ES2168260T3 - 3-aminoquinuclidinas sustituidas. - Google Patents

3-aminoquinuclidinas sustituidas.

Info

Publication number
ES2168260T3
ES2168260T3 ES92911350T ES92911350T ES2168260T3 ES 2168260 T3 ES2168260 T3 ES 2168260T3 ES 92911350 T ES92911350 T ES 92911350T ES 92911350 T ES92911350 T ES 92911350T ES 2168260 T3 ES2168260 T3 ES 2168260T3
Authority
ES
Spain
Prior art keywords
aminoquinuclidins
substituted
compounds
disorders
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92911350T
Other languages
English (en)
Inventor
Fumitaka Ito
Toshihide Kokura
Masami Nakane
Kunio Satake
Hiroaki Wakabayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2168260T3 publication Critical patent/ES2168260T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPUESTOS DE FORMULA (I), DONDE W, AR1, AR2 Y AR3 SE DEFINEN AQUI ABAJO; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE TALES COMPUESTOS. ESTOS COMPUESTOS SON ANTAGONISTAS P DE SUSTANCIA Y UTILES EN EL TRATAMIENTO DE TRASTORNOS GASTROINTESTINALES, TRASTORNOS INFLAMATORIOS, TRASTORNOS DE SISTEMA NERVIOSO Y DOLORES.
ES92911350T 1991-05-22 1992-05-19 3-aminoquinuclidinas sustituidas. Expired - Lifetime ES2168260T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14682691 1991-05-22

Publications (1)

Publication Number Publication Date
ES2168260T3 true ES2168260T3 (es) 2002-06-16

Family

ID=15416402

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92911350T Expired - Lifetime ES2168260T3 (es) 1991-05-22 1992-05-19 3-aminoquinuclidinas sustituidas.

Country Status (25)

Country Link
EP (1) EP0585328B1 (es)
KR (1) KR100246065B1 (es)
CN (1) CN1041827C (es)
AT (1) ATE211743T1 (es)
AU (1) AU658898B2 (es)
BR (1) BR9206044A (es)
CA (1) CA2109415C (es)
CZ (1) CZ247993A3 (es)
DE (2) DE69232334T2 (es)
DK (1) DK0585328T3 (es)
EG (1) EG20218A (es)
ES (1) ES2168260T3 (es)
FI (1) FI935134A (es)
HU (1) HUT65771A (es)
IE (1) IE921662A1 (es)
IL (1) IL101960A (es)
MX (1) MX9202449A (es)
NO (1) NO305173B1 (es)
NZ (2) NZ272941A (es)
PL (4) PL170513B1 (es)
PT (1) PT100514B (es)
RU (1) RU2092486C1 (es)
UA (1) UA26401C2 (es)
WO (1) WO1992020676A1 (es)
ZA (1) ZA923773B (es)

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UA39168C2 (uk) * 1991-06-20 2001-06-15 Пфайзер, Інк. Фторалкоксифенільні похідні піперидину або хінуклідину, що є антагоністами речовини p і фармацевтична композиція на їх основі
JP2656702B2 (ja) * 1992-03-23 1997-09-24 ファイザー製薬株式会社 ペプチド性キヌクリジン
AU4224993A (en) * 1992-08-19 1994-03-15 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
JP2656699B2 (ja) * 1992-10-21 1997-09-24 ファイザー製薬株式会社 置換ベンジルアミノキヌクリジン
US5837711A (en) * 1992-10-28 1998-11-17 Pfizer Inc. Substituted quinuclidines as substance P antagonists
JP2656700B2 (ja) * 1992-10-28 1997-09-24 ファイザー製薬株式会社 置換キヌクリジン誘導体
DE69328975T2 (de) * 1992-12-10 2000-11-09 Pfizer Inc., New York Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
JP2822274B2 (ja) * 1993-05-19 1998-11-11 ファイザー製薬株式会社 Ｐ物質拮抗剤としてのヘテロ原子置換アルキルベンジルアミノキヌクリジン類
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US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
DE69413822T2 (de) * 1993-07-15 1999-02-25 Pfizer Inc., New York, N.Y. Benzyloxychinuclidine als substanz p antagonisten
DE69433744T2 (de) * 1993-09-17 2004-10-14 Pfizer Inc. 3-amino-5-carboxy-substituierte piperidine und 3-amino-4-carboxy-substituierte pyrrolidine als tachykinin-antagonisten
US6083943A (en) * 1993-09-17 2000-07-04 Pfizer Inc Substituted azaheterocyclecarboxylic acid
EP0653208A3 (en) * 1993-11-17 1995-10-11 Pfizer Substance P antagonists for the treatment or prevention of sunburn.
EP0659409A3 (en) * 1993-11-23 1995-08-09 Pfizer Substance P antagonists for the inhibition of angiogenesis.
EP0655246A1 (en) * 1993-11-30 1995-05-31 Pfizer Inc. Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
PE8798A1 (es) * 1995-07-17 1998-03-02 Pfizer Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
MX9706944A (es) * 1996-09-12 1998-08-30 Pfizer Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.
NZ329807A (en) * 1997-04-23 2000-07-28 Pfizer NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome
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US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
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DOP2002000332A (es) 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
US6861526B2 (en) * 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
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US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
PL2109608T3 (pl) 2007-01-10 2011-08-31 Msd Italia Srl Indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy)-(PARP)
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KR20100126467A (ko) 2008-03-03 2010-12-01 타이거 파마테크 티로신 키나아제 억제제
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UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005525A1 (en) * 1988-11-23 1990-05-31 Pfizer Inc. Quinuclidine derivatives as substance p antagonists

Also Published As

Publication number Publication date
CN1068571A (zh) 1993-02-03
UA26401C2 (uk) 1999-08-30
DE9290057U1 (de) 1994-01-05
HUT65771A (en) 1994-07-28
ZA923773B (en) 1993-11-22
MX9202449A (es) 1993-03-01
EP0585328B1 (en) 2002-01-09
PL171921B1 (pl) 1997-06-30
FI935134A0 (fi) 1993-11-19
IL101960A0 (en) 1994-04-12
NO305173B1 (no) 1999-04-12
DE69232334D1 (de) 2002-02-14
KR100246065B1 (en) 2000-04-01
EP0585328A1 (en) 1994-03-09
PL172069B1 (pl) 1997-07-31
CN1041827C (zh) 1999-01-27
FI935134A (fi) 1993-11-19
PL170513B1 (en) 1996-12-31
BR9206044A (pt) 1995-03-01
HU9303307D0 (en) 1994-03-28
ATE211743T1 (de) 2002-01-15
AU1927592A (en) 1992-12-30
NZ272941A (en) 1997-05-26
EG20218A (en) 1997-11-30
NO934195D0 (no) 1993-11-19
IL101960A (en) 1999-03-12
PT100514B (pt) 1999-06-30
AU658898B2 (en) 1995-05-04
NO934195L (no) 1993-11-19
CZ247993A3 (en) 1994-07-13
DE69232334T2 (de) 2002-11-14
PL170525B1 (en) 1996-12-31
RU2092486C1 (ru) 1997-10-10
CA2109415C (en) 1998-12-29
CA2109415A1 (en) 1992-11-23
PT100514A (pt) 1993-09-30
IE921662A1 (en) 1992-12-02
DK0585328T3 (da) 2002-02-11
NZ242880A (en) 1995-10-26
WO1992020676A1 (en) 1992-11-26

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