HUP0100831A2 - Eljárás n2-(1(s)karboxi-3-fenilpropil)-L-lizil-L-prolin előállítására - Google Patents

Eljárás n2-(1(s)karboxi-3-fenilpropil)-L-lizil-L-prolin előállítására

Info

Publication number
HUP0100831A2
HUP0100831A2 HU0100831A HUP0100831A HUP0100831A2 HU P0100831 A2 HUP0100831 A2 HU P0100831A2 HU 0100831 A HU0100831 A HU 0100831A HU P0100831 A HUP0100831 A HU P0100831A HU P0100831 A2 HUP0100831 A2 HU P0100831A2
Authority
HU
Hungary
Prior art keywords
lysyl
phenylpropyl
proline
carboxy
preparation
Prior art date
Application number
HU0100831A
Other languages
English (en)
Inventor
Yoshihide Fuse
Tadashi Moroshima
Yasuyoshi Ueda
Yoshifumi Yanagida
Original Assignee
Kaneka Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corporation filed Critical Kaneka Corporation
Publication of HUP0100831A2 publication Critical patent/HUP0100831A2/hu
Publication of HUP0100831A3 publication Critical patent/HUP0100831A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

A találmány tárgya eljárás a (2) képletű N2-(1-(S)-karboxi--3-fenilpropil)-L-lizil-L-prolin előállítására. A találmány szerinti eljárásban valamely (1) általános képletű N2-(1-(S)-alkoxikarbonil-3-fenilpropil)-N6-trifluoracetil-L-lizil-L-prolint - ahol R jelentése alkilcsoport alkálikus hidrolízisnek vetikalá víz és egy szerves oldószer alkotta oldószerelegy és víz közülmegválasztott oldószerrendszerben egy szervetlen bázist használva;majd a hidrolízis termékét semlegesítik egy szervetlen savathasználva; és a képződött sót elkülönítik és eltávolítják areakcióelegyből úgy, hogy az oldószerrendszerből kicsapódnikényszerítik a szervetlen só szolubilitásának csökkentése útján. Ó
HU0100831A 1998-09-22 1999-09-22 Process for the preparation of n2-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline HUP0100831A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26867698 1998-09-22
PCT/JP1999/005189 WO2000017229A1 (fr) 1998-09-22 1999-09-22 Procede de preparation de n2-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline

Publications (2)

Publication Number Publication Date
HUP0100831A2 true HUP0100831A2 (hu) 2001-08-28
HUP0100831A3 HUP0100831A3 (en) 2001-12-28

Family

ID=17461854

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100831A HUP0100831A3 (en) 1998-09-22 1999-09-22 Process for the preparation of n2-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline

Country Status (16)

Country Link
US (1) US6271393B1 (hu)
EP (1) EP1035131B1 (hu)
JP (1) JP4307733B2 (hu)
KR (1) KR100625553B1 (hu)
CN (1) CN1200946C (hu)
AT (1) ATE346086T1 (hu)
CA (1) CA2311407A1 (hu)
CZ (1) CZ292494B6 (hu)
DE (1) DE69934084T2 (hu)
ES (1) ES2277446T3 (hu)
HU (1) HUP0100831A3 (hu)
IL (1) IL136271A (hu)
PL (1) PL340685A1 (hu)
RU (1) RU2220152C2 (hu)
SI (1) SI20271A (hu)
WO (1) WO2000017229A1 (hu)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168769A3 (en) * 1984-07-16 1989-02-08 Merck & Co. Inc. Process for preparing carboxyalkyl dipeptides
JPH0653757B2 (ja) * 1985-12-06 1994-07-20 味の素株式会社 プロリン誘導体の芳香族スルホン酸塩
JPH01254651A (ja) * 1988-04-04 1989-10-11 Kanegafuchi Chem Ind Co Ltd Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体及び該化合物を用いるリジノプリルの製造法
EP1243594B1 (en) * 1993-01-08 2004-05-12 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for crystallizing N2-((S)-1-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysyl-L-proline
DE4331540A1 (de) * 1993-09-17 1995-03-23 Degussa Verfahren zur Reinigung von 1-[N·2·-((S)-Ethoxycarbonyl)-3-phenylpropyl)-N·6·-trifluoracetyl]-L-lysyl-L-prolin (Lisinopril(Tfa)ethylester)
HU214579B (hu) * 1995-03-14 1998-04-28 Richter Gedeon Vegyészeti Gyár Rt. Új eljárás lizinopril előállítására
JP3792777B2 (ja) * 1996-05-10 2006-07-05 株式会社カネカ １−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法

Also Published As

Publication number Publication date
EP1035131A4 (en) 2002-05-02
US6271393B1 (en) 2001-08-07
ES2277446T3 (es) 2007-07-01
IL136271A (en) 2005-06-19
ATE346086T1 (de) 2006-12-15
HUP0100831A3 (en) 2001-12-28
CA2311407A1 (en) 2000-03-30
CN1200946C (zh) 2005-05-11
KR100625553B1 (ko) 2006-09-20
PL340685A1 (en) 2001-02-26
EP1035131A1 (en) 2000-09-13
DE69934084D1 (de) 2007-01-04
EP1035131B1 (en) 2006-11-22
RU2220152C2 (ru) 2003-12-27
IL136271A0 (en) 2001-05-20
SI20271A (sl) 2000-12-31
DE69934084T2 (de) 2007-04-05
CN1286695A (zh) 2001-03-07
WO2000017229A1 (fr) 2000-03-30
JP4307733B2 (ja) 2009-08-05
KR20010032238A (ko) 2001-04-16
CZ20001897A3 (cs) 2000-10-11
CZ292494B6 (cs) 2003-10-15

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Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished