BR0214605A - Composto, composição farmacêutica, processos para preparar os mesmos, uso de um composto, e, método para tratar câncer, e para modular a atividade do receptor do fator-1 de crescimento semelhante à insulina - Google Patents

Composto, composição farmacêutica, processos para preparar os mesmos, uso de um composto, e, método para tratar câncer, e para modular a atividade do receptor do fator-1 de crescimento semelhante à insulina

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Publication number
BR0214605A
BR0214605A BR0214605-3A BR0214605A BR0214605A BR 0214605 A BR0214605 A BR 0214605A BR 0214605 A BR0214605 A BR 0214605A BR 0214605 A BR0214605 A BR 0214605A
Authority
BR
Brazil
Prior art keywords
compound
processes
growth factor
pharmaceutical composition
preparing
Prior art date
Application number
BR0214605-3A
Other languages
English (en)
Inventor
Bernard Barlaam
Andrew Pape
Andrew Thomas
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0214605A publication Critical patent/BR0214605A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, PROCESSOS PARA PREPARAR OS MESMOS, USO DE UM COMPOSTO, E, MéTODOS PARA TRATAR CâNCER, E PARA MODULAR A ATIVIDADE DO RECEPTOR DO FATOR-1 DE CRESCIMENTO SEMELHANTE à INSULINA". A invenção provê compostos da Fórmula (a fórmula química deve ser inserida aqui. Favor ver a cópia do documento), em que R^ 1^, R^ 2^ R^ 3^ e R^ 4^ têm os significados definidos no relatório descritivo; processos para sua preparação; composições farmacêuticas contendo-os; um processo para preparar as composições farmacêuticas; e seu uso em terapia.
BR0214605-3A 2001-12-07 2002-12-03 Composto, composição farmacêutica, processos para preparar os mesmos, uso de um composto, e, método para tratar câncer, e para modular a atividade do receptor do fator-1 de crescimento semelhante à insulina BR0214605A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104140A SE0104140D0 (sv) 2001-12-07 2001-12-07 Novel Compounds
PCT/SE2002/002221 WO2003048133A1 (en) 2001-12-07 2002-12-03 Pyrimidine derivatives as modulators of insuline-like growth factor-1 receptor (igf-i)

Publications (1)

Publication Number Publication Date
BR0214605A true BR0214605A (pt) 2004-09-14

Family

ID=20286257

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0214605-3A BR0214605A (pt) 2001-12-07 2002-12-03 Composto, composição farmacêutica, processos para preparar os mesmos, uso de um composto, e, método para tratar câncer, e para modular a atividade do receptor do fator-1 de crescimento semelhante à insulina

Country Status (33)

Country Link
US (3) US7521453B2 (pt)
EP (1) EP1456182B1 (pt)
JP (1) JP4347051B2 (pt)
KR (1) KR100930558B1 (pt)
CN (1) CN1289486C (pt)
AR (1) AR037736A1 (pt)
AT (1) ATE425150T1 (pt)
AU (1) AU2002365864B2 (pt)
BR (1) BR0214605A (pt)
CA (1) CA2467838C (pt)
CO (1) CO5590919A2 (pt)
CY (1) CY1109101T1 (pt)
DE (1) DE60231542D1 (pt)
DK (1) DK1456182T3 (pt)
EG (1) EG24930A (pt)
ES (1) ES2323125T3 (pt)
HK (1) HK1067631A1 (pt)
HU (1) HUP0401855A3 (pt)
IL (2) IL162376A0 (pt)
IS (1) IS7294A (pt)
MX (1) MXPA04005347A (pt)
MY (1) MY135705A (pt)
NO (1) NO327502B1 (pt)
NZ (1) NZ533130A (pt)
PL (1) PL369528A1 (pt)
PT (1) PT1456182E (pt)
RU (1) RU2317291C2 (pt)
SE (1) SE0104140D0 (pt)
SI (1) SI1456182T1 (pt)
TW (1) TWI324152B (pt)
UA (1) UA78259C2 (pt)
WO (1) WO2003048133A1 (pt)
ZA (1) ZA200404223B (pt)

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IL162376A0 (en) 2005-11-20
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WO2003048133A1 (en) 2003-06-12
NO327502B1 (no) 2009-07-27
US20050054638A1 (en) 2005-03-10
CA2467838A1 (en) 2003-06-12
CO5590919A2 (es) 2005-12-30
TW200409634A (en) 2004-06-16
MXPA04005347A (es) 2004-09-27
ZA200404223B (en) 2005-08-29
MY135705A (en) 2008-06-30
EG24930A (en) 2011-01-11
UA78259C2 (en) 2007-03-15
NO20042872L (no) 2004-07-06
NZ533130A (en) 2006-11-30
SI1456182T1 (sl) 2009-08-31
KR20050044698A (ko) 2005-05-12
CA2467838C (en) 2010-10-12
JP4347051B2 (ja) 2009-10-21
AR037736A1 (es) 2004-12-01
HUP0401855A2 (hu) 2004-12-28
US7521453B2 (en) 2009-04-21
RU2004121029A (ru) 2006-01-10
EP1456182B1 (en) 2009-03-11
CN1617858A (zh) 2005-05-18
DE60231542D1 (de) 2009-04-23
ES2323125T3 (es) 2009-07-07
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US20120095011A1 (en) 2012-04-19
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US20090131463A1 (en) 2009-05-21
SE0104140D0 (sv) 2001-12-07
JP2005515998A (ja) 2005-06-02
PL369528A1 (en) 2005-05-02
CN1289486C (zh) 2006-12-13
RU2317291C2 (ru) 2008-02-20
IS7294A (is) 2004-06-03
DK1456182T3 (da) 2009-06-29
CY1109101T1 (el) 2014-07-02
AU2002365864A1 (en) 2003-06-17
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ATE425150T1 (de) 2009-03-15
PT1456182E (pt) 2009-05-26

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