HRP990318B1 - PROCESS FOR PREPARATION OF PYRAZOLO/4,3-d/PYRIMIDIN-7-ONES AND INTERMEDIATES THEREOF - Google Patents

PROCESS FOR PREPARATION OF PYRAZOLO/4,3-d/PYRIMIDIN-7-ONES AND INTERMEDIATES THEREOF

Info

Publication number
HRP990318B1
HRP990318B1 HR990318A HRP990318A HRP990318B1 HR P990318 B1 HRP990318 B1 HR P990318B1 HR 990318 A HR990318 A HR 990318A HR P990318 A HRP990318 A HR P990318A HR P990318 B1 HRP990318 B1 HR P990318B1
Authority
HR
Croatia
Prior art keywords
pyrazolo
pyrimidin
intermediates
ones
preparation
Prior art date
Application number
HR990318A
Other languages
English (en)
Inventor
Peter James Dunn
Philip Charles Levett
Original Assignee
Pfizer Res And Dev Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP990318(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Res And Dev Company filed Critical Pfizer Res And Dev Company
Publication of HRP990318A2 publication Critical patent/HRP990318A2/hr
Publication of HRP990318B1 publication Critical patent/HRP990318B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR990318A 1998-10-12 1999-10-12 PROCESS FOR PREPARATION OF PYRAZOLO/4,3-d/PYRIMIDIN-7-ONES AND INTERMEDIATES THEREOF HRP990318B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (2)

Publication Number Publication Date
HRP990318A2 HRP990318A2 (en) 2000-06-30
HRP990318B1 true HRP990318B1 (en) 2004-06-30

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
HR990318A HRP990318B1 (en) 1998-10-12 1999-10-12 PROCESS FOR PREPARATION OF PYRAZOLO/4,3-d/PYRIMIDIN-7-ONES AND INTERMEDIATES THEREOF

Country Status (49)

Country Link
US (3) US6207829B1 (fr)
EP (1) EP0994115B1 (fr)
JP (1) JP3721021B2 (fr)
KR (1) KR100380954B1 (fr)
CN (2) CN1473831A (fr)
AP (1) AP1233A (fr)
AR (1) AR019244A1 (fr)
AT (1) ATE290003T1 (fr)
AU (1) AU756463B2 (fr)
BG (1) BG63205B1 (fr)
BR (1) BR9905092A (fr)
CA (1) CA2285733C (fr)
CO (1) CO5150214A1 (fr)
CR (1) CR6118A (fr)
CU (1) CU22928A3 (fr)
CZ (1) CZ296816B6 (fr)
DE (1) DE69923906T2 (fr)
DK (1) DK0994115T3 (fr)
DZ (1) DZ2912A1 (fr)
EA (1) EA003774B1 (fr)
EE (1) EE04192B1 (fr)
EG (1) EG22630A (fr)
ES (1) ES2237049T3 (fr)
GB (1) GB9822238D0 (fr)
GE (1) GEP20022700B (fr)
GT (1) GT199900172A (fr)
HK (1) HK1027559A1 (fr)
HR (1) HRP990318B1 (fr)
HU (1) HU226162B1 (fr)
ID (1) ID23351A (fr)
IL (11) IL152927A (fr)
IS (1) IS1951B (fr)
MA (1) MA25007A1 (fr)
MY (1) MY124620A (fr)
NO (1) NO313700B1 (fr)
OA (1) OA11165A (fr)
PE (1) PE20001086A1 (fr)
PL (1) PL198150B1 (fr)
PT (1) PT994115E (fr)
RS (1) RS49762B (fr)
SG (1) SG118060A1 (fr)
SI (1) SI0994115T1 (fr)
SK (1) SK285215B6 (fr)
TN (1) TNSN99189A1 (fr)
TR (1) TR199902541A2 (fr)
TW (1) TW589314B (fr)
UA (1) UA66787C2 (fr)
UY (1) UY25750A1 (fr)
ZA (1) ZA996412B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
ATE272626T1 (de) * 2000-06-22 2004-08-15 Pfizer Verfahren zur herstellung von pyrazolopyrimidinonen
EP1176142A1 (fr) * 2000-07-28 2002-01-30 Pfizer Inc. Procédé pour la préparation de pyrazoles
YU51701A (sh) * 2000-07-28 2003-12-31 Pfizer Inc. Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
IL162602A0 (en) 2001-12-20 2005-11-20 Applied Research Systems Pyrrolidine derivatives as prostaglandin modulators
AU2002367023A1 (en) * 2001-12-21 2003-07-30 Cytokinetics, Inc. Compositions and methods for treating heart failure
EP1719772A1 (fr) 2002-05-31 2006-11-08 Schering Corporation Procédé de préparation d'inhibiteurs de la phosphodiesterase v de la xanthine et leur précurseurs
WO2004072079A1 (fr) * 2003-02-11 2004-08-26 Pfizer Limited Compose d'hemi-citrate de sildenafil hydrate et anhydre
JP4969238B2 (ja) * 2003-03-27 2012-07-04 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007141805A2 (fr) * 2006-06-05 2007-12-13 Matrix Laboratories Limited Nouveau procédé de préparation du citrate de sildénafil
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (fr) 2016-04-02 2017-10-05 N4 Pharma Uk Limited Nouvelles formes pharmaceutiques du sildénafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
TR199902646T2 (xx) * 1997-04-25 2000-05-22 Pfizer Inc. Seks�el bozuklu�un tedavisi i�in pirazolopirimidinonlar.

Also Published As

Publication number Publication date
IL152923A (en) 2004-02-08
JP3721021B2 (ja) 2005-11-30
CZ353299A3 (cs) 2000-05-17
GB9822238D0 (en) 1998-12-09
CR6118A (es) 2005-09-16
TR199902541A2 (xx) 2000-07-21
IL152927A (en) 2004-06-01
EP0994115A2 (fr) 2000-04-19
SG118060A1 (en) 2006-01-27
BG103794A (en) 2000-09-29
EE04192B1 (et) 2003-12-15
IL152926A0 (en) 2003-06-24
IL152928A0 (en) 2003-06-24
CU22928A3 (es) 2004-02-20
DE69923906T2 (de) 2006-04-06
NO994943D0 (no) 1999-10-11
EP0994115B1 (fr) 2005-03-02
PT994115E (pt) 2005-06-30
DZ2912A1 (fr) 2004-03-01
EG22630A (en) 2003-05-31
PL198150B1 (pl) 2008-05-30
UA66787C2 (en) 2004-06-15
DE69923906D1 (de) 2005-04-07
BG63205B1 (bg) 2001-06-29
CZ296816B6 (cs) 2006-06-14
RS49762B (sr) 2008-04-04
IS1951B (is) 2004-10-13
MY124620A (en) 2006-06-30
SK285215B6 (sk) 2006-09-07
CA2285733C (fr) 2004-08-24
GT199900172A (es) 2001-03-28
EA199900822A3 (ru) 2000-08-28
US6207829B1 (en) 2001-03-27
EA003774B1 (ru) 2003-08-28
AR019244A1 (es) 2001-12-26
HUP9903469A2 (hu) 2000-08-28
SI0994115T1 (fr) 2005-08-31
KR20000028987A (ko) 2000-05-25
CA2285733A1 (fr) 2000-04-12
CN1207295C (zh) 2005-06-22
HRP990318A2 (en) 2000-06-30
EP0994115A3 (fr) 2000-05-24
AU756463B2 (en) 2003-01-16
TNSN99189A1 (fr) 2005-11-10
IL152928A (en) 2007-07-04
KR100380954B1 (ko) 2003-04-21
HUP9903469A3 (en) 2000-10-30
GEP20022700B (en) 2002-05-27
IL132273A0 (en) 2001-03-19
SK138599A3 (en) 2000-05-16
JP2000119273A (ja) 2000-04-25
IS5209A (is) 2000-04-13
HU9903469D0 (en) 1999-12-28
ATE290003T1 (de) 2005-03-15
ID23351A (id) 2000-04-13
OA11165A (en) 2003-04-22
IL132273A (en) 2004-06-20
CN1255497A (zh) 2000-06-07
AP1233A (en) 2003-12-18
IL152924A0 (en) 2003-06-24
PL335959A1 (en) 2000-04-25
CN1473831A (zh) 2004-02-11
UY25750A1 (es) 2001-08-27
MA25007A1 (fr) 2000-07-01
ZA996412B (en) 2001-04-11
TW589314B (en) 2004-06-01
AU5358199A (en) 2000-04-13
CO5150214A1 (es) 2002-04-29
DK0994115T3 (da) 2005-06-20
IL152923A0 (en) 2003-06-24
PE20001086A1 (es) 2000-10-18
IL152926A (en) 2004-02-19
YU48999A (sh) 2002-06-19
EA199900822A2 (ru) 2000-04-24
HK1027559A1 (en) 2001-01-19
AP9901672A0 (en) 1999-12-31
HU226162B1 (en) 2008-05-28
ES2237049T3 (es) 2005-07-16
US20010009962A1 (en) 2001-07-26
NO313700B1 (no) 2002-11-18
NO994943L (no) 2000-04-13
BR9905092A (pt) 2000-08-08
EE9900507A (et) 2000-06-15
IL152924A (en) 2004-02-19
US20030069422A1 (en) 2003-04-10
IL152927A0 (en) 2003-06-24

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: PFIZER OVERSEAS PHARMACEUTICALS, IE

PPPP Transfer of rights

Owner name: PFIZER IRELAND PHARMACEUTICALS, IE

Owner name: PFIZER FINANCE INTERNATIONAL LIMITED, IE

ODRP Renewal fee for the maintenance of a patent

Payment date: 20080926

Year of fee payment: 10

PBON Lapse due to non-payment of renewal fee

Effective date: 20091013