IL157651A0 - N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor - Google Patents

N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor

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Publication number
IL157651A0
IL157651A0 IL15765102A IL15765102A IL157651A0 IL 157651 A0 IL157651 A0 IL 157651A0 IL 15765102 A IL15765102 A IL 15765102A IL 15765102 A IL15765102 A IL 15765102A IL 157651 A0 IL157651 A0 IL 157651A0
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IL
Israel
Prior art keywords
antagonists
receptor
arylethyl
benzylamines
formula
Prior art date
Application number
IL15765102A
Other languages
English (en)
Original Assignee
Lilly Co Eli
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Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL157651A0 publication Critical patent/IL157651A0/xx

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
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    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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    • C07D209/04—Indoles; Hydrogenated indoles
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ATE372768T1 (de) 2007-09-15
EA007493B1 (ru) 2006-10-27
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AU2002303094B2 (en) 2006-11-23
SI1859798T1 (sl) 2016-07-29
SK12052003A3 (sk) 2004-09-08
IL157651A (en) 2010-02-17
EP1379239B1 (en) 2007-09-12
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CA2442114A1 (en) 2002-10-10
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BR0208179A (pt) 2004-03-02
NO20034289L (no) 2003-11-28
ES2566056T3 (es) 2016-04-08
JP2004532209A (ja) 2004-10-21
IL185871A0 (en) 2008-01-06
EP1379239A2 (en) 2004-01-14
ZA200306795B (en) 2005-02-23
WO2002078693A3 (en) 2002-12-05
HK1061649A1 (en) 2004-09-30
PL220721B1 (pl) 2015-12-31
DZ3493A1 (fr) 2002-10-10
NZ527815A (en) 2005-05-27
NO326160B1 (no) 2008-10-13
US20090306110A1 (en) 2009-12-10
ES2292758T3 (es) 2008-03-16
PL364458A1 (en) 2004-12-13
WO2002078693A2 (en) 2002-10-10
CA2442114C (en) 2011-06-21
HRP20030771B1 (hr) 2008-10-31
CN1610547A (zh) 2005-04-27
US20040132800A1 (en) 2004-07-08
KR100894189B1 (ko) 2009-04-22
MXPA03008726A (es) 2003-12-12
DK1859798T3 (en) 2016-03-21
US7157488B2 (en) 2007-01-02
HU230322B1 (hu) 2016-01-28
US20060009511A9 (en) 2006-01-12
CY1110362T1 (el) 2015-04-29
US20070099909A1 (en) 2007-05-03
CZ20032614A3 (en) 2004-03-17
US8044090B2 (en) 2011-10-25
DE60222396T2 (de) 2008-05-15
CZ305838B6 (cs) 2016-04-06
PT1379239E (pt) 2007-12-06
PT1859798E (pt) 2016-03-31
HRP20030771A2 (en) 2005-08-31
KR20030090694A (ko) 2003-11-28
EA200301073A1 (ru) 2004-02-26

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