IL142372A0 - 2-ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents - Google Patents
2-ureido-thiazole derivatives, process for their preparation, and their use as antitumor agentsInfo
- Publication number
- IL142372A0 IL142372A0 IL14237299A IL14237299A IL142372A0 IL 142372 A0 IL142372 A0 IL 142372A0 IL 14237299 A IL14237299 A IL 14237299A IL 14237299 A IL14237299 A IL 14237299A IL 142372 A0 IL142372 A0 IL 142372A0
- Authority
- IL
- Israel
- Prior art keywords
- ureido
- preparation
- antitumor agents
- thiazole derivatives
- thiazole
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9823873.6A GB9823873D0 (en) | 1998-10-30 | 1998-10-30 | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
PCT/EP1999/008307 WO2000026203A1 (en) | 1998-10-30 | 1999-10-27 | 2-ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
IL142372A0 true IL142372A0 (en) | 2002-03-10 |
Family
ID=10841640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14237299A IL142372A0 (en) | 1998-10-30 | 1999-10-27 | 2-ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents |
Country Status (22)
Country | Link |
---|---|
US (2) | US6863647B2 (xx) |
EP (1) | EP1124811A1 (xx) |
JP (1) | JP2002528538A (xx) |
KR (1) | KR20010085984A (xx) |
CN (1) | CN1325390A (xx) |
AR (1) | AR023060A1 (xx) |
AU (1) | AU771166C (xx) |
BR (1) | BR9914868A (xx) |
CA (1) | CA2347060A1 (xx) |
CZ (1) | CZ20011413A3 (xx) |
EA (1) | EA200100486A1 (xx) |
GB (1) | GB9823873D0 (xx) |
HK (1) | HK1041260A1 (xx) |
HU (1) | HUP0104167A3 (xx) |
ID (1) | ID28971A (xx) |
IL (1) | IL142372A0 (xx) |
NO (1) | NO20012058L (xx) |
NZ (1) | NZ510967A (xx) |
PL (1) | PL347506A1 (xx) |
SK (1) | SK4752001A3 (xx) |
WO (1) | WO2000026203A1 (xx) |
ZA (1) | ZA200102869B (xx) |
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US6407124B1 (en) | 1998-06-18 | 2002-06-18 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
JP2002534468A (ja) | 1999-01-13 | 2002-10-15 | バイエル コーポレイション | p38キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素 |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
ATE309237T1 (de) * | 1999-03-12 | 2005-11-15 | Boehringer Ingelheim Pharma | Aromatische heterozyklische verbindungen als antientzündungwirkstoffe |
RU2260592C9 (ru) | 1999-04-15 | 2017-04-07 | Бристол-Маерс Сквибб Ко. | Циклические ингибиторы протеинтирозинкиназ |
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JP2001106673A (ja) * | 1999-07-26 | 2001-04-17 | Banyu Pharmaceut Co Ltd | ビアリールウレア誘導体 |
WO2001007411A1 (fr) * | 1999-07-26 | 2001-02-01 | Banyu Pharmaceutical Co., Ltd. | Derives de biaryluree |
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CH451156A (de) * | 1962-09-18 | 1968-05-15 | Ciba Geigy | Verfahren zur Herstellung des neuen N-(2-Chlor-äthyl)-N'-(5-nitro-thiazolyl-2)-harnstoffes |
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EP0928790B1 (en) * | 1998-01-02 | 2003-03-05 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
-
1998
- 1998-10-30 GB GBGB9823873.6A patent/GB9823873D0/en not_active Ceased
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1999
- 1999-10-27 PL PL99347506A patent/PL347506A1/xx not_active Application Discontinuation
- 1999-10-27 EA EA200100486A patent/EA200100486A1/ru unknown
- 1999-10-27 AU AU10447/00A patent/AU771166C/en not_active Ceased
- 1999-10-27 CN CN99812929A patent/CN1325390A/zh active Pending
- 1999-10-27 NZ NZ510967A patent/NZ510967A/en unknown
- 1999-10-27 WO PCT/EP1999/008307 patent/WO2000026203A1/en not_active Application Discontinuation
- 1999-10-27 SK SK475-2001A patent/SK4752001A3/sk unknown
- 1999-10-27 ID IDW00200101144A patent/ID28971A/id unknown
- 1999-10-27 CA CA002347060A patent/CA2347060A1/en not_active Abandoned
- 1999-10-27 EP EP99953959A patent/EP1124811A1/en not_active Withdrawn
- 1999-10-27 HU HU0104167A patent/HUP0104167A3/hu unknown
- 1999-10-27 US US09/830,668 patent/US6863647B2/en not_active Expired - Fee Related
- 1999-10-27 CZ CZ20011413A patent/CZ20011413A3/cs unknown
- 1999-10-27 JP JP2000579592A patent/JP2002528538A/ja not_active Withdrawn
- 1999-10-27 IL IL14237299A patent/IL142372A0/xx unknown
- 1999-10-27 BR BR9914868-4A patent/BR9914868A/pt not_active IP Right Cessation
- 1999-10-27 KR KR1020017005437A patent/KR20010085984A/ko not_active Application Discontinuation
- 1999-10-29 AR ARP990105475A patent/AR023060A1/es unknown
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2001
- 2001-04-06 ZA ZA200102869A patent/ZA200102869B/en unknown
- 2001-04-26 NO NO20012058A patent/NO20012058L/no not_active Application Discontinuation
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2002
- 2002-04-15 HK HK02102810.2A patent/HK1041260A1/zh unknown
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2004
- 2004-02-02 US US10/770,019 patent/US20040157827A1/en not_active Abandoned
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CA2347060A1 (en) | 2000-05-11 |
EA200100486A1 (ru) | 2001-12-24 |
BR9914868A (pt) | 2001-07-03 |
ID28971A (id) | 2001-07-19 |
SK4752001A3 (en) | 2002-02-05 |
HK1041260A1 (zh) | 2002-07-05 |
US6863647B2 (en) | 2005-03-08 |
AU771166C (en) | 2005-01-13 |
PL347506A1 (en) | 2002-04-08 |
KR20010085984A (ko) | 2001-09-07 |
ZA200102869B (en) | 2001-10-10 |
EP1124811A1 (en) | 2001-08-22 |
CZ20011413A3 (cs) | 2001-09-12 |
HUP0104167A2 (hu) | 2002-03-28 |
WO2000026203A1 (en) | 2000-05-11 |
NZ510967A (en) | 2003-10-31 |
AU771166B2 (en) | 2004-03-18 |
AR023060A1 (es) | 2002-09-04 |
CN1325390A (zh) | 2001-12-05 |
GB9823873D0 (en) | 1998-12-30 |
NO20012058D0 (no) | 2001-04-26 |
HUP0104167A3 (en) | 2003-12-29 |
JP2002528538A (ja) | 2002-09-03 |
US20030187040A1 (en) | 2003-10-02 |
AU1044700A (en) | 2000-05-22 |
NO20012058L (no) | 2001-06-28 |
US20040157827A1 (en) | 2004-08-12 |
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