IL117105A - Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL117105A
IL117105A IL117105A IL11710592A IL117105A IL 117105 A IL117105 A IL 117105A IL 117105 A IL117105 A IL 117105A IL 11710592 A IL11710592 A IL 11710592A IL 117105 A IL117105 A IL 117105A
Authority
IL
Israel
Prior art keywords
formula
compound
tetrahydrocarbazole
give
amino
Prior art date
Application number
IL117105A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL117105(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of IL117105A publication Critical patent/IL117105A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL117105A 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them IL117105A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments

Publications (1)

Publication Number Publication Date
IL117105A true IL117105A (en) 1998-01-04

Family

ID=10697363

Family Applications (4)

Application Number Title Priority Date Filing Date
IL117105A IL117105A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL117104A IL117104A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL11710596A IL117105A0 (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL117104A IL117104A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL11710596A IL117105A0 (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments

Country Status (34)

Country Link
US (2) US5464864A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0591280B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3261502B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100251571B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1034072C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AP (1) AP344A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE170746T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (2) BR9206237A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2113726C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (3) CZ282327B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE69226953T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0591280T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI103967B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB9113802D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU218907B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE922062A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (4) IL117105A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU90939I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MA (1) MA22563A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9203444A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL300103I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (2) NO304774B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ243288A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (3) PL169392B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT100620B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2137474C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SA (1) SA92130141B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG47877A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SI (1) SI9200125B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (3) SK280907B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW214544B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
UA (1) UA41254C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1993000086A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA924658B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
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US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
AU2002338726B2 (en) * 2001-09-28 2007-03-15 F. Hoffmann-La Roche Ag Pseudopolymorphic forms of carvedilol
RU2340619C2 (ru) 2002-06-21 2008-12-10 Сувен Лайф Сайенсиз Лимитед Новые тетрациклические арилсульфонилиндолы с аффинностью к серотониновым рецепторам, пригодные в качестве лекарственных средств, способ их получения и содержащие их фармацевтические композиции
ES2336664T3 (es) 2002-06-21 2010-04-15 Suven Life Sciences Limited Arilaquil indoles que tienen afinidad por receptores de serotonina utiles como agentes terapeuticos, procesos para su preparacion y composiciones farmaceuticas que los contienen.
AU2003237599B2 (en) 2002-11-28 2009-06-18 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
PT1567492E (pt) 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxi-indóis
KR100739987B1 (ko) 2002-12-18 2007-07-16 수벤 라이프 사이언시스 리미티드 세로토닌 수용체 친화력을 가지는 테트라사이클릭 3-치환인돌
RU2430088C2 (ru) * 2004-07-14 2011-09-27 Центарис Гмбх Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
JP5220013B2 (ja) * 2006-08-07 2013-06-26 アクテリオン ファーマシューティカルズ リミテッド （３−アミノ−１，２，３，４−テトラヒドロ−９ｈ−カルバゾール−９−イル）−酢酸誘導体
JP2010522135A (ja) 2006-10-09 2010-07-01 チャールストン ラボラトリーズ，インコーポレイテッド 医薬組成物
ES2691033T3 (es) 2007-02-11 2018-11-23 Map Pharmaceuticals Inc. Método de administración terapéutica de DHE para activar el alivio rápido de la migraña a la vez que se reduce al mínimo el perfil de los efectos secundarios
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
CA2905541C (en) 2008-01-09 2020-02-11 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
CA2767576C (en) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
WO2011050140A1 (en) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
EP2734634B1 (en) 2011-07-22 2019-08-21 The University of Chicago Igf-1 for use in the treatment of migraine
CA2895816C (en) 2012-12-21 2021-02-23 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
US10179109B2 (en) 2016-03-04 2019-01-15 Charleston Laboratories, Inc. Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
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US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
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EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
PL169392B1 (pl) 1996-07-31
NL300103I1 (nl) 2002-12-02
NO2005011I1 (no) 2005-05-18
SI9200125B (en) 2001-12-31
AU1977592A (en) 1993-01-25
DE69226953T2 (de) 1999-05-12
CA2113726A1 (en) 1993-01-07
NO934800L (no) 1993-12-23
TW214544B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-10-11
NL300103I2 (nl) 2003-02-03
EP0591280B1 (en) 1998-09-09
IL117104A (en) 1997-09-30
CZ150696A3 (en) 1997-06-11
CZ282083B6 (cs) 1997-05-14
CN1034072C (zh) 1997-02-19
DK0591280T3 (da) 1999-02-15
GB9113802D0 (en) 1991-08-14
NO934800D0 (no) 1993-12-23
EP0591280A1 (en) 1994-04-13
NO2005011I2 (no) 2008-02-11
IL117105A0 (en) 1996-06-18
SA92130141B1 (ar) 2005-12-18
WO1993000086A1 (en) 1993-01-07
FI935842A0 (fi) 1993-12-23
FI935842A7 (fi) 1993-12-23
FI103967B (fi) 1999-10-29
ATE170746T1 (de) 1998-09-15
HK1014669A1 (en) 1999-09-30
DE10299042I2 (de) 2005-02-03
CA2113726C (en) 2008-02-19
SK280905B6 (sk) 2000-09-12
HUT68961A (en) 1995-08-28
SK280907B6 (sk) 2000-09-12
IL102322A (en) 1997-09-30
SK280906B6 (sk) 2000-09-12
AP344A (en) 1994-07-05
PL169410B1 (pl) 1996-07-31
JPH06508827A (ja) 1994-10-06
US5637611A (en) 1997-06-10
MX9203444A (es) 1993-12-01
CN1069726A (zh) 1993-03-10
SG47877A1 (en) 1998-04-17
NO304774B1 (no) 1999-02-15
ZA924658B (en) 1993-12-24
DE69226953D1 (de) 1998-10-15
HU218907B (hu) 2000-12-28
DE10299042I1 (de) 2003-02-20
AP9200403A0 (en) 1992-07-31
FI103967B1 (fi) 1999-10-29
UA41254C2 (uk) 2001-09-17
IL102322A0 (en) 1993-01-14
BR9206237A (pt) 1995-04-11
KR100251571B1 (ko) 2000-07-01
JP3261502B2 (ja) 2002-03-04
CZ150596A3 (en) 1997-05-14
CZ282327B6 (cs) 1997-06-11
BR1100460A (pt) 2000-07-18
AU652842B2 (en) 1994-09-08
RU2137474C1 (ru) 1999-09-20
LU90939I2 (fr) 2002-09-24
PL171034B1 (en) 1997-02-28
MA22563A1 (fr) 1992-12-31
CZ286193A3 (en) 1994-07-13
SI9200125A (en) 1992-12-31
IL117104A0 (en) 1996-06-18
PT100620B (pt) 1999-01-29
PT100620A (pt) 1993-09-30
CZ282061B6 (cs) 1997-05-14
SK131993A3 (en) 1994-06-08
IE922062A1 (en) 1992-12-30
NZ243288A (en) 1994-09-27
US5464864A (en) 1995-11-07

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