2006-06-30 | 2009-01-19 | Astrazeneca Ab | Derivados de pirimidina utiles en el tratamiento de cancer. |
WO2008005538A2 (en) * | 2006-07-05 | 2008-01-10 | Exelixis, Inc. | Methods of using igf1r and abl kinase modulators |
EP2155742A1 (en) * | 2007-04-18 | 2010-02-24 | AstraZeneca AB | 5-aminopyrazol-3-yl-3h-imidazo [4,5-b]pyridine derivatives and their use for the treatment of cancer |
UA99459C2 (xx) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | ПОХІДНІ 9-(ПІРАЗОЛ-3-ІЛ)-9H-ПУРИН-2-АМІНУ І 3-(ПІРАЗОЛ-3-ІЛ)-3H-ІМІДАЗО$4,5-b]ПІРИДИН-5-АМІНУ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ РАКУ$ПРОИЗВОДНЫЕ 9-(ПИРАЗОЛ-3-ИЛ)-9H-ПУРИН-2-АМИНА И 3-(ПИРАЗОЛ-3-ИЛ)-3H-ИМИДАЗО$4,5-b]ПИРИДИН-5-АМИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАКА |
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US8178091B2 (en) | 2007-05-21 | 2012-05-15 | University Of Washington | Compositions and methods for the treatment of respiratory disorders |
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JP2011510018A (ja) * | 2008-01-18 | 2011-03-31 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 癌治療のためのイミダゾピラジノール誘導体 |
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KR20110017445A (ko) * | 2008-06-11 | 2011-02-21 | 아스트라제네카 아베 | 암 및 골수증식성 장애의 치료에 유용한 트리시클릭 2,4-디아미노-l,3,5-트리아진 유도체 |
DE102008041214A1 (de) | 2008-08-13 | 2010-02-18 | Bayer Cropscience Ag | N-substituierte Azinylakyl-azincarboxamide und deren Analoge |
CA2737217A1 (en) * | 2008-09-30 | 2010-04-08 | Astrazeneca Ab | Heterocyclic jak kinase inhibitors |
US20120189641A1 (en) | 2009-02-25 | 2012-07-26 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
US20110171124A1 (en) | 2009-02-26 | 2011-07-14 | Osi Pharmaceuticals, Inc. | In situ methods for monitoring the EMT status of tumor cells in vivo |
WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
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US8465912B2 (en) | 2009-02-27 | 2013-06-18 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010123792A1 (en) | 2009-04-20 | 2010-10-28 | Osi Pharmaceuticals, Inc. | Preparation of c-pyrazine-methylamines |
EP2427192A1 (en) * | 2009-05-07 | 2012-03-14 | OSI Pharmaceuticals, LLC | Use of osi-906 for treating adrenocortical carcinoma |
US20100316639A1 (en) | 2009-06-16 | 2010-12-16 | Genentech, Inc. | Biomarkers for igf-1r inhibitor therapy |
EP2542893A2 (en) | 2010-03-03 | 2013-01-09 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
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