IL101960A - 3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them - Google Patents

3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them

Info

Publication number
IL101960A
IL101960A IL10196092A IL10196092A IL101960A IL 101960 A IL101960 A IL 101960A IL 10196092 A IL10196092 A IL 10196092A IL 10196092 A IL10196092 A IL 10196092A IL 101960 A IL101960 A IL 101960A
Authority
IL
Israel
Prior art keywords
disorders
compound according
optionally substituted
substituted
alkyl
Prior art date
Application number
IL10196092A
Other languages
English (en)
Hebrew (he)
Other versions
IL101960A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL101960A0 publication Critical patent/IL101960A0/xx
Publication of IL101960A publication Critical patent/IL101960A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
IL10196092A 1991-05-22 1992-05-21 3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them IL101960A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14682691 1991-05-22

Publications (2)

Publication Number Publication Date
IL101960A0 IL101960A0 (en) 1994-04-12
IL101960A true IL101960A (en) 1999-03-12

Family

ID=15416402

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10196092A IL101960A (en) 1991-05-22 1992-05-21 3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them

Country Status (25)

Country Link
EP (1) EP0585328B1 (fr)
KR (1) KR100246065B1 (fr)
CN (1) CN1041827C (fr)
AT (1) ATE211743T1 (fr)
AU (1) AU658898B2 (fr)
BR (1) BR9206044A (fr)
CA (1) CA2109415C (fr)
CZ (1) CZ247993A3 (fr)
DE (2) DE9290057U1 (fr)
DK (1) DK0585328T3 (fr)
EG (1) EG20218A (fr)
ES (1) ES2168260T3 (fr)
FI (1) FI935134A (fr)
HU (1) HUT65771A (fr)
IE (1) IE921662A1 (fr)
IL (1) IL101960A (fr)
MX (1) MX9202449A (fr)
NO (1) NO305173B1 (fr)
NZ (2) NZ272941A (fr)
PL (4) PL171921B1 (fr)
PT (1) PT100514B (fr)
RU (1) RU2092486C1 (fr)
UA (1) UA26401C2 (fr)
WO (1) WO1992020676A1 (fr)
ZA (1) ZA923773B (fr)

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US5138060A (en) * 1991-01-03 1992-08-11 Pfizer Inc. Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
JPH07110850B2 (ja) * 1991-06-20 1995-11-29 フアイザー・インコーポレイテツド 窒素含有複素環化合物のフルオロアルコキシベンジルアミノ誘導体
JP2656702B2 (ja) * 1992-03-23 1997-09-24 ファイザー製薬株式会社 ペプチド性キヌクリジン
JP2909214B2 (ja) * 1992-08-19 1999-06-23 フアイザー・インコーポレイテツド 置換ベンジルアミノ窒素含有非芳香族複素環化合物
JP2656699B2 (ja) * 1992-10-21 1997-09-24 ファイザー製薬株式会社 置換ベンジルアミノキヌクリジン
US5837711A (en) * 1992-10-28 1998-11-17 Pfizer Inc. Substituted quinuclidines as substance P antagonists
JP2656700B2 (ja) * 1992-10-28 1997-09-24 ファイザー製薬株式会社 置換キヌクリジン誘導体
ES2147759T3 (es) * 1992-12-10 2000-10-01 Pfizer Heterociclos no aromaticos sustituidos con aminometileno y uso como antagonistas de la sustancia p.
IL109646A0 (en) * 1993-05-19 1994-08-26 Pfizer Heteroatom substituted alkyl benzylamino-quinuclidines
JP2822274B2 (ja) * 1993-05-19 1998-11-11 ファイザー製薬株式会社 Ｐ物質拮抗剤としてのヘテロ原子置換アルキルベンジルアミノキヌクリジン類
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
DE69413822T2 (de) * 1993-07-15 1999-02-25 Pfizer Benzyloxychinuclidine als substanz p antagonisten
PT719253E (pt) * 1993-09-17 2004-07-30 Pfizer Piperidinas 3-amino-5-carboxi-substituidas e pirrolidinas 3-amino-4-carboxi-substituidas como antagonistas de taquicinina
US6083943A (en) * 1993-09-17 2000-07-04 Pfizer Inc Substituted azaheterocyclecarboxylic acid
EP0653208A3 (fr) * 1993-11-17 1995-10-11 Pfizer Antagonistes de la substance P pour le traitement et la prévention de l'erythème solaire.
EP0659409A3 (fr) * 1993-11-23 1995-08-09 Pfizer Antagonistes de la substance P pour l'inhibition de l'angiogénése.
EP0655246A1 (fr) * 1993-11-30 1995-05-31 Pfizer Inc. Antagonistes de la substance P pour le traitement des maladies causées par Helicobacter Pylori ou d'autres bacteries spirales, ureare-positives, gram-négatives
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
PE8798A1 (es) * 1995-07-17 1998-03-02 Pfizer Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
MX9706944A (es) * 1996-09-12 1998-08-30 Pfizer Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.
NZ329807A (en) * 1997-04-23 2000-07-28 Pfizer NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome
EP1246806B1 (fr) 1999-11-03 2008-02-27 AMR Technology, Inc. Tetrahydroisoquinolines a substitution aryle et heteroaryle et utilisation de ces composes pour bloquer le recaptage de norepinephrine, de dopamine et de serotonine
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US6861526B2 (en) * 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
WO2006020049A2 (fr) 2004-07-15 2006-02-23 Amr Technology, Inc. Tetrahydroisoquinolines a substitution aryle et heteroaryle et leur utilisation pour bloquer le recaptage de la norepinephrine, la dopamine et la serotonine
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US7956050B2 (en) 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
JP4879988B2 (ja) 2005-09-29 2012-02-22 メルク・シャープ・エンド・ドーム・コーポレイション メラノコルチン−４受容体モジュレーターとしてのアシル化スピロピペリジン誘導体
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JP2011515343A (ja) 2008-03-03 2011-05-19 タイガー ファーマテック チロシンキナーゼ阻害薬
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DK2429296T3 (en) 2009-05-12 2018-03-12 Albany Molecular Res Inc 7 - ([1,2,4,] TRIAZOLO [1,5, -A] PYRIDIN-6-YL) -4- (3,4-DICHLORPHENYL) -1,2,3,4- TETRAHYDROISOQUINOLINE AND USE thereof
JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
US8859776B2 (en) 2009-10-14 2014-10-14 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
EP2584903B1 (fr) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk
JP6043285B2 (ja) 2010-08-02 2016-12-14 サーナ・セラピューティクス・インコーポレイテッドＳｉｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低分子干渉核酸（ｓｉＮＡ）を用いたカテニン（カドヘリン結合型タンパク質）β１（ＣＴＮＮＢ１）遺伝子発現のＲＮＡ干渉媒介性阻害
RU2624045C2 (ru) 2010-08-17 2017-06-30 Сирна Терапьютикс,Инк ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
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EP2613782B1 (fr) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Dérivés d'indazole utilisables en tant qu'inhibiteurs de la voie erk
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WO2012087772A1 (fr) 2010-12-21 2012-06-28 Schering Corporation Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
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Also Published As

Publication number Publication date
AU658898B2 (en) 1995-05-04
WO1992020676A1 (fr) 1992-11-26
DK0585328T3 (da) 2002-02-11
ES2168260T3 (es) 2002-06-16
PL170513B1 (en) 1996-12-31
HU9303307D0 (en) 1994-03-28
CZ247993A3 (en) 1994-07-13
ATE211743T1 (de) 2002-01-15
PL172069B1 (pl) 1997-07-31
CN1041827C (zh) 1999-01-27
PL170525B1 (en) 1996-12-31
EG20218A (en) 1997-11-30
FI935134A0 (fi) 1993-11-19
FI935134A (fi) 1993-11-19
CA2109415C (fr) 1998-12-29
UA26401C2 (uk) 1999-08-30
BR9206044A (pt) 1995-03-01
EP0585328B1 (fr) 2002-01-09
PT100514A (pt) 1993-09-30
HUT65771A (en) 1994-07-28
RU2092486C1 (ru) 1997-10-10
CN1068571A (zh) 1993-02-03
AU1927592A (en) 1992-12-30
PL171921B1 (pl) 1997-06-30
EP0585328A1 (fr) 1994-03-09
NZ272941A (en) 1997-05-26
DE9290057U1 (de) 1994-01-05
IL101960A0 (en) 1994-04-12
MX9202449A (es) 1993-03-01
NO934195D0 (no) 1993-11-19
ZA923773B (en) 1993-11-22
NO305173B1 (no) 1999-04-12
DE69232334D1 (de) 2002-02-14
CA2109415A1 (fr) 1992-11-23
NO934195L (no) 1993-11-19
PT100514B (pt) 1999-06-30
KR100246065B1 (en) 2000-04-01
NZ242880A (en) 1995-10-26
IE921662A1 (en) 1992-12-02
DE69232334T2 (de) 2002-11-14

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