BRPI0515549A - compostos, composições e métodos de inibição de toxicidade de alfa-sinucleìna - Google Patents

compostos, composições e métodos de inibição de toxicidade de alfa-sinucleìna

Info

Publication number
BRPI0515549A
BRPI0515549A BRPI0515549-5A BRPI0515549A BRPI0515549A BR PI0515549 A BRPI0515549 A BR PI0515549A BR PI0515549 A BRPI0515549 A BR PI0515549A BR PI0515549 A BRPI0515549 A BR PI0515549A
Authority
BR
Brazil
Prior art keywords
compositions
methods
alpha
synuclein
synuclein toxicity
Prior art date
Application number
BRPI0515549-5A
Other languages
English (en)
Inventor
Susan L Lindquist
Tiago Outeiro
Richard Labaudiniere
Original Assignee
Whitehead Biomedical Inst
Foldrx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst, Foldrx Pharmaceuticals Inc filed Critical Whitehead Biomedical Inst
Publication of BRPI0515549A publication Critical patent/BRPI0515549A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

"COMPOSTOS, COMPOSIçõES E MéTODOS DE INIBIçãO DE TOXIDADE DE ALFA-SINUCLEìNA". São fornecidos compostos e composições para tratamento ou melhora de um ou mais sintomas de toxidade de <244>-sinucleína, doenças medidas por <244>-sinucleína ou doenças em que as fibrilas de <244>-sinucleína são um sintoma ou causa da doença. Em uma modalidade, os compostos para uso nas composições e métodos são acilguanidinas de heteroarila, heteroarilhidrazonas, diidropiridonas, heteroarila e cetonas de estirila de arila, e heteroarilpirazóis.
BRPI0515549-5A 2004-09-17 2005-09-16 compostos, composições e métodos de inibição de toxicidade de alfa-sinucleìna BRPI0515549A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61079604P 2004-09-17 2004-09-17
PCT/US2005/033050 WO2006034003A2 (en) 2004-09-17 2005-09-16 Compounds, compositions and methods of inhibiting a-synuclein toxicity

Publications (1)

Publication Number Publication Date
BRPI0515549A true BRPI0515549A (pt) 2008-07-29

Family

ID=36090510

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515549-5A BRPI0515549A (pt) 2004-09-17 2005-09-16 compostos, composições e métodos de inibição de toxicidade de alfa-sinucleìna

Country Status (14)

Country Link
US (1) US8440705B2 (pt)
EP (2) EP1802303B1 (pt)
JP (1) JP5001843B2 (pt)
CN (2) CN102379872A (pt)
AT (1) ATE531367T1 (pt)
AU (1) AU2005287137B2 (pt)
BR (1) BRPI0515549A (pt)
CA (1) CA2580767A1 (pt)
ES (1) ES2376108T3 (pt)
HK (1) HK1105893A1 (pt)
NO (1) NO20071860L (pt)
NZ (4) NZ554545A (pt)
WO (1) WO2006034003A2 (pt)
ZA (1) ZA200703110B (pt)

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Also Published As

Publication number Publication date
US20080261953A1 (en) 2008-10-23
NZ588431A (en) 2012-02-24
ATE531367T1 (de) 2011-11-15
ZA200703110B (en) 2008-08-27
CN102379872A (zh) 2012-03-21
NZ584773A (en) 2012-07-27
EP2433634A3 (en) 2012-07-18
ES2376108T3 (es) 2012-03-09
EP1802303A4 (en) 2009-12-16
CA2580767A1 (en) 2006-03-30
NO20071860L (no) 2007-06-05
WO2006034003A2 (en) 2006-03-30
EP1802303B1 (en) 2011-11-02
US8440705B2 (en) 2013-05-14
AU2005287137B2 (en) 2012-03-22
JP5001843B2 (ja) 2012-08-15
EP2433634A2 (en) 2012-03-28
NZ554545A (en) 2010-10-29
AU2005287137A1 (en) 2006-03-30
WO2006034003A3 (en) 2006-07-13
EP1802303A2 (en) 2007-07-04
JP2008513471A (ja) 2008-05-01
NZ588432A (en) 2012-03-30
HK1105893A1 (en) 2008-02-29
CN101060839A (zh) 2007-10-24

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