ZA200703110B - Compounds, compositions and methods of inhibiting α-synuclein toxicity - Google Patents

Compounds, compositions and methods of inhibiting α-synuclein toxicity

Info

Publication number
ZA200703110B
ZA200703110B ZA200703110A ZA200703110A ZA200703110B ZA 200703110 B ZA200703110 B ZA 200703110B ZA 200703110 A ZA200703110 A ZA 200703110A ZA 200703110 A ZA200703110 A ZA 200703110A ZA 200703110 B ZA200703110 B ZA 200703110B
Authority
ZA
South Africa
Prior art keywords
compositions
compounds
methods
inhibiting
synuclein
Prior art date
Application number
ZA200703110A
Other languages
English (en)
Inventor
Susan L Lindquist
Outeiro Tiago
Labaudiniere Richard
Original Assignee
Whitehead Biomedical Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitehead Biomedical Inst filed Critical Whitehead Biomedical Inst
Publication of ZA200703110B publication Critical patent/ZA200703110B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
ZA200703110A 2004-09-17 2007-04-16 Compounds, compositions and methods of inhibiting α-synuclein toxicity ZA200703110B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61079604P 2004-09-17 2004-09-17

Publications (1)

Publication Number Publication Date
ZA200703110B true ZA200703110B (en) 2008-08-27

Family

ID=36090510

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200703110A ZA200703110B (en) 2004-09-17 2007-04-16 Compounds, compositions and methods of inhibiting α-synuclein toxicity

Country Status (14)

Country Link
US (1) US8440705B2 (xx)
EP (2) EP1802303B1 (xx)
JP (1) JP5001843B2 (xx)
CN (2) CN102379872A (xx)
AT (1) ATE531367T1 (xx)
AU (1) AU2005287137B2 (xx)
BR (1) BRPI0515549A (xx)
CA (1) CA2580767A1 (xx)
ES (1) ES2376108T3 (xx)
HK (1) HK1105893A1 (xx)
NO (1) NO20071860L (xx)
NZ (4) NZ554545A (xx)
WO (1) WO2006034003A2 (xx)
ZA (1) ZA200703110B (xx)

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US11242353B2 (en) 2020-01-24 2022-02-08 Trustees Of Boston University Heterocyclic LSF inhibitors and their uses
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Also Published As

Publication number Publication date
US20080261953A1 (en) 2008-10-23
NZ588431A (en) 2012-02-24
ATE531367T1 (de) 2011-11-15
CN102379872A (zh) 2012-03-21
NZ584773A (en) 2012-07-27
EP2433634A3 (en) 2012-07-18
ES2376108T3 (es) 2012-03-09
EP1802303A4 (en) 2009-12-16
CA2580767A1 (en) 2006-03-30
NO20071860L (no) 2007-06-05
WO2006034003A2 (en) 2006-03-30
EP1802303B1 (en) 2011-11-02
US8440705B2 (en) 2013-05-14
AU2005287137B2 (en) 2012-03-22
JP5001843B2 (ja) 2012-08-15
EP2433634A2 (en) 2012-03-28
NZ554545A (en) 2010-10-29
BRPI0515549A (pt) 2008-07-29
AU2005287137A1 (en) 2006-03-30
WO2006034003A3 (en) 2006-07-13
EP1802303A2 (en) 2007-07-04
JP2008513471A (ja) 2008-05-01
NZ588432A (en) 2012-03-30
HK1105893A1 (en) 2008-02-29
CN101060839A (zh) 2007-10-24

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