IL137802A0 - A method and kit for detecting rare cells in a mixed cell population - Google Patents

A method and kit for detecting rare cells in a mixed cell population

Info

Publication number
IL137802A0
IL137802A0 IL13780299A IL13780299A IL137802A0 IL 137802 A0 IL137802 A0 IL 137802A0 IL 13780299 A IL13780299 A IL 13780299A IL 13780299 A IL13780299 A IL 13780299A IL 137802 A0 IL137802 A0 IL 137802A0
Authority
IL
Israel
Prior art keywords
kit
cell population
mixed cell
rare cells
detecting rare
Prior art date
Application number
IL13780299A
Other languages
English (en)
Original Assignee
Immunivest Corp
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunivest Corp, Univ Texas filed Critical Immunivest Corp
Publication of IL137802A0 publication Critical patent/IL137802A0/xx

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00Magnetic separation
    • B03C1/005Pretreatment specially adapted for magnetic separation
    • B03C1/01Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/549Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic with antigen or antibody entrapped within the carrier
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
IL13780299A 1998-02-12 1999-02-12 A method and kit for detecting rare cells in a mixed cell population IL137802A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7453598P 1998-02-12 1998-02-12
US11027998P 1998-11-30 1998-11-30
US11020298P 1998-11-30 1998-11-30
PCT/US1999/003073 WO1999041613A1 (en) 1998-02-12 1999-02-12 Methods and reagents for the rapid and efficient isolation of circulating cancer cells

Publications (1)

Publication Number Publication Date
IL137802A0 true IL137802A0 (en) 2001-10-31

Family

ID=27372495

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13780299A IL137802A0 (en) 1998-02-12 1999-02-12 A method and kit for detecting rare cells in a mixed cell population
IL137802A IL137802A (en) 1998-02-12 2000-08-10 A method for isolating and diagnosing cancer cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL137802A IL137802A (en) 1998-02-12 2000-08-10 A method for isolating and diagnosing cancer cells

Country Status (10)

Country Link
US (3) US6365362B1 (xx)
EP (1) EP1062515B1 (xx)
JP (4) JP2002503814A (xx)
KR (1) KR100399475B1 (xx)
AU (1) AU760560B2 (xx)
BR (1) BR9907852A (xx)
CA (1) CA2320418C (xx)
DE (1) DE69941689D1 (xx)
IL (2) IL137802A0 (xx)
WO (1) WO1999041613A1 (xx)

Families Citing this family (301)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
US6215892B1 (en) * 1995-11-30 2001-04-10 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US6718053B1 (en) * 1996-11-27 2004-04-06 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
JP2002503814A (ja) * 1998-02-12 2002-02-05 イムニベスト・コーポレイション 循環ガン細胞の迅速かつ効率的な単離のための方法および試薬
US7282350B2 (en) 1998-02-12 2007-10-16 Immunivest Corporation Labeled cell sets for use as functional controls in rare cell detection assays
FR2782730B1 (fr) * 1998-08-25 2002-05-17 Biocom Sa Procede de separation cellulaire pour l'isolation de cellules pathogeniques, notamment cancereuses rares, equipement et reactif pour la mise en oeuvre du procede et application du procede
JP2002529704A (ja) * 1998-10-29 2002-09-10 セル ワークス インコーポレイテッド 単一細胞の複数マーカー特徴付け
US20040058401A1 (en) * 1999-04-13 2004-03-25 Blaise Bossy Method for detecting rare event
GB9910975D0 (en) * 1999-05-13 1999-07-14 Univ Strathclyde Rapid dehydration of proteins
CA2413835A1 (en) * 1999-05-25 2000-11-30 Britta Christensen Isolation and culturing of fetal cells
FR2804126B1 (fr) * 2000-01-21 2005-09-30 Patrick Rambaud Procede et systeme de gestion de lots de cellules immuno-competentes prelevees sur des sujets humains ou animaux en vue d'utilisations differees
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US6953656B2 (en) * 2000-07-14 2005-10-11 Massachusetts Institute Of Technology Direct, externally imposed control of polypeptides
US6379550B1 (en) * 2000-07-24 2002-04-30 Health Research, Inc. Method for detecting PSA and its molecular forms using thiophilic gel
EP1368813B1 (en) * 2000-12-15 2014-12-03 The Arizona Board of Regents on behalf of the University of Arizona Method for patterning metal using nanoparticle containing precursors
WO2003065042A1 (en) * 2001-02-16 2003-08-07 Immunivest Corporation Methods and reagents for the rapid and efficient isolation of circulating cancer cells
WO2002081656A2 (en) * 2001-04-05 2002-10-17 The Henry M. Jackson Foundation Enhanced diagnostic potential of prostate-specific antigen expressing cells
MXPA03010035A (es) 2001-05-02 2004-06-30 Purdue Research Foundation Tratamiento y diagnostico de enfermedades mediadas por macrofagos.
US20030007974A1 (en) * 2001-05-30 2003-01-09 Nanus David M. Endopeptidase/anti-PSMA antibody fusion proteins for treatment of cancer
DE10127079A1 (de) * 2001-06-02 2002-12-12 Ulrich Pachmann Verfahren zum quantitativen Nachweis vitaler epithelialer Tumorzellen in einer Körperflüssigkeit
GB0116074D0 (en) * 2001-06-29 2001-08-22 Univ Strathclyde Nanoparticle structures
EP1427810B9 (en) 2001-08-21 2012-04-25 Ventana Medical Systems, Inc. Method and quantification assay for determining c-kit/scf/pakt status
EP1425383A4 (en) * 2001-08-23 2005-11-09 Immunivest Corp STABILIZATION OF CELLS AND BIOLOGICAL PREPARATIONS FOR ANALYSIS
US7863012B2 (en) 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
EP1432811A4 (en) * 2001-08-28 2005-02-16 Wen-Tien Chen CELL SEPARATION MATRIX
US20030064359A1 (en) * 2001-09-21 2003-04-03 Joel Lanoix Preparation of highly-purified plasma membranes
ES2338305T3 (es) * 2001-09-28 2010-05-06 Purdue Research Foundation Metodo de tratamiento que utiliza conjugados ligando-inmunogeno.
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
BR0213520A (pt) * 2001-10-26 2006-05-23 Immunivest Corp método para diagnosticar a gravidade de uma doença em um indivìduo de teste, e, kit de teste para triagem de uma amostra de paciente quanto à presença de células cancerosas circulantes
JP2005538929A (ja) 2002-01-16 2005-12-22 ダイナル バイオテック エイエスエイ 単一サンプルからの核酸及びタンパク質の単離方法
US8043603B2 (en) * 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8043602B2 (en) * 2002-02-07 2011-10-25 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US7764821B2 (en) * 2002-02-14 2010-07-27 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
KR20040105717A (ko) * 2002-02-14 2004-12-16 이뮤니베스트 코포레이션 저비용 세포 분석기에서의 세포 계산 방법 및 알고리즘
AU2003242815A1 (en) * 2002-03-13 2003-09-22 Biomerieux Method for the characterisation of circulating tumour cells stemming from solid cancers
US20030175818A1 (en) * 2002-03-15 2003-09-18 Ross Amelia A. Devices and methods for isolating and recovering target cells
US7754155B2 (en) * 2002-03-15 2010-07-13 Ross Amelia A Devices and methods for isolating target cells
US20040241707A1 (en) * 2002-04-01 2004-12-02 Gao Chun L. Enhanced diagnostic potential of prostate-specific antigen expressing cells
US20040021073A1 (en) * 2002-04-12 2004-02-05 California Institute Of Technology Apparatus and method for magnetic-based manipulation of microscopic particles
WO2005027037A2 (en) * 2002-05-01 2005-03-24 Immunivest Corporation Devices and methods to image objects by time delay integration
WO2004039830A2 (en) * 2002-05-07 2004-05-13 Regents Of The University Of California Bioactivation of particles
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
PT1585966E (pt) * 2002-07-15 2012-02-20 Hoffmann La Roche Tratamento de cancro com o anticorpo anti-erbb2 rhumab 2c4
US9435799B2 (en) * 2002-07-31 2016-09-06 Janssen Diagnostics, Inc. Methods and reagents for improved selection of biological materials
ES2375724T3 (es) 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
CA2445204C (en) * 2002-10-16 2014-08-12 Streck Laboratories, Inc. Method and device for collecting and preserving cells for analysis
JPWO2004042401A1 (ja) * 2002-11-08 2006-03-09 高橋 弘 癌細胞の検査方法及びそのための試薬
US20040109824A1 (en) * 2002-12-06 2004-06-10 Hinds Kathleen Allison Particles for imaging cells
US20040110241A1 (en) * 2002-12-06 2004-06-10 Segal Mark S. Materials and methods for monitoring vascular endothelial function
GB0229287D0 (en) * 2002-12-16 2003-01-22 Dna Res Innovations Ltd Polyfunctional reagents
FR2848850B1 (fr) * 2002-12-20 2005-06-24 Guerbet Sa Nouvelles compositions de particules magnetiques recouvertes de derives gem-bisphosphonates.
CA2516795C (en) * 2003-02-27 2013-01-15 Immunivest Corporation Circulating tumor cells (ctc's): early assessment of time to progression,_survival and response to therapy in metastatic cancer patients
WO2004102196A1 (en) * 2003-04-30 2004-11-25 Chengdu Kuachang Medical Industrial Limited Apparatus including nanostructures used for separation or analysis, and the preparation and application thereof
EP1627083A2 (en) * 2003-05-07 2006-02-22 Agilent Technologies, Inc. Systems and methods for determining cell type composition of mixed cell populations using gene expression signatures
CA2527196C (en) 2003-05-30 2012-10-16 Purdue Research Foundation Diagnostic method for atherosclerosis
CA2542984A1 (en) * 2003-07-07 2005-01-27 David H. Wagner Methods for predicting development of auto-immune diseases and treatment of same
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
NZ545873A (en) * 2003-08-11 2009-05-31 Monogram Biosciences Inc Detecting and profiling molecular complexes
US8068988B2 (en) 2003-09-08 2011-11-29 Ventana Medical Systems, Inc. Method for automated processing of digital images of tissue micro-arrays (TMA)
US20050136509A1 (en) 2003-09-10 2005-06-23 Bioimagene, Inc. Method and system for quantitatively analyzing biological samples
CA2539108A1 (en) * 2003-09-18 2005-03-31 Immunivest Corporation Operator independent programmable sample preparation and analysis system
WO2005036180A1 (en) * 2003-10-08 2005-04-21 The Government Of The United States Of America As Represented By The Secretary Of Department Of Health And Human Services Analysis methods using biomarkers concentrated with biomarkers attractant molecules
EP1680079A4 (en) 2003-10-24 2008-01-02 Adhesives Res Inc QUICKLY FILING FILMS FOR THE DISTRIBUTION OF PHARMACEUTICAL OR COSMETIC AGENTS
AU2003285133A1 (en) * 2003-11-05 2005-06-24 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Biofunctionalized quantum dots for biological imaging
AU2004237844B2 (en) 2003-12-23 2011-01-27 Therakos, Inc. Extracorporeal photopheresis in combination with anti-TNF treatment
US8592219B2 (en) 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
US20050181353A1 (en) * 2004-02-17 2005-08-18 Rao Galla C. Stabilization of cells and biological specimens for analysis
AU2005218622A1 (en) * 2004-03-03 2005-09-15 Living Microsystems Magnetic device for isolation of cells and biomolecules in a microfluidic environment
WO2005098046A2 (en) * 2004-04-01 2005-10-20 Immunivest Corporation Methods for the determination of cell specific biomarkers
WO2005116264A2 (en) * 2004-05-24 2005-12-08 Immunivest Corporation A blood test to monitor the genetic changes of progressive cancer using immunomagnetic enrichment and fluorescence in situ hybridization (fish)
WO2006093516A2 (en) * 2004-06-22 2006-09-08 The Regents Of The University Of California Peptide-coated nanoparticles with graded shell compositions
US9790539B2 (en) * 2004-06-30 2017-10-17 Russell Biotech, Inc. Methods and reagents for improved selection of biological molecules
US8189899B2 (en) * 2004-07-30 2012-05-29 Veridex, Llc Methods and algorithms for cell enumeration in a low-cost cytometer
JP5537771B2 (ja) 2004-08-17 2014-07-02 ベリデックス・リミテッド・ライアビリティ・カンパニー 循環する希少細胞の分析用の画像診断機器
US9494581B2 (en) * 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
US7910315B2 (en) * 2004-09-10 2011-03-22 The Regents Of The University Of Colorado, A Body Corporate Early detection of hemangiosarcoma and angiosarcoma
WO2006041453A1 (en) * 2004-09-30 2006-04-20 Immunivest Corporation Circulating tumor cells (ctc’s): apoptotic assessment in prostate cancer patients
DE602005026143D1 (de) * 2004-10-06 2011-03-10 Wellstat Biologics Corp Erkennung eines erhöhten spiegels von her-2/neu-proteinen in zirkulierenden krebszellen und dessen behandlung
JP4999103B2 (ja) 2004-10-27 2012-08-15 セフィード 閉鎖系の多段階核酸増幅反応
US7939267B2 (en) * 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
US7879569B2 (en) * 2004-11-09 2011-02-01 The Trustees Of The University Of Pennsylvania Methods for diagnosis of myelodysplastic syndromes (MDS)
WO2006054991A1 (en) * 2004-11-17 2006-05-26 Immunivest Corporation Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection
EP1827239B1 (en) * 2004-12-23 2019-04-17 Purdue Research Foundation Positron emission tomography imaging method
US7699979B2 (en) * 2005-01-07 2010-04-20 Board Of Trustees Of The University Of Arkansas Separation system and efficient capture of contaminants using magnetic nanoparticles
US20060217893A1 (en) * 2005-01-07 2006-09-28 Yanbin Li Method for detecting an unknown contaminant concentration in a substance
US20080135490A1 (en) * 2005-01-07 2008-06-12 Board Of Trustees Of The University Of Arkansas Quantum dot biolabeling and immunomagnetic separation for detection of contaminants
EP1849005A1 (en) * 2005-01-17 2007-10-31 Gyros Patent Ab A method for detecting an at least bivalent analyte using two affinity reactants
US8399205B2 (en) 2005-01-21 2013-03-19 The University Of Rochester Device and method for separation, concentration, and/or purification of cells
US20060183223A1 (en) 2005-01-21 2006-08-17 King Michael R Continuous flow chamber device for separation, concentration, and/or purification of cells
EP1861509B1 (en) * 2005-03-14 2015-09-09 Janssen Diagnostics, LLC A method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
ATE490462T1 (de) * 2005-04-08 2010-12-15 Medical Discovery Partners Llc Verfahren zum anreichern von subpopulationen seltener zellen aus dem blut
WO2006130737A1 (en) * 2005-06-02 2006-12-07 Immunivest Corporation A method for assessing metastatic carcinomas from circulating endothelial cells and disseminated tumor cells
US20070037173A1 (en) * 2005-08-12 2007-02-15 Allard Jeffrey W Circulating tumor cells (CTC's): early assessment of time to progression, survival and response to therapy in metastatic cancer patients
US20060281104A1 (en) * 2005-06-13 2006-12-14 Macevicz Stephen C Leuco dye particles and uses thereof
ES2565670T3 (es) 2005-06-20 2016-04-06 Advanced Cell Diagnostics, Inc. Métodos de detección de ácidos nucleicos en células individuales y de identificación de células raras en grandes poblaciones de células heterogéneas
JP4693902B2 (ja) * 2005-06-23 2011-06-01 バイエル ヘルスケア エルエルシー 体液中のrasp21の定量的検定法
EP1738773A1 (de) * 2005-06-29 2007-01-03 Schering AG Magnetische Eisenoxidpartikel enthaltende Zusammensetzung und deren Vervendung in bildgebenden Verfahren
JP5175723B2 (ja) 2005-07-05 2013-04-03 パーデュー・リサーチ・ファウンデーション 単球介在性疾患を治療するための組成物の調製
US8921102B2 (en) * 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US7901950B2 (en) * 2005-08-12 2011-03-08 Veridex, Llc Method for assessing disease states by profile analysis of isolated circulating endothelial cells
US7777885B2 (en) * 2005-08-17 2010-08-17 Veridex, Llc Diagnostic imaging device for the analysis of circulating rare cells
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
CA2623405C (en) 2005-09-20 2014-11-25 Immunivest Corporation Methods and composition to generate unique sequence dna probes labeling of dna probes and the use of these probes
US9134237B2 (en) * 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
EP1940473A2 (en) * 2005-09-23 2008-07-09 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
WO2007044642A2 (en) * 2005-10-06 2007-04-19 President And Fellows Of Harvard College And Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
NZ597304A (en) 2005-10-13 2013-06-28 Anthrogenesis Corp Immunomodulation using placental stem cells
US9169461B2 (en) 2005-11-02 2015-10-27 Therakos, Inc. Use of apoptotic cells ex vivo to generate regulatory T cells
US20100062426A1 (en) * 2005-11-03 2010-03-11 O'hara Shawn Mark AGR2 and TFF3 Regulation in the Diagnosis and Treatment of Cancer
US20070178084A1 (en) * 2005-12-02 2007-08-02 King Michael R Continuous flow chamber device for separation, concentration, and/or purfication of cells
CA2632261A1 (en) * 2005-12-05 2007-06-14 Guava Technologies Particle-based analyte characterization
WO2007079250A2 (en) * 2005-12-29 2007-07-12 Cellpoint Diagnostics, Inc. Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20090022768A1 (en) * 2006-01-20 2009-01-22 King Michael R Continuous flow chamber device for separation, concentration, and/or purification of cells
WO2007085156A1 (fr) * 2006-01-25 2007-08-02 Chengdu Kuachang Medical Industrial Limited Composant actif, composition nanostructurée comprenant des composants actifs et préparation de celle-ci
CN1811427A (zh) * 2006-01-25 2006-08-02 成都夸常医学工业有限公司 用于生物芯片的活性载体、其制备方法及其应用
WO2007089911A2 (en) * 2006-01-30 2007-08-09 The Scripps Research Institute Methods for detection of circulating tumor cells and methods of diagnosis of cancer in a mammalian subject
US8337755B2 (en) * 2006-03-13 2012-12-25 Veridex, Llc Operator independent programmable sample preparation and analysis system
US20070238137A1 (en) * 2006-04-07 2007-10-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Constitutively resistant cancer stem cells in diagnosis
US7615358B2 (en) 2006-04-20 2009-11-10 Ulrich Pachmann Method for determining the concentration of vital epithelial tumor cells in a body fluid
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
CA2652027C (en) * 2006-05-12 2017-06-06 Immunivest Corporation A laser illumination system in fluorescent microscopy
CN101600966B (zh) * 2006-06-02 2014-07-02 辉瑞产品公司 循环肿瘤细胞分析
WO2008111990A1 (en) * 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
CN101583722A (zh) * 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 从生物学样品检测稀有细胞的方法和组合物
US7993918B2 (en) * 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
MX2009002397A (es) * 2006-09-05 2009-03-16 Veridex Llc Metodos para clasificar imagenes celulares.
BRPI0718050A2 (pt) * 2006-11-02 2013-11-05 Veridex Llc Formação de imegens do endotélio vascular ativado usando agentes de contraste de mri imunomagnéticos
EP2087337A4 (en) * 2006-11-03 2010-09-08 Purdue Research Foundation METHOD AND DEVICE FOR EX-VIVO FLOW CYTOMETRY
WO2008089270A2 (en) * 2007-01-16 2008-07-24 University Of Rochester Flow chamber device for neutralization of cancer cells
CA2677792C (en) 2007-02-07 2015-04-14 Purdue Research Foundation Positron emission tomography imaging method
CN103356711A (zh) * 2007-02-12 2013-10-23 人类起源公司 利用胎盘干细胞治疗炎性疾病
HUE028487T2 (en) * 2007-02-27 2016-12-28 Sentoclone Int Ab Detection of tumor cell multiplex using panel of agents associated with extracellular markers
MX2009011228A (es) * 2007-04-19 2009-11-02 Wellstat Biologics Corp Deteccion de niveles elevados de la proteina her-2/neu de celulas cancerosas circulantes no aisladas y tratamiento.
WO2009017525A2 (en) * 2007-04-27 2009-02-05 Regents Of The University Of California Superparamagnetic colloidal nanocrystal structures
CA2688308A1 (en) * 2007-05-25 2008-12-04 Purdue Research Foundation Method of imaging localized infections
US8110101B2 (en) * 2007-08-30 2012-02-07 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US7828968B2 (en) * 2007-08-30 2010-11-09 Veridex, Llc Method and apparatus for imaging target components in a biological sample using permanent magnets
US20090061456A1 (en) * 2007-08-30 2009-03-05 Allard William J Method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells
US20090117532A1 (en) * 2007-11-01 2009-05-07 Doyle Gerald V Pre-clinical method for monitoring serial changes in circulating breast cancer cells in mice
CA2706442C (en) * 2007-11-27 2017-07-11 Veridex, Llc Automated enumeration and characterization of circulating melanoma cells in blood
US8071395B2 (en) * 2007-12-12 2011-12-06 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for magnetic separation of cells
US20090191535A1 (en) * 2007-12-22 2009-07-30 Mark Carle Connelly Method of assessing metastatic carcinomas from circulating endothelial cells and disseminated tumor cells
KR101384142B1 (ko) * 2007-12-28 2014-04-14 삼성디스플레이 주식회사 표시기판, 이의 제조방법 및 이를 갖는 표시장치
US8008032B2 (en) 2008-02-25 2011-08-30 Cellective Dx Corporation Tagged ligands for enrichment of rare analytes from a mixed sample
US20090233324A1 (en) * 2008-03-11 2009-09-17 Kopf-Sill Anne R Methods for Diagnosing Cancer Using Samples Collected From A Central Vein Location or an Arterial Location
US20090258365A1 (en) * 2008-03-25 2009-10-15 Terstappen Leon W M M METHOD FOR DETECTING IGF1R/Chr 15 in CIRCULATING TUMOR CELLS USING FISH
US8053250B2 (en) * 2008-06-27 2011-11-08 Rex Chin-Yih Hong Method and system for suppressing bindings on magnetic particles
KR20180108887A (ko) 2008-08-20 2018-10-04 안트로제네시스 코포레이션 단리된 태반 세포를 사용한 뇌졸중 치료
JP6169316B2 (ja) 2008-08-20 2017-07-26 アンスロジェネシス コーポレーション 改良型細胞組成物およびその作製方法
MX2011001992A (es) 2008-08-22 2011-03-29 Anthrogenesis Corp Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias.
WO2010028288A2 (en) 2008-09-05 2010-03-11 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
CA2736178A1 (en) * 2008-09-05 2010-03-11 Peter Kuhn Methods for the detection of circulating tumor cells
SI2334812T1 (sl) 2008-09-20 2017-05-31 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 Neinvazivna diagnoza fetalne anevploidije s sekvenciranjem
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
GB2467704B (en) 2008-11-07 2011-08-24 Mlc Dx Inc A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells
US20100151573A1 (en) * 2008-11-17 2010-06-17 King Michael R Compositions and methods for delivery of molecules to selectin-ligand-expressing and selectin-expressing cells
EP2359164A4 (en) 2008-12-10 2012-05-30 Abqmr Inc CORE MAGNETIC RESONANCE DEVICE, METHOD AND ASSOCIATED TECHNOLOGY
EP2377947A4 (en) * 2008-12-18 2012-05-30 Sysmex Corp METHOD FOR DETECTING CANCER CELLS IN A BLOOD TEST
EP2199798A1 (en) * 2008-12-18 2010-06-23 Universite Libre De Bruxelles Diagnostic method and kit of circulating tumor cells
WO2010078194A1 (en) * 2008-12-30 2010-07-08 Streck, Inc. Method for screening blood using a preservative that may be in a substantially solid state form
WO2010123594A2 (en) * 2009-01-15 2010-10-28 Children's Medical Center Corporation Device for filtration of fluids there through and accompanying method
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
US20120055854A1 (en) * 2009-02-05 2012-03-08 Tibbe Arjan G J Filter Method for Separating Unbound Ferrofluid from Target-bound Ferrofluid in a Biological Sample
EP3290530B1 (en) 2009-02-18 2020-09-02 Streck Inc. Preservation of cell-free nucleic acids
US8167871B2 (en) 2009-02-25 2012-05-01 The Invention Science Fund I, Llc Device for actively removing a target cell from blood or lymph of a vertebrate subject
US8317737B2 (en) * 2009-02-25 2012-11-27 The Invention Science Fund I, Llc Device for actively removing a target component from blood or lymph of a vertebrate subject
JP4849278B2 (ja) 2009-03-27 2012-01-11 セイコーエプソン株式会社 細胞処理デバイス、細胞処理カートリッジおよび体液処理システム
US8790916B2 (en) * 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
JP5692738B2 (ja) * 2009-07-28 2015-04-01 国立大学法人 鹿児島大学 ウイルスの濃縮方法および磁性体組成物
US20130023433A1 (en) 2009-09-28 2013-01-24 Yuling Luo Methods of detecting nucleic acid sequences with high specificity
EP2491395B1 (en) 2009-10-21 2015-09-16 The Scripps Research Institute Method of using non-rare cells to detect rare cells
ES2571104T3 (es) * 2009-11-09 2016-05-24 Streck Inc Estabilización del ARN y extracción del ARN presente en células intactas dentro de una muestra de sangre
US20130171621A1 (en) 2010-01-29 2013-07-04 Advanced Cell Diagnostics Inc. Methods of in situ detection of nucleic acids
JP5808349B2 (ja) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
KR101878749B1 (ko) * 2010-03-05 2018-07-17 삼성전자주식회사 표적 세포의 분리 방법 및 키트
US9448163B2 (en) 2010-03-05 2016-09-20 Konica Minolta Holdings, Inc. Method for detecting rare cell on observation region
BR112012025593A2 (pt) 2010-04-06 2019-06-25 Caris Life Sciences Luxembourg Holdings biomarcadores em circulação para doença
EP2555783A1 (en) 2010-04-08 2013-02-13 Anthrogenesis Corporation Treatment of sarcoidosis using placental stem cells
US20110262989A1 (en) * 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
US9428547B2 (en) 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
WO2011139371A1 (en) 2010-05-06 2011-11-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
EP3572528A1 (en) 2010-09-24 2019-11-27 The Board of Trustees of the Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
JP5960146B2 (ja) * 2010-10-14 2016-08-02 ジャンセン ダイアグノスティックス,エルエルシー 多特異性捕捉試薬及び混合検出試薬を用いる膵臓患者の循環腫瘍細胞を検出する方法及びキット
US9624474B2 (en) 2010-12-01 2017-04-18 Samsung Electronics Co, Ltd. Method of separating target cell in biological sample
CN104152530B (zh) * 2010-12-24 2017-09-19 爱科来株式会社 癌细胞的检测方法
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
WO2012112013A2 (en) * 2011-02-18 2012-08-23 Korea Research Institute Of Bioscience And Biotechnology A marker comprising anti-ck8/18 complex autoantibody and its use for diagnosing cancer
KR101374758B1 (ko) * 2011-02-18 2014-03-17 한국생명공학연구원 항-사이토케라틴 8/18 복합체 자가면역항체를 포함하는 암 진단 마커 및 이의 항원을 포함하는 암 진단용 조성물
CN103732136A (zh) * 2011-03-22 2014-04-16 通用医疗公司 利用磁共振检测目的物
US20120252038A1 (en) * 2011-04-01 2012-10-04 Chianese David A Steroid receptor assays
US20140134630A1 (en) * 2011-04-05 2014-05-15 Serrata, Llc Risk analysis for disease development
WO2012151391A2 (en) 2011-05-04 2012-11-08 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
ES2707579T3 (es) 2011-06-01 2019-04-04 Celularity Inc Tratamiento del dolor usando citoblastos placentarios
US9541480B2 (en) 2011-06-29 2017-01-10 Academia Sinica Capture, purification, and release of biological substances using a surface coating
WO2013006774A1 (en) 2011-07-07 2013-01-10 Veridex, Llc Genomic diagnostics using circulating endothelial cells
EP2734307B1 (en) 2011-07-21 2020-03-25 Menarini Silicon Biosystems S.p.A. Assay to capture and detect circulating multiple myeloma cells from blood
TW201312117A (zh) 2011-07-28 2013-03-16 Univ Pennsylvania 用以診斷與漿液相關之腫瘤細胞的症狀及特性的方法及試劑
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US9103754B2 (en) 2011-08-01 2015-08-11 Denovo Sciences, Inc. Cell capture system and method of use
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
EP2753924B1 (en) * 2011-09-06 2022-10-26 Becton Dickinson and Company Methods and compositions for cytometric detection of circulating tumor cells in a sample
JP2012022002A (ja) * 2011-09-12 2012-02-02 Veridex Llc 循環腫瘍細胞を用いる転移性乳癌患者の療法中の各追跡期間ポイントでの無増悪および全生存を予測する方法
US9645149B2 (en) 2011-09-30 2017-05-09 The Regents Of The University Of Michigan System for detecting rare cells
US10130946B2 (en) 2011-09-30 2018-11-20 The Regents Of The University Of Michigan System for detecting rare cells
SG11201402711SA (en) 2011-11-29 2014-06-27 Genentech Inc Compositions and methods for prostate cancer analysis
BR112014015424A2 (pt) 2011-12-23 2018-05-22 Depuy Synthes Products Llc detecção de células derivadas de tecido do cordão umbilical humano
US20130197296A1 (en) * 2012-01-13 2013-08-01 Karl-Heinz Ott Removing Cells from an Organism
WO2013149265A1 (en) * 2012-03-31 2013-10-03 Nvigen, Inc. Magnetic nanocompositions for highly sensitive molecular and cellular enrichment, purification and detection
CN103376228B (zh) * 2012-04-27 2016-02-17 中国人民解放军军事医学科学院放射与辐射医学研究所 一种检测或辅助检测放射性肺纤维化的试剂盒
WO2013174948A1 (en) * 2012-05-24 2013-11-28 Rarecells Process for multi-analyses of rare cells extracted or isolated from biological samples through filtration
JP6208473B2 (ja) 2012-06-20 2017-10-04 アークレイ株式会社 血液成分を含む試料の処理方法
US10032064B2 (en) * 2012-08-21 2018-07-24 Cambridge Research & Instrumentation, Inc. Visualization and measurement of cell compartments
JP6421123B2 (ja) * 2012-10-19 2018-11-07 ウェイン ステイト ユニヴァーシティ 出生前診断のための頚管粘液における胎性栄養膜細胞の同定および分析
US10073024B2 (en) 2012-10-29 2018-09-11 The Regents Of The University Of Michigan Microfluidic device and method for detecting rare cells
CA2891028C (en) 2012-11-09 2017-02-07 F. Hoffmann-La Roche Ag In vitro capture and analysis of circulating tumor cells
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
CA2895791A1 (en) 2013-01-25 2014-07-31 Xcell Biosciences, Inc. Methods, compositions, kits, and systems for selective enrichment of target cells
US9752181B2 (en) 2013-01-26 2017-09-05 Denovo Sciences, Inc. System and method for capturing and analyzing cells
GB2546213B (en) 2013-02-02 2017-12-06 Univ Duke Method of isolating circulating tumour cells
KR101568573B1 (ko) 2013-03-13 2015-11-20 고려대학교 산학협력단 혈중 희소 세포의 검출 및 계수 장치와 방법
WO2014142559A1 (ko) * 2013-03-13 2014-09-18 고려대학교 산학협력단 혈중 희소 세포의 검출 및 계수 장치와 방법
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
EP2972359B1 (en) 2013-03-15 2020-09-23 Menarini Silicon Biosystems S.p.A. Enrichment of circulating tumor cells by depleting white blood cells
WO2014160796A1 (en) * 2013-03-29 2014-10-02 Siemens Healthcare Diagnostics Inc. Rare cell concentration
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
EP3017308A4 (en) 2013-07-05 2017-04-26 University Of Washington Through Its Center For Commercialization Methods, compositions and systems for microfluidic assays
WO2015013244A1 (en) 2013-07-24 2015-01-29 Streck, Inc. Compositions and methods for stabilizing circulating tumor cells
US10022659B2 (en) 2013-07-24 2018-07-17 Aichi Prefecture Device for isolating periphery circulating tumor cells or rare cells, and method of isolating periphery circulating tumor cells or rare cells
WO2015112955A1 (en) 2014-01-27 2015-07-30 Epic Sciences, Inc. Circulating tumor cell diagnostics for prostate cancer biomarkers
EA201691682A1 (ru) 2014-02-21 2017-02-28 Эпик Сайенсиз, Инк. Способы анализирования редких циркулирующих в крови клеток
CN106662514A (zh) 2014-04-01 2017-05-10 中央研究院 用于癌症诊断及预后的方法和系统
EP2998026B1 (en) 2014-08-26 2024-01-17 Academia Sinica Collector architecture layout design
JP6673224B2 (ja) * 2014-12-25 2020-03-25 コニカミノルタ株式会社 細胞画像解析方法及び細胞画像解析装置
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US10317406B2 (en) 2015-04-06 2019-06-11 The Regents Of The University Of Michigan System for detecting rare cells
CN108064343B (zh) 2015-04-21 2021-07-09 基因泰克公司 用于前列腺癌分析的组合物和方法
KR101701618B1 (ko) 2015-06-23 2017-02-13 국립암센터 전도성 고분자를 이용한 세포 유리 dna 검출용 구조체 및 이의 용도
WO2017040686A1 (en) * 2015-09-01 2017-03-09 University Of Miami Identification of circulating cancer associated fibroblasts
CN108368543B (zh) 2015-10-12 2023-06-13 领先细胞医疗诊断有限公司 高噪声样品中原位检测核苷酸变体及相关的组合物和方法
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
EP3440209A4 (en) 2016-04-06 2019-11-27 Wayne State University ISOLATION AND ANALYSIS OF FETAL DNA FROM EXTRAVILLE THROPHOBLAST CELLS RECOVERED FROM THE ENDOZERVICAL CHANNEL
KR101876725B1 (ko) * 2016-05-09 2018-07-13 주식회사 싸이토젠 전립선 암 환자의 혈중 순환 종양세포를 활용한 안드로겐 수용체 과발현 환자의 맞춤형 항암제 선별시스템 및 선별방법
KR101876724B1 (ko) * 2016-05-09 2018-07-13 주식회사 싸이토젠 폐암 환자의 혈중 순환 종양세포를 활용한 egfr-tki 내성 환자의 맞춤형 항암제 선별시스템 및 방법
NZ749272A (en) 2016-06-14 2023-01-27 Cellectar Biosciences Inc Phospholipid ether analogs for the identification and isolation of circulating tumor cells
WO2018022991A1 (en) 2016-07-29 2018-02-01 Streck, Inc. Suspension composition for hematology analysis control
AU2017361521B2 (en) 2016-11-21 2020-08-27 Nanostring Technologies, Inc. Chemical compositions and methods of using same
BR112019018767A2 (pt) 2017-04-03 2020-05-05 Hoffmann La Roche anticorpos, molécula de ligação ao antígeno biespecífica, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, usos, método para tratar uma doença em um indivíduo e invenção
CN111344570A (zh) * 2017-06-08 2020-06-26 卡西迪亚生物技术公司 分离和检测癌症干细胞的方法
JP6980904B2 (ja) 2017-08-29 2021-12-15 バイオ−ラッド ラボラトリーズ インコーポレイテッド 細胞を単離し分析するためのシステムおよび方法
WO2019103103A1 (ja) * 2017-11-24 2019-05-31 Jsr株式会社 細胞を分離する方法、細胞分離または濃縮用粒子およびキット
WO2019109077A1 (en) * 2017-12-01 2019-06-06 Cornell University Nanoparticles and distinct exosome subsets for detection and treatment of cancer
WO2019141779A1 (en) * 2018-01-18 2019-07-25 F. Hoffmann-La Roche Ag Hypercrosslinking with diamine crosslinkers
SG11202011274YA (en) 2018-05-14 2020-12-30 Nanostring Technologies Inc Chemical compositions and methods of using same
CN108918398A (zh) * 2018-05-18 2018-11-30 宁波永新光学股份有限公司 一种循环肿瘤细胞检测方法
US20200172768A1 (en) 2018-12-04 2020-06-04 Adhesives Research, Inc. Disintegrable thin film adhesive barrier
US20200199567A1 (en) * 2018-12-20 2020-06-25 Medimmune, Llc Methods for selection and expansion of t cells expressing pd-1
EP3908678A1 (en) 2019-01-10 2021-11-17 Iovance Biotherapeutics, Inc. System and methods for monitoring adoptive cell therapy clonality and persistence
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11578322B2 (en) 2019-05-07 2023-02-14 Bio-Rad Laboratories, Inc. System and method for automated single cell processing
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
CN110196327B (zh) * 2019-05-18 2022-04-29 贵州医科大学附属医院 基于基因变异分析检测直肠癌细胞药物敏感性的试剂盒
KR20220033484A (ko) 2019-06-14 2022-03-16 바이오 래드 래버러토리스 인코오포레이티드 자동화된 단일 세포 처리 및 분석을 위한 시스템 및 방법
EP3999856A1 (en) 2019-07-15 2022-05-25 Menarini Biomarkers Singapore Pte Ltd Compositions and methods for isolating, detecting, and analyzing fetal cells
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
WO2023007793A1 (ja) * 2021-07-28 2023-02-02 ソニーグループ株式会社 細胞試料調製試薬

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970518A (en) 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4018886A (en) 1975-07-01 1977-04-19 General Electric Company Diagnostic method and device employing protein-coated magnetic particles
US4267234A (en) 1978-03-17 1981-05-12 California Institute Of Technology Polyglutaraldehyde synthesis and protein bonding substrates
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
US4375407A (en) 1981-06-22 1983-03-01 The Franklin Institute High gradient magnetic separation device
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
NO155316C (no) 1982-04-23 1987-03-11 Sintef Fremgangsmaate for fremstilling av magnetiske polymerpartikler.
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
US4554088A (en) 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
WO1985003132A1 (en) * 1984-01-06 1985-07-18 The Regents Of The University Of California Cytokeratin tumor markers and assays for their detection
US5512332A (en) 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
US4795698A (en) * 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US5597531A (en) * 1985-10-04 1997-01-28 Immunivest Corporation Resuspendable coated magnetic particles and stable magnetic particle suspensions
NO162946C (no) 1987-08-21 1990-03-14 Otto Soerensen Anordning for magnetisk separasjon av celler.
US5238811A (en) * 1988-04-26 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus therefor and superparamagnetic material-labeled body and method for the manufacture of same
US5512657A (en) * 1988-12-12 1996-04-30 Bainbridge Sciences, Inc. Detection of complexes which include basement membrane components as diagnostic of cancer and other diseases
US5385707A (en) 1988-12-28 1995-01-31 Stefan Miltenyi Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same
US5081030A (en) 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
US5698271A (en) 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5541072A (en) * 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
US5466574A (en) 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
US5186827A (en) 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US5714325A (en) * 1993-09-24 1998-02-03 New England Medical Center Hospitals Prenatal diagnosis by isolation of fetal granulocytes from maternal blood
NO180658C (no) 1994-03-10 1997-05-21 Oeystein Fodstad Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner
US5545527A (en) * 1994-07-08 1996-08-13 Visible Genetics Inc. Method for testing for mutations in DNA from a patient sample
US5660990A (en) * 1995-08-18 1997-08-26 Immunivest Corporation Surface immobilization of magnetically collected materials
US6190870B1 (en) 1995-08-28 2001-02-20 Amcell Corporation Efficient enrichment and detection of disseminated tumor cells
WO1997015597A1 (en) * 1995-10-25 1997-05-01 Centocor B.V. HUMAN EPITHELIAL ANTIGEN Ep-CAM DERIVED PEPTIDES AND THEIR USE
US5993665A (en) 1996-06-07 1999-11-30 Immunivest Corporation Quantitative cell analysis methods employing magnetic separation
JP2002503814A (ja) * 1998-02-12 2002-02-05 イムニベスト・コーポレイション 循環ガン細胞の迅速かつ効率的な単離のための方法および試薬
WO2000047998A1 (en) 1999-02-10 2000-08-17 Cell Works Inc. Class characterization of circulating cancer cells isolated from body fluids and methods of use

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US6365362B1 (en) 2002-04-02
JP5766168B2 (ja) 2015-08-19
IL137802A (en) 2006-08-01
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DE69941689D1 (de) 2010-01-07
CA2320418A1 (en) 1999-08-19
US20030129676A1 (en) 2003-07-10
US6645731B2 (en) 2003-11-11
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