IL152926A - Process for the preparation of 11 ethyl – 4 [–3 {3 ethyl 66, 77 dihydro - 7 - oxo - 2 - (pyridylmethyl) H2 - pyrazolo [4, 3 - [d pyrimidine - 5 - ile] propoxysulfonyl} - piperazine and intermediates –4 [2 Transformed –– 5 (–4 ethyl –– 1 piperazinylsulfonyl) - benzamide] - 5 - ethyl –– 1 (–2 pyridylmethyl) - H1 - pyrazole - 3 - carboxamide for it - Google Patents

Process for the preparation of 11 ethyl – 4 [–3 {3 ethyl 66, 77 dihydro - 7 - oxo - 2 - (pyridylmethyl) H2 - pyrazolo [4, 3 - [d pyrimidine - 5 - ile] propoxysulfonyl} - piperazine and intermediates –4 [2 Transformed –– 5 (–4 ethyl –– 1 piperazinylsulfonyl) - benzamide] - 5 - ethyl –– 1 (–2 pyridylmethyl) - H1 - pyrazole - 3 - carboxamide for it

Info

Publication number
IL152926A
IL152926A IL15292699A IL15292699A IL152926A IL 152926 A IL152926 A IL 152926A IL 15292699 A IL15292699 A IL 15292699A IL 15292699 A IL15292699 A IL 15292699A IL 152926 A IL152926 A IL 152926A
Authority
IL
Israel
Prior art keywords
compound
tertiary
ethyl
formula
alkanol
Prior art date
Application number
IL15292699A
Other languages
English (en)
Hebrew (he)
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL152926(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of IL152926A publication Critical patent/IL152926A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL15292699A 1998-10-12 1999-10-07 Process for the preparation of 11 ethyl – 4 [–3 {3 ethyl 66, 77 dihydro - 7 - oxo - 2 - (pyridylmethyl) H2 - pyrazolo [4, 3 - [d pyrimidine - 5 - ile] propoxysulfonyl} - piperazine and intermediates –4 [2 Transformed –– 5 (–4 ethyl –– 1 piperazinylsulfonyl) - benzamide] - 5 - ethyl –– 1 (–2 pyridylmethyl) - H1 - pyrazole - 3 - carboxamide for it IL152926A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
IL13227399A IL132273A (en) 1998-10-12 1999-10-07 -5 [(- 4-methyl-1-piperazinylsulfonyl) -2-benazamidomethmer] -1-methyl-3-profile-H1-ferrous-5-carboxamides, their preparation and process for the preparation of sildenafil from them

Publications (1)

Publication Number Publication Date
IL152926A true IL152926A (en) 2004-02-19

Family

ID=10840421

Family Applications (11)

Application Number Title Priority Date Filing Date
IL15292699A IL152926A (en) 1998-10-12 1999-10-07 Process for the preparation of 11 ethyl – 4 [–3 {3 ethyl 66, 77 dihydro - 7 - oxo - 2 - (pyridylmethyl) H2 - pyrazolo [4, 3 - [d pyrimidine - 5 - ile] propoxysulfonyl} - piperazine and intermediates –4 [2 Transformed –– 5 (–4 ethyl –– 1 piperazinylsulfonyl) - benzamide] - 5 - ethyl –– 1 (–2 pyridylmethyl) - H1 - pyrazole - 3 - carboxamide for it
IL15292499A IL152924A (en) 1998-10-12 1999-10-07 Acids-5 (-4-ethyl-1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL152928A IL152928A (en) 1998-10-12 1999-10-07 1 - ethyl - 4 - [3 - [3 - ethyl - 6, 7 - dihydro - 7 oxo - 2 - (2 - pyridylmethyl) - 2H - pyrazolo [4, 3 - d] pyramidine - 5 - ile] (4 - Transformed phenyl (sulfonyl) piperazines
IL15292799A IL152927A (en) 1998-10-12 1999-10-07 1- [3- (7,6-Dihydro-1-methyl-7-oxo-3-profile-1H-pyrazolo [3,4-d] pyrimidin-5-yl) - (Phenyl converted at position 4) Sulfonyl] -4-methyl piperazines
IL15292399A IL152923A (en) 1998-10-12 1999-10-07 Acids-5 (–4 methyl –– 1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL13227399A IL132273A (en) 1998-10-12 1999-10-07 -5 [(- 4-methyl-1-piperazinylsulfonyl) -2-benazamidomethmer] -1-methyl-3-profile-H1-ferrous-5-carboxamides, their preparation and process for the preparation of sildenafil from them
IL15292802A IL152928A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292302A IL152923A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292702A IL152927A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292402A IL152924A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof

Family Applications After (10)

Application Number Title Priority Date Filing Date
IL15292499A IL152924A (en) 1998-10-12 1999-10-07 Acids-5 (-4-ethyl-1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL152928A IL152928A (en) 1998-10-12 1999-10-07 1 - ethyl - 4 - [3 - [3 - ethyl - 6, 7 - dihydro - 7 oxo - 2 - (2 - pyridylmethyl) - 2H - pyrazolo [4, 3 - d] pyramidine - 5 - ile] (4 - Transformed phenyl (sulfonyl) piperazines
IL15292799A IL152927A (en) 1998-10-12 1999-10-07 1- [3- (7,6-Dihydro-1-methyl-7-oxo-3-profile-1H-pyrazolo [3,4-d] pyrimidin-5-yl) - (Phenyl converted at position 4) Sulfonyl] -4-methyl piperazines
IL15292399A IL152923A (en) 1998-10-12 1999-10-07 Acids-5 (–4 methyl –– 1-piperazinylsulfonyl) position-converted benzoic acids in position 2
IL13227399A IL132273A (en) 1998-10-12 1999-10-07 -5 [(- 4-methyl-1-piperazinylsulfonyl) -2-benazamidomethmer] -1-methyl-3-profile-H1-ferrous-5-carboxamides, their preparation and process for the preparation of sildenafil from them
IL15292802A IL152928A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292302A IL152923A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292702A IL152927A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo [4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292602A IL152926A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof
IL15292402A IL152924A0 (en) 1998-10-12 2002-11-18 Process for preparation of pyrazolo[4,3-d] pyrimidin-7-ones and intermediates thereof

Country Status (49)

Country Link
US (3) US6207829B1 (fr)
EP (1) EP0994115B1 (fr)
JP (1) JP3721021B2 (fr)
KR (1) KR100380954B1 (fr)
CN (2) CN1473831A (fr)
AP (1) AP1233A (fr)
AR (1) AR019244A1 (fr)
AT (1) ATE290003T1 (fr)
AU (1) AU756463B2 (fr)
BG (1) BG63205B1 (fr)
BR (1) BR9905092A (fr)
CA (1) CA2285733C (fr)
CO (1) CO5150214A1 (fr)
CR (1) CR6118A (fr)
CU (1) CU22928A3 (fr)
CZ (1) CZ296816B6 (fr)
DE (1) DE69923906T2 (fr)
DK (1) DK0994115T3 (fr)
DZ (1) DZ2912A1 (fr)
EA (1) EA003774B1 (fr)
EE (1) EE04192B1 (fr)
EG (1) EG22630A (fr)
ES (1) ES2237049T3 (fr)
GB (1) GB9822238D0 (fr)
GE (1) GEP20022700B (fr)
GT (1) GT199900172A (fr)
HK (1) HK1027559A1 (fr)
HR (1) HRP990318B1 (fr)
HU (1) HU226162B1 (fr)
ID (1) ID23351A (fr)
IL (11) IL152926A (fr)
IS (1) IS1951B (fr)
MA (1) MA25007A1 (fr)
MY (1) MY124620A (fr)
NO (1) NO313700B1 (fr)
OA (1) OA11165A (fr)
PE (1) PE20001086A1 (fr)
PL (1) PL198150B1 (fr)
PT (1) PT994115E (fr)
RS (1) RS49762B (fr)
SG (1) SG118060A1 (fr)
SI (1) SI0994115T1 (fr)
SK (1) SK285215B6 (fr)
TN (1) TNSN99189A1 (fr)
TR (1) TR199902541A2 (fr)
TW (1) TW589314B (fr)
UA (1) UA66787C2 (fr)
UY (1) UY25750A1 (fr)
ZA (1) ZA996412B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
CA2411961C (fr) * 2000-06-22 2007-02-06 Pfizer Inc. Procede de preparation de pyrazolopyrimidinones
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
YU51701A (sh) * 2000-07-28 2003-12-31 Pfizer Inc. Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
EP1176142A1 (fr) * 2000-07-28 2002-01-30 Pfizer Inc. Procédé pour la préparation de pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
CA2469075C (fr) * 2001-12-20 2011-09-13 Applied Research Systems Ars Holding N.V. Derives de pyrrolidine utilises en tant que modulateurs de la prostaglandine
WO2003059258A2 (fr) * 2001-12-21 2003-07-24 Cytokinetics, Inc. Compositions et methodes permettant de traiter l'insuffisance cardiaque
EP1719772A1 (fr) 2002-05-31 2006-11-08 Schering Corporation Procédé de préparation d'inhibiteurs de la phosphodiesterase v de la xanthine et leur précurseurs
WO2004072079A1 (fr) * 2003-02-11 2004-08-26 Pfizer Limited Compose d'hemi-citrate de sildenafil hydrate et anhydre
JP4969238B2 (ja) * 2003-03-27 2012-07-04 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007141805A2 (fr) * 2006-06-05 2007-12-13 Matrix Laboratories Limited Nouveau procédé de préparation du citrate de sildénafil
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (fr) 2016-04-02 2017-10-05 N4 Pharma Uk Limited Nouvelles formes pharmaceutiques du sildénafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
CZ299633B6 (cs) * 1997-04-25 2008-09-24 Pfizer Inc. Pyrazolopyrimidinony, meziprodukty pro jejich výrobu a farmaceutické a veterinární kompozice na jejich bázi

Also Published As

Publication number Publication date
ID23351A (id) 2000-04-13
EG22630A (en) 2003-05-31
US20010009962A1 (en) 2001-07-26
IS1951B (is) 2004-10-13
AP9901672A0 (en) 1999-12-31
GEP20022700B (en) 2002-05-27
UY25750A1 (es) 2001-08-27
OA11165A (en) 2003-04-22
AP1233A (en) 2003-12-18
EP0994115B1 (fr) 2005-03-02
AU5358199A (en) 2000-04-13
CN1255497A (zh) 2000-06-07
IL152928A (en) 2007-07-04
HRP990318B1 (en) 2004-06-30
EP0994115A3 (fr) 2000-05-24
HU9903469D0 (en) 1999-12-28
CN1473831A (zh) 2004-02-11
SK138599A3 (en) 2000-05-16
AR019244A1 (es) 2001-12-26
EA003774B1 (ru) 2003-08-28
JP3721021B2 (ja) 2005-11-30
SG118060A1 (en) 2006-01-27
IL152923A (en) 2004-02-08
CA2285733A1 (fr) 2000-04-12
IL152928A0 (en) 2003-06-24
PE20001086A1 (es) 2000-10-18
HK1027559A1 (en) 2001-01-19
RS49762B (sr) 2008-04-04
CR6118A (es) 2005-09-16
UA66787C2 (en) 2004-06-15
CN1207295C (zh) 2005-06-22
NO994943D0 (no) 1999-10-11
BG63205B1 (bg) 2001-06-29
KR100380954B1 (ko) 2003-04-21
PT994115E (pt) 2005-06-30
IL152927A (en) 2004-06-01
PL335959A1 (en) 2000-04-25
IL132273A0 (en) 2001-03-19
MY124620A (en) 2006-06-30
DE69923906T2 (de) 2006-04-06
DK0994115T3 (da) 2005-06-20
NO994943L (no) 2000-04-13
TNSN99189A1 (fr) 2005-11-10
HRP990318A2 (en) 2000-06-30
TR199902541A2 (xx) 2000-07-21
MA25007A1 (fr) 2000-07-01
ZA996412B (en) 2001-04-11
CZ353299A3 (cs) 2000-05-17
EE04192B1 (et) 2003-12-15
IL152926A0 (en) 2003-06-24
DE69923906D1 (de) 2005-04-07
EP0994115A2 (fr) 2000-04-19
EA199900822A3 (ru) 2000-08-28
AU756463B2 (en) 2003-01-16
CA2285733C (fr) 2004-08-24
KR20000028987A (ko) 2000-05-25
IL152923A0 (en) 2003-06-24
BR9905092A (pt) 2000-08-08
HU226162B1 (en) 2008-05-28
YU48999A (sh) 2002-06-19
IL152924A0 (en) 2003-06-24
HUP9903469A3 (en) 2000-10-30
CU22928A3 (es) 2004-02-20
GB9822238D0 (en) 1998-12-09
SI0994115T1 (fr) 2005-08-31
PL198150B1 (pl) 2008-05-30
IL152924A (en) 2004-02-19
CO5150214A1 (es) 2002-04-29
DZ2912A1 (fr) 2004-03-01
US6207829B1 (en) 2001-03-27
IS5209A (is) 2000-04-13
IL152927A0 (en) 2003-06-24
BG103794A (en) 2000-09-29
ES2237049T3 (es) 2005-07-16
IL132273A (en) 2004-06-20
HUP9903469A2 (hu) 2000-08-28
GT199900172A (es) 2001-03-28
EE9900507A (et) 2000-06-15
TW589314B (en) 2004-06-01
JP2000119273A (ja) 2000-04-25
NO313700B1 (no) 2002-11-18
SK285215B6 (sk) 2006-09-07
CZ296816B6 (cs) 2006-06-14
US20030069422A1 (en) 2003-04-10
EA199900822A2 (ru) 2000-04-24
ATE290003T1 (de) 2005-03-15

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