IL121541A - Oxazoline derivatives and processes for the preparation of same - Google Patents

Oxazoline derivatives and processes for the preparation of same

Info

Publication number
IL121541A
IL121541A IL12154193A IL12154193A IL121541A IL 121541 A IL121541 A IL 121541A IL 12154193 A IL12154193 A IL 12154193A IL 12154193 A IL12154193 A IL 12154193A IL 121541 A IL121541 A IL 121541A
Authority
IL
Israel
Prior art keywords
preparation
oxazoline
processes
same
sidechain
Prior art date
Application number
IL12154193A
Other languages
English (en)
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL121541A publication Critical patent/IL121541A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL12154193A 1992-12-23 1993-12-23 Oxazoline derivatives and processes for the preparation of same IL121541A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99544392A 1992-12-23 1992-12-23
IL10816193A IL108161A (en) 1992-12-23 1993-12-23 Methods for preparing Texan history and new history of Texan produced by him

Publications (1)

Publication Number Publication Date
IL121541A true IL121541A (en) 2000-11-21

Family

ID=25541806

Family Applications (13)

Application Number Title Priority Date Filing Date
IL12154193A IL121541A (en) 1992-12-23 1993-12-23 Oxazoline derivatives and processes for the preparation of same
IL145280A IL145280A (en) 1992-12-23 1993-12-23 Isoserine derivatives
IL10816193A IL108161A (en) 1992-12-23 1993-12-23 Methods for preparing Texan history and new history of Texan produced by him
IL12153993A IL121539A (en) 1992-12-23 1993-12-23 History of oxazoline and processes for their preparation
IL12154093A IL121540A (en) 1992-12-23 1993-12-23 Use of isoserine derivatives for preparing taxane derivatives
IL12154293A IL121542A (en) 1992-12-23 1993-12-23 Methods for the preparation of taxane derivatives and novel taxane derivatives prepared thereby
IL12154097A IL121540A0 (en) 1992-12-23 1997-08-13 Isoserine derivatives
IL12154197A IL121541A0 (en) 1992-12-23 1997-08-13 Oxazoline derivatives and processes for the preparation of same
IL12154297A IL121542A0 (en) 1992-12-23 1997-08-13 Methods for the preparation of taxane derivatives and novel taxane derivatives prepared thereby
IL12153997A IL121539A0 (en) 1992-12-23 1997-08-13 Oxazoline derivatives and processes for the preparation of same
IL12220997A IL122209A0 (en) 1992-12-23 1997-11-16 Water-soluble prodrug forms of sidechain-bearing taxanes and pharmaceutical compositions containing them
IL12220897A IL122208A0 (en) 1992-12-23 1997-11-16 Sidechain-bearing taxanes methods for the preparation thereof and pharmaceutical compositions containing them
IL14528001A IL145280A0 (en) 1992-12-23 2001-09-04 Isoserine derivatives

Family Applications After (12)

Application Number Title Priority Date Filing Date
IL145280A IL145280A (en) 1992-12-23 1993-12-23 Isoserine derivatives
IL10816193A IL108161A (en) 1992-12-23 1993-12-23 Methods for preparing Texan history and new history of Texan produced by him
IL12153993A IL121539A (en) 1992-12-23 1993-12-23 History of oxazoline and processes for their preparation
IL12154093A IL121540A (en) 1992-12-23 1993-12-23 Use of isoserine derivatives for preparing taxane derivatives
IL12154293A IL121542A (en) 1992-12-23 1993-12-23 Methods for the preparation of taxane derivatives and novel taxane derivatives prepared thereby
IL12154097A IL121540A0 (en) 1992-12-23 1997-08-13 Isoserine derivatives
IL12154197A IL121541A0 (en) 1992-12-23 1997-08-13 Oxazoline derivatives and processes for the preparation of same
IL12154297A IL121542A0 (en) 1992-12-23 1997-08-13 Methods for the preparation of taxane derivatives and novel taxane derivatives prepared thereby
IL12153997A IL121539A0 (en) 1992-12-23 1997-08-13 Oxazoline derivatives and processes for the preparation of same
IL12220997A IL122209A0 (en) 1992-12-23 1997-11-16 Water-soluble prodrug forms of sidechain-bearing taxanes and pharmaceutical compositions containing them
IL12220897A IL122208A0 (en) 1992-12-23 1997-11-16 Sidechain-bearing taxanes methods for the preparation thereof and pharmaceutical compositions containing them
IL14528001A IL145280A0 (en) 1992-12-23 2001-09-04 Isoserine derivatives

Country Status (22)

Country Link
EP (2) EP0626953A4 (zh)
JP (2) JP3492690B2 (zh)
KR (3) KR100327625B1 (zh)
CN (4) CN1590386A (zh)
AT (1) ATE309229T1 (zh)
AU (3) AU679206B2 (zh)
CA (1) CA2119261C (zh)
CZ (1) CZ292993B6 (zh)
DE (1) DE69333905T2 (zh)
DK (1) DK1251127T3 (zh)
ES (1) ES2252362T3 (zh)
FI (2) FI115056B (zh)
HK (1) HK1048310B (zh)
HU (3) HU225294B1 (zh)
IL (13) IL121541A (zh)
NO (7) NO304521B1 (zh)
NZ (1) NZ261070A (zh)
PL (1) PL186176B1 (zh)
RU (1) RU2125042C1 (zh)
TW (1) TW247908B (zh)
WO (1) WO1994014787A1 (zh)
ZA (1) ZA939672B (zh)

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US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
US5840929A (en) * 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
JP4192208B2 (ja) * 1995-09-12 2008-12-10 セファロン リミテッド 加水分解促進性のタキサン疎水性誘導体
FR2740451B1 (fr) * 1995-10-27 1998-01-16 Seripharm Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
US5773629A (en) * 1996-06-14 1998-06-30 Industrial Technology Research Institute Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivative as taxol side-chain precursor
US5635531A (en) * 1996-07-08 1997-06-03 Bristol-Myers Squibb Company 3'-aminocarbonyloxy paclitaxels
US5773464A (en) * 1996-09-30 1998-06-30 Bristol-Myers Squibb Company C-10 epoxy taxanes
US5977386A (en) * 1996-12-24 1999-11-02 Bristol-Myers Squibb Company 6-thio-substituted paclitaxels
US5902822A (en) * 1997-02-28 1999-05-11 Bristol-Myers Squibb Company 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
HUP0101457A3 (en) 1997-12-31 2003-01-28 Bristol Myers Squibb Co Antitumor 2-aroyl-4-acyl paclitaxel analogs and medicaments containing them , their intermediates and method for producing them
HUP0202448A3 (en) * 1999-08-11 2005-02-28 Bristol Myers Squibb Co Process for preparation of paclitaxel c-4 methyl carbonate analog
EP1391459A1 (en) * 1999-08-11 2004-02-25 Bristol-Myers Squibb Company Process for the preparation of a paclitaxel C-4 methyl carbonate analog and intermediates
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
AU2001290636A1 (en) * 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
CZ2003837A3 (cs) 2000-09-22 2004-12-15 Bristol-Myers Squibb Company Způsob pro snížení toxicity při kombinovaných chemoterapiích
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
JP2006506338A (ja) 2002-08-04 2006-02-23 ナチュラル ファーマシュウティクルズ インク． タキサンアミドをパクリタキセルまたは他のタキサンに変換する方法および組成物
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
JP4499383B2 (ja) * 2003-07-11 2010-07-07 良明 木曽 水溶性プロドラッグ
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
WO2005087222A1 (en) 2004-03-05 2005-09-22 Florida State University Research Foundation, Inc. C7 lactyloxy-substituted taxanes
RS52438B (en) * 2005-03-31 2013-02-28 Accord Healthcare Inc. PREPARATION OF 9-DIHYDRO-13-ACETYLBACCATINE TAXAN III
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
WO2008122039A2 (en) 2007-04-02 2008-10-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selenocysteine mediated hybrid antibody molecules
WO2009023967A1 (en) * 2007-08-22 2009-02-26 6570763 Canada Inc. Process for converting 9-dihydro-13-acetylbaccatin iii into docetaxel or paclitaxel
EP2833905B1 (en) 2012-04-04 2018-05-02 Halozyme, Inc. Combination therapy with hyaluronidase and a tumor-targeted taxane
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
WO2014144715A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

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JPS55145650A (en) * 1979-04-28 1980-11-13 Nippon Kayaku Co Ltd Intermediate and its preparation
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
WO1985004876A1 (en) * 1984-04-24 1985-11-07 Takeda Chemical Industries, Ltd. 2-azetidinone derivatives and process for their preparation
JP2503994B2 (ja) * 1986-09-02 1996-06-05 味の素株式会社 オキサゾリンカルボン酸誘導体及びその製造法
DE3825242A1 (de) * 1987-07-27 1989-02-09 Ciba Geigy Ag Durch schwefelhaltige gruppen substituierte histidinylamino-verbindungen
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
JP2847584B2 (ja) * 1991-06-21 1999-01-20 高砂香料工業株式会社 シクロヘキシル酪酸誘導体及びその製造法
CA2418125C (en) * 1991-09-23 2007-12-04 Florida State University Beta-lactams useful in the preparation of substituted isoserine esters
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
KR0146931B1 (ko) * 1992-04-30 1998-08-17 고바야시 유끼오 옥사졸리딘 유도체 및 그의 약학적으로 허용가능한 염
MX9308012A (es) * 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.

Also Published As

Publication number Publication date
NO304521B1 (no) 1999-01-04
IL121542A0 (en) 1998-02-08
CN1590386A (zh) 2005-03-09
TW247908B (zh) 1995-05-21
DE69333905T2 (de) 2006-08-03
CZ146594A3 (en) 1995-06-14
AU679206B2 (en) 1997-06-26
KR100356448B1 (ko) 2002-10-19
ATE309229T1 (de) 2005-11-15
IL108161A0 (en) 1994-04-12
NO973256L (no) 1994-08-16
IL121542A (en) 2001-03-19
CN1235973A (zh) 1999-11-24
NO316071B1 (no) 2003-12-08
NO982744L (no) 1994-08-16
EP0626953A4 (en) 1995-05-03
CZ292993B6 (cs) 2004-01-14
HU225294B1 (en) 2006-09-28
WO1994014787A1 (en) 1994-07-07
AU697836B2 (en) 1998-10-15
CN1150178C (zh) 2004-05-19
HUT75195A (en) 1997-04-28
FI943852A0 (fi) 1994-08-22
AU3246497A (en) 1997-10-09
IL121541A0 (en) 1998-02-08
NO973254L (no) 1994-08-16
NO20033865D0 (no) 2003-09-01
JP2003113166A (ja) 2003-04-18
CA2119261A1 (en) 1994-06-24
DE69333905D1 (de) 2005-12-15
PL186176B1 (pl) 2003-11-28
CN1230542A (zh) 1999-10-06
NO973253D0 (no) 1997-07-14
AU6014694A (en) 1994-07-19
NO943021D0 (no) 1994-08-16
FI943852A (fi) 1994-08-22
IL108161A (en) 1999-03-12
HU0203995D0 (en) 2003-04-28
HK1048310A1 (en) 2003-03-28
IL122208A0 (en) 1998-04-05
FI20031464A (fi) 2003-10-07
NO943021L (no) 1994-08-16
IL145280A0 (en) 2002-06-30
NO982744D0 (no) 1998-06-15
EP1251127B1 (en) 2005-11-09
NO20033865L (no) 1994-08-16
NO973255D0 (no) 1997-07-14
DK1251127T3 (da) 2006-03-06
EP1251127A1 (en) 2002-10-23
NO973254D0 (no) 1997-07-14
FI115056B (fi) 2005-02-28
NO311217B1 (no) 2001-10-29
HU222175B1 (hu) 2003-04-28
KR100327625B1 (ko) 2002-11-07
NO314355B1 (no) 2003-03-10
IL121540A0 (en) 1998-02-08
AU715633B2 (en) 2000-02-10
JP3492690B2 (ja) 2004-02-03
NO973253L (no) 1994-08-16
NZ261070A (en) 1997-10-24
KR950700269A (ko) 1995-01-16
IL145280A (en) 2007-05-15
HK1048310B (zh) 2006-02-17
CN1089761C (zh) 2002-08-28
KR100378612B1 (ko) 2003-04-03
ZA939672B (en) 1995-06-23
HU9401449D0 (en) 1994-09-28
IL121539A0 (en) 1998-02-08
IL121540A (en) 2005-05-17
JPH07504444A (ja) 1995-05-18
AU3246397A (en) 1997-10-30
IL122209A0 (en) 1998-04-05
IL121539A (en) 2004-07-25
NO973255L (no) 1994-08-16
RU2125042C1 (ru) 1999-01-20
CA2119261C (en) 2006-01-31
CN1094725A (zh) 1994-11-09
NO973256D0 (no) 1997-07-14
ES2252362T3 (es) 2006-05-16
NO309426B1 (no) 2001-01-29
NO313802B1 (no) 2002-12-02
EP0626953A1 (en) 1994-12-07
CN1109026C (zh) 2003-05-21

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