IL131309A - Process for making aprosartan - Google Patents

Process for making aprosartan

Info

Publication number
IL131309A
IL131309A IL13130998A IL13130998A IL131309A IL 131309 A IL131309 A IL 131309A IL 13130998 A IL13130998 A IL 13130998A IL 13130998 A IL13130998 A IL 13130998A IL 131309 A IL131309 A IL 131309A
Authority
IL
Israel
Prior art keywords
compound
formula
acid
process according
butyl
Prior art date
Application number
IL13130998A
Other languages
English (en)
Hebrew (he)
Other versions
IL131309A0 (en
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of IL131309A0 publication Critical patent/IL131309A0/xx
Publication of IL131309A publication Critical patent/IL131309A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
IL13130998A 1997-02-14 1998-02-13 Process for making aprosartan IL131309A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3819597P 1997-02-14 1997-02-14
PCT/US1998/002412 WO1998035963A1 (en) 1997-02-14 1998-02-13 Process for preparing eprosartan

Publications (2)

Publication Number Publication Date
IL131309A0 IL131309A0 (en) 2001-01-28
IL131309A true IL131309A (en) 2002-09-12

Family

ID=21898583

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13130998A IL131309A (en) 1997-02-14 1998-02-13 Process for making aprosartan

Country Status (41)

Country Link
US (1) US6172237B1 (pt)
EP (1) EP0970073B1 (pt)
JP (1) JP4537499B2 (pt)
KR (1) KR100573638B1 (pt)
CN (1) CN1085208C (pt)
AP (1) AP1128A (pt)
AR (1) AR011125A1 (pt)
AT (1) ATE280765T1 (pt)
AU (1) AU730383B2 (pt)
BG (1) BG63804B1 (pt)
BR (1) BR9808664A (pt)
CA (1) CA2281708C (pt)
CO (1) CO4950550A1 (pt)
CY (1) CY2555B1 (pt)
CZ (1) CZ296349B6 (pt)
DE (1) DE69827240T2 (pt)
DK (1) DK0970073T3 (pt)
EA (1) EA001659B1 (pt)
EG (1) EG23935A (pt)
ES (1) ES2231963T3 (pt)
HU (1) HU228781B1 (pt)
ID (1) ID23181A (pt)
IL (1) IL131309A (pt)
IN (2) IN187999B (pt)
MA (1) MA24470A1 (pt)
MY (1) MY118704A (pt)
NO (1) NO317194B1 (pt)
NZ (1) NZ337180A (pt)
OA (1) OA11146A (pt)
PE (1) PE59299A1 (pt)
PL (1) PL192838B1 (pt)
PT (1) PT970073E (pt)
RO (1) RO119719B1 (pt)
SA (1) SA98190082B1 (pt)
SI (1) SI0970073T1 (pt)
SK (1) SK285036B6 (pt)
TR (1) TR199901936T2 (pt)
TW (1) TW399050B (pt)
UA (1) UA54487C2 (pt)
WO (1) WO1998035963A1 (pt)
ZA (1) ZA981207B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008078330A1 (en) * 2006-12-27 2008-07-03 Hetero Drugs Limited Improved process for eprosartan
EP2295431A3 (en) * 2007-07-25 2011-08-03 Hetero Drugs Limited Substantially pure eprosartan free base
EP2181109A4 (en) * 2007-07-25 2011-08-03 Hetero Drugs Ltd CRYSTALLINE PARTICLES OF EPROSARTAN MESYLATE AND PROCESS FOR PREPARING PURE EPROSARTAN
WO2009084028A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd Improved process for manufacturing anhydrous (e)-3-[2-butyl-1- {(4-carboxyphenyl) methyl}-1h-imidazole-5-yl]-(thiophen-2- ylmethyl)prop-2-enoic acid methane sulfonate
CN101215284B (zh) * 2007-12-31 2010-10-13 浙江华海药业股份有限公司 一种改进的依普罗沙坦的制备方法
US20110054186A1 (en) * 2008-03-31 2011-03-03 Hetero Research Foundation Process for eprosartan intermediate
WO2010023688A2 (en) * 2008-08-25 2010-03-04 Matrix Laboratories Limited An improved process for the preparation of eprosartan
WO2011004384A2 (en) 2009-06-05 2011-01-13 Glochem Industries Limited Process for the preparation of eprosartan
WO2011051975A1 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of pure eprosartanand its pharmaceutical acceptable salts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
JP3214856B2 (ja) * 1990-12-14 2001-10-02 スミスクライン・ビーチャム・コーポレイション イミダゾリル−アルケン酸
US5395847A (en) * 1993-12-02 1995-03-07 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
MX9605794A (es) * 1994-05-20 1997-12-31 Smithkline Beecham Corp Intermediario para preparar un compuesto farmaceuticamente activo.

Also Published As

Publication number Publication date
DK0970073T3 (da) 2005-02-21
PT970073E (pt) 2005-02-28
US6172237B1 (en) 2001-01-09
CA2281708A1 (en) 1998-08-20
PL335075A1 (en) 2000-04-10
ID23181A (id) 2000-03-23
JP4537499B2 (ja) 2010-09-01
ATE280765T1 (de) 2004-11-15
DE69827240D1 (de) 2004-12-02
SK285036B6 (sk) 2006-05-04
AP9901620A0 (en) 1999-09-30
AP1128A (en) 2002-12-06
HUP0001994A3 (en) 2001-07-30
CN1247539A (zh) 2000-03-15
HUP0001994A2 (hu) 2001-06-28
KR100573638B1 (ko) 2006-04-26
DE69827240T2 (de) 2005-10-13
NO993913D0 (no) 1999-08-13
TR199901936T2 (xx) 2000-04-21
KR20000071007A (ko) 2000-11-25
EP0970073A1 (en) 2000-01-12
OA11146A (en) 2003-04-16
TW399050B (en) 2000-07-21
PE59299A1 (es) 1999-09-09
SI0970073T1 (en) 2005-02-28
AU730383B2 (en) 2001-03-08
IL131309A0 (en) 2001-01-28
EA199900740A1 (ru) 2000-02-28
JP2001510466A (ja) 2001-07-31
CA2281708C (en) 2007-08-14
HU228781B1 (en) 2013-05-28
EP0970073B1 (en) 2004-10-27
IN187999B (pt) 2002-08-03
UA54487C2 (uk) 2003-03-17
AU6150898A (en) 1998-09-08
MY118704A (en) 2005-01-31
IN192743B (pt) 2004-05-15
NO993913L (no) 1999-08-13
BG103650A (en) 2000-06-30
BR9808664A (pt) 2000-07-11
BG63804B1 (bg) 2003-01-31
NO317194B1 (no) 2004-09-13
ES2231963T3 (es) 2005-05-16
EP0970073A4 (en) 2001-01-24
AR011125A1 (es) 2000-08-02
CZ285299A3 (cs) 2000-02-16
CO4950550A1 (es) 2000-09-01
CY2555B1 (en) 2008-07-02
MA24470A1 (fr) 1998-10-01
CZ296349B6 (cs) 2006-02-15
NZ337180A (en) 2000-11-24
EA001659B1 (ru) 2001-06-25
SA98190082B1 (ar) 2006-08-20
PL192838B1 (pl) 2006-12-29
CN1085208C (zh) 2002-05-22
RO119719B1 (ro) 2005-02-28
SK108799A3 (en) 2000-05-16
WO1998035963A1 (en) 1998-08-20
EG23935A (en) 2008-01-14
ZA981207B (en) 1998-11-12

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Legal Events

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