IL136271A - Process for the preparation of n<2>-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline - Google Patents
Process for the preparation of n<2>-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-prolineInfo
- Publication number
- IL136271A IL136271A IL13627199A IL13627199A IL136271A IL 136271 A IL136271 A IL 136271A IL 13627199 A IL13627199 A IL 13627199A IL 13627199 A IL13627199 A IL 13627199A IL 136271 A IL136271 A IL 136271A
- Authority
- IL
- Israel
- Prior art keywords
- lysyl
- phenylpropyl
- proline
- inorganic
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26867698 | 1998-09-22 | ||
| PCT/JP1999/005189 WO2000017229A1 (fr) | 1998-09-22 | 1999-09-22 | Procede de preparation de n2-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL136271A0 IL136271A0 (en) | 2001-05-20 |
| IL136271A true IL136271A (en) | 2005-06-19 |
Family
ID=17461854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13627199A IL136271A (en) | 1998-09-22 | 1999-09-22 | Process for the preparation of n<2>-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6271393B1 (es) |
| EP (1) | EP1035131B1 (es) |
| JP (1) | JP4307733B2 (es) |
| KR (1) | KR100625553B1 (es) |
| CN (1) | CN1200946C (es) |
| AT (1) | ATE346086T1 (es) |
| CA (1) | CA2311407A1 (es) |
| CZ (1) | CZ292494B6 (es) |
| DE (1) | DE69934084T2 (es) |
| ES (1) | ES2277446T3 (es) |
| HU (1) | HUP0100831A3 (es) |
| IL (1) | IL136271A (es) |
| PL (1) | PL340685A1 (es) |
| RU (1) | RU2220152C2 (es) |
| SI (1) | SI20271A (es) |
| WO (1) | WO2000017229A1 (es) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0168769A3 (en) * | 1984-07-16 | 1989-02-08 | Merck & Co. Inc. | Process for preparing carboxyalkyl dipeptides |
| JPH0653757B2 (ja) * | 1985-12-06 | 1994-07-20 | 味の素株式会社 | プロリン誘導体の芳香族スルホン酸塩 |
| JPH01254651A (ja) * | 1988-04-04 | 1989-10-11 | Kanegafuchi Chem Ind Co Ltd | Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体及び該化合物を用いるリジノプリルの製造法 |
| EP0645398B1 (en) * | 1993-01-08 | 2003-03-05 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Method of crystallizing n?2 -((s)-1-ethoxycarbonyl-3-phenylpropyl)-n?6 -trifluoroacetyl-l-lysyl-l-proline |
| DE4331540A1 (de) * | 1993-09-17 | 1995-03-23 | Degussa | Verfahren zur Reinigung von 1-[N·2·-((S)-Ethoxycarbonyl)-3-phenylpropyl)-N·6·-trifluoracetyl]-L-lysyl-L-prolin (Lisinopril(Tfa)ethylester) |
| HU214579B (hu) * | 1995-03-14 | 1998-04-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új eljárás lizinopril előállítására |
| JP3792777B2 (ja) * | 1996-05-10 | 2006-07-05 | 株式会社カネカ | １−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法 |
-
1999
- 1999-09-22 EP EP99944783A patent/EP1035131B1/en not_active Expired - Lifetime
- 1999-09-22 DE DE69934084T patent/DE69934084T2/de not_active Expired - Lifetime
- 1999-09-22 RU RU2000116019/04A patent/RU2220152C2/ru not_active IP Right Cessation
- 1999-09-22 US US09/554,827 patent/US6271393B1/en not_active Expired - Lifetime
- 1999-09-22 HU HU0100831A patent/HUP0100831A3/hu unknown
- 1999-09-22 SI SI9920011A patent/SI20271A/sl not_active IP Right Cessation
- 1999-09-22 ES ES99944783T patent/ES2277446T3/es not_active Expired - Lifetime
- 1999-09-22 JP JP2000574137A patent/JP4307733B2/ja not_active Expired - Fee Related
- 1999-09-22 CZ CZ20001897A patent/CZ292494B6/cs not_active IP Right Cessation
- 1999-09-22 KR KR1020007005439A patent/KR100625553B1/ko not_active IP Right Cessation
- 1999-09-22 CA CA002311407A patent/CA2311407A1/en not_active Abandoned
- 1999-09-22 CN CNB99801639XA patent/CN1200946C/zh not_active Expired - Fee Related
- 1999-09-22 IL IL13627199A patent/IL136271A/xx not_active IP Right Cessation
- 1999-09-22 AT AT99944783T patent/ATE346086T1/de not_active IP Right Cessation
- 1999-09-22 WO PCT/JP1999/005189 patent/WO2000017229A1/ja active IP Right Grant
- 1999-09-22 PL PL99340685A patent/PL340685A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2220152C2 (ru) | 2003-12-27 |
| EP1035131A1 (en) | 2000-09-13 |
| HUP0100831A3 (en) | 2001-12-28 |
| SI20271A (sl) | 2000-12-31 |
| HUP0100831A2 (hu) | 2001-08-28 |
| CZ20001897A3 (cs) | 2000-10-11 |
| CN1200946C (zh) | 2005-05-11 |
| ES2277446T3 (es) | 2007-07-01 |
| IL136271A0 (en) | 2001-05-20 |
| DE69934084T2 (de) | 2007-04-05 |
| US6271393B1 (en) | 2001-08-07 |
| DE69934084D1 (de) | 2007-01-04 |
| WO2000017229A1 (fr) | 2000-03-30 |
| JP4307733B2 (ja) | 2009-08-05 |
| EP1035131B1 (en) | 2006-11-22 |
| ATE346086T1 (de) | 2006-12-15 |
| PL340685A1 (en) | 2001-02-26 |
| CZ292494B6 (cs) | 2003-10-15 |
| KR20010032238A (ko) | 2001-04-16 |
| EP1035131A4 (en) | 2002-05-02 |
| KR100625553B1 (ko) | 2006-09-20 |
| CA2311407A1 (en) | 2000-03-30 |
| CN1286695A (zh) | 2001-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |